Two tarantula peptides inhibit activation of multiple sodium channels

Biochemistry

Volumn 41, Issue 50, 2002, Pages 14734-14747

  Middleton, Richard E ^a   Warren, Vivien A ^a   Kraus, Richard L ^a   Hwang, Jeremy C ^a   Liu, Chou J ^a   Dai, Ge ^a   Brochu, Richard M ^a   Kohler, Martin G ^a   Gao, Ying Duo ^a   Garsky, Victor M ^a   Bogusky, Michael J ^a   Mehl, John T ^a   Cohen, Charles J ^a   Smith, McHardy M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHANNEL INHIBITION;

SODIUM; TOXIC MATERIALS;

BIOCHEMISTRY;

CALCIUM CHANNEL; PEPTIDE; PROTX I PEPTIDE; PROTX II PEPTIDE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN; UNCLASSIFIED DRUG; VENOM;

ARTICLE; CHANNEL GATING; LIGAND BINDING; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; SPIDER; STRUCTURE ANALYSIS; TOXIN ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CALCIUM CHANNEL BLOCKERS; CELL LINE; DISULFIDES; ELECTROPHYSIOLOGY; HUMANS; ION CHANNEL GATING; MOLECULAR SEQUENCE DATA; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, WISTAR; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPIDER VENOMS;

ARANEAE; INVERTEBRATA; THRIXOPELMA PRURIENS;

EID: 0037126684     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026546a     Document Type: Article

References (58)

1. Cestele, S., and Catterall, W. A. (2000) Molecular mechanisms of neurotoxin action on voltage-gated sodium channels, Biochimie 82, 883-892.
2. Safo, P., Rosenbaum, T., Shcherbatko, A., Choi, D. Y., Han, E., Toledo-Aral, J. J., Olivera, B. M., Brehm, P., and Mandel, G. (2000) Distinction among neuronal subtypes of voltage-activated sodium channels by μ-conotoxin PIIIA, J. Neurosci. 20, 76-80.
3. + channel outer vestibule determined by mutant cycle analysis, Biophys. J. 80, 698-706.
4. Cruz, L., Gray, W., Olivera, B., Zeikus, R., Kerr, L., Yoshikami, D., and Moczydlowski, E. (1985) Conus geographus toxins that discriminate between neuronal and muscle sodium channels, J. Biol. Chem. 260, 9280-9288.
5. + channel α subunit, J. Biol. Chem. 271, 15950-15962.
6. Benzinger, G. R., Kyle, J. W., Blumenthal, K. M., and Hanck, D. A. (1998) A Specific Interaction between the Cardiac Sodium Channel and Site-3 Toxin Anthopleurin B, J. Biol. Chem. 273, 80-84.
7. Shon, K. J. Hasson, A., Spira, M., Cruz, L., Gray, W., and Olivera, B. (1994) δ-Conotoxin GmVIA, a novel peptide from the venom of conus gloriamaris, Biochemistry 33, 11420-11425.
8. Cestele, S., Qu, Y., Rogers, J. C., Rochat, H., Scheuer, T., and Catterall, W. A. (1998) Voltage Sensor-Trapping: Enhanced Activation of Sodium Channels by β-Scorpion Toxin Bound to the S3-S4 Loop in Domain II, Neuron 21, 919-931.
9. Escoubas, P., Diochot, S., and Corzo, G. (2000) Structure and pharmacology of spider venom neurotoxins, Biochimie 82, 893-907.
10. Norton, R. S., and Pallaghy, P. K. (1998) The cystine knot structure of ion channel toxins and related polypeptides, Toxicon 36, 1573-1583.
11. Craik, D. J., Daly, N. L., and Waine, C. (2001) The cystine knot motif in toxins and implications for drug design, Toxicon 39, 43-60.
12. Harrison, P. M., and Sternberg, M. J. (1996) The disulphide β-cross: From cystine geometry and clustering to classification of small disulphide-rich protein folds, J. Mol. Biol. 264, 603-623.
13. McDonough, S. I., Mintz, I. M., and Bean, B. P. (1997) Alteration of P-type calcium channel gating by the spider toxin ω-Aga-IVA, Biophys. J. 72, 2117-2128.
14. Winterfield, J. R., and Swartz, K. J. (2000) A hot spot for the interaction of gating modifier toxins with voltage-dependent ion channels, J. Gen. Physiol. 116, 637-644.
15. 1Acontaining high-voltage-activated calcium channels, Biophys. J. 76, 1384-1400.
16. + Channels, Neuron 18, 675-682.
17. 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels, Nat. Neurosci. 2, 407-415.
18. v4 subfamilies, Mol. Pharmacol. 62, 48-57.
19. + channels, Proc. Natl. Acad. Sci. U.S.A. 95, 8585-8589.
20. Middleton, R., Cohen, C. J., Dai, G., Kohler, M., Liu, J., Brochu, R., Hwang, C., Warren, V. A., and Smith., M. M. (1998) A spider toxin that inhibits TTX-resistant and other mammalian sodium channels, Biophys. J. 74, A81.
21. 1C calcium channels by the spider toxin ProTx-II, Soc. Neurosci. Abstr. 26, 623.
22. Kraus, R. L., Warren, V. A., Smith, M. M., Middleton, R. E., Blumenthal, K. M., and Cohen, C. J. (2002) A spider toxin that inhibits activation of voltage-gated sodium channels, Biophys. J. 82, 85a.
23. Schmidt, G. (1998) Die chilenischen vogelspinnen der gattungen Grammostola Simon, 1892, Paraphysa Simon, 1892, Euathlus Ausserer, 1875 Und Thrixopelma Schmidt, 1994 (Araneae: Mygalomorphae: Theraphosidae: Theraphosinae) mit beschreibung einer neuen Thrixoplema-Spezies, Arthropoda 6, 3-10.
24. Ertel, E. A., Warren, V. A., Adams, M. E., Griffin, P. R., Cohen, C. J., and Smith, M. M. (1994) Type III ω-agatoxins: A family of probes for similar binding sites on L- and N-Type calcium channels, Biochemistry 33, 5098-5108.
25. Garsky, V. M., Lumma, P. K., Freidinger, R. M., Smith, M. M., and Cohen, C. J. (1995) The Total Chemical Synthesis of μ-Agatoxin-IV: A Spider Toxin Selective for Insect Na Channels, in Peptides 1994 (Maia, H. L. S., Ed.) pp 375-376, ESCOM Science Publishers B.V., Leiden.
26. Braunschweiler, L., and Ernst, R. R. (1983) Coherence transfer by isotropic mixing: Application to proton correlation spectroscopy, J. Magn. Reson. 53, 521-528.
27. Bax, A., and Davis, D. G. (1985) MLEV-17-based two-dimensional homonuclear magnetization transfer spectroscopy, J. Magn. Reson. 65, 355-360.
28. Jeener, J., Meier, M. H., Bachmann, P., and Ernst, R. R. (1979) Investigation of exchange processes by two-dimensional NMR spectroscopy, J. Chem. Phys. 71, 4546-4553.
29. Wuthrich, K. (1986) NMR of Proteins and Nucleic Acids, John Wiley & Sons, New York.
30. States, D. J., Haberkorn, R. A., and Ruben, D. J. (1982) A two-dimensional nuclear overhauser experiment with pure absorption phase in four quadrants, J. Magn. Reson. 48, 286-292.
31. Levitt, M. H., Freeman, R., and Frenkiel, T. (1982) broadband heteronuclear decoupling, J. Magn. Reson. 47, 328-330.
32. Akopian, A. N., Sivilotti, L., and Wood, J. N. (1996) A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons, Nature 379, 257-262.
33. Goldin, A. L. (1991) Expression of ion channels by injection of mRNA into xenopus oocytes, Methods Cell Biol. 36, 487-509.
34. + channel inactivation gating, Circ. Res. 75, 114-122.
35. Klugbauer, N., Lacinova, L., Flockerzi, V., and Hofmann, F. (1995) Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells, EMBO J. 14, 1084-1090.
36. Perez-Reyes, E., Cribbs, L. L., Daud, A., Lacerda, A. E., Barclay, J., Williamson, M. P., Fox, M., Rees, M., and Lee, J. H. (1998) Molecular characterization of a neuronal low-voltage-activated T-type calcium channel, Nature 391, 896-900.
37. Gonzalez, J. E., and Tsien, R. Y. (1997) Improved indicators of cell membrane potential that use fluorescence resonance energy transfer, Chem. Biol. 4, 269-277.
38. Gonzalez, J. E., and Tsien, R. Y. (1995) Voltage sensing by fluorescence resonance energy transfer in single cells, Biophys. J. 69, 1272-1280.
39. + channels: Common surface features of gating modifier toxins, J. Mol. Biol. 297, 771-780.
40. Liang, S. P., Zhang, D. Y., Pan, X., Chen, Q., and Zhou, P. A. (1993) Properties and amino acid sequence of huwentoxin-I, a neurotoxin purified from the venom of the chinese bird spider selenocosmia huwena, Toxicon 31, 969-978.
41. v2.1 potassium channel isolated from the venom of a chilean tarantula, Neuron 15, 941-949.
42. Jones, M. D., Patterson, S. D., and Lu, H. S. (1998) Determination of disulfide bonds in highly bridged disulfide-linked peptides by matrix-assisted laser desorption/ionization mass spectrometry with postsource decay, Anal. Chem. 70, 136-143.
43. McDonough, S. I., Lampe, R. A., Keith, R. A., and Bean, B. P. (1997) Voltage-dependent inhibition of N- and P-type calcium channels by the peptide toxin ω-grammotoxin-SIA, Mol. Pharmacol. 52, 1095-1104.
44. Chuang, R. S. I., Jaffe, H., Cribbs, L., Perez-Reyes, E., and Swartz, K. J. (1998) Inhibition of T-type voltage-gated calcium channels by a new scorpion toxin, Nat. Neurosci. 1, 668-674.
45. Bezanilla, F. (2000) The Voltage Sensor in Voltage-Dependent Ion Channels, Physiol. Rev. 80, 555-592.
46. + channel through multiple binding sites, Neuron 18, 665-673.
47. Gonzalez, J. E., and Negulescu, P. A. (1998) Intracellular detection assays for high-throughput screening. Curr. Opin. Biotechnol. 9, 624-631.
48. Wanner, S. G., Glossmann, H., Knaus, H. G., Baker, R., Parsons, W., Rupprecht, K. M., Brochu, R., Cohen, C. J., Schmalhofer, W., Smith, M., Warren, V., Garcia, M. L., and Kaczorowski, G. J. (1999) WIN 17317-3, a New High-Affinity Probe for Voltage-Gated Sodium Channels, Biochemistry 38, 11137-11146.
49. Catterall, W. A. (1992) Cellular and molecular biology of voltage-gated sodium channels, Physiol. Rev. 72, S15-S48.
50. Sidach, S., and Mintz, I. (2002) Kurtoxin, a gating modifier of neuronal high- and low-threshold Ca channels, J. Neurosci. 22, 2023-2034.
51. Fainzilber, M., van der Schors, R., Lodder, J. C., Li, K. W., Geraerts, W. P. M., and Kits, K. S. (1995) New sodium channel bocking conotoxins also affect calcium currents in Lymnaea neurons, Biochemistry 34, 5364-5371.
52. 2+ channels, Trends Pharmacol. Sci. 16, 139-142.
53. Zhang, J. H., Chung, T. D., and Oldenburg, K. R. (1999) A simple statistical parameter for use in evaluation and validation of high throughput screening assays, J. Biomol. Screen 4, 67-73.
54. Shu, Q., Lu, S.-Y., Gu, X.-C., and Liang, S.-P. (2002) The structure of spider toxin huwentoxin-II with unique disulfide linkage: Evidence for structural evolution, Protein Sci. 11, 245-252.
55. Shu, Q., Huang, R., and Liang, S. (2001) Assignment of the disulfide bonds of huwentoxin-II by Edman Degradation sequencing and stepwise thiol modification, Eur. J. Biochem. 268, 2301-2307.
56. Chemical Computing Group Inc. (2002) Molecular Operating Environment (MOE), Version 2002.03, Montreal, Canada.
57. v2.3) calcium channels, Biophys. J. 81, 79-88.
58. Sheets, M. F., and Hanck, D. A. (1995) Voltage-dependent open-state inactivation of cardiac sodium channels: Gating current studies with anthopleurin - A toxin, J. Gen. Physiol. 106, 617-640.