Tetrodotoxin inhibits neuropathic ectopic activity in neuromas, dorsal root ganglia and dorsal horn neurons

Pain

Volumn 72, Issue 1-2, 1997, Pages 41-49

  Omana Zapata, I ^a   Khabbaz, M A ^a   Hunter, J C ^a   Clarke, D E ^a   Bley, K R ^a  

^a ROCHE BIOSCIENCE   (United States)

Author keywords

Dorsal root ganglia; Na+ channels; Neuroma; Pain; Sciatic nerve; Spinal cord; TTX

Indexed keywords

SODIUM CHANNEL; TETRODOTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DYSESTHESIA; MALE; NERVE CELL EXCITABILITY; NEUROMA; NEUROPATHY; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SPINAL CORD DORSAL HORN; SPINAL GANGLION;

EID: 0030861765     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(97)00012-2     Document Type: Article

References (45)

1. Akopian, A.N., Sivilotti, L. and Wood, J.N., A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons, Nature, 379 (1996) 257–262.
2. max in guinea pig cardiac Purkinje and papillary muscle fibers, Gen. Pharmacol., 20 (1989a) 575–579.
3. Aomine, M., Tetrodotoxin-sensitive component in action potential plateau of guinea pig Purkinje fibers: comparison with the papillary muscle fibers, Gen. Pharmacol., 20 (1989b) 791–797.
4. Basbaum, A. and Wall, P.D., Chronic changes in the response of cells in adult cat dorsal horn following partial deafferentation: the appearance of responding cells in a previously non-responding region, Brain Res., 116 (1976) 181–204.
5. Caffrey, J.M., Eng, D.L., Black, J.A., Waxman, S.G. and Kocsis, J.D., Three types of sodium channels in adult rat dorsal root ganglion neurons, Brain Res., 592 (1992) 283–297.
6. Catterall, W.A., Structure and function of voltage-gated ion channels, Trends Neurosci., 16 (1993) 500–506.
7. Chabal, C., Russell, L. and Burchiel, K.J., The effect of intravenous lidocaine, tocainide and mexiletine on spontaneously active fibers originating in rat sciatic neuromas, Pain, 38 (1989) 333–338.
8. Devor, M., The pathophysiology of damaged peripheral nerves. In: P.D. Wall and R. Melzack (Eds.), Textbook of Pain, Churchill Livingstone, Edinburgh, 1994, pp. 79–100.
9. + channel accumulation on axolemma of afferent endings in nerve end neuromas in Apteronotus, Neurosci. Lett., 102 (1989) 149–154.
10. Devor, M., Wall, P.D. and Catalan, N., Systemic lidocaine silences ectopic neuroma and DRG discharge without blocking nerve conduction, Pain, 48 (1992) 261–268.
11. + channel immunolocalization in peripheral mammalian axons and changes following nerve injury and neuroma formation, J. Neurosci., 13 (1993) 1976–1992.
12. Devor, M., Lomazov, P. and Matzner, O., Sodium channel accumulation in injured axons as a substrate for neuropathic pain. In: J. Boivie, P. Hansson and U. Lindblom (Eds.), Touch, Temperature, and Pain in Health and Disease: Mechanisms and Assessments, Progress in Pain Research and Management, Vol. 3., IASP Press, Seattle, 1994, pp. 207–230.
13. Dyck, P.J., Lambert, E.H. and Nichols, P.C., Quantitative measurement of sensation related to compound action potential and number and size of myelinated and unmyelinated fibers of sural nerve in health, Friedreich's ataxia, hereditary sensory neuropathy and tabes dorsalis. In: A. Remond (Ed.), Handbook of Electroencephalograph and Clinical Neurophysiology, Vol. 9, Elsevier, Amsterdam, 1971, pp. 83–118.
14. Elliott, A.A. and Elliott, J.R., Characterization of TTX-sensitive and TTX-resistant sodium currents in small cells from adult rat dorsal root ganglia, J. Physiol., 463 (1993) 39–56.
15. 2 modifies tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones in culture, J. Physiol., 491P (1996) 145P.
16. Evans, M.H., Topical application of saxitoxin and tetrodotoxin to peripheral nerves and spinal roots in cat, Toxicon., 5 (1968) 289–294.
17. + current in nociceptors, Proc. Natl. Acad. Sci. USA, 93 (1996) 1108–1112.
18. Govrin-Lippmann, R. and Devor, M., Ongoing activity in severed nerves: source and variation with time, Brain Res., 159 (1978) 406–410.
19. Kajander, K.C., Wakisaka, S. and Bennett, G.J., Spontaneous discharges originate in the dorsal root ganglion at the onset of a painful peripheral neuropathy in the rat, Neurosci. Lett., 138 (1992) 225–228.
20. Laiken, N.D. and Fanesti, D.D., Physiology of the body fluids, In: J.B. West (Ed.), Physiological Basis of Medical Practice, Williams and Wilkins, Baltimore, 1968, pp. 438–450.
21. Laird, J.M.A. and Bennett, G., An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy, J. Neurophysiol., 69 (1993) 2072–2085.
22. Lang, W.R., Puffer fish poisoning, Am. Fam. Physician, 42 (1990) 1029–1033.
23. Leung, E., Michelson, S., Villarubia, C., Perkins, L.A. and Eglen, R.M., Analysis of concentration-response relationships by seemingly unrelated non-linear regression (SUNR) technique, J. Pharmacol. Toxicol. Meth., 28 (1992) 209.
24. 2+-overload inhibitor, protects against aconitine-induced cardiac arrhythmias in vivo, J. Cardiovasc. Pharmacol., 22 (1993) 120–125.
25. Mandel, G., Tissue-specific expression of the voltage-sensitive sodium channel, J. Membrane Biol., 125 (1992) 193–205.
26. + conductance and the threshold for repetitive neuronal firing, Brain Res., 597 (1992) 92–98.
27. + channels, J. Neurophysiol., 72 (1994) 349–359.
28. Ochoa, J. and Torebjork, H.E., Paraesthesiae from ectopic impulse generation in human sensory nerves, Brain, 103 (1980) 835–854.
29. Palecek, J., Paleckova, V., Dougherty, P.M. Carlton, S.M. and Willis, W.D., Responses of spinothalamic tract cells to mechanical and thermal stimulation of skin in rats with experimental peripheral neuropathy, J. Neurophysiol., 67 (1992) 1562–1573.
30. + channels following axotomy in cutaneous afferent DRG neurons of adult rat, Soc. Neurosci. Abstr., 21 (1995) 1819.
31. Sangameswaran, L., Delgado, S.G., Fish, L.M., Koch, B., Jakeman, L.B., Stewart, G.R., Sze, P., Hunter, J.C., Eglen, R.M. and Herman, R.C., Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons, J. Biol. Chem., 271 (1996) 5953–5956.
32. Saporta, S., Spinal cord blood barrier alteration following peripheral nerve damage, Soc. Neurosci. Abstr., 20 (1994) 306.
33. Scadding, J.W., Development of ongoing activity, mechanosensitivity, and adrenaline sensitivity in severed peripheral nerve axons, Exp. Neurol., 73 (1981) 345–364.
34. Scadding, J.W., Peripheral neuropathies. In: P.D. Wall and R. Melzack (Eds.), Textbook of Pain, Churchill Livingstone, Edinburgh, 1994, pp. 667–684.
35. Sotgiu, M.L., Lacerenza, M. and Marchettini, P., Effect of systemic lidocaine on dorsal horn neuron hyperactivity following chronic peripheral nerve injury in rats, Somatosens. Motor Res., 9 (1992) 227–233.
36. Sotgiu, M.L., Biella, G., Castagna, A., Lacerenza, M. and Marchettini, P., Different time-courses of i.v. lidocaine effect on ganglionic and spinal units in neuropathic rats, Neuroreport, 5 (1994) 873–876.
37. Thomas, P.F., Morphological basis for alterations in nerve conduction in peripheral neuropathy, Proc. R. Soc. Med., 64 (1971) 295–298.
38. Torda, T.A., Sinclair, E. and Ulyatt, D.B., Puffer fish (tetrodotoxin) poisoning: clinical record and suggested management, Med. J. Australia, 1 (1973) 599–602.
39. Wall, P.D. and Devor, M., Sensory afferent impulses originate from dorsal root ganglia as well from the periphery in normal and nerve injured rats, Pain, 4 (1983) 321–340.
40. Wall, P.D. and Gutnik, M., Properties of afferent nerve impulse originating from neuroma, Nature (Lond.), 248 (1974) 740–743.
41. Waxman, S.G. and Ritchie, J.M., Organization of sodium channels in the myelinated nerve fiber, Science, 228 (1985) 1502–1507.
42. Woolf, C.J., Evidence for a central component of post-injury pain hypersensitivity, Nature, 306 (1983) 386–388.
43. Woolf, C.J. and Wall, P.D., Chronic peripheral nerve section diminishes the primary afferent A-fibre mediated inhibition of rat dorsal horn neurons, Brain Res., 242 (1982) 77–85.
44. Woolf, C.J. and Doubell, T.P., The pathophysiology of chronic pain-increased sensitivity to low threshold A β -fibre inputs, Curr. Opin. Neurobiol., 4 (1994) 525–534.
45. Yoshida, S., Tetrodotoxin-resistant sodium channels, Cell. Mol. Neurobiol., 14 (1994) 227–244.