An SCN9A channelopathy causes congenital inability to experience pain

Nature

Volumn 444, Issue 7121, 2006, Pages 894-898

  Cox, James J ^a   Reimann, Frank ^a   Nicholas, Adeline K ^a   Thornton, Gemma ^a   Roberts, Emma ^b   Springell, Kelly ^b   Karbani, Gulshan ^c   Jafri, Hussain ^d   Mannan, Jovaria ^e   Raashid, Yasmin ^f   Al Gazali, Lihadh ^g   Hamamy, Henan ^h   Valente, Enza Maria ⁱ   Gorman, Shaun ^j   Williams, Richard ^k   McHale, Duncan P ^k   Wood, John N ^l   Gribble, Fiona M ^a   Woods, C Geoffrey ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

^c ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^d Gene Tech Lab 146/1   (Pakistan)

^e FATIMA JINNAH MEDICAL COLLEGE   (Pakistan)

^f KING EDWARD MEDICAL UNIVERSITY   (Pakistan)

^g UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^h National Center for Diabetes Endocrinology and Genetics Jordan   (Jordan)

ⁱ IRCCS FONDAZIONE BIETTI   (Italy)

^j ST LUKE S HOSPITAL   (United Kingdom)

^k PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^l UNIVERSITY COLLEGE LONDON   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM CHANNEL; TETRODOTOXIN; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

ABNORMALITY; GENE EXPRESSION; MECHANORECEPTION; MUTATION; PHENOTYPE;

ACTION POTENTIAL; ALPHA CHAIN; ARTICLE; AUTONOMIC NERVOUS SYSTEM; AUTOSOMAL RECESSIVE INHERITANCE; BETA CHAIN; CELL STRAIN HEK293; CHROMOSOME 2Q; CLINICAL ARTICLE; CONGENITAL ANALGESIA; CONSANGUINITY; GENE; GENE MAPPING; GENE SCN9A; HAPLOTYPE; HOMOZYGOSITY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOTOR NEUROPATHY; NERVE BIOPSY; NOCICEPTION; NONSENSE MUTATION; PAKISTAN; PHENOTYPE; PRIORITY JOURNAL; SENSORY NEUROPATHY; SEQUENCE ANALYSIS; SPINAL GANGLION;

ASIA; EURASIA; PAKISTAN; SOUTH ASIA;

EID: 33845901486     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05413     Document Type: Article

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