-
1
-
-
0035905867
-
-
Anger, T.; Madge, D. J.; Mulla, M.; Riddall, D. J. Med. Chem. 2001, 44, 115.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 115
-
-
Anger, T.1
Madge, D.J.2
Mulla, M.3
Riddall, D.4
-
2
-
-
28844448678
-
-
Lindia, J. A.; Kohler, M. G.; Martin, W. J.; Abbadie, C. Pain 2005, 117, 145.
-
(2005)
Pain
, vol.117
, pp. 145
-
-
Lindia, J.A.1
Kohler, M.G.2
Martin, W.J.3
Abbadie, C.4
-
3
-
-
4344670206
-
-
Nassar, M. A.; Stirling, L. C.; Forlani, G.; Baker, M. D.; Matthews, E. A.; Dickenson, A. H.; Wood, J. N. Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 12706.
-
(2004)
Proc. Natl. Acad. Sci. U.S.A.
, vol.101
, pp. 12706
-
-
Nassar, M.A.1
Stirling, L.C.2
Forlani, G.3
Baker, M.D.4
Matthews, E.A.5
Dickenson, A.H.6
Wood, J.N.7
-
4
-
-
0033363999
-
-
Akopian, A. N.; Souslova, V.; England, S.; Okuse, K.; Ogata, N.; Ure, J.; Smith, A.; Kerr, B. J.; McMahon, S. B.; Boyce, S.; Hill, R.; Stanfa, L. C.; Dickenson, A. H.; Wood, J. N. Nat. Neurosci. 1999, 2, 541.
-
(1999)
Nat. Neurosci.
, vol.2
, pp. 541
-
-
Akopian, A.N.1
Souslova, V.2
England, S.3
Okuse, K.4
Ogata, N.5
Ure, J.6
Smith, A.7
Kerr, B.J.8
McMahon, S.B.9
Boyce, S.10
Hill, R.11
Stanfa, L.C.12
Dickenson, A.H.13
Wood, J.N.14
-
5
-
-
0346654133
-
-
Coggeshall, R. E.; Tate, S.; Carlton, S. M. Neurosci. Lett. 2004, 355, 45.
-
(2004)
Neurosci. Lett.
, vol.355
, pp. 45
-
-
Coggeshall, R.E.1
Tate, S.2
Carlton, S.M.3
-
6
-
-
21544455502
-
-
Priest, B. T.; Murphy, B. A.; Lindia, J. A.; Diaz, C.; Abbadie, C.; Ritter, A. M.; Liberatore, P.; Iyer, L. M.; Kash, S. F.; Kohler, M. G.; Kaczorowski, G. J.; MacIntyre, D. E.; Martin, W. J. Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 9382.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 9382
-
-
Priest, B.T.1
Murphy, B.A.2
Lindia, J.A.3
Diaz, C.4
Abbadie, C.5
Ritter, A.M.6
Liberatore, P.7
Iyer, L.M.8
Kash, S.F.9
Kohler, M.G.10
Kaczorowski, G.J.11
MacIntyre, D.E.12
Martin, W.J.13
-
7
-
-
77149139677
-
-
WO 2006011050, CAN 144:192112, AN 2006:101079
-
Lane, C. A. L.; Maw, G. N.; Rawson, D. J.; Thompson, L. R. PCT Int. Appl. WO 2006011050, CAN 144:192112, AN 2006:101079, 2006.
-
(2006)
PCT Int. Appl.
-
-
Lane, C.A.L.1
Maw, G.N.2
Rawson, D.J.3
Thompson, L.R.4
-
10
-
-
77149124767
-
-
WO 98/38174, also commercially available from Alfa Aesar, Heysham, Lancashire, U.K., cat. no. L17511, CAS 212779-19-6
-
Cox, B.; Nobbs, M. S.; Shah, G. P.; Edney, D. D.; Loft, M. S. PCT Int. Appl. WO 98/38174, 1998, CAN 129:230741, AN 1998:608606; also commercially available from Alfa Aesar, Heysham, Lancashire, U.K., cat. no. L17511, CAS 212779-19-6.
-
(1998)
PCT Int. Appl.
-
-
Cox, B.1
Nobbs, M.S.2
Shah, G.P.3
Edney, D.D.4
Loft, M.S.5
-
11
-
-
0005861625
-
-
CAS registry 126325-46-0. We purchased from Asymchem, Morrisville, NC, U.S.A
-
Dunn, A. D.; Currie, A.; Hayes, L. E. J. Prakt. Chem. (Leipzig) 1989, 331, 369. CAS registry 126325-46-0. We purchased from Asymchem, Morrisville, NC, U.S.A.
-
(1989)
J. Prakt. Chem. (Leipzig)
, vol.331
, pp. 369
-
-
Dunn, A.D.1
Currie, A.2
Hayes, L.E.3
-
12
-
-
0030512291
-
-
Pomel, V.; Rovera, J. C.; Godard, A.; Marsais, F.; Queguiner, G. J. Heterocycl. Chem. 1996, 33, 1995.
-
(1996)
J. Heterocycl. Chem.
, vol.33
, pp. 1995
-
-
Pomel, V.1
Rovera, J.C.2
Godard, A.3
Marsais, F.4
Queguiner, G.5
-
13
-
-
37049109963
-
-
Pyridine has been used as solvent in conjunction with permanganate. See
-
Pyridine has been used as solvent in conjunction with permanganate. See: Sala, T.; Sargent, M. V. J. Chem. Soc. Chem. Commun. 1978, 253
-
(1978)
J. Chem. Soc. Chem. Commun.
, pp. 253
-
-
Sala, T.1
Sargent, M.V.2
-
16
-
-
0034693279
-
-
for the des-bromo case, but interestingly they isolated the acetate salt, not the free base
-
Compare Zafar, A.; Geib, S. J.; Hamuro, Y.; Carr, A. J.; Hamilton, A. D. Tetrahedron 2000, 56, 8419. ; for the des-bromo case, but interestingly they isolated the acetate salt, not the free base.
-
(2000)
Tetrahedron
, vol.56
, pp. 8419
-
-
Zafar, A.1
Geib, S.J.2
Hamuro, Y.3
Carr, A.J.4
Hamilton, A.D.5
-
17
-
-
77149171333
-
-
5-Bromo-4-chloro-3-methoxypyridine-2-carboxylic acid readily de- carboxylates at only 120 °C
-
5-Bromo-4-chloro-3-methoxypyridine-2-carboxylic acid readily de- carboxylates at only 120 °C
-
-
-
-
18
-
-
2442578226
-
-
more typically high temperature (>200 °C) is requirEd.
-
see: Looker, J. H.; Prokop, R. J.; Serbousek, W. E.; Clifton, M. D. J. Org. Chem. 1979, 44, 3408. more typically high temperature (>200 °C) is requirEd.
-
(1979)
J. Org. Chem.
, vol.44
, pp. 3408
-
-
Looker, J.H.1
Prokop, R.J.2
Serbousek, W.E.3
Clifton, M.D.4
-
19
-
-
0008607712
-
-
see: de Bie, D. A.; Geurtsen, B.; van de Plas, H. C. J. Org. Chem. 1985, 50, 484.
-
(1985)
J. Org. Chem.
, vol.50
, pp. 484
-
-
De Bie, D.A.1
Geurtsen, B.2
Van De Plas, H.C.3
-
20
-
-
4444369859
-
-
Stanforth, S. P.; Tarbit, B.; Watson, M. D. Tetrahedron 2004, 60, 8893.
-
(2004)
Tetrahedron
, vol.60
, pp. 8893
-
-
Stanforth, S.P.1
Tarbit, B.2
Watson, M.D.3
-
21
-
-
0034804379
-
-
Addition of phosphate to the permanganate oxidation of aldehydes has been found to be beneficial, see
-
Addition of phosphate to the permanganate oxidation of aldehydes has been found to be beneficial, see: Takemoto, T.; Yasuda, K.; Ley, S. V. Synlett 2001, 1555.
-
(2001)
SynLett.
, pp. 1555
-
-
Takemoto, T.1
Yasuda, K.2
Ley, S.V.3
-
22
-
-
0000325998
-
-
Abiko, A.; Roberts, J. C.; Takemasa, T.; Masumune, S. Tetrahedron Lett. 1986, 27, 4537.
-
(1986)
Tetrahedron Lett.
, vol.27
, pp. 4537
-
-
Abiko, A.1
Roberts, J.C.2
Takemasa, T.3
Masumune, S.4
-
23
-
-
0033521580
-
-
Littke, A. F.; Fu, G. C. Angew. Chem., Int. Ed. 1999, 37, 3387.
-
(1999)
Angew. Chem., Int. Ed.
, vol.37
, pp. 3387
-
-
Littke, A.F.1
Fu, G.C.2
-
24
-
-
0034600318
-
-
Littke, A. F.; Dai, C.; Fu, G. C. J. Am. Chem. Soc. 2000, 122, 4020.
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 4020
-
-
Littke, A.F.1
Dai, C.2
Fu, G.C.3
-
27
-
-
0037047555
-
-
Kataoka, N.; Shelby, Q.; Stambuli, J. P.; Hartwig, J. F. J. Org. Chem. 2002, 67, 5553.
-
(2002)
J. Org. Chem.
, vol.67
, pp. 5553
-
-
Kataoka, N.1
Shelby, Q.2
Stambuli, J.P.3
Hartwig, J.F.4
-
28
-
-
0033549829
-
-
Wolfe, J. P.; Buchwald, S. L. Angew. Chem., Int. Ed. 1999, 38, 2413.
-
(1999)
Angew. Chem., Int. Ed.
, vol.38
, pp. 2413
-
-
Wolfe, J.P.1
Buchwald, S.L.2
-
29
-
-
0032747809
-
-
Wolfe, J. P.; Singer, R. A.; Yang, B. H.; Buchwald, S. L. J. Am. Chem. Soc. 1999, 121, 9550.
-
(1999)
J. Am. Chem. Soc.
, vol.121
, pp. 9550
-
-
Wolfe, J.P.1
Singer, R.A.2
Yang, B.H.3
Buchwald, S.L.4
-
30
-
-
77149137880
-
-
More recently the search for alternatives to phosphine ligands has provided a number of catalyst systems capable of achieving biaryl cross-couplings in good yield
-
More recently the search for alternatives to phosphine ligands has provided a number of catalyst systems capable of achieving biaryl cross-couplings in good yield
-
-
-
-
31
-
-
36349007126
-
-
see, for example:and references therein
-
see, for example:Mohanty, S.; Suresh, D.; Balakrishna, M. S.; Mague, J. T. Tetrahedron 2008, 64, 240, and references therein.
-
(2008)
Tetrahedron
, vol.64
, pp. 240
-
-
Mohanty, S.1
Suresh, D.2
Balakrishna, M.S.3
Mague, J.T.4
-
32
-
-
33751158485
-
-
Wright, S. W.; Hageman, D. L.; McClure, L. D. J. Org. Chem. 1994, 59, 6095.
-
(1994)
J. Org. Chem.
, vol.59
, pp. 6095
-
-
Wright, S.W.1
Hageman, D.L.2
McClure, L.D.3
-
33
-
-
15144355008
-
-
Edwards, J. P.; Zhi, L.; Pooley, C. L. F.; Tegley, C. M.; West, S. J.; Wang, M.-W.; Gottardis, M. M.; Palhirana, C.; Schrader, M. T.; Jones, T. K. J. Med. Chem. 1998, 41, 2779.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 2779
-
-
Edwards, J.P.1
Zhi, L.2
Pooley, C.L.F.3
Tegley, C.M.4
West, S.J.5
Wang, M.-W.6
Gottardis, M.M.7
Palhirana, C.8
Schrader, M.T.9
Jones, T.K.10
-
34
-
-
77149133581
-
-
2 and gave 70-75% yield on 10-18 g scale
-
2 and gave 70-75% yield on 10-18 g scale.
-
-
-
-
35
-
-
77149158651
-
-
This was important as over-reaction was observed if the temperature was allowed to rise unduly with the excess boronic acid coupling to a chloro substituent
-
This was important as over-reaction was observed if the temperature was allowed to rise unduly with the excess boronic acid coupling to a chloro substituent.
-
-
-
-
37
-
-
24744457059
-
-
Su, B.; Zhao, J.; Cui, Y.; Liang, Y.; Sun, W. Synth. Commun. 2005, 35, 2317.
-
(2005)
Synth. Commun.
, vol.35
, pp. 2317
-
-
Su, B.1
Zhao, J.2
Cui, Y.3
Liang, Y.4
Sun, W.5
-
38
-
-
0037241144
-
-
Meier, P.; Legraverant, S.; Mueller, S.; Schaub, J. Synthesis 2003, 551.
-
(2003)
Synthesis
, pp. 551
-
-
Meier, P.1
Legraverant, S.2
Mueller, S.3
Schaub, J.4
-
39
-
-
0025037110
-
-
Ashimori, A.; Ono, T.; Uchida, T.; Ohtaki, Y.; Fukaya, C.; Watanabe, M.; Yokoyama, K. Chem. Pharm. Bull. 1990, 38, 2446.
-
(1990)
Chem. Pharm. Bull.
, vol.38
, pp. 2446
-
-
Ashimori, A.1
Ono, T.2
Uchida, T.3
Ohtaki, Y.4
Fukaya, C.5
Watanabe, M.6
Yokoyama, K.7
-
42
-
-
0001480580
-
-
Kuivila, H. G.; Reuwer, J. F., Jr.; Mangravite, J. A. Can. J. Chem. 1963, 41, 3081.
-
(1963)
Can. J. Chem.
, vol.41
, pp. 3081
-
-
Kuivila, H.G.1
Reuwer Jr., J.F.2
Mangravite, J.A.3
-
43
-
-
33748924131
-
-
Cammidge, A. N.; Goddard, V. H. M.; Gopee, H.; Harrison, N. L.; Hughes, D. L.; Schubert, C. J.; Sutton, B. M.; Watts, G. L.; Whitehead, A. J. Org. Lett. 2006, 8, 4071.
-
(2006)
Org. Lett.
, vol.8
, pp. 4071
-
-
Cammidge, A.N.1
Goddard, V.H.M.2
Gopee, H.3
Harrison, N.L.4
Hughes, D.L.5
Schubert, C.J.6
Sutton, B.M.7
Watts, G.L.8
Whitehead, A.J.9
-
46
-
-
77149145067
-
-
WO 2008142333, 2008, CAN AN 2008:1426135
-
Le Drian, C.; Becht, J.-M.; Schweizer, S. PCT Int. Appl. 2008, WO 2008142333, 2008, CAN 149:576721, AN 2008:1426135.
-
(2008)
PCT Int. Appl.
, vol.149
, pp. 576721
-
-
Le Drian, C.1
Becht, J.-M.2
Schweizer, S.3
-
47
-
-
0035804514
-
-
Guo, Z.; Dowdy, E. D.; Li, W.-S.; Polniaszek, R.; Delaney, E. Tetrahedron Lett. 2001, 42, 1843.
-
(2001)
Tetrahedron Lett.
, vol.42
, pp. 1843
-
-
Guo, Z.1
Dowdy, E.D.2
Li, W.-S.3
Polniaszek, R.4
Delaney, E.5
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