Voltage-gated sodium channels in pain states: Role in pathophysiology and targets for treatment

Brain Research Reviews

Volumn 60, Issue 1, 2009, Pages 65-83

  Dib Hajj, Sulayman D ^a,b   Binshtok, Alexander M ^c   Cummins, Theodore R ^d   Jarvis, Michael F ^e   Samad, Tarek ^f   Zimmermann, Katharina ^c,g  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e ABBOTT LABORATORIES   (United States)

^f PFIZER INC   (United States)

^g BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Cold nocicptors; Cytokines; Dorsal root ganglion; Genetic of pain; Local anesthetics; Neurotoxins; Pharmacotherapy; Sensory neurons; Sodium channelopathy

Indexed keywords

A 803467; ANTISENSE OLIGONUCLEOTIDE; CAPSAICIN; COCAINE; CYCLOOXYGENASE 2; CYTOKINE; FM1 43; HARKOSERIDE; INTERLEUKIN 1BETA; LIDOCAINE; LIDOCAINE ETHOBROMIDE; LOCAL ANESTHETIC AGENT; NEUROTOXIN; OMEGA CONOTOXIN; PROSTAGLANDIN E2; SODIUM CHANNEL BLOCKING AGENT; TETRODOTOXIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ALLODYNIA; ANTINOCICEPTION; CANCER PAIN; CYTOKINE RELEASE; ERYTHROMELALGIA; GENE MUTATION; GENETICS; HYPERALGESIA; IMMUNOLOCALIZATION; LOCAL ANESTHESIA; MOUSE; NEUROPATHIC PAIN; NOCICEPTIVE RECEPTOR; NONHUMAN; PAIN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; REVIEW; SENSORY NERVE CELL; SODIUM CHANNELOPATHY; SODIUM CURRENT; SPINAL GANGLION;

ANIMALS; HUMANS; ION CHANNEL GATING; NEUROPEPTIDES; NOCICEPTORS; PAIN; SENSORY RECEPTOR CELLS; SODIUM CHANNELS; SYNAPTIC TRANSMISSION;

EID: 63449107353     PISSN: 01650173     EISSN: 18726321     Source Type: Journal    
DOI: 10.1016/j.brainresrev.2008.12.005     Document Type: Review

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