메뉴 건너뛰기




Volumn 24, Issue 20, 2004, Pages 4832-4839

Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury

Author keywords

Dorsal horn; Ion channel; Neuropathy; Pain; Sensitization; Wide dynamic range

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; MESSENGER RNA; PROTEIN; SODIUM CHANNEL;

EID: 2442651551     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0300-04.2004     Document Type: Article
Times cited : (232)

References (48)
  • 1
    • 0017181505 scopus 로고
    • Chronic changes in the response of cells in adult cat dorsal horn following partial deafferentation: The appearance of responding cells in a previously non-responsive region
    • Basbaum AI, Wall PD (1976) Chronic changes in the response of cells in adult cat dorsal horn following partial deafferentation: the appearance of responding cells in a previously non-responsive region. Brain Res 116:181-204.
    • (1976) Brain Res , vol.116 , pp. 181-204
    • Basbaum, A.I.1    Wall, P.D.2
  • 2
    • 0024810594 scopus 로고
    • Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development
    • Beckh S, Noda M, Lubbert H, Numa S (1989) Differential regulation of three sodium channel messenger RNAs in the rat central nervous system during development. EMBO J 8:3611-3616.
    • (1989) EMBO J , vol.8 , pp. 3611-3616
    • Beckh, S.1    Noda, M.2    Lubbert, H.3    Numa, S.4
  • 3
    • 0023895875 scopus 로고
    • A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man
    • Bennett GJ, Xie YK (1988) A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33:87-107.
    • (1988) Pain , vol.33 , pp. 87-107
    • Bennett, G.J.1    Xie, Y.K.2
  • 5
    • 0030758723 scopus 로고    scopus 로고
    • NGF has opposing effects on Na+ channel III and SNS gene expression in spinal sensory neurons
    • Black JA, Langworthy K, Hinson AW, Dib-Hajj SD, Waxman SG (1997) NGF has opposing effects on Na+ channel III and SNS gene expression in spinal sensory neurons. NeuroReport 8:2331-2335.
    • (1997) NeuroReport , vol.8 , pp. 2331-2335
    • Black, J.A.1    Langworthy, K.2    Hinson, A.W.3    Dib-Hajj, S.D.4    Waxman, S.G.5
  • 8
    • 0024576754 scopus 로고
    • Intrathecal fentanyl depresses nociceptive flexion reflexes in patients with chronic pain
    • Chabal C, Jacobson L, Little J (1989) Intrathecal fentanyl depresses nociceptive flexion reflexes in patients with chronic pain. Anesthesiology 70:226-229.
    • (1989) Anesthesiology , vol.70 , pp. 226-229
    • Chabal, C.1    Jacobson, L.2    Little, J.3
  • 10
    • 0030997916 scopus 로고    scopus 로고
    • Down-regulation of tetrodotoxin-resistant sodium currents and up-regulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons following nerve injury
    • Cummins TR, Waxman SG (1997) Down-regulation of tetrodotoxin-resistant sodium currents and up-regulation of a rapidly repriming tetrodotoxin-sensitive sodium current in small spinal sensory neurons following nerve injury. J Neurosci 17:3503-3514.
    • (1997) J Neurosci , vol.17 , pp. 3503-3514
    • Cummins, T.R.1    Waxman, S.G.2
  • 11
    • 0035882277 scopus 로고    scopus 로고
    • Nav1.3 sodium channels: Rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons
    • Cummins TR, Aglieco F, Renganathan M, Herzog RI, Dib-Hajj SD, Waxman SG (2001) Nav1.3 sodium channels: rapid repriming and slow closed-state inactivation display quantitative differences after expression in a mammalian cell line and in spinal sensory neurons. J Neurosci 21:5952-5961.
    • (2001) J Neurosci , vol.21 , pp. 5952-5961
    • Cummins, T.R.1    Aglieco, F.2    Renganathan, M.3    Herzog, R.I.4    Dib-Hajj, S.D.5    Waxman, S.G.6
  • 12
    • 0024361770 scopus 로고
    • Na+ channel accumulation on axolemma of afferent endings in nerve end neuromas in Apteronotus
    • Devor M, Keller CH, Deerinck TJ, Levinson SR, Ellisman MH (1989) Na+ channel accumulation on axolemma of afferent endings in nerve end neuromas in Apteronotus. Neurosci Lett 102:149-154.
    • (1989) Neurosci Lett , vol.102 , pp. 149-154
    • Devor, M.1    Keller, C.H.2    Deerinck, T.J.3    Levinson, S.R.4    Ellisman, M.H.5
  • 13
    • 0026565417 scopus 로고
    • Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction
    • Devor M, Wall PD, Catalan N (1992) Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction. Pain 48:261-268.
    • (1992) Pain , vol.48 , pp. 261-268
    • Devor, M.1    Wall, P.D.2    Catalan, N.3
  • 14
    • 0029907091 scopus 로고    scopus 로고
    • Down-regulation of transcripts for Na channel alpha-SNS in spinal sensory neurons following axotomy
    • Dib-Hajj S, Black JA, Felts P, Waxman SG (1996) Down-regulation of transcripts for Na channel alpha-SNS in spinal sensory neurons following axotomy. Proc Natl Acad Sci USA 93:14950-14954.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14950-14954
    • Dib-Hajj, S.1    Black, J.A.2    Felts, P.3    Waxman, S.G.4
  • 15
    • 0032723079 scopus 로고    scopus 로고
    • Plasticity of sodium channel expression in DRG neurons in the chronic constriction model of neuropathic pain
    • Dib-Hajj SD, Fjell J, Cummins TR, Zheng Z, Fried K, LaMotte R, Black JA, Waxman SG (1999) Plasticity of sodium channel expression in DRG neurons in the chronic constriction model of neuropathic pain. Pain 83:591-600.
    • (1999) Pain , vol.83 , pp. 591-600
    • Dib-Hajj, S.D.1    Fjell, J.2    Cummins, T.R.3    Zheng, Z.4    Fried, K.5    LaMotte, R.6    Black, J.A.7    Waxman, S.G.8
  • 16
    • 0030853718 scopus 로고    scopus 로고
    • Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli
    • Dirig DM, Salami A, Rathbun ML, Ozaki GT, Yaksh TL (1997) Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli. J Neurosci Methods 76:183-191.
    • (1997) J Neurosci Methods , vol.76 , pp. 183-191
    • Dirig, D.M.1    Salami, A.2    Rathbun, M.L.3    Ozaki, G.T.4    Yaksh, T.L.5
  • 17
    • 0018867072 scopus 로고
    • Efficient analysis of experimental observations
    • Dixon WJ (1980) Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol 20:441-462.
    • (1980) Annu Rev Pharmacol Toxicol , vol.20 , pp. 441-462
    • Dixon, W.J.1
  • 18
    • 0031127498 scopus 로고    scopus 로고
    • Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): Different expression patterns in developing rat nervous system
    • Felts PA, Yokoyama S, Dib-Hajj S, Black JA, Waxman SG (1997) Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): different expression patterns in developing rat nervous system. Brain Res Mol Brain Res 45:71-82.
    • (1997) Brain Res Mol Brain Res , vol.45 , pp. 71-82
    • Felts, P.A.1    Yokoyama, S.2    Dib-Hajj, S.3    Black, J.A.4    Waxman, S.G.5
  • 19
    • 0018127665 scopus 로고
    • Ongoing activity in severed nerves: Source and variation with time
    • Govrin-Lippmann R, Devor M (1978) Ongoing activity in severed nerves: source and variation with time. Brain Res 159:406-410.
    • (1978) Brain Res , vol.159 , pp. 406-410
    • Govrin-Lippmann, R.1    Devor, M.2
  • 20
    • 0037110631 scopus 로고    scopus 로고
    • Primary motor neurons fail to up-regulate voltage-gated sodium channel Na(v)1.3/brain type III following axotomy resulting from spinal cord injury
    • Hains BC, Black JA, Waxman SG (2002) Primary motor neurons fail to up-regulate voltage-gated sodium channel Na(v)1.3/brain type III following axotomy resulting from spinal cord injury. J Neurosci Res 70:546-552.
    • (2002) J Neurosci Res , vol.70 , pp. 546-552
    • Hains, B.C.1    Black, J.A.2    Waxman, S.G.3
  • 21
    • 0037470570 scopus 로고    scopus 로고
    • Engraftment of serotonergic precursors amends hyperexcitability of dorsal horn neurons after spinal hemisection-induced central sensitization
    • Hains BC, Eaton MJ, Willis WD, Hulsebosch CE (2003a) Engraftment of serotonergic precursors amends hyperexcitability of dorsal horn neurons after spinal hemisection-induced central sensitization. Neuroscience 116:1097-1110.
    • (2003) Neuroscience , vol.116 , pp. 1097-1110
    • Hains, B.C.1    Eaton, M.J.2    Willis, W.D.3    Hulsebosch, C.E.4
  • 22
    • 0037466347 scopus 로고    scopus 로고
    • Temporal plasticity of dorsal horn somatosensory neurons after acute and chronic spinal cord hemisection in rat
    • Hains BC, Willis WD, Hulsebosch CE (2003b) Temporal plasticity of dorsal horn somatosensory neurons after acute and chronic spinal cord hemisection in rat. Brain Res 970:238-241.
    • (2003) Brain Res , vol.970 , pp. 238-241
    • Hains, B.C.1    Willis, W.D.2    Hulsebosch, C.E.3
  • 23
    • 0141529982 scopus 로고    scopus 로고
    • Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury
    • Hains BC, Klein JP, Saab CY, Craner MJ, Black JA, Waxman SG (2003c) Upregulation of sodium channel Nav1.3 and functional involvement in neuronal hyperexcitability associated with central neuropathic pain after spinal cord injury. J Neurosci 23:8881-8892.
    • (2003) J Neurosci , vol.23 , pp. 8881-8892
    • Hains, B.C.1    Klein, J.P.2    Saab, C.Y.3    Craner, M.J.4    Black, J.A.5    Waxman, S.G.6
  • 24
    • 0030580562 scopus 로고    scopus 로고
    • Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts
    • Ibuki T, Hama AT, Wang XT, Pappas GD, Sagen J (1997) Loss of GABA-immunoreactivity in the spinal dorsal horn of rats with peripheral nerve injury and promotion of recovery by adrenal medullary grafts. Neuroscience 76:845-858.
    • (1997) Neuroscience , vol.76 , pp. 845-858
    • Ibuki, T.1    Hama, A.T.2    Wang, X.T.3    Pappas, G.D.4    Sagen, J.5
  • 26
    • 0028158052 scopus 로고
    • Distinct regulation of sodium channel types I, II and III following nerve transection
    • Iwahashi Y, Furuyama T, Inagaki S, Morita Y, Takagi H (1994) Distinct regulation of sodium channel types I, II and III following nerve transection. Brain Res Mol Brain Res 22:341-345.
    • (1994) Brain Res Mol Brain Res , vol.22 , pp. 341-345
    • Iwahashi, Y.1    Furuyama, T.2    Inagaki, S.3    Morita, Y.4    Takagi, H.5
  • 27
    • 0026572227 scopus 로고
    • Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat
    • Kajander KC, Wakisaka S, Bennett GJ (1992) Spontaneous discharge originates in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat. Neurosci Lett 138:225-228.
    • (1992) Neurosci Lett , vol.138 , pp. 225-228
    • Kajander, K.C.1    Wakisaka, S.2    Bennett, G.J.3
  • 28
    • 0035500407 scopus 로고    scopus 로고
    • The changes in expression of three subtypes of TTX sensitive sodium channels in sensory neurons after spinal nerve ligation
    • Kim CH, Oh Y, Chung JM, Chung K (2001) The changes in expression of three subtypes of TTX sensitive sodium channels in sensory neurons after spinal nerve ligation. Brain Res Mol Brain Res 95:153-161.
    • (2001) Brain Res Mol Brain Res , vol.95 , pp. 153-161
    • Kim, C.H.1    Oh, Y.2    Chung, J.M.3    Chung, K.4
  • 29
    • 0032951898 scopus 로고    scopus 로고
    • Alteration of Na+ currents in dorsal root ganglion neurons from rats with a painful neuropathy
    • Kral MG, Xiong Z, Study RE (1999) Alteration of Na+ currents in dorsal root ganglion neurons from rats with a painful neuropathy. Pain 81:15-24.
    • (1999) Pain , vol.81 , pp. 15-24
    • Kral, M.G.1    Xiong, Z.2    Study, R.E.3
  • 30
    • 0027238585 scopus 로고
    • An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy
    • Laird JM, Bennett GJ (1993) An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy. J Neurophysiol 69:2072-2085.
    • (1993) J Neurophysiol , vol.69 , pp. 2072-2085
    • Laird, J.M.1    Bennett, G.J.2
  • 31
    • 0036337021 scopus 로고    scopus 로고
    • GDNF and NGF reverse changes in repriming of TTX-sensitive Na+ currents following axotomy of dorsal root ganglion neurons
    • Leffler A, Cummins TR, Dib-Hajj SD, Hormuzdiar WN, Black JA, Waxman SG (2002) GDNF and NGF reverse changes in repriming of TTX-sensitive Na+ currents following axotomy of dorsal root ganglion neurons. J Neurophysiol 88:650-658.
    • (2002) J Neurophysiol , vol.88 , pp. 650-658
    • Leffler, A.1    Cummins, T.R.2    Dib-Hajj, S.D.3    Hormuzdiar, W.N.4    Black, J.A.5    Waxman, S.G.6
  • 32
    • 0028068798 scopus 로고
    • Hyperexcitability at sites of nerve injury depends on voltage-sensitive Na+ channels
    • Matzner O, Devor M (1994) Hyperexcitability at sites of nerve injury depends on voltage-sensitive Na+ channels. J Neurophysiol 72:349-359.
    • (1994) J Neurophysiol , vol.72 , pp. 349-359
    • Matzner, O.1    Devor, M.2
  • 34
    • 0030840239 scopus 로고    scopus 로고
    • QX-314 inhibits ectopic nerve activity associated with neuropathic pain
    • Omana-Zapata I, Khabbaz MA, Hunter JC, Bley KR (1997) QX-314 inhibits ectopic nerve activity associated with neuropathic pain. Brain Res 771:228-237.
    • (1997) Brain Res , vol.771 , pp. 228-237
    • Omana-Zapata, I.1    Khabbaz, M.A.2    Hunter, J.C.3    Bley, K.R.4
  • 35
    • 0026751792 scopus 로고
    • Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy
    • Palecek J, Paleckova V, Dougherty PM, Carlton SM, Willis WD (1992) Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy. J Neurophysiol 67:1562-1573.
    • (1992) J Neurophysiol , vol.67 , pp. 1562-1573
    • Palecek, J.1    Paleckova, V.2    Dougherty, P.M.3    Carlton, S.M.4    Willis, W.D.5
  • 36
    • 0030831490 scopus 로고    scopus 로고
    • Successful treatment of painful traumatic mononeuropathy with carbamazepine: Insights into a possible molecular pain mechanism
    • Rizzo MA (1997) Successful treatment of painful traumatic mononeuropathy with carbamazepine: insights into a possible molecular pain mechanism. J Neurol Sci 152:103-106.
    • (1997) J Neurol Sci , vol.152 , pp. 103-106
    • Rizzo, M.A.1
  • 37
    • 0029279185 scopus 로고
    • Selective loss of slow and enhancement of fast Na+ currents in cutaneous afferent dorsal root ganglion neurones following axotomy
    • Rizzo MA, Kocsis JD, Waxman SG (1995) Selective loss of slow and enhancement of fast Na+ currents in cutaneous afferent dorsal root ganglion neurones following axotomy. Neurobiol Dis 2:87-96.
    • (1995) Neurobiol Dis , vol.2 , pp. 87-96
    • Rizzo, M.A.1    Kocsis, J.D.2    Waxman, S.G.3
  • 38
    • 0019479305 scopus 로고
    • Development of ongoing activity, mechanosensitivity, and adrenaline sensitivity in severed peripheral nerve axons
    • Scadding JW (1981) Development of ongoing activity, mechanosensitivity, and adrenaline sensitivity in severed peripheral nerve axons. Exp Neurol 73:345-364.
    • (1981) Exp Neurol , vol.73 , pp. 345-364
    • Scadding, J.W.1
  • 39
    • 0037012780 scopus 로고    scopus 로고
    • Dorsal horn synaptosomal content of aspartate, glutamate, glycine and GABA are differentially altered following chronic constriction injury to the rat sciatic nerve
    • Somers DL, Clemente FR (2002) Dorsal horn synaptosomal content of aspartate, glutamate, glycine and GABA are differentially altered following chronic constriction injury to the rat sciatic nerve. Neurosci Lett 323:171-174.
    • (2002) Neurosci Lett , vol.323 , pp. 171-174
    • Somers, D.L.1    Clemente, F.R.2
  • 40
    • 0034049215 scopus 로고    scopus 로고
    • Contribution of central sensitization to the pain-related abnormal activity in neuropathic rats
    • Sotgiu ML, Biella G (2000) Contribution of central sensitization to the pain-related abnormal activity in neuropathic rats. Somatosens Mot Res 17:32-38.
    • (2000) Somatosens Mot Res , vol.17 , pp. 32-38
    • Sotgiu, M.L.1    Biella, G.2
  • 41
    • 0029954479 scopus 로고    scopus 로고
    • Release of gamma-aminobutyric acid in the dorsal horn and suppression of tactile allodynia by spinal cord stimulation in mononeuropathic rats
    • Stiller CO, Cui JG, O'Connor WT, Brodin E, Meyerson BA, Linderoth B (1996) Release of gamma-aminobutyric acid in the dorsal horn and suppression of tactile allodynia by spinal cord stimulation in mononeuropathic rats. Neurosurgery 39:367-375.
    • (1996) Neurosurgery , vol.39 , pp. 367-375
    • Stiller, C.O.1    Cui, J.G.2    O'Connor, W.T.3    Brodin, E.4    Meyerson, B.A.5    Linderoth, B.6
  • 42
    • 0030152343 scopus 로고    scopus 로고
    • Spontaneous action potential activity in isolated dorsal root ganglion neurons from rats with a painful neuropathy
    • Study RE, Kral MG (1996) Spontaneous action potential activity in isolated dorsal root ganglion neurons from rats with a painful neuropathy. Pain 65:235-242.
    • (1996) Pain , vol.65 , pp. 235-242
    • Study, R.E.1    Kral, M.G.2
  • 43
    • 0021015545 scopus 로고
    • Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats
    • Wall PD, Devor M (1983) Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats. Pain 17:321-339.
    • (1983) Pain , vol.17 , pp. 321-339
    • Wall, P.D.1    Devor, M.2
  • 44
    • 0016319790 scopus 로고
    • Properties of afferent nerve impulses originating from a neuroma
    • Wall PD, Gutnick M (1974) Properties of afferent nerve impulses originating from a neuroma. Nature 248:740-743.
    • (1974) Nature , vol.248 , pp. 740-743
    • Wall, P.D.1    Gutnick, M.2
  • 45
    • 0027933696 scopus 로고
    • Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy
    • Waxman SG, Kocsis JD, Black JA (1994) Type III sodium channel mRNA is expressed in embryonic but not adult spinal sensory neurons, and is reexpressed following axotomy. J Neurophysiol 72:466-471.
    • (1994) J Neurophysiol , vol.72 , pp. 466-471
    • Waxman, S.G.1    Kocsis, J.D.2    Black, J.A.3
  • 46
    • 0021014399 scopus 로고
    • Evidence for a central component of post-injury pain hypersensitivity
    • Woolf CJ (1983) Evidence for a central component of post-injury pain hypersensitivity. Nature 306:686-688.
    • (1983) Nature , vol.306 , pp. 686-688
    • Woolf, C.J.1
  • 47
    • 0022921468 scopus 로고
    • Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat
    • Woolf CJ, Wall PD (1986) Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat. J Neurosci 6:1433-1442.
    • (1986) J Neurosci , vol.6 , pp. 1433-1442
    • Woolf, C.J.1    Wall, P.D.2
  • 48
    • 0030724424 scopus 로고    scopus 로고
    • Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons
    • Zhang JM, Donnelly DF, Song XJ, Lamotte RH (1997) Axotomy increases the excitability of dorsal root ganglion cells with unmyelinated axons. J Neurophysiol 78:2790-2794.
    • (1997) J Neurophysiol , vol.78 , pp. 2790-2794
    • Zhang, J.M.1    Donnelly, D.F.2    Song, X.J.3    Lamotte, R.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.