Subtype-selective Nav1.8 sodium channel blockers: Identification of potent, orally active nicotinamide derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6812-6815

  Kort, Michael E ^a   Atkinson, Robert N ^b   Thomas, James B ^b   Drizin, Irene ^a   Johnson, Matthew S ^b   Secrest, Matthew A ^b   Gregg, Robert J ^a   Scanio, Marc J C ^a   Shi, Lei ^a   Hakeem, Ahmed H ^a   Matulenko, Mark A ^a   Chapman, Mark L ^b   Krambis, Michael J ^b   Liu, Dong ^b   Shieh, Char Chang ^a   Zhang, Xufeng ^a   Simler, Gricelda ^a   Mikusa, Joseph P ^a   Zhong, Chengmin ^a   Joshi, Shailen ^a   Honore, Prisca ^a   Roeloffs, Rosemarie ^b   Werness, Stephen ^b   Antonio, Brett ^b   Marsh, Kennan C ^a   Faltynek, Connie R ^a   Krafte, Douglas S ^b   Jarvis, Michael F ^a   Marron, Brian E ^b   more..

^a ABBOTT LABORATORIES   (United States)

^b Icagen Inc   (United States)

Author keywords

Nav1.8; Pain; PN3; Sodium channel blocker

Indexed keywords

A 803467; NICOTINAMIDE DERIVATIVE; SODIUM CHANNEL BLOCKING AGENT; SODIUM CHANNEL NAV1.8; UNCLASSIFIED DRUG;

ARTICLE; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG SELECTIVITY; INFLAMMATION; NEUROPATHIC PAIN;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; NIACINAMIDE; RATS; SODIUM CHANNEL BLOCKERS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 77958051422     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.121     Document Type: Article

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