Phenoxyphenyl pyridines as novel state-dependent, high-potency sodium channel inhibitors

Journal of Medicinal Chemistry

Volumn 47, Issue 17, 2004, Pages 4277-4285

  Shao, Bin ^a,b   Victory, Sam ^a   Ilyin, Victor I ^a   Goehring, R Richard ^a   Sun, Qun ^a   Hogenkamp, Derk ^a,c   Hodges, Diane D ^a,d   Islam, Khondaker ^a   Sha, Deyou ^a   Zhang, Chongwu ^a   Nguyen, Phong ^a,d   Robledo, Silvia ^a,d   Sakellaropoulos, George ^a,e   Carter, Richard B ^a,f  

^a Purdue Pharma Discovery Research   (United States)

^b PURDUE PHARMA L P   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ALLERGAN INC   (United States)

^e UNIVERSITY OF TORONTO   (Canada)

^f NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

6 [4 (4 FLUOROPHENOXY)PHENYL] 4 MORPHOLIN 4 YLPYRIDINE 2 CARBOXYLIC ACID AMIDE; 6 [4 (4 FLUOROPHENOXY)PHENYL]PYRIDINE 2 CARBOXYLIC ACID AMIDE; BENZALDEHYDE DERIVATIVE; CARBAMAZEPINE; LAMOTRIGINE; PYRIDINE DERIVATIVE; SEMICARBAZIDE DERIVATIVE; SODIUM CHANNEL BLOCKING AGENT; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; HUMAN; HUMAN CELL; MALE; NEUROPATHIC PAIN; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANALGESICS; ANIMALS; ANIMALS, NEWBORN; BRAIN; CELL LINE; HUMANS; MALE; NERVE TISSUE PROTEINS; PAIN; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM DISEASES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 3843101697     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040048d     Document Type: Article

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