메뉴 건너뛰기




Volumn 68, Issue 3, 2006, Pages 210-219

Humanized transgenic mice expressing HLA DR4-DQ3 haplotype: Reconstitution of phenotype and HLA-restricted T-cell responses

Author keywords

HLA haplotype; MHC class II; T cell repertoire; Transgenic; Yeast artificial chromosome

Indexed keywords

CD4 ANTIGEN; HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; HLA DQ3 ANTIGEN; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; HLA DR4 ANTIGEN; HLA DRB4 ANTIGEN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

EID: 33748439524     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2006.00656.x     Document Type: Article
Times cited : (10)

References (51)
  • 1
    • 0025817428 scopus 로고
    • MHC class-II molecules and autoimmunity
    • Nepom GT, Erlich H. MHC class-II molecules and autoimmunity. Annu Rev Immunol 1991: 9: 493-525.
    • (1991) Annu Rev Immunol , vol.9 , pp. 493-525
    • Nepom, G.T.1    Erlich, H.2
  • 2
    • 0032403094 scopus 로고    scopus 로고
    • The role of MHC class II molecules in susceptibility and resistance to autoimmunity
    • McDevitt HO. The role of MHC class II molecules in susceptibility and resistance to autoimmunity. Curr Opin Immunol 1998: 10: 677-81.
    • (1998) Curr Opin Immunol , vol.10 , pp. 677-681
    • McDevitt, H.O.1
  • 4
    • 84991145247 scopus 로고
    • Disease associations with complotypes, supratypes and haplotypes
    • Dawkins RL, Christiansen FT, Kay PH et al. Disease associations with complotypes, supratypes and haplotypes. Immunol Rev 1983: 70: 1-22.
    • (1983) Immunol Rev , vol.70 , pp. 1-22
    • Dawkins, R.L.1    Christiansen, F.T.2    Kay, P.H.3
  • 5
    • 0034079792 scopus 로고    scopus 로고
    • Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice
    • Abraham RS, Kudva YC, Wilson SB, Strominger JL, David CS. Co-expression of HLA DR3 and DQ8 results in the development of spontaneous insulitis and loss of tolerance to GAD65 in transgenic mice. Diabetes 2000: 49: 548-54.
    • (2000) Diabetes , vol.49 , pp. 548-554
    • Abraham, R.S.1    Kudva, Y.C.2    Wilson, S.B.3    Strominger, J.L.4    David, C.S.5
  • 6
    • 0033994751 scopus 로고    scopus 로고
    • Complementation between specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis
    • Das P, Drescher KM, Geluk A, Bradley DS, Rodriguez M, David CS. Complementation between specific HLA-DR and HLA-DQ genes in transgenic mice determines susceptibility to experimental autoimmune encephalomyelitis. Hum Immunol 2000: 61: 279-89.
    • (2000) Hum Immunol , vol.61 , pp. 279-289
    • Das, P.1    Drescher, K.M.2    Geluk, A.3    Bradley, D.S.4    Rodriguez, M.5    David, C.S.6
  • 7
    • 0029135615 scopus 로고
    • HLA associated disease susceptibility: Which genes are primarily responsible?
    • Thorsby E. HLA associated disease susceptibility: which genes are primarily responsible? The Immunologist 1995: 3: 51.
    • (1995) The Immunologist , vol.3 , pp. 51
    • Thorsby, E.1
  • 8
    • 0033405948 scopus 로고    scopus 로고
    • HLA class II transgenic mice: Models of the human CD4+ T-cell immune response
    • Sonderstrup G, Cope AP, Patel S et al. HLA class II transgenic mice: models of the human CD4+ T-cell immune response. Immunol Rev 1999: 172: 335-43.
    • (1999) Immunol Rev , vol.172 , pp. 335-343
    • Sonderstrup, G.1    Cope, A.P.2    Patel, S.3
  • 9
    • 0034089844 scopus 로고    scopus 로고
    • HLA transgenic mice as models of human autoimmune diseases
    • Das P, Abraham R, David C. HLA transgenic mice as models of human autoimmune diseases. Rev Immunogenet 2000: 2: 105-14.
    • (2000) Rev Immunogenet , vol.2 , pp. 105-114
    • Das, P.1    Abraham, R.2    David, C.3
  • 10
    • 0003403213 scopus 로고
    • The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique
    • Acha-Orbea H, McDevitt HO. The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique. Proc Natl Acad Sci U S A 1987: 84: 2435-9.
    • (1987) Proc Natl Acad Sci U S A , vol.84 , pp. 2435-2439
    • Acha-Orbea, H.1    McDevitt, H.O.2
  • 11
    • 0025783584 scopus 로고
    • Nonobese diabetic and nonobese nondiabetic mice have unique MHC class II haplotypes
    • Acha-Orbea H, Scarpellino L. Nonobese diabetic and nonobese nondiabetic mice have unique MHC class II haplotypes. Immunogenetics 1991: 34: 57-9.
    • (1991) Immunogenetics , vol.34 , pp. 57-59
    • Acha-Orbea, H.1    Scarpellino, L.2
  • 12
    • 0030070997 scopus 로고    scopus 로고
    • Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM)
    • Yasunaga S, Kimura A, Hamaguchi K, Ronningen KS, Sasazuki T. Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM). Tissue Antigens 1996: 47: 37-48.
    • (1996) Tissue Antigens , vol.47 , pp. 37-48
    • Yasunaga, S.1    Kimura, A.2    Hamaguchi, K.3    Ronningen, K.S.4    Sasazuki, T.5
  • 13
    • 0031709101 scopus 로고    scopus 로고
    • Modulation of HLA-DQ-restricted collagen-induced arthritis by HLA-DRB1 polymorphism
    • Taneja V, Griffiths MM, Luthra H, David CS. Modulation of HLA-DQ-restricted collagen-induced arthritis by HLA-DRB1 polymorphism. Int Immunol 1998: 10: 1449-57.
    • (1998) Int Immunol , vol.10 , pp. 1449-1457
    • Taneja, V.1    Griffiths, M.M.2    Luthra, H.3    David, C.S.4
  • 14
    • 0032902704 scopus 로고    scopus 로고
    • The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases
    • Price P, Witt C, Allcock R et al. The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple immunopathological diseases. Immunol Rev 1999: 167: 257-74.
    • (1999) Immunol Rev , vol.167 , pp. 257-274
    • Price, P.1    Witt, C.2    Allcock, R.3
  • 15
    • 0035061420 scopus 로고    scopus 로고
    • The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model
    • Wen L, Chen NY, Tang J, Sherwin R, Wong FS. The regulatory role of DR4 in a spontaneous diabetes DQ8 transgenic model. J Clin Invest 2001: 107: 871-80.
    • (2001) J Clin Invest , vol.107 , pp. 871-880
    • Wen, L.1    Chen, N.Y.2    Tang, J.3    Sherwin, R.4    Wong, F.S.5
  • 16
    • 0028922437 scopus 로고
    • Genetic control of autoimmune diabetes in the NOD mouse
    • Wicker LS, Todd JA, Peterson LB. Genetic control of autoimmune diabetes in the NOD mouse. Annu Rev Immunol 1995: 13: 179-200.
    • (1995) Annu Rev Immunol , vol.13 , pp. 179-200
    • Wicker, L.S.1    Todd, J.A.2    Peterson, L.B.3
  • 17
    • 0028306138 scopus 로고
    • Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response
    • Fugger L, Michie SA, Rulifson I, Lock CB, McDevitt GS. Expression of HLA-DR4 and human CD4 transgenes in mice determines the variable region beta-chain T-cell repertoire and mediates an HLA-DR-restricted immune response. Proc Natl Acad Sci U S A 1994: 91: 6151-5.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 6151-6155
    • Fugger, L.1    Michie, S.A.2    Rulifson, I.3    Lock, C.B.4    McDevitt, G.S.5
  • 18
    • 0029987134 scopus 로고    scopus 로고
    • Immune response of HLA-DQ8 transgenic mice to peptides from the third hypervariable region of HLA-DRB1 correlates with predisposition to rheumatoid arthritis
    • Zanelli E, Krco CJ, Baisch JM, Cheng S, David CS. Immune response of HLA-DQ8 transgenic mice to peptides from the third hypervariable region of HLA-DRB1 correlates with predisposition to rheumatoid arthritis. Proc Natl Acad Sci U S A 1996: 93: 1814-9.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 1814-1819
    • Zanelli, E.1    Krco, C.J.2    Baisch, J.M.3    Cheng, S.4    David, C.S.5
  • 19
    • 0028333939 scopus 로고
    • Human major histocompatibility complex class II-restricted T cell responses in transgenic mice
    • Woods A, Chen HY, Trumbauer ME, Sirotina A, Cummings R, Zaller DM. Human major histocompatibility complex class II-restricted T cell responses in transgenic mice. J Exp Med 1994: 180: 173-81.
    • (1994) J Exp Med , vol.180 , pp. 173-181
    • Woods, A.1    Chen, H.Y.2    Trumbauer, M.E.3    Sirotina, A.4    Cummings, R.5    Zaller, D.M.6
  • 20
    • 0032832918 scopus 로고    scopus 로고
    • Complementation between HLA-DR4 (DRB1&z.ast;0401) and specific H2-A molecule in transgenic mice leads to collagen-induced arthritis
    • Pan S, Taneja V, Griffiths MM, Luthra H, David CS. Complementation between HLA-DR4 (DRB1&z.ast;0401) and specific H2-A molecule in transgenic mice leads to collagen-induced arthritis. Hum Immunol 1999: 60: 816-25.
    • (1999) Hum Immunol , vol.60 , pp. 816-825
    • Pan, S.1    Taneja, V.2    Griffiths, M.M.3    Luthra, H.4    David, C.S.5
  • 21
    • 0030042640 scopus 로고    scopus 로고
    • Expression and function of HLA-DQ8 (DQA1&z.ast;0301/DQB1&z. ast;0302) genes in transgenic mice
    • Cheng S, Baisch J, Krco C et al. Expression and function of HLA-DQ8 (DQA1&z.ast;0301/DQB1&z.ast;0302) genes in transgenic mice. Eur J Immunogenet 1996: 23: 15-20.
    • (1996) Eur J Immunogenet , vol.23 , pp. 15-20
    • Cheng, S.1    Baisch, J.2    Krco, C.3
  • 22
    • 0037087479 scopus 로고    scopus 로고
    • A 320-kilobase artificial chromosome encoding the human HLA DR3-DQ2 MHC haplotype confers HLA restriction in transgenic mice
    • Chen Z, Dudek N, Wijburg O et al. A 320-kilobase artificial chromosome encoding the human HLA DR3-DQ2 MHC haplotype confers HLA restriction in transgenic mice. J Immunol 2002: 168: 3050-6.
    • (2002) J Immunol , vol.168 , pp. 3050-3056
    • Chen, Z.1    Dudek, N.2    Wijburg, O.3
  • 23
    • 0017878054 scopus 로고
    • Association of the B-cell alloantigen DRw4 with rheumatoid arthritis
    • Stastny P. Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med 1978: 298: 869-71.
    • (1978) N Engl J Med , vol.298 , pp. 869-871
    • Stastny, P.1
  • 24
    • 0024829522 scopus 로고
    • HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region
    • Wordsworth BP, Lanchbury JS, Sakkas LI, Welsh KI, Panayi GS, Bell JI. HLA-DR4 subtype frequencies in rheumatoid arthritis indicate that DRB1 is the major susceptibility locus within the HLA class II region. Proc Natl Acad Sci U S A 1989: 86: 10049-53.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 10049-10053
    • Wordsworth, B.P.1    Lanchbury, J.S.2    Sakkas, L.I.3    Welsh, K.I.4    Panayi, G.S.5    Bell, J.I.6
  • 25
    • 0023500817 scopus 로고
    • The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis
    • Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987: 30: 1205-13.
    • (1987) Arthritis Rheum , vol.30 , pp. 1205-1213
    • Gregersen, P.K.1    Silver, J.2    Winchester, R.J.3
  • 26
    • 0029982537 scopus 로고    scopus 로고
    • Genetic analysis of autoimmune disease
    • Vyse TJ, Todd JA. Genetic analysis of autoimmune disease. Cell 1996: 85: 311-8.
    • (1996) Cell , vol.85 , pp. 311-318
    • Vyse, T.J.1    Todd, J.A.2
  • 27
    • 0025331496 scopus 로고
    • Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus
    • Baisch JM, Weeks T, Giles R, Hoover M, Stastny P, Capra JD. Analysis of HLA-DQ genotypes and susceptibility in insulin-dependent diabetes mellitus. N Engl J Med 1990: 322: 1836-41.
    • (1990) N Engl J Med , vol.322 , pp. 1836-1841
    • Baisch, J.M.1    Weeks, T.2    Giles, R.3    Hoover, M.4    Stastny, P.5    Capra, J.D.6
  • 28
    • 0028130006 scopus 로고
    • Molecular biology of IDDM
    • Lernmark A. Molecular biology of IDDM. Diabetologia 1994: 37 (Suppl 2): S73-81.
    • (1994) Diabetologia , vol.37 , Issue.2 SUPPL.
    • Lernmark, A.1
  • 29
    • 0023252262 scopus 로고
    • HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
    • Todd JA, Bell JI, McDevitt HO. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 1987: 329: 599-604.
    • (1987) Nature , vol.329 , pp. 599-604
    • Todd, J.A.1    Bell, J.I.2    McDevitt, H.O.3
  • 30
    • 0036226776 scopus 로고    scopus 로고
    • HLA-DR and HLA-DQ polymorphism in human thyroglobulin-induced autoimmune thyroiditis: DR3 and DQ8 transgenic mice are susceptible
    • Wan Q, Shah R, Panos JC, Giraldo AA, David CS, Kong YM. HLA-DR and HLA-DQ polymorphism in human thyroglobulin-induced autoimmune thyroiditis: DR3 and DQ8 transgenic mice are susceptible. Hum Immunol 2002: 63: 301-10.
    • (2002) Hum Immunol , vol.63 , pp. 301-310
    • Wan, Q.1    Shah, R.2    Panos, J.C.3    Giraldo, A.A.4    David, C.S.5    Kong, Y.M.6
  • 31
    • 0027973459 scopus 로고
    • Cloning the human major histocompatibility complex in YACs
    • Abderrahim H, Sambucy JL, Iris F et al. Cloning the human major histocompatibility complex in YACs. Genomics 1994: 23: 520-7.
    • (1994) Genomics , vol.23 , pp. 520-527
    • Abderrahim, H.1    Sambucy, J.L.2    Iris, F.3
  • 32
    • 0029690309 scopus 로고    scopus 로고
    • Markers, selection, and media in YAC cloning
    • Markie D. Markers, selection, and media in YAC cloning. Methods Mol Biol 1996: 54: 359-71.
    • (1996) Methods Mol Biol , vol.54 , pp. 359-371
    • Markie, D.1
  • 33
    • 0029690468 scopus 로고    scopus 로고
    • Purification of YAC-containing total yeast DNA
    • Silverman GA. Purification of YAC-containing total yeast DNA. Methods Mol Biol 1996: 54: 65-8.
    • (1996) Methods Mol Biol , vol.54 , pp. 65-68
    • Silverman, G.A.1
  • 34
    • 0029689508 scopus 로고    scopus 로고
    • Restriction analysis of YACs
    • Ragoussis J. Restriction analysis of YACs. Methods Mol Biol 1996: 54: 69-74.
    • (1996) Methods Mol Biol , vol.54 , pp. 69-74
    • Ragoussis, J.1
  • 35
    • 0029684555 scopus 로고    scopus 로고
    • End rescue from YACs using the vectorette
    • Ogilvie DJ, James LA. End rescue from YACs using the vectorette. Methods Mol Biol 1996: 54: 131-8.
    • (1996) Methods Mol Biol , vol.54 , pp. 131-138
    • Ogilvie, D.J.1    James, L.A.2
  • 36
    • 0025037630 scopus 로고
    • Generation of deletion derivatives by targeted transformation of human-derived yeast artificial chromosomes
    • Pavan WJ, Hieter P, Reeves RH. Generation of deletion derivatives by targeted transformation of human-derived yeast artificial chromosomes. Proc Natl Acad Sci U S A 1990: 87: 1300-4.
    • (1990) Proc Natl Acad Sci U S A , vol.87 , pp. 1300-1304
    • Pavan, W.J.1    Hieter, P.2    Reeves, R.H.3
  • 37
    • 0029687570 scopus 로고    scopus 로고
    • YAC transfer into mammalian cells by cell fusion
    • Davies NP, Huxley C. YAC transfer into mammalian cells by cell fusion. Methods Mol Biol 1996: 54: 281-92.
    • (1996) Methods Mol Biol , vol.54 , pp. 281-292
    • Davies, N.P.1    Huxley, C.2
  • 38
    • 0030458409 scopus 로고    scopus 로고
    • A method for high efficiency YAC lipofection into murine embryonic stem cells
    • Lee JT, Jaenisch R. A method for high efficiency YAC lipofection into murine embryonic stem cells. Nucleic Acids Res 1996: 24: 5054-5.
    • (1996) Nucleic Acids Res , vol.24 , pp. 5054-5055
    • Lee, J.T.1    Jaenisch, R.2
  • 40
    • 0027460824 scopus 로고
    • Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4
    • Killeen N, Sawada S, Littman DR. Regulated expression of human CD4 rescues helper T cell development in mice lacking expression of endogenous CD4. Embo J 1993: 12: 1547-53.
    • (1993) Embo J , vol.12 , pp. 1547-1553
    • Killeen, N.1    Sawada, S.2    Littman, D.R.3
  • 41
    • 0018937455 scopus 로고
    • Two populations of Ia-like molecules on a human B cell line
    • Lampson LA, Levy R. Two populations of Ia-like molecules on a human B cell line. J Immunol 1980: 125: 293-9.
    • (1980) J Immunol , vol.125 , pp. 293-299
    • Lampson, L.A.1    Levy, R.2
  • 42
    • 0020526349 scopus 로고
    • Human T4+ and T8+ cytotoxic T lymphocyte clones directed at products of different class II major histocompatibility complex loci
    • Spits H, Ijssel H, Thompson A, de Vries JE. Human T4+ and T8+ cytotoxic T lymphocyte clones directed at products of different class II major histocompatibility complex loci. J Immunol 1983: 131: 678-83.
    • (1983) J Immunol , vol.131 , pp. 678-683
    • Spits, H.1    Ijssel, H.2    Thompson, A.3    De Vries, J.E.4
  • 43
    • 0025056497 scopus 로고
    • Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes
    • Mellins E, Smith L, Arp B, Cotner T, Celis E, Pious D. Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes. Nature 1990: 343: 71-4.
    • (1990) Nature , vol.343 , pp. 71-74
    • Mellins, E.1    Smith, L.2    Arp, B.3    Cotner, T.4    Celis, E.5    Pious, D.6
  • 44
    • 0022649020 scopus 로고
    • Expression of HLA-DR, -DQ, and -DP antigens on renal tubular cells during rejection episodes
    • Russ GR, Pascoe V, d'Apice AJ, Seymour AE. Expression of HLA-DR, -DQ, and -DP antigens on renal tubular cells during rejection episodes. Transplant Proc 1986: 18: 293-7.
    • (1986) Transplant Proc , vol.18 , pp. 293-297
    • Russ, G.R.1    Pascoe, V.2    D'Apice, A.J.3    Seymour, A.E.4
  • 45
    • 0034002680 scopus 로고    scopus 로고
    • Dual role for macrophages in vivo in pathogenesis and control of murine Salmonella enterica var. Typhimurium infections
    • Wijburg OL, Simmons CP, van Rooijen N, Strugnell RA. Dual role for macrophages in vivo in pathogenesis and control of murine Salmonella enterica var. Typhimurium infections. Eur J Immunol 2000: 30: 944-53.
    • (2000) Eur J Immunol , vol.30 , pp. 944-953
    • Wijburg, O.L.1    Simmons, C.P.2    Van Rooijen, N.3    Strugnell, R.A.4
  • 46
    • 0033649516 scopus 로고    scopus 로고
    • Production of transgenic mice with yeast artificial chromosomes
    • Jakobovits A, Lamb BT, Peterson KR. Production of transgenic mice with yeast artificial chromosomes. Methods Mol Biol 2000: 136: 435-53.
    • (2000) Methods Mol Biol , vol.136 , pp. 435-453
    • Jakobovits, A.1    Lamb, B.T.2    Peterson, K.R.3
  • 47
    • 15844398106 scopus 로고    scopus 로고
    • HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis
    • Ito K, Bian HJ, Molina M et al. HLA-DR4-IE chimeric class II transgenic, murine class II-deficient mice are susceptible to experimental allergic encephalomyelitis. J Exp Med 1996: 183: 2635-44.
    • (1996) J Exp Med , vol.183 , pp. 2635-2644
    • Ito, K.1    Bian, H.J.2    Molina, M.3
  • 49
    • 0025887850 scopus 로고
    • Effect of natural polymorphism at residue 86 of the HLA-DR beta chain on peptide binding
    • Busch R, Hill CM, Hayball JD, Lamb JR, Rothbard JB. Effect of natural polymorphism at residue 86 of the HLA-DR beta chain on peptide binding. J Immunol 1991: 147: 1292-8.
    • (1991) J Immunol , vol.147 , pp. 1292-1298
    • Busch, R.1    Hill, C.M.2    Hayball, J.D.3    Lamb, J.R.4    Rothbard, J.B.5
  • 50
    • 0029886029 scopus 로고    scopus 로고
    • Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: Major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location
    • Hess J, Ladel C, Miko D, Kaufmann SH. Salmonella typhimurium aroA- infection in gene-targeted immunodeficient mice: major role of CD4+ TCR-alpha beta cells and IFN-gamma in bacterial clearance independent of intracellular location. J Immunol 1996: 156: 3321-6.
    • (1996) J Immunol , vol.156 , pp. 3321-3326
    • Hess, J.1    Ladel, C.2    Miko, D.3    Kaufmann, S.H.4
  • 51
    • 0031716214 scopus 로고    scopus 로고
    • Characterization of self-glutamic acid decarboxylase 65-reactive CD4+ T-cell clones established from Japanese patients with insulin-dependent diabetes mellitus
    • Tabata H, Kanai T, Yoshizumi H et al. Characterization of self-glutamic acid decarboxylase 65-reactive CD4+ T-cell clones established from Japanese patients with insulin-dependent diabetes mellitus. Hum Immunol 1998: 59: 549-60.
    • (1998) Hum Immunol , vol.59 , pp. 549-560
    • Tabata, H.1    Kanai, T.2    Yoshizumi, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.