Substituted biaryl pyrazoles as sodium channel blockers

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 18, 2010, Pages 5480-5483

  Tyagarajan, Sriram ^a   Chakravarty, Prasun K ^a   Zhou, Bishan ^a   Taylor, Brett ^a   Fisher, Michael H ^a   Wyvratt, Mathew J ^a   Lyons, Kathy ^a   Klatt, Tracy ^a   Li, Xiaohua ^a   Kumar, Sanjeev ^a   Williams, Brande ^a   Felix, John ^a   Priest, Birgit T ^a   Brochu, Richard M ^a   Warren, Vivien ^a   Smith, McHardy ^a   Garcia, Maria ^a   Kaczorowski, Gregory J ^a   Martin, William J ^a   Abbadie, Catherine ^a   McGowan, Erin ^a   Jochnowitz, Nina ^a   Parsons, William H ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Biaryl pyrazoles; Chung model; Nav1.7 blockers; Neuropathic pain; Voltage gated sodium channel

Indexed keywords

AMIDE; AMITRIPTYLINE; BIPHENYL 5 CARBOXAMIDE 1H PYRAZOLE; BIPHENYL PYRAZOLE CARBOXAMIDE; CARBAMAZEPINE; DILTIAZEM; GABAPENTIN; LAMOTRIGINE; LIDOCAINE; MEXILETINE; PYRAZOLE CARBOXAMIDE; PYRAZOLE DERIVATIVE; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DESIGN; DRUG EFFICACY; DRUG HALF LIFE; DRUG POTENCY; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; LIVER MICROSOME; MOLECULAR WEIGHT; NEUROPATHIC PAIN; NONHUMAN; RAT;

ANIMALS; DOGS; HAPLORHINI; HUMANS; MICROSOMES, LIVER; NEURALGIA; PYRAZOLES; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956170618     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.080     Document Type: Article

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