Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 18, 2010, Pages 5536-5540

  Tyagarajan, Sriram ^a   Chakravarty, Prasun K ^a   Zhou, Bishan ^a   Fisher, Michael H ^a   Wyvratt, Mathew J ^a   Lyons, Kathy ^a   Klatt, Tracy ^a   Li, Xiaohua ^a   Kumar, Sanjeev ^a   Williams, Brande ^a   Felix, John ^a   Priest, Birgit T ^a   Brochu, Richard M ^a   Warren, Vivien ^a   Smith, McHardy ^a   Garcia, Maria ^a   Kaczorowski, Gregory J ^a   Martin, William J ^a   Abbadie, Catherine ^a   McGowan, Erin ^a   Jochnowitz, Nina ^a   Parsons, William H ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Biaryl imidazoles; Biaryl oxazoles; Biaryl thiazoles; Nav1.7 blockers; Neuropathic pain; Voltage gated sodium channel

Indexed keywords

AMIDE; AMITRIPTYLINE; ANALGESIC AGENT; CARBAMAZEPINE; GABAPENTIN; IMIDAZOLE DERIVATIVE; LAMOTRIGINE; LIDOCAINE; MEXILETINE; OXAZOLE DERIVATIVE; SODIUM CHANNEL BLOCKING AGENT; THIAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CYCLIZATION; DOG; DRUG CLEARANCE; DRUG HALF LIFE; DRUG POTENCY; DRUG STRUCTURE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER MICROSOME; NEUROPATHIC PAIN; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ANIMALS; DOGS; HUMANS; IMIDAZOLES; MICROSOMES, LIVER; NEURALGIA; OXAZOLES; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; THIAZOLES;

EID: 77956176991     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.064     Document Type: Article

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