Synthetic μO-conotoxin MrVIB blocks TTX-resistant sodium channel Na V1.8 and has a long-lasting analgesic activity

Biochemistry

Volumn 45, Issue 23, 2006, Pages 7404-7414

  Bulaj, Grzegorz ^a,b   Zhang, Min Min ^a   Green, Brad R ^a   Fiedler, Brian ^a   Layer, Richard T ^b   Wei, Sue ^b   Nielsen, Jacob S ^b   Low, Scott J ^b   Klein, Brian D ^b   Wagstaff, John D ^b   Chicoine, Linda ^b   Harty, T Patrick ^b   Terlau, Heinrich ^c   Yoshikami, Doju ^a   Olivera, Baldomero M ^a  

^a UNIVERSITY OF UTAH   (United States)

^b Cognetix Inc ^*  (United States)

^c MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

POLYPEPTIDES; SODIUM; SYNTHESIS (CHEMICAL);

ANALGESIC; ANTINOCICEPTIVE MECHANISMS; CONOTOXINS; THERAPEUTIC POTENTIAL;

BIOCHEMISTRY;

CHI CONOTOXIN MRIA; CONANTOKIN G; CONOTOXIN; CONOTOXIN ACV 1; CONTULAKIN G; MU O CONOTOXIN MRVIB; OMEGA CONOTOXIN MVIIA; SODIUM CHANNEL; SODIUM CHANNEL NAV1.8; SYNTHETIC PEPTIDE; TETRODOTOXIN; UNCLASSIFIED DRUG; ANALGESIC AGENT; NA(V)1.8 PROTEIN, RAT; NERVE PROTEIN;

ACTION POTENTIAL; AFFERENT NERVE GROUP 1; ANALGESIC ACTIVITY; ANESTHESIA; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BETA NERVE FIBER; CONTROLLED STUDY; FEMALE; FROG; MALE; NONHUMAN; OXIDATION; PAIN; PRIORITY JOURNAL; PROTEIN FOLDING; RAT; SCIATIC NERVE; SKELETAL MUSCLE; TOXIN ANALYSIS; TOXIN STRUCTURE; TOXIN SYNTHESIS; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; DRUG ANTAGONISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR GENETICS; SPRAGUE DAWLEY RAT;

AMINO ACID SEQUENCE; ANALGESICS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONOTOXINS; MALE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; TETRODOTOXIN;

EID: 33745034230     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060159+     Document Type: Article

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