Human leukocyte antigen-DRB1*1502 (DR2Dw 12) transgene reduces incidence and severity of arthritis in mice

Human Immunology

Volumn 50, Issue 1, 1996, Pages 54-60

  Gonzalez Gay, Miguel A ^a,d   Zanelli, Eric ^a   Khare, Sanjay D ^a   Krco, Christopher J ^a   Zhou, Paul ^a,e   Inoko, Hidetoshi ^b   Griffiths, Marie M ^c   Luthra, Harvinder S ^a   David, Chella S ^a,f  

^a MAYO CLINIC   (United States)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d HOSPITAL XERAL CALDE   (Spain)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

^f MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA DR ANTIGEN;

ANIMAL CELL; ANIMAL MODEL; ANTIBODY DETECTION; ARTHRITIS; ARTICLE; DISEASE SEVERITY; FLOW CYTOMETRY; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENE; TRANSGENIC MOUSE;

EID: 0030587504     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/0198-8859(96)00123-1     Document Type: Article

References (33)

1. 1. Statsny P: Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med 298:869, 1978.
2. 2. Tan PLJ, Farmiloe S, Roberts M, Geursen A, Skinner MA: HLA-DR4 subtypes in New Zealand Polynesians. Predominance of Dw13 in the healthy population and association of Dw15 with rheumatoid arthritis. Arthritis Rheum 36:15, 1993.
3. 3. Yelamos J, Garcia Lozano JR, Moreno I, Aguilera I, Gonzalez F, Garcia A, Nuñez-Roldan A, Sanchez B: Association of HLA-DR4-Dw15 (DRB1 *0405) and DR10 with rheumatoid arthritis in a Spanish population. Arthritis Rheum 36:811, 1993.
4. 4. Gregersen PK, Silver J, Winchester RJ: The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 30:1205, 1987.
5. 5. Weyand CM, Goronzy JJ: HLA-DRB1 alleles as severity markers in rheumatoid arthritis. Bull Rheum Dis 43:5, 1994.
6. 6. Taneja V, Mehra NK, Kailash S, Anand C, Malaviya AN: Protective and risk DR phenotypes in Asian Indian patients with rheumatoid arthritis. Ind J Med Res 96:16, 1992.
7. 7. Legrand L, Lathrop GM, Bardin T, Marcelli-Barge A, Dryll A, Debeyre N, Ryckewaert A: HLA haplotypes in non-familial rheumatoid arthritis. Ann Rheum Dis 46: 395, 1987.
8. 8. Larsen BA, Alderice CA, Howkins D, Martin JR, Mitchell DM, Sheridan DP: Protective HLA-DR phenotypes in rheumatoid arthritis. J Rheumatol 16:455, 1989.
9. 9. Ohta NY, Nishimura K, Tanimoto K, Horiuchi Y, Abe C, Shiokawa Y, Abe T, Katagiri M, Yoshiki T, Sasazuki T: Association between HLA and Japanese patients with rheumatoid arthritis. Hum Immunol 5:123, 1982.
10. 10. Taneja V, Giphart MJ, Verduijn W, Naipal A, Malaviya AN, Mehra NK: Polymorphism of HLA-DRB, DQA1 and DQB1 in rheumatoid arthritis in Asian Indians: Association with DRB1 *0405 and DRB1 *1001. Hum Immunol 46:35-41, 1996.
11. d transgene on collagen-induced arthritis. J Exp Med 180:1559, 1994.
12. 12. Gonzalez-Gay MA, Zanelli E, Krco CJ, Nabozny GH, Hanson J, Griffiths MM, Luthra HS, David CS: Polymorphism of the MHC class II Eb gene determines the protection against collagen-induced arthritis. Immunogenetics 42:35, 1995.
13. 13. Zanelli E, Krco CJ, Baisch J, Sheng C, David CS: Immune response of HLA-DQ8 transgenic mice to HLA-DRB1 HV3 peptides correlates with predisposition to rheumatoid arthritis. Proc Natl Acad Sci USA 93:1814, 1996.
14. 14. Zanelli E, Gonzalez-Gay MA, David CS: Could HLA-DRB1 be the protective locus in rheumatoid arthritis? Immunol Today 16:274, 1995.
15. 15. Kawai J, Ando A, Sato T, Nakatsuji T, Tsuji K, Inoko H: Analysis of gene structure and antigen determinants of DR2 antigens using DR gene transfer into mouse L cells. J Immunol 142:312, 1989.
16. 16. Grumet FC, Charron DJ, Fendly BM, Levy R, Ness DB: HLA-DR epitope region definition by use of monoclonal antibody probes. J Immunol 125:2785, 1980.
17. 17. Krco CJ, Beito TG, David CS: Determination of tolerance to self Eα peptides by clonal elimination of H-2E reactive T cells and antigen presentation by H-2A molecules. Transplantation 54:920, 1992.
18. 18. Khare SD, Krco CJ, Griffiths MM, Luthra HS, David CS: Oral administration of an immunodominant collagen peptide modulates collagen-induced arthritis. J Immunol 155:3653, 1995.
19. o mutant mice. Cell 58: 583, 1989.
20. 20. Anderson GD, David CS: In vivo expression and function of hybrid la dimers (Eα Aβ) in recombinant and transgenic mice. J Exp Med 170:1003, 1989.
21. 21. Wooley PH, Luthra HS, Griffiths MM, Stuart JM, Huse A, David CS: Type II collagen-induced arthritis in mice: IV. Variations in immunogenetic regulation provide evidence for multiple arthritogenic epitopes on the collagen molecule. J Immunol 135:2443, 1985.
22. 22. Bendtzen K, Morling N, Fomsgaard A, Svenson M, Jakobsen B, Ødum N, Svejgaard A: Association between HLA-DR2 and production of tumor necrosis factor α and Interleukin-1 by mononuclear cells activated by lipopolysaccharide. Scand J Immunol 28:599, 1988.
23. 23. Elliot MJ, Maini RN, Feldmann M, Kalden JR, Antoni C, Smolen J, Leeb B, Breedveld FC, Macfarlane JD, Bijl H, Woody JN: Randomised double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor a (cA2) versus placebo in rheumatoid arthritis. Lancet 344: 1105, 1994.
24. 24. Salvat S, Auger I, Rochelle L, Begovich A, Geburher L, Sette A, Roudier J: Tolerance to a self-peptide from the third hypervariable region of HLA DRB1 *0401 in rheumatoid arthritis patients and normal subjects. J Immunol 153:5321, 1994.
25. 25. Hammer J, Gallazzi F, Bono E, Karr RW, Guenot J, Valsasnini P, Nagy ZA, Shingaglia F: Peptide binding specificity of HLA-DR4 molecules: correlation with rheumatoid arthritis association. J Exp Med 181:1847, 1995.
26. s chain. Implications for molecular mimicry model of autoimmune disease. Eur J Immunol 21:2063, 1991.
27. 27. Roudier J, Petersen J, Rhodes GH, Luka J, Carson DA: Susceptibility to rheumatoid arthritis maps to a T-cell epitope shared by the HLA-Dw4 DRb1 chain and the Epstein-Barr virus and the glycoprotein gp110. Proc Natl Acad Sci USA 86:5104, 1989.
28. 28. Urban RG, Chicz RM, Vignali DA, Strominger JL: The dichotomy of peptide presentation by class I and class II MHC proteins. Chem Immunol 57:197, 1993.
29. 29. Rigby AS, Silman AJ, Voelm L, Gregory JC, Ollier WE, Khan MA, Nepom GT, Thomson G: Investigating the HLA component in rheumatoid arthritis: an additive (dominant) mode of inheritance is rejected, a recessive mode is preferred. Gen Epidemiol 8:153, 1991.
30. 30. Weyand CM, Hicok KC, Conn DL, Goronzy JJ: The influence of HLA-DRB1 gene on disease severity in rheumatoid arthritis. Ann Intern Med 117:801, 1992.
31. 31. Honen J, Reijonen H, Arvilommi H, Jokinen I, Möttönen T, Hannonen P: HLA-DR antigens and HLA-DQ beta chain polymorphism in susceptibility to rheumatoid arthritis. Ann Rheum Dis 49:494, 1990.
32. 32. McCusker CT, Reid B, Green D, Gladman DD, Buchanan WW, Singal DP: HLA-D region antigens in patients with rheumatoid arthritis. Arthritis Rheum 34:192, 1991.
33. 33. Nabozny GH, Baisch JM, Cheng S, Cosgrove D, Griffiths MM, Luthra HS, David CS: HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis. J Exp Med 183:27, 1996.