GTP-induced tetrodotoxin-resistant Na+ current regulates excitability in mouse and rat small diameter sensory neurones

Journal of Physiology

Volumn 548, Issue 2, 2003, Pages 373-382

  Baker, Mark D ^a   Chandra, Sonia Y ^a   Ding, Yanning ^a   Waxman, Stephen G ^b   Wood, John N ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE 5' O (3 THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; SODIUM ION; TETRODOTOXIN; GUANINE NUCLEOTIDE BINDING PROTEIN; SODIUM CHANNEL NAV1.9;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL SIZE; CONTROLLED STUDY; DEPOLARIZATION; MOUSE; NERVE CELL EXCITABILITY; NOCICEPTIVE RECEPTOR; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SENSORY NERVE CELL; SODIUM CURRENT; UPREGULATION; VOLTAGE CLAMP; ADULT; ANIMAL TISSUE; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE POTENTIAL; PAIN RECEPTOR; SIGNAL TRANSDUCTION;

ACTION POTENTIALS; ALGORITHMS; ANIMALS; ELECTROPHYSIOLOGY; EXCITATORY POSTSYNAPTIC POTENTIALS; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE TRIPHOSPHATE; MICE; NEURONS, AFFERENT; NEUROPEPTIDES; PATCH-CLAMP TECHNIQUES; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN; UP-REGULATION;

EID: 0037731500     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.039131     Document Type: Article

References (36)

1. Akopian AN, Okuse K, Souslova V, England S, Ogata N & Wood JN (1999a). Trans-splicing of a voltage-gated sodium channel is regulated by nerve growth factor. FEBS Lett 445, 177-182.
2. Akopian AN, Souslova V, England S, Okuse K, Ogata N, Ure J, Smith A, Kerr BJ, McMahon SB, Boyce S, Hill R, Stanfa LC, Dickenson AH & Wood JN (1999b). The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways. Nat Neurosci 2, 541-548.
3. Alroy G, Su H & Yaari Y (1999). Protein kinase C mediates muscarinic block of intrinsic bursting in rat hippocampal neurons. J Physiol 518, 71-79.
4. Amaya F, Decosterd I, Samad TA, Plumpton C, Tate S, Mannion RJ, Costigan M & Woolf CJ (2000). Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2. Mol Cell Neurosci 15, 331-342.
5. Baker MD & Bostock H (1997). Low-threshold, persistent sodium current in rat large dorsal root ganglion neurons in culture. J Neurophys 77, 1503-1513.
6. v1.9 (NaN) changes firing properties of small diameter sensory neurones. J Physiol 544.P, 74P.
7. + channels involved in pain pathways. Trends Pharmacol Sci 22, 27-31.
8. Black JA & Waxman SG (2002). Molecular identities of two tetrodotoxin-resistant sodium channels in corneal axons. Exp Eye Res 75, 193-199.
9. Blum R, Kafitz KW & Konnerth A (2002). Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9. Nature 419, 687-693.
10. Bostock H & Grafe P (1985). Activity-dependent excitability changes in normal and demyelinated rat spinal root axons. J Physiol 365, 239-257.
11. Brock JA, McLachlan EM & Belmonte C (1998). Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig cornea. J Physiol 512, 211-217.
12. Cardenas CG, Mar LP, Vysokanov AV, Arnold PB, Cardenas LM, Surmeier DJ & Scroggs RS (1999). Serotonergic modulation of hyperpolarization-activated current in acutely isolated rat dorsal root ganglion neurons. J Physiol 518, 507-523.
13. Chernov MV, Bean LJ, Lerner N & Stark GR (2001). Regulation of ubiquitination and degradation of p53 in unstressed cells through C-terminal phosphorylation. J Biol Chem 276, 31819-31824.
14. Cummins TR, Dib-Hajj SD, Black JA, Akopian AN, Wood JN & Waxman SG (1999). A novel persistent tetrodotoxin-resistant sodium current in SNS-null and wild-type small primary sensory neurons. J Neurosci 19, RC43.
15. Dib-Hajj S, Black JA, Cummins TR & Waxman SG (2002). NaN/Nav1.9: a sodium channel with unique properties. Trends Neurosci 25, 253-259.
16. Dib-Hajj SD, Tyrrell L, Black JA & Waxman SG (1998). NaN, a novel voltage-gated Na channel, is expressed preferentially in peripheral sensory neurons and down-regulated after axotomy. Proc Natl Acad Sci U S A 95, 8963-8968.
17. 2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade. J Physiol 495, 429-440.
18. v1.9 (NaN) in nociceptive primary afferent neurons. J Neurosci 22, 7425-7433.
19. Fitzgerald EM, Okuse K, Wood JN, Dolphin AC & Moss SJ (1999). cAMP-dependent phosphorylation of the tetrodotoxin-resistant voltage-dependent sodium channel SNS. J Physiol 516, 433-446
20. Fjell J, Hjelmstrom P, Hormuzdiar W, Milenkovic M, Aglieco F, Tyrell L, Dib-Hajj S, Waxman SG & Black J (2000). Localization of the tetrodotoxin-resistant sodium channel NaN in nociceptors. NeuroReport 11, 199-202.
21. + current in nociceptors. Proc Natl Acad Sci U S A 93, 1108-1112.
22. + current affects resting potential and response to depolarization in simulated spinal sensory neurons. J Neurophysiol 86, 1351-1364.
23. Irnich D, Burgstahler R, Bostock H & Grafe P (2001). ATP affects both axons and Schwann cells of unmyelinated C fibres. Pain 92, 343-350.
24. Isom LL (2001). Sodium channel beta subunits: anything but auxiliary. Neuroscientist 7, 42-54.
25. Kovalchuk Y, Hanse E, Kafitz KW & Konnerth A (2002). Postsynaptic induction of BDNF-mediated long-term potentiation. Science 295, 1729-1734.
26. Ma JY, Catterall WA & Scheuer T (1997). Persistent sodium currents through brain sodium channels induced by G protein βγ subunits. Neuron 19, 443-452.
27. Messaoudi E, Ying SW, Kanhema T, Croll SD & Bramham CR (2002). Brain-derived neurotrophic factor triggers transcription-dependent, late phase long-term potentiation in vivo. J Neurosci 22, 7453-7461.
28. Michaelis M, Vogel C, Blenk KH, Arnarson A & Janig W (1998). Inflammatory mediators sensitize acutely axotomized nerve fibers to mechanical stimulation in the rat. J Neurosci 18, 7581-7587.
29. Okuse K, Malik-Hall M, Baker MD, Poon W-YL, Kong H, Chao MV & Wood JN (2002). Annexin II light chain regulates sensory neuron specific sodium channel expression. Nature 417, 653-656.
30. Schmidt R, Schmelz M, Forster C, Ringkamp M, Torebjork E & Handwerker H (1995). Novel classes of responsive and unresponsive C nociceptors in human skin. J Neurosci 15, 333-341.
31. 2+ currents elicited by action potential waveforms in acutely isolated adult rat dorsal root ganglion neurons. J Neurosci 12, 1789-1801.
32. Serra J, Campero M, Ochoa J & Bostock H (1999). Activity-dependent slowing of conduction differentiates functional subtypes of C fibres innervating human skin. J Physiol 515, 799-811.
33. 2+ and mechanisms of block. Toxicol Lett 99, 207-221.
34. Strassman AM & Raymond SA (1999). Electrophysiological evidence for tetrodotoxin-resistant sodium channels in slowly conducting dural sensory fibers. J Neurophysiol 81, 413-424.
35. Taiwo YO & Levine JD (1992). Serotonin is a directly-acting hyperalgesic agent in the rat. Neuroscience 48, 485-490.
36. Wang Z, Van Den Berg RJ & Ypey DL (1994). Resting membrane potentials and excitability at different regions of rat dorsal root ganglion neurons in culture. Neuroscience 60, 245-254.