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Volumn 158, Issue 6, 2009, Pages 1413-1425

Subtype-selective targeting of voltage-gated sodium channels

Author keywords

Local anaesthetic; Structural biology; Subtype selectivity; Toxin; Voltage gated sodium channel

Indexed keywords

VOLTAGE GATED SODIUM CHANNEL;

EID: 70350547576     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00437.x     Document Type: Review
Times cited : (100)

References (118)
  • 1
    • 33744920321 scopus 로고    scopus 로고
    • Brugada electrocardiographic pattern due to tricyclic antidepressant overdose
    • Akhtar M, Goldschlager NF (2006). Brugada electrocardiographic pattern due to tricyclic antidepressant overdose. J Electrocardiol 39 : 336 339.
    • (2006) J Electrocardiol , vol.39 , pp. 336-339
    • Akhtar, M.1    Goldschlager, N.F.2
  • 2
    • 0033363999 scopus 로고    scopus 로고
    • The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways
    • Akopian AN, Souslova V, England S, Okuse K, Ogata N, Ure J et al. (1999). The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci 2 : 541 548.
    • (1999) Nat Neurosci , vol.2 , pp. 541-548
    • Akopian, A.N.1    Souslova, V.2    England, S.3    Okuse, K.4    Ogata, N.5    Ure, J.6
  • 3
    • 40949095655 scopus 로고    scopus 로고
    • Guide to receptors and channels (GRAC), 3rd edition (2008 revision)
    • Suppl.
    • Alexander SPH, Mathie A, Peters JA (2008). Guide to receptors and channels (GRAC), 3rd edition (2008 revision). Br J Pharmacol 153 (Suppl. 2 S1 S209.
    • (2008) Br J Pharmacol , vol.153 , Issue.2
    • Alexander, S.P.H.1    Mathie, A.2    Peters, J.A.3
  • 5
    • 0031567882 scopus 로고    scopus 로고
    • Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose
    • Bolognesi R, Tsialtas D, Vasini P, Conti M, Manca C (1997). Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose. Am J Cardiol 79 : 242 245.
    • (1997) Am J Cardiol , vol.79 , pp. 242-245
    • Bolognesi, R.1    Tsialtas, D.2    Vasini, P.3    Conti, M.4    Manca, C.5
  • 6
    • 0020056644 scopus 로고
    • Characterization of antiarrhythmic drugs by alternating current induced arrhythmias in isolated heart tissues
    • Borchard U, Bösken R, Greeff K (1982). Characterization of antiarrhythmic drugs by alternating current induced arrhythmias in isolated heart tissues. Arch Int Pharmacodyn Ther 256 : 253 268.
    • (1982) Arch Int Pharmacodyn Ther , vol.256 , pp. 253-268
    • Borchard, U.1    Bösken, R.2    Greeff, K.3
  • 7
    • 31044432475 scopus 로고    scopus 로고
    • Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes
    • Bosmans F, Rash L, Zhu S, Diochot S, Lazdunski M, Escoubas P et al. (2006). Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes. Mol Pharmacol 69 : 419 429.
    • (2006) Mol Pharmacol , vol.69 , pp. 419-429
    • Bosmans, F.1    Rash, L.2    Zhu, S.3    Diochot, S.4    Lazdunski, M.5    Escoubas, P.6
  • 8
    • 0022556533 scopus 로고
    • 3H-batrachotoxinin-A benzoate binding to voltage-sensitive sodium channels: Inhibition by the channel blockers tetrodotoxin and saxitoxin
    • Brown GB (1986). 3H-batrachotoxinin-A benzoate binding to voltage-sensitive sodium channels: inhibition by the channel blockers tetrodotoxin and saxitoxin. J Neurosci 6 : 2064 2070.
    • (1986) J Neurosci , vol.6 , pp. 2064-2070
    • Brown, G.B.1
  • 9
    • 67449089458 scopus 로고    scopus 로고
    • Structural determinants of drugs acting on the nav1.8 channel
    • Browne LE, Blaney FE, Yusaf SP, Clare JJ, Wray D (2009). Structural determinants of drugs acting on the nav1.8 channel. J Biol Chem 284 : 10523 10536.
    • (2009) J Biol Chem , vol.284 , pp. 10523-10536
    • Browne, L.E.1    Blaney, F.E.2    Yusaf, S.P.3    Clare, J.J.4    Wray, D.5
  • 10
    • 0033929242 scopus 로고    scopus 로고
    • Spectrum of sodium channel disturbances in the nondystrophic myotonias and periodic paralyses
    • Cannon SC (2000). Spectrum of sodium channel disturbances in the nondystrophic myotonias and periodic paralyses. Kidney Int 57 : 772 779.
    • (2000) Kidney Int , vol.57 , pp. 772-779
    • Cannon, S.C.1
  • 11
    • 59149098688 scopus 로고    scopus 로고
    • First mutation in the voltage-gated Nav1.1 subunit gene SCN1A with co-occurring familial hemiplegic migraine and epilepsy
    • Castro MJ, Stam AH, Lemos C, de Vries B, Vanmolkot KR, Barros J et al. (2009). First mutation in the voltage-gated Nav1.1 subunit gene SCN1A with co-occurring familial hemiplegic migraine and epilepsy. Cephalalgia 29 : 308 313.
    • (2009) Cephalalgia , vol.29 , pp. 308-313
    • Castro, M.J.1    Stam, A.H.2    Lemos, C.3    De Vries, B.4    Vanmolkot, K.R.5    Barros, J.6
  • 12
    • 29844438166 scopus 로고    scopus 로고
    • International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels
    • Catterall WA, Goldin AL, Waxman SG (2005). International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev 57 : 397 409.
    • (2005) Pharmacol Rev , vol.57 , pp. 397-409
    • Catterall, W.A.1    Goldin, A.L.2    Waxman, S.G.3
  • 13
    • 58149326824 scopus 로고    scopus 로고
    • Inherited neuronal ion channelopathies: New windows on complex neurological diseases
    • Catterall WA, Dib-Hajj S, Meisler MH, Pietrobon D (2008). Inherited neuronal ion channelopathies: new windows on complex neurological diseases. J Neurosci 28 : 11768 11777.
    • (2008) J Neurosci , vol.28 , pp. 11768-11777
    • Catterall, W.A.1    Dib-Hajj, S.2    Meisler, M.H.3    Pietrobon, D.4
  • 14
    • 0031808799 scopus 로고    scopus 로고
    • Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site
    • Chahine M, Sirois J, Marcotte P, Chen L, Kallen RG (1998). Extrapore residues of the S5-S6 loop of domain 2 of the voltage-gated skeletal muscle sodium channel (rSkM1) contribute to the mu-conotoxin GIIIA binding site. Biophys J 75 : 236 246.
    • (1998) Biophys J , vol.75 , pp. 236-246
    • Chahine, M.1    Sirois, J.2    Marcotte, P.3    Chen, L.4    Kallen, R.G.5
  • 15
    • 40449087926 scopus 로고    scopus 로고
    • Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade
    • Cheng X, Dib-Hajj SD, Tyrrell L, Waxman SG (2008). Mutation I136V alters electrophysiological properties of the Na(v)1.7 channel in a family with onset of erythromelalgia in the second decade. Mol Pain 4 : 1.
    • (2008) Mol Pain , vol.4 , pp. 1
    • Cheng, X.1    Dib-Hajj, S.D.2    Tyrrell, L.3    Waxman, S.G.4
  • 16
    • 36448995359 scopus 로고    scopus 로고
    • High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor
    • Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS et al. (2007). High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science 318 : 1258 1265.
    • (2007) Science , vol.318 , pp. 1258-1265
    • Cherezov, V.1    Rosenbaum, D.M.2    Hanson, M.A.3    Rasmussen, S.G.4    Thian, F.S.5    Kobilka, T.S.6
  • 17
    • 0025349160 scopus 로고
    • Kinetic analysis of phasic inhibition of neuronal sodium currents by lidocaine and bupivacaine
    • Chernoff DM (1990). Kinetic analysis of phasic inhibition of neuronal sodium currents by lidocaine and bupivacaine. Biophys J 58 : 53 68.
    • (1990) Biophys J , vol.58 , pp. 53-68
    • Chernoff, D.M.1
  • 18
    • 0025324264 scopus 로고
    • Kinetics of local anesthetic inhibition of neuronal sodium currents. pH and hydrophobicity dependence
    • Chernoff DM, Strichartz GR (1990). Kinetics of local anesthetic inhibition of neuronal sodium currents. pH and hydrophobicity dependence. Biophys J 58 : 69 81.
    • (1990) Biophys J , vol.58 , pp. 69-81
    • Chernoff, D.M.1    Strichartz, G.R.2
  • 20
    • 0018245196 scopus 로고
    • The rates of interaction of local anesthetics with sodium channels in nerve
    • Courtney KR, Kendig JJ, Cohen EN (1978). The rates of interaction of local anesthetics with sodium channels in nerve. J Pharmacol Exp Ther 207 : 594 604.
    • (1978) J Pharmacol Exp Ther , vol.207 , pp. 594-604
    • Courtney, K.R.1    Kendig, J.J.2    Cohen, E.N.3
  • 22
    • 0037737799 scopus 로고    scopus 로고
    • Binding of the anticonvulsant drug lamotrigine and the neurotoxin batrachotoxin to voltage-gated sodium channels induces conformational changes associated with block and steady-state activation
    • Cronin NB, O'Reilly A, Duclohier H, Wallace BA (2003). Binding of the anticonvulsant drug lamotrigine and the neurotoxin batrachotoxin to voltage-gated sodium channels induces conformational changes associated with block and steady-state activation. J Biol Chem 278 : 10675 10682.
    • (2003) J Biol Chem , vol.278 , pp. 10675-10682
    • Cronin, N.B.1    O'Reilly, A.2    Duclohier, H.3    Wallace, B.A.4
  • 23
    • 0036237688 scopus 로고    scopus 로고
    • Critical molecular determinants of voltage-gated sodium channel sensitivity to mu-conotoxins GIIIA/B
    • Cummins TR, Aglieco F, Dib-Hajj SD (2002). Critical molecular determinants of voltage-gated sodium channel sensitivity to mu-conotoxins GIIIA/B. Mol Pharmacol 61 : 1192 1201.
    • (2002) Mol Pharmacol , vol.61 , pp. 1192-1201
    • Cummins, T.R.1    Aglieco, F.2    Dib-Hajj, S.D.3
  • 24
    • 4644268452 scopus 로고    scopus 로고
    • Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy
    • Cummins TR, Dib-Hajj SD, Waxman SG (2004). Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy. J Neurosci 24 : 8232 8236.
    • (2004) J Neurosci , vol.24 , pp. 8232-8236
    • Cummins, T.R.1    Dib-Hajj, S.D.2    Waxman, S.G.3
  • 25
    • 37249050304 scopus 로고    scopus 로고
    • Trafficking and cellular distribution of voltage-gated sodium channels
    • Cusdin FS, Clare JJ, Jackson AP (2008). Trafficking and cellular distribution of voltage-gated sodium channels. Traffic 9 : 17 26.
    • (2008) Traffic , vol.9 , pp. 17-26
    • Cusdin, F.S.1    Clare, J.J.2    Jackson, A.P.3
  • 26
    • 0035150579 scopus 로고    scopus 로고
    • Interictal spikes in focal epileptogenesis
    • De Curtis M, Avanzini G (2001). Interictal spikes in focal epileptogenesis. Prog Neurobiol 63 (5 541 567.
    • (2001) Prog Neurobiol , vol.63 , Issue.5 , pp. 541-567
    • De Curtis, M.1    Avanzini, G.2
  • 27
    • 0000282772 scopus 로고
    • A case of congenital pure analgesia
    • Dearborn GVN (1932). A case of congenital pure analgesia. Nerv Ment Dis 75 : 612 615.
    • (1932) Nerv Ment Dis , vol.75 , pp. 612-615
    • Dearborn, G.V.N.1
  • 28
    • 0032723079 scopus 로고    scopus 로고
    • Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain
    • Dib-Hajj SD, Fjell J, Cummins TR, Zheng Z, Fried K, LaMotte R et al. (1999). Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain. Pain 83 : 591 600.
    • (1999) Pain , vol.83 , pp. 591-600
    • Dib-Hajj, S.D.1    Fjell, J.2    Cummins, T.R.3    Zheng, Z.4    Fried, K.5    Lamotte, R.6
  • 31
    • 0026773355 scopus 로고
    • Clinical characteristics and pathophysiology of erythromelalgia and erythermalgia
    • Drenth JP, Michiels JJ (1992). Clinical characteristics and pathophysiology of erythromelalgia and erythermalgia. Am J Med 93 : 111 114.
    • (1992) Am J Med , vol.93 , pp. 111-114
    • Drenth, J.P.1    Michiels, J.J.2
  • 32
    • 41149172710 scopus 로고    scopus 로고
    • Primary erythermalgia as a sodium channelopathy: Screening for SCN9A mutations: Exclusion of a causal role of SCN10A and SCN11A
    • Drenth JP, Te Morsche RH, Mansour S, Mortimer PS (2008). Primary erythermalgia as a sodium channelopathy: screening for SCN9A mutations: exclusion of a causal role of SCN10A and SCN11A. Arch Dermatol 144 : 320 324.
    • (2008) Arch Dermatol , vol.144 , pp. 320-324
    • Drenth, J.P.1    Te Morsche, R.H.2    Mansour, S.3    Mortimer, P.S.4
  • 33
    • 44649119304 scopus 로고    scopus 로고
    • Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain
    • Drizin I, Gregg RJ, Scanio MJ, Shi L, Gross MF, Atkinson RN et al. (2008). Discovery of potent furan piperazine sodium channel blockers for treatment of neuropathic pain. Bioorg Med Chem 16 : 6379 6386.
    • (2008) Bioorg Med Chem , vol.16 , pp. 6379-6386
    • Drizin, I.1    Gregg, R.J.2    Scanio, M.J.3    Shi, L.4    Gross, M.F.5    Atkinson, R.N.6
  • 34
    • 64249125023 scopus 로고    scopus 로고
    • Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides
    • Du Y, Lee JE, Nomura Y, Zhang T, Zhorov BS, Dong K (2009). Identification of a cluster of residues in transmembrane segment 6 of domain III of the cockroach sodium channel essential for the action of pyrethroid insecticides. Biochem J 419 : 377 385.
    • (2009) Biochem J , vol.419 , pp. 377-385
    • Du, Y.1    Lee, J.E.2    Nomura, Y.3    Zhang, T.4    Zhorov, B.S.5    Dong, K.6
  • 35
    • 0026011647 scopus 로고
    • Mortality and morbidity in patients receiving encainide, flecainide, or placebo. the Cardiac Arrhythmia Suppression Trial
    • Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH et al. (1991). Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial. N Engl J Med 324 : 781 788.
    • (1991) N Engl J Med , vol.324 , pp. 781-788
    • Echt, D.S.1    Liebson, P.R.2    Mitchell, L.B.3    Peters, R.W.4    Obias-Manno, D.5    Barker, A.H.6
  • 36
    • 33750941949 scopus 로고    scopus 로고
    • MuO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits
    • Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mould J et al. (2006). muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proc Natl Acad Sci USA 103 : 17030 17035.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 17030-17035
    • Ekberg, J.1    Jayamanne, A.2    Vaughan, C.W.3    Aslan, S.4    Thomas, L.5    Mould, J.6
  • 37
    • 33847168937 scopus 로고    scopus 로고
    • SCN9A mutations in paroxysmal extreme pain disorder: Allelic variants underlie distinct channel defects and phenotypes
    • Fertleman CR, Baker MD, Parker KA, Moffatt S, Elmslie FV, Abrahamsen B et al. (2006). SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. Neuron 52 : 767 774.
    • (2006) Neuron , vol.52 , pp. 767-774
    • Fertleman, C.R.1    Baker, M.D.2    Parker, K.A.3    Moffatt, S.4    Elmslie, F.V.5    Abrahamsen, B.6
  • 39
    • 44249086114 scopus 로고    scopus 로고
    • Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7
    • Fiedler B, Zhang MM, Buczek O, Azam L, Bulaj G, Norton RS et al. (2008). Specificity, affinity and efficacy of iota-conotoxin RXIA, an agonist of voltage-gated sodium channels Na(V)1.2, 1.6 and 1.7. Biochem Pharmacol 75 : 2334 2344.
    • (2008) Biochem Pharmacol , vol.75 , pp. 2334-2344
    • Fiedler, B.1    Zhang, M.M.2    Buczek, O.3    Azam, L.4    Bulaj, G.5    Norton, R.S.6
  • 40
    • 0013050469 scopus 로고
    • Congenital universal insensitiveness to pain. A clinical report of three cases in children with discussion of the literature
    • Ford FR, Wilkins L (1938). Congenital universal insensitiveness to pain. A clinical report of three cases in children with discussion of the literature. Bull Johns Hopkins Hosp 62 : 448 446.
    • (1938) Bull Johns Hopkins Hosp , vol.62 , pp. 448-446
    • Ford, F.R.1    Wilkins, L.2
  • 41
    • 22944453069 scopus 로고    scopus 로고
    • Mechanism of local anesthetic drug action on voltage-gated sodium channels
    • Fozzard HA, Lee PJ, Lipkind GM (2005). Mechanism of local anesthetic drug action on voltage-gated sodium channels. Curr Pharm Des 11 : 2671 2686.
    • (2005) Curr Pharm des , vol.11 , pp. 2671-2686
    • Fozzard, H.A.1    Lee, P.J.2    Lipkind, G.M.3
  • 42
    • 0344672944 scopus 로고    scopus 로고
    • Mutations of sodium channel alpha subunit type 1 (SCN1A) in intractable childhood epilepsies with frequent generalized tonic-clonic seizures
    • Fujiwara T, Sugawara T, Mazaki-Miyazaki E, Takahashi Y, Fukushima K, Watanabe M et al. (2003). Mutations of sodium channel alpha subunit type 1 (SCN1A) in intractable childhood epilepsies with frequent generalized tonic-clonic seizures. Brain 126 : 531 546.
    • (2003) Brain , vol.126 , pp. 531-546
    • Fujiwara, T.1    Sugawara, T.2    Mazaki-Miyazaki, E.3    Takahashi, Y.4    Fukushima, K.5    Watanabe, M.6
  • 43
    • 34247874778 scopus 로고    scopus 로고
    • Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations
    • Goldberg YP, MacFarlane J, MacDonald ML, Thompson J, Dube MP, Mattice M et al. (2007). Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations. Clin Genet 71 : 311 319.
    • (2007) Clin Genet , vol.71 , pp. 311-319
    • Goldberg, Y.P.1    MacFarlane, J.2    MacDonald, M.L.3    Thompson, J.4    Dube, M.P.5    Mattice, M.6
  • 44
    • 0037118293 scopus 로고    scopus 로고
    • Overdose of cyclic antidepressants and the Brugada syndrome
    • Goldgran-Toledano D, Sideris G, Kevorkian JP (2002). Overdose of cyclic antidepressants and the Brugada syndrome. N Engl J Med 346 : 1591 1592.
    • (2002) N Engl J Med , vol.346 , pp. 1591-1592
    • Goldgran-Toledano, D.1    Sideris, G.2    Kevorkian, J.P.3
  • 45
    • 67650066369 scopus 로고    scopus 로고
    • Early- and late-onset inherited erythromelalgia: Genotype-phenotype correlation
    • Han C, Dib-Hajj SD, Lin Z, Li Y, Eastman EM, Tyrrell L et al. (2009). Early- and late-onset inherited erythromelalgia: genotype-phenotype correlation. Brain 132 : 1711 1722.
    • (2009) Brain , vol.132 , pp. 1711-1722
    • Han, C.1    Dib-Hajj, S.D.2    Lin, Z.3    Li, Y.4    Eastman, E.M.5    Tyrrell, L.6
  • 46
    • 70350542247 scopus 로고
    • Spinal anesthesia with nupercaine and procaine: A comparative study
    • Harris A, Goldberg LG (1931). Spinal anesthesia with nupercaine and procaine: a comparative study. Ann Surg 94 : 934 938.
    • (1931) Ann Surg , vol.94 , pp. 934-938
    • Harris, A.1    Goldberg, L.G.2
  • 48
    • 0017332486 scopus 로고
    • Local anesthetics: Hydrophilic and hydrophobic pathways for the drug-receptor reaction
    • Hille B (1977). Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol 69 : 497 515.
    • (1977) J Gen Physiol , vol.69 , pp. 497-515
    • Hille, B.1
  • 50
    • 0029076187 scopus 로고
    • Congenital indifference to pain: Long-term follow-up of two cases
    • Hirsch E, Moye D, Dimon JH 3rd. (1995). Congenital indifference to pain: long-term follow-up of two cases. South Med J 88 : 851 857.
    • (1995) South Med J , vol.88 , pp. 851-857
    • Hirsch, E.1    Moye, D.2    Dimon III, J.H.3
  • 51
    • 0029743181 scopus 로고    scopus 로고
    • Na+ channel subunits and Ig domains
    • Isom LL, Catterall WA (1996). Na+ channel subunits and Ig domains. Nature 383 : 307 308.
    • (1996) Nature , vol.383 , pp. 307-308
    • Isom, L.L.1    Catterall, W.A.2
  • 52
    • 51749085389 scopus 로고    scopus 로고
    • Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation
    • Jarecki BW, Sheets PL, Jackson JO 2nd., Cummins TR (2008). Paroxysmal extreme pain disorder mutations within the D3/S4-S5 linker of Nav1.7 cause moderate destabilization of fast inactivation. J Physiol 586 : 4137 4153.
    • (2008) J Physiol , vol.586 , pp. 4137-4153
    • Jarecki, B.W.1    Sheets, P.L.2    Jackson II, J.O.3    Cummins, T.R.4
  • 53
    • 34347213786 scopus 로고    scopus 로고
    • A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
    • Jarvis MF, Honore P, Shieh CC, Chapman M, Joshi S, Zhang XF et al. (2007). A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat. Proc Natl Acad Sci USA 104 : 8520 8525.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 8520-8525
    • Jarvis, M.F.1    Honore, P.2    Shieh, C.C.3    Chapman, M.4    Joshi, S.5    Zhang, X.F.6
  • 54
    • 0016196463 scopus 로고
    • Kinetics and steady-state properties of the charged system controlling sodium conductance in the squid giant axon
    • Keynes RD, Rojas E (1974). Kinetics and steady-state properties of the charged system controlling sodium conductance in the squid giant axon. J Physiol 239 : 393 434.
    • (1974) J Physiol , vol.239 , pp. 393-434
    • Keynes, R.D.1    Rojas, E.2
  • 55
    • 64349101308 scopus 로고    scopus 로고
    • Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion
    • Khoo KK, Feng ZP, Smith BJ, Zhang MM, Yoshikami D, Olivera BM et al. (2009). Structure of the analgesic mu-conotoxin KIIIA and effects on the structure and function of disulfide deletion. Biochemistry 48 : 1210 1219.
    • (2009) Biochemistry , vol.48 , pp. 1210-1219
    • Khoo, K.K.1    Feng, Z.P.2    Smith, B.J.3    Zhang, M.M.4    Yoshikami, D.5    Olivera, B.M.6
  • 56
    • 4344645978 scopus 로고    scopus 로고
    • Can the pharmaceutical industry reduce attrition rates?
    • Kola I, Landis J (2004). Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Disc 3 : 711 715.
    • (2004) Nat Rev Drug Disc , vol.3 , pp. 711-715
    • Kola, I.1    Landis, J.2
  • 57
    • 39149092391 scopus 로고    scopus 로고
    • Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain
    • Kort ME, Drizin I, Gregg RJ, Scanio MJ, Shi L, Gross MF et al. (2008). Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain. J Med Chem 51 : 407 416.
    • (2008) J Med Chem , vol.51 , pp. 407-416
    • Kort, M.E.1    Drizin, I.2    Gregg, R.J.3    Scanio, M.J.4    Shi, L.5    Gross, M.F.6
  • 58
    • 0030787547 scopus 로고    scopus 로고
    • Characterization of lamotrigine inhibition of Na+ channels in rat hippocampal neurones
    • Kuo CC, Lu L (1997). Characterization of lamotrigine inhibition of Na+ channels in rat hippocampal neurones. Br J Pharmacol 121 : 1231 1238.
    • (1997) Br J Pharmacol , vol.121 , pp. 1231-1238
    • Kuo, C.C.1    Lu, L.2
  • 59
    • 33745594600 scopus 로고    scopus 로고
    • The distribution and targeting of neuronal voltage-gated ion channels
    • Lai HC, Jan LY (2006). The distribution and targeting of neuronal voltage-gated ion channels. Nat Rev Neurosci 7 : 548 562.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 548-562
    • Lai, H.C.1    Jan, L.Y.2
  • 60
    • 0032733781 scopus 로고    scopus 로고
    • Blockade of neuropathic pain by antisense targeting of tetrodotoxin-resistant sodium channels in sensory neurons
    • Lai J, Hunter JC, Ossipov MH, Porreca F (2000). Blockade of neuropathic pain by antisense targeting of tetrodotoxin-resistant sodium channels in sensory neurons. Methods Enzymol 314 : 201 213.
    • (2000) Methods Enzymol , vol.314 , pp. 201-213
    • Lai, J.1    Hunter, J.C.2    Ossipov, M.H.3    Porreca, F.4
  • 61
    • 33847158419 scopus 로고    scopus 로고
    • Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels
    • Lewis RJ, Schroeder CI, Ekberg J, Nielsen KJ, Loughnan M, Thomas L et al. (2007). Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels. Mol Pharmacol 71 : 676 685.
    • (2007) Mol Pharmacol , vol.71 , pp. 676-685
    • Lewis, R.J.1    Schroeder, C.I.2    Ekberg, J.3    Nielsen, K.J.4    Loughnan, M.5    Thomas, L.6
  • 62
    • 33845927150 scopus 로고    scopus 로고
    • Solution structure and functional characterization of jingzhaotoxin-XI: A novel gating modifier of both potassium and sodium channels
    • Liao Z, Yuan C, Deng M, Li J, Chen J, Yang Y et al. (2006). Solution structure and functional characterization of jingzhaotoxin-XI: a novel gating modifier of both potassium and sodium channels. Biochemistry 45 : 15591 15600.
    • (2006) Biochemistry , vol.45 , pp. 15591-15600
    • Liao, Z.1    Yuan, C.2    Deng, M.3    Li, J.4    Chen, J.5    Yang, Y.6
  • 63
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski CA, Lombardo F, Dominy BW, Feeney PJ (1997). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 23 : 3 25.
    • (1997) Adv Drug Deliv Rev , vol.23 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 64
    • 0028055161 scopus 로고
    • A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel
    • Lipkind GM, Fozzard HA (1994). A structural model of the tetrodotoxin and saxitoxin binding site of the Na+ channel. Biophys J 66 : 1 13.
    • (1994) Biophys J , vol.66 , pp. 1-13
    • Lipkind, G.M.1    Fozzard, H.A.2
  • 65
    • 27844589940 scopus 로고    scopus 로고
    • Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels
    • Lipkind GM, Fozzard HA (2005). Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels. Mol Pharmacol 68 : 1611 1622.
    • (2005) Mol Pharmacol , vol.68 , pp. 1611-1622
    • Lipkind, G.M.1    Fozzard, H.A.2
  • 67
    • 23244456428 scopus 로고    scopus 로고
    • Crystal structure of a mammalian voltage-dependent Shaker family K+ channel
    • Long SB, Campbell EB, Mackinnon R (2005). Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science 309 : 897 903.
    • (2005) Science , vol.309 , pp. 897-903
    • Long, S.B.1    Campbell, E.B.2    MacKinnon, R.3
  • 68
    • 36248982122 scopus 로고    scopus 로고
    • Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment
    • Long SB, Tao X, Campbell EB, MacKinnon R (2007). Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature 450 : 376 382.
    • (2007) Nature , vol.450 , pp. 376-382
    • Long, S.B.1    Tao, X.2    Campbell, E.B.3    MacKinnon, R.4
  • 70
    • 0347479237 scopus 로고    scopus 로고
    • Epilepsy-associated dysfunction in the voltage-gated neuronal sodium channel SCN1A
    • Lossin C, Rhodes TH, Desai RR, Vanoye CG, Wang D, Carniciu S et al. (2003). Epilepsy-associated dysfunction in the voltage-gated neuronal sodium channel SCN1A. J Neurosci 23 : 11289 11295.
    • (2003) J Neurosci , vol.23 , pp. 11289-11295
    • Lossin, C.1    Rhodes, T.H.2    Desai, R.R.3    Vanoye, C.G.4    Wang, D.5    Carniciu, S.6
  • 71
    • 84916775015 scopus 로고
    • The relative sensitivity of muscle nerve fibres to procaine
    • Matthews PB, Rushworth G (1957). The relative sensitivity of muscle nerve fibres to procaine. J Physiol 135 : 263 269.
    • (1957) J Physiol , vol.135 , pp. 263-269
    • Matthews, P.B.1    Rushworth, G.2
  • 72
    • 23644439941 scopus 로고    scopus 로고
    • Sodium channel mutations in epilepsy and other neurological disorders
    • Meisler MH, Kearney JA (2005). Sodium channel mutations in epilepsy and other neurological disorders. J Clin Invest 115 : 2010 2017.
    • (2005) J Clin Invest , vol.115 , pp. 2010-2017
    • Meisler, M.H.1    Kearney, J.A.2
  • 73
    • 51249105941 scopus 로고    scopus 로고
    • Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures
    • Misra SN, Kahlig KM, George AL Jr. (2008). Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures. Epilepsia 49 : 1535 1545.
    • (2008) Epilepsia , vol.49 , pp. 1535-1545
    • Misra, S.N.1    Kahlig, K.M.2    George, Jr.A.L.3
  • 75
    • 0037316882 scopus 로고    scopus 로고
    • Congenital insensitivity to pain: An update
    • Nagasako EM, Oaklander AL, Dworkin RH (2003). Congenital insensitivity to pain: an update. Pain 101 : 213 219.
    • (2003) Pain , vol.101 , pp. 213-219
    • Nagasako, E.M.1    Oaklander, A.L.2    Dworkin, R.H.3
  • 76
    • 29144494740 scopus 로고    scopus 로고
    • Genetic testing in the long QT syndrome: Development and validation of an efficient approach to genotyping in clinical practice
    • Napolitano C, Priori SG, Schwartz PJ, Bloise R, Ronchetti E, Nastoli J et al. (2005). Genetic testing in the long QT syndrome: development and validation of an efficient approach to genotyping in clinical practice. JAMA 294 : 2975 2980.
    • (2005) JAMA , vol.294 , pp. 2975-2980
    • Napolitano, C.1    Priori, S.G.2    Schwartz, P.J.3    Bloise, R.4    Ronchetti, E.5    Nastoli, J.6
  • 79
    • 33845187874 scopus 로고    scopus 로고
    • Neuropathic pain develops normally in mice lacking both Nav1.7 and Nav1.8
    • Nassar MA, Levato A, Stirling LC, Wood JN (2005). Neuropathic pain develops normally in mice lacking both Nav1.7 and Nav1.8. Mol Pain 1 : 24.
    • (2005) Mol Pain , vol.1 , pp. 24
    • Nassar, M.A.1    Levato, A.2    Stirling, L.C.3    Wood, J.N.4
  • 80
    • 33751014049 scopus 로고    scopus 로고
    • Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice
    • Nassar MA, Baker MD, Levato A, Ingram R, Mallucci G, McMahon SB et al. (2006). Nerve injury induces robust allodynia and ectopic discharges in Nav1.3 null mutant mice. Mol Pain 2 : 33.
    • (2006) Mol Pain , vol.2 , pp. 33
    • Nassar, M.A.1    Baker, M.D.2    Levato, A.3    Ingram, R.4    Mallucci, G.5    McMahon, S.B.6
  • 81
    • 11244253209 scopus 로고    scopus 로고
    • Interactions of local anesthetics with voltage-gated Na+ channels
    • Nau C, Wang GK (2004). Interactions of local anesthetics with voltage-gated Na+ channels. J Membr Biol 201 : 1 8.
    • (2004) J Membr Biol , vol.201 , pp. 1-8
    • Nau, C.1    Wang, G.K.2
  • 82
    • 33847416219 scopus 로고    scopus 로고
    • Insect-selective spider toxins targeting voltage-gated sodium channels
    • Nicholson GM (2007). Insect-selective spider toxins targeting voltage-gated sodium channels. Toxicon 49 : 490 512.
    • (2007) Toxicon , vol.49 , pp. 490-512
    • Nicholson, G.M.1
  • 84
    • 48649087167 scopus 로고    scopus 로고
    • Tetrameric bacterial sodium channels: Characterization of structure, stability, and drug binding
    • Nurani G, Radford M, Charalambous K, O'Reilly AO, Cronin NB, Haque S et al. (2008). Tetrameric bacterial sodium channels: characterization of structure, stability, and drug binding. Biochemistry 47 : 8114 8121.
    • (2008) Biochemistry , vol.47 , pp. 8114-8121
    • Nurani, G.1    Radford, M.2    Charalambous, K.3    O'Reilly, A.O.4    Cronin, N.B.5    Haque, S.6
  • 85
    • 34249791771 scopus 로고    scopus 로고
    • Na(v)1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: A circuit basis for epileptic seizures in mice carrying an Sc1a gene mutation
    • Ogiwara I, Miyamoto H, Morita N, Atapour N, Mazaki E, Inoue I et al. (2007). Na(v)1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Sc1a gene mutation. J Neurosci 27 : 5903 5914.
    • (2007) J Neurosci , vol.27 , pp. 5903-5914
    • Ogiwara, I.1    Miyamoto, H.2    Morita, N.3    Atapour, N.4    Mazaki, E.5    Inoue, I.6
  • 86
    • 0022541472 scopus 로고
    • Effects of antiepileptic drugs on pentylenetetrazole-induced epileptiform activity in the in vitro hippocampus
    • Piredda S, Yonekawa W, Whittingham TS, Kupferberg HJ (1986). Effects of antiepileptic drugs on pentylenetetrazole-induced epileptiform activity in the in vitro hippocampus. Epilepsia 27 : 341 346.
    • (1986) Epilepsia , vol.27 , pp. 341-346
    • Piredda, S.1    Yonekawa, W.2    Whittingham, T.S.3    Kupferberg, H.J.4
  • 88
    • 0021288483 scopus 로고
    • Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by local anesthetics
    • Postma SW, Catterall WA (1984). Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by local anesthetics. Mol Pharmacol 25 : 219 227.
    • (1984) Mol Pharmacol , vol.25 , pp. 219-227
    • Postma, S.W.1    Catterall, W.A.2
  • 89
    • 21544455502 scopus 로고    scopus 로고
    • Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior
    • Priest BT, Murphy BA, Lindia JA, Diaz C, Abbadie C, Ritter AM et al. (2005). Contribution of the tetrodotoxin-resistant voltage-gated sodium channel NaV1.9 to sensory transmission and nociceptive behavior. Proc Natl Acad Sci U S A 102 : 9382 9387.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 9382-9387
    • Priest, B.T.1    Murphy, B.A.2    Lindia, J.A.3    Diaz, C.4    Abbadie, C.5    Ritter, A.M.6
  • 90
    • 45649085478 scopus 로고    scopus 로고
    • How do mutant Nav1.1 sodium channels cause epilepsy?
    • Ragsdale DS (2008). How do mutant Nav1.1 sodium channels cause epilepsy? Brain Res Rev 58 : 149 159.
    • (2008) Brain Res Rev , vol.58 , pp. 149-159
    • Ragsdale, D.S.1
  • 91
    • 0027944683 scopus 로고
    • Molecular determinants of state-dependent block of Na+ channels by local anesthetics
    • Ragsdale DS, McPhee JC, Scheuer T, Catterall WA (1994). Molecular determinants of state-dependent block of Na+ channels by local anesthetics. Science 265 : 1724 1728.
    • (1994) Science , vol.265 , pp. 1724-1728
    • Ragsdale, D.S.1    McPhee, J.C.2    Scheuer, T.3    Catterall, W.A.4
  • 92
    • 0029787945 scopus 로고    scopus 로고
    • Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels
    • Ragsdale DS, McPhee JC, Scheuer T, Catterall WA (1996). Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels. Proc Natl Acad Sci USA 93 : 9270 9275.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9270-9275
    • Ragsdale, D.S.1    McPhee, J.C.2    Scheuer, T.3    Catterall, W.A.4
  • 96
    • 0035143625 scopus 로고    scopus 로고
    • Transient ST-segment elevation in right precordial leads induced by psychotropic drugs: Relationship to Brugada syndrome
    • Rouleau F, Asfar P, Boulet S, Dube L, Dupuis JM, Alquier P et al. (2001). Transient ST-segment elevation in right precordial leads induced by psychotropic drugs: relationship to Brugada syndrome. J Cardiovasc Electrophysiol 12 : 61 65.
    • (2001) J Cardiovasc Electrophysiol , vol.12 , pp. 61-65
    • Rouleau, F.1    Asfar, P.2    Boulet, S.3    Dube, L.4    Dupuis, J.M.5    Alquier, P.6
  • 97
    • 0035931906 scopus 로고    scopus 로고
    • The voltage-sensitive sodium channel is a bell-shaped molecule with several cavities
    • Sato C, Ueno Y, Asai K, Takahashi K, Sato M, Engel A et al. (2001). The voltage-sensitive sodium channel is a bell-shaped molecule with several cavities. Nature 409 : 1047 1051.
    • (2001) Nature , vol.409 , pp. 1047-1051
    • Sato, C.1    Ueno, Y.2    Asai, K.3    Takahashi, K.4    Sato, M.5    Engel, A.6
  • 98
    • 54349114035 scopus 로고    scopus 로고
    • ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors
    • Schmalhofer WA, Calhoun J, Burrows R, Bailey T, Kohler MG, Weinglass AB et al. (2008). ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors. Mol Pharmacol 74 : 1476 1484.
    • (2008) Mol Pharmacol , vol.74 , pp. 1476-1484
    • Schmalhofer, W.A.1    Calhoun, J.2    Burrows, R.3    Bailey, T.4    Kohler, M.G.5    Weinglass, A.B.6
  • 99
    • 0026488158 scopus 로고
    • Familial rectal pain: A type of reflex epilepsy?
    • Schubert R, Cracco JB (1992). Familial rectal pain: a type of reflex epilepsy? Ann Neurol 32 : 824 826.
    • (1992) Ann Neurol , vol.32 , pp. 824-826
    • Schubert, R.1    Cracco, J.B.2
  • 100
    • 1442356568 scopus 로고    scopus 로고
    • Sodium channel gene (SCN5A) mutations in 44 index patients with Brugada syndrome: Different incidences in familial and sporadic disease
    • Schulze-Bahr E, Eckardt L, Breithardt G, Seidl K, Wichter T, Wolpert C et al. (2003). Sodium channel gene (SCN5A) mutations in 44 index patients with Brugada syndrome: different incidences in familial and sporadic disease. Hum Mutat 21 : 651 652.
    • (2003) Hum Mutat , vol.21 , pp. 651-652
    • Schulze-Bahr, E.1    Eckardt, L.2    Breithardt, G.3    Seidl, K.4    Wichter, T.5    Wolpert, C.6
  • 101
    • 56049102613 scopus 로고    scopus 로고
    • Models of the structure and gating mechanisms of the pore domain of the NaChBac ion channel
    • Shafrir Y, Durell SR, Guy HR (2008a). Models of the structure and gating mechanisms of the pore domain of the NaChBac ion channel. Biophys J 95 : 3650 3662.
    • (2008) Biophys J , vol.95 , pp. 3650-3662
    • Shafrir, Y.1    Durell, S.R.2    Guy, H.R.3
  • 102
    • 56049083760 scopus 로고    scopus 로고
    • Models of voltage-dependent conformational changes in NaChBac channels
    • Shafrir Y, Durell SR, Guy HR (2008b). Models of voltage-dependent conformational changes in NaChBac channels. Biophys J 95 : 3663 3676.
    • (2008) Biophys J , vol.95 , pp. 3663-3676
    • Shafrir, Y.1    Durell, S.R.2    Guy, H.R.3
  • 103
    • 63849342117 scopus 로고    scopus 로고
    • The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking
    • Sharkey LM, Cheng X, Drews V, Buchner DA, Jones JM, Justice MJ et al. (2009). The ataxia3 mutation in the N-terminal cytoplasmic domain of sodium channel Na(v)1.6 disrupts intracellular trafficking. J Neurosci 29 : 2733 2741.
    • (2009) J Neurosci , vol.29 , pp. 2733-2741
    • Sharkey, L.M.1    Cheng, X.2    Drews, V.3    Buchner, D.A.4    Jones, J.M.5    Justice, M.J.6
  • 105
    • 33745281204 scopus 로고    scopus 로고
    • Heterozygosity for a protein truncation mutation of sodium channel SCN8A in a patient with cerebellar atrophy, ataxia, and mental retardation
    • Trudeau MM, Dalton JC, Day JW, Ranum LP, Meisler MH (2006). Heterozygosity for a protein truncation mutation of sodium channel SCN8A in a patient with cerebellar atrophy, ataxia, and mental retardation. J Med Genet 43 : 527 530.
    • (2006) J Med Genet , vol.43 , pp. 527-530
    • Trudeau, M.M.1    Dalton, J.C.2    Day, J.W.3    Ranum, L.P.4    Meisler, M.H.5
  • 107
    • 33845567864 scopus 로고    scopus 로고
    • Polarized distribution of ion channels within microdomains of the axon initial segment
    • Van Wart A, Trimmer JS, Matthews G (2007). Polarized distribution of ion channels within microdomains of the axon initial segment. J Comp Neurol 500 : 339 352.
    • (2007) J Comp Neurol , vol.500 , pp. 339-352
    • Van Wart, A.1    Trimmer, J.S.2    Matthews, G.3
  • 108
    • 47749089321 scopus 로고    scopus 로고
    • Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a
    • Vega AV, Henry DL, Matthews G (2008). Reduced expression of Na(v)1.6 sodium channels and compensation by Na(v)1.2 channels in mice heterozygous for a null mutation in Scn8a. Neurosci Lett 442 : 69 73.
    • (2008) Neurosci Lett , vol.442 , pp. 69-73
    • Vega, A.V.1    Henry, D.L.2    Matthews, G.3
  • 110
    • 17344367657 scopus 로고    scopus 로고
    • Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B
    • Wallace RH, Wang DW, Singh R, Scheffer IE, George AL Jr., Phillips HA et al. (1998). Febrile seizures and generalized epilepsy associated with a mutation in the Na+-channel beta1 subunit gene SCN1B. Nat Genet 19 : 366 370.
    • (1998) Nat Genet , vol.19 , pp. 366-370
    • Wallace, R.H.1    Wang, D.W.2    Singh, R.3    Scheffer, I.E.4    George, Jr.A.L.5    Phillips, H.A.6
  • 112
    • 0027933696 scopus 로고
    • Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy
    • Waxman SG, Kocsis JD, Black JA (1994). Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy. J Neurophysiol 72 : 466 470.
    • (1994) J Neurophysiol , vol.72 , pp. 466-470
    • Waxman, S.G.1    Kocsis, J.D.2    Black, J.A.3
  • 113
    • 37249070254 scopus 로고    scopus 로고
    • Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7
    • Williams BS, Felix JP, Priest BT, Brochu RM, Dai K, Hoyt SB et al. (2007). Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1.7. Biochemistry 46 : 14693 14703.
    • (2007) Biochemistry , vol.46 , pp. 14693-14703
    • Williams, B.S.1    Felix, J.P.2    Priest, B.T.3    Brochu, R.M.4    Dai, K.5    Hoyt, S.B.6
  • 114
    • 0020334077 scopus 로고
    • Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine
    • Willow M, Catterall WA (1982). Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol 22 : 627 635.
    • (1982) Mol Pharmacol , vol.22 , pp. 627-635
    • Willow, M.1    Catterall, W.A.2
  • 115
    • 55249117019 scopus 로고    scopus 로고
    • Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain II voltage sensor in the closed configuration
    • Xiao Y, Bingham JP, Zhu W, Moczydlowski E, Liang S, Cummins TR (2008). Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain II voltage sensor in the closed configuration. J Biol Chem 283 : 27300 27313.
    • (2008) J Biol Chem , vol.283 , pp. 27300-27313
    • Xiao, Y.1    Bingham, J.P.2    Zhu, W.3    Moczydlowski, E.4    Liang, S.5    Cummins, T.R.6
  • 116
    • 33748115786 scopus 로고    scopus 로고
    • Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy
    • Yu FH, Mantegazza M, Westenbroek RE, Robbins CA, Kalume F, Burton KA et al. (2006). Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nat Neurosci 9 : 1142 1149.
    • (2006) Nat Neurosci , vol.9 , pp. 1142-1149
    • Yu, F.H.1    Mantegazza, M.2    Westenbroek, R.E.3    Robbins, C.A.4    Kalume, F.5    Burton, K.A.6
  • 117
    • 1842422868 scopus 로고    scopus 로고
    • A gating hinge in Na+ channels; A molecular switch for electrical signaling
    • Zhao Y, Yarov-Yarovoy V, Scheuer T, Catterall WA (2004). A gating hinge in Na+ channels; a molecular switch for electrical signaling. Neuron 41 : 859 865.
    • (2004) Neuron , vol.41 , pp. 859-865
    • Zhao, Y.1    Yarov-Yarovoy, V.2    Scheuer, T.3    Catterall, W.A.4
  • 118
    • 61849156873 scopus 로고    scopus 로고
    • SCN5A channelopathies- An update on mutations and mechanisms
    • Zimmer T, Surber R (2008). SCN5A channelopathies- An update on mutations and mechanisms. Prog Biophys Mol Biol 98 : 120 136.
    • (2008) Prog Biophys Mol Biol , vol.98 , pp. 120-136
    • Zimmer, T.1    Surber, R.2


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