Hypoxia as a target for tissue specific gene therapy

Journal of Controlled Release

Volumn 172, Issue 2, 2013, Pages 484-494

  Rhim, Taiyoun ^a   Lee, Dong Yun ^a   Lee, Minhyung ^a  

^a Hanyang University   (South Korea)

Author keywords

Gene regulation; Gene therapy; Hypoxia; Oxygen dependent degradation; Promoter; Untranslated region

Indexed keywords

HYPOXIA; INDUCIBLE GENE-EXPRESSION SYSTEMS; ISCHEMIC HEART DISEASE; PROMOTER; SPINAL CORD INJURIES (SCI); TRANSCRIPTIONAL REGULATION; TRANSLATIONAL REGULATION; UNTRANSLATED REGIONS;

GENE EXPRESSION; OXYGEN; PLANTS (BOTANY); TISSUE;

GENE THERAPY;

COMPLEMENTARY DNA; ELONGATION FACTOR 1ALPHA; ERYTHROPOIETIN; FERRITIN; FIBROBLAST GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MATRIX METALLOPROTEINASE; MESSENGER RNA; MICRORNA; SCATTER FACTOR; SMALL INTERFERING RNA; TRANSFERRIN RECEPTOR; VASCULOTROPIN;

3' UNTRANSLATED REGION; 5' UNTRANSLATED REGION; AMINO ACID SEQUENCE; ANGIOGENESIS; CANCER THERAPY; EX VIVO GENE TRANSFER; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE EXPRESSION SYSTEM; GENE THERAPY; GLYCOLYSIS; GOLGI COMPLEX; HYPOXIA; ISCHEMIC HEART DISEASE; NEOPLASM; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROMOTER REGION; REVIEW; RNA STABILITY; SPINAL CORD INJURY;

ACTIVATING TRANSCRIPTION FACTOR-4; ARNT; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; ATF-4; BASIC HELIX-LOOP-HELIX; BASSO, BEATTIE, AND BRESNAHAN; BBB; BHLH; CELLULAR FLICE-INHIBITORY PROTEIN; CFLIP; CYGB; CYP2B6; CYT C; CYTOCHROME C; CYTOCHROME P450 ISOFORM 2B6; CYTOGLOBIN; DBD; DEXAMETHASONE-INDUCED GENE 2; DIG2; DNA BINDING DOMAIN; EPO; ERE; ERYTHROPOIETIN; ESTROGEN RESPONSE ELEMENT; GAPDH; GENE REGULATION; GENE THERAPY; GLP-1; GLUCAGON-LIKE PEPTIDE-1; GLUTATHIONE PEROXIDASE-1; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; GPX-1; HIF-1; HRE; HYPOXIA; HYPOXIA INDUCIBLE FACTOR-1; HYPOXIA RESPONSE ELEMENT; IRES; IRON RESPONSIVE ELEMENTS; MAMMALIAN TARGET OF RAPAMYCIN; METALLOTHIONEIN; MICRORNAS; MIRNAS; MT; MTOR; ODD; OXYGEN DEPENDENT DEGRADATION; PGK-1; PHDS; PHOSPHOGLYCERATE KINASE-1; PROLYL HYDROXYLASES; PROMOTER; PVHL; RCC; REACTIVE OXYGEN SPECIES; REDD1; REGULATED IN DEVELOPMENT AND DNA DAMAGE RESPONSES 1; RENAL CELL CARCINOMAS; ROS; SECRETION SIGNAL PEPTIDE; SHORT HAIRPIN RNA; SHP-1; SHRNA; SIMIAN VIRUS 40; SIRNA; SMALL INTERFERING RNA; SP-1; SRC HOMOLOGY DOMAIN-2 CONTAINING TYROSINE PHOSPHATASE-1; SSP; STIMULATING PROTEIN-1; SV40; TAD; TH; TRANSACTIVATION DOMAIN; TSTA; TWO-STEP TRANSCRIPTION AMPLIFICATION; TYROSINE HYDROXYLASE; UNFOLDED PROTEIN RESPONSE; UNTRANSLATED REGION; UPR; UTR; VASCULAR ENDOTHELIAL GROWTH FACTOR; VEGF; VON HIPPEL-LINDAU PROTEIN; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN; XIAP;

ANIMALS; ANOXIA; GENE EXPRESSION REGULATION; GENETIC THERAPY; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; PROMOTER REGIONS, GENETIC; UNTRANSLATED REGIONS;

EID: 84887048090     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.05.021     Document Type: Review

References (141)

1. H.A. Kim, R.I. Mahato, and M. Lee Hypoxia-specific gene expression for ischemic disease gene therapy Adv. Drug Deliv. Rev. 61 2009 614 622
2. M. Lee Hypoxia targeting gene expression for breast cancer gene therapy Adv. Drug Deliv. Rev. 61 2009 842 849
3. K.E. Dionne, C.K. Colton, and M.L. Yarmush Effect of oxygen on isolated pancreatic tissue ASAIO Trans. 35 1989 739 741 (Pubitemid 20118362)
4. J. Schrezenmeir, L. Gero, C. Laue, J. Kirchgessner, A. Muller, A. Huls, R. Passmann, H.J. Hahn, L. Kunz, W. Mueller-Klieser, and J.J. Altmann The role of oxygen supply in islet transplantation Transplant. Proc. 24 1992 2925 2929 (Pubitemid 23011764)
5. B. Vasir, L.P. Aiello, K.H. Yoon, R.R. Quickel, S. Bonner-Weir, and G.C. Weir Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells Diabetes 47 1998 1894 1903 (Pubitemid 28549196)
6. G.L. Wang, and G.L. Semenza General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia Proc. Natl. Acad. Sci. U.S.A. 90 1993 4304 4308 (Pubitemid 23134215)
7. H. Zhu, and H.F. Bunn Oxygen sensing and signaling: impact on the regulation of physiologically important genes Respir. Physiol. 115 1999 239 247 (Pubitemid 29206488)
8. G.L. Semenza, P.H. Roth, H.M. Fang, and G.L. Wang Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1 J. Biol. Chem. 269 1994 23757 23763 (Pubitemid 24293585)
9. B.H. Jiang, E. Rue, G.L. Wang, R. Roe, and G.L. Semenza Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1 J. Biol. Chem. 271 1996 17771 17778 (Pubitemid 26250751)
10. 2 tension Am. J. Physiol. 271 1996 C1172 C1180
11. I.J. Rondon, L.A. MacMillan, B.S. Beckman, M.A. Goldberg, T. Schneider, H.F. Bunn, and J.S. Malter Hypoxia up-regulates the activity of a novel erythropoietin mRNA binding protein J. Biol. Chem. 266 1991 16594 16598 (Pubitemid 21907840)
12. A.P. Levy, N.S. Levy, and M.A. Goldberg Post-transcriptional regulation of vascular endothelial growth factor by hypoxia J. Biol. Chem. 271 1996 2746 2753 (Pubitemid 26047892)
13. A.B. Scandurro, and B.S. Beckman Common proteins bind mRNAs encoding erythropoietin, tyrosine hydroxylase, and vascular endothelial growth factor Biochem. Biophys. Res. Commun. 246 1998 436 440 (Pubitemid 28412619)
14. H. Harada, S. Kizaka-Kondoh, S. Itasaka, K. Shibuya, A. Morinibu, K. Shinomiya, and M. Hiraoka The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts Biochem. Biophys. Res. Commun. 360 2007 791 796 (Pubitemid 47077390)
15. S.J. Goldman, E. Chen, R. Taylor, S. Zhang, W. Petrosky, M. Reiss, and S. Jin Use of the ODD-luciferase transgene for the non-invasive imaging of spontaneous tumors in mice PLoS One 6 2011 e18269
16. J. Liu, A. Barradas, H. Fernandes, F. Janssen, B. Papenburg, D. Stamatialis, A. Martens, C. van Blitterswijk, and J. de Boer In vitro and in vivo bioluminescent imaging of hypoxia in tissue-engineered grafts Tissue Eng. Part C, Methods 16 2010 479 485
17. B.H. Jiang, J.Z. Zheng, S.W. Leung, R. Roe, and G.L. Semenza Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension J. Biol. Chem. 272 1997 19253 19260 (Pubitemid 27337716)
18. 2-dependent degradation domain via the ubiquitin-proteasome pathway Proc. Natl. Acad. Sci. U.S.A. 95 1998 7987 7992
19. F. Wang, H. Sekine, Y. Kikuchi, C. Takasaki, C. Miura, O. Heiwa, T. Shuin, Y. Fujii-Kuriyama, and K. Sogawa HIF-1alpha-prolyl hydroxylase: molecular target of nitric oxide in the hypoxic signal transduction pathway Biochem. Biophys. Res. Commun. 295 2002 657 662 (Pubitemid 34756899)
20. N. Masson, and P.J. Ratcliffe HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels J. Cell. Sci. 116 2003 3041 3049 (Pubitemid 37038953)
21. A. Gorlach, G. Camenisch, I. Kvietikova, L. Vogt, R.H. Wenger, and M. Gassmann Efficient translation of mouse hypoxia-inducible factor-1alpha under normoxic and hypoxic conditions Biochim. Biophys. Acta 1493 2000 125 134
22. E. Minet, I. Ernest, G. Michel, I. Roland, J. Remacle, M. Raes, and C. Michiels HIF1A gene transcription is dependent on a core promoter sequence encompassing activating and inhibiting sequences located upstream from the transcription initiation site and cis elements located within the 5′UTR Biochem. Biophys. Res. Commun. 261 1999 534 540 (Pubitemid 29392511)
23. Q. Xu, Y.S. Ji, and J.F. Schmedtje Jr. Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium. Implications for the mechanisms of aortic aneurysm and heart failure J. Biol. Chem. 275 2000 24583 24589 (Pubitemid 30626555)
24. Y. Tsuzuki, D. Fukumura, B. Oosthuyse, C. Koike, P. Carmeliet, and R.K. Jain Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1alpha → hypoxia response element → VEGF cascade differentially regulates vascular response and growth rate in tumors Cancer Res. 60 2000 6248 6252
25. J.D. Firth, B.L. Ebert, C.W. Pugh, and P.J. Ratcliffe Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3′ enhancer Proc. Natl. Acad. Sci. U.S.A. 91 1994 6496 6500
26. S. Lu, X. Gu, S. Hoestje, and D.E. Epner Identification of an additional hypoxia responsive element in the glyceraldehyde-3-phosphate dehydrogenase gene promoter Biochim. Biophys. Acta 1574 2002 152 156 (Pubitemid 34304326)
27. R. McCormick, F.M. Buffa, J. Ragoussis, and A.L. Harris The role of hypoxia regulated microRNAs in cancer Curr. Top. Microbiol. Immunol. 345 2010 47 70
28. E.C. McGary, I.J. Rondon, and B.S. Beckman Post-transcriptional regulation of erythropoietin mRNA stability by erythropoietin mRNA-binding protein J. Biol. Chem. 272 1997 8628 8634 (Pubitemid 27147829)
29. J.A. Dibbens, D.L. Miller, A. Damert, W. Risau, M.A. Vadas, and G.J. Goodall Hypoxic regulation of vascular endothelial growth factor mRNA stability requires the cooperation of multiple RNA elements Mol. Biol. Cell. 10 1999 907 919 (Pubitemid 29193720)
30. T. Shibata, A.J. Giaccia, and J.M. Brown Development of a hypoxia-responsive vector for tumor-specific gene therapy Gene Ther. 7 2000 493 498 (Pubitemid 30156563)
31. B.D. Schneider, and E.A. Leibold Effects of iron regulatory protein regulation on iron homeostasis during hypoxia Blood 102 2003 3404 3411 (Pubitemid 37314783)
32. G.U. Dachs, A.V. Patterson, J.D. Firth, P.J. Ratcliffe, K.M. Townsend, I.J. Stratford, and A.L. Harris Targeting gene expression to hypoxic tumor cells Nat. Med. 3 1997 515 520 (Pubitemid 27198648)
33. K. Binley, S. Iqball, A. Kingsman, S. Kingsman, and S. Naylor An adenoviral vector regulated by hypoxia for the treatment of ischaemic disease and cancer Gene Ther. 6 1999 1721 1727 (Pubitemid 29485947)
34. K. Binley, Z. Askham, S. Iqball, H. Spearman, L. Martin, M. de Alwis, A.J. Thrasher, R.R. Ali, P.H. Maxwell, S. Kingsman, and S. Naylor Long-term reversal of chronic anemia using a hypoxia-regulated erythropoietin gene therapy Blood 100 2002 2406 2413
35. H. Su, J. Arakawa-Hoyt, and Y.W. Kan Adeno-associated viral vector-mediated hypoxia response element-regulated gene expression in mouse ischemic heart model Proc. Natl. Acad. Sci. U.S.A. 99 2002 9480 9485 (Pubitemid 34764639)
36. M. Lee, J. Rentz, M. Bikram, S. Han, D.A. Bull, and S.W. Kim Hypoxia-inducible VEGF gene delivery to ischemic myocardium using water-soluble lipopolymer Gene Ther. 10 2003 1535 1542 (Pubitemid 37063258)
37. M. Lee, E.S. Lee, Y.S. Kim, B.H. Choi, S.R. Park, H.S. Park, H.C. Park, S.W. Kim, and Y. Ha Ischemic injury-specific gene expression in the rat spinal cord injury model using hypoxia-inducible system Spine 30 2005 2729 2734 (Pubitemid 43011032)
38. S.H. Bhang, J.H. Kim, H.S. Yang, W.G. La, T.J. Lee, G.H. Kim, H.A. Kim, M. Lee, and B.S. Kim Combined gene therapy with hypoxia-inducible factor-1alpha and heme oxygenase-1 for therapeutic angiogenesis Tissue Eng. Part A 17 2011 915 926
39. H. Lu, Y. Zhang, D.D. Roberts, C.K. Osborne, and N.S. Templeton Enhanced gene expression in breast cancer cells in vitro and tumors in vivo Mol. Ther. 6 2002 783 792 (Pubitemid 36054311)
40. R. Hernandez-Alcoceba, M. Pihalja, D. Qian, and M.F. Clarke New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication Hum. Gene Ther. 13 2002 1737 1750 (Pubitemid 35191748)
41. L. Yang, Z. Cao, F. Li, D.E. Post, E.G. Van Meir, H. Zhong, and W.C. Wood Tumor-specific gene expression using the survivin promoter is further increased by hypoxia Gene Ther. 11 2004 1215 1223 (Pubitemid 39136785)
42. Y. Tang, M. Jackson, K. Qian, and M.I. Phillips Hypoxia inducible double plasmid system for myocardial ischemia gene therapy Hypertension 39 2002 695 698 (Pubitemid 34165208)
43. M. Lee, D. Choi, M.J. Choi, J.H. Jeong, W.J. Kim, S. Oh, Y.H. Kim, D.A. Bull, and S.W. Kim Hypoxia-inducible gene expression system using the erythropoietin enhancer and 3′-untranslated region for the VEGF gene therapy J. Control. Release 115 2006 113 119 (Pubitemid 44415080)
44. B.H. Choi, Y. Ha, C.H. Ahn, X. Huang, J.M. Kim, S.R. Park, H. Park, H.C. Park, S.W. Kim, and M. Lee A hypoxia-inducible gene expression system using erythropoietin 3′ untranslated region for the gene therapy of rat spinal cord injury Neurosci. Lett. 412 2007 118 122 (Pubitemid 46074362)
45. H.A. Kim, S. Lim, H.H. Moon, S.W. Kim, K.C. Hwang, M. Lee, S.H. Kim, and D. Choi Hypoxia-inducible vascular endothelial growth factor gene therapy using the oxygen-dependent degradation domain in myocardial ischemia Pharm. Res. 27 2010 2075 2084
46. C.H. Tator, and M.G. Fehlings Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms J. Neurosurg. 75 1991 15 26
47. M. Sakurai, K. Abe, T. Hayashi, Y. Setoguchi, G. Yaginuma, T. Meguro, and K. Tabayashi Adenovirus-mediated glial cell line-derived neurotrophic factor gene delivery reduces motor neuron injury after transient spinal cord ischemia in rabbits J. Thorac. Cardiovasc. Surg. 120 2000 1148 1157
48. A. Blesch, P. Lu, and M.H. Tuszynski Neurotrophic factors, gene therapy, and neural stem cells for spinal cord repair Brain Res. Bull. 57 2002 833 838 (Pubitemid 34522160)
49. A. Blesch, and M.H. Tuszynski Gene therapy and cell transplantation for Alzheimer's disease and spinal cord injury Yonsei Med. J. 45 2004 28 31 (Suppl.) (Pubitemid 39010730)
50. K. Jin, Y. Zhu, Y. Sun, X.O. Mao, L. Xie, and D.A. Greenberg Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo Proc. Natl. Acad. Sci. USA 99 2002 11946 11950 (Pubitemid 34994504)
51. P. Carmeliet, and E. Storkebaum Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders Semin. Cell Dev. Biol. 13 2002 39 53 (Pubitemid 35418313)
52. F. Facchiano, E. Fernandez, S. Mancarella, G. Maira, M. Miscusi, D. D'Arcangelo, G. Cimino-Reale, M.L. Falchetti, M.C. Capogrossi, and R. Pallini Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor J. Neurosurg. 97 2002 161 168 (Pubitemid 34693714)
53. J. Widenfalk, A. Lipson, M. Jubran, C. Hofstetter, T. Ebendal, Y. Cao, and L. Olson Vascular endothelial growth factor improves functional outcome and decreases secondary degeneration in experimental spinal cord contusion injury Neuroscience 120 2003 951 960 (Pubitemid 36966647)
54. R.J. Lee, M.L. Springer, W.E. Blanco-Bose, R. Shaw, P.C. Ursell, and H.M. Blau VEGF gene delivery to myocardium: deleterious effects of unregulated expression Circulation 102 2000 898 901
55. M. Lee, M. Bikram, S. Oh, D.A. Bull, and S.W. Kim Sp1-dependent regulation of the RTP801 promoter and its application to hypoxia-inducible VEGF plasmid for ischemic disease Pharm. Res. 21 2004 736 741 (Pubitemid 39011293)
56. U.H. Choi, Y. Ha, X. Huang, S.R. Park, J. Chung, D.K. Hyun, H. Park, H.C. Park, S.W. Kim, and M. Lee Hypoxia-inducible expression of vascular endothelial growth factor for the treatment of spinal cord injury in a rat model J. Neurosurg. Spine 7 2007 54 60 (Pubitemid 47067739)
57. J.W. Yockman, D. Choi, M.G. Whitten, C.W. Chang, A. Kastenmeier, H. Erickson, A. Albanil, M. Lee, S.W. Kim, and D.A. Bull Polymeric gene delivery of ischemia-inducible VEGF significantly attenuates infarct size and apoptosis following myocardial infarct Gene Ther. 16 2009 127 135
58. Y.W. Won, M. Lee, H.A. Kim, D.A. Bull, and S.W. Kim Hypoxia-inducible plasmid expressing both miSHP-1 and HO-1 for the treatment of ischemic disease J. Control. Release 165 2013 22 28
59. H. Zhou, X.G. Xia, and Z. Xu An RNA polymerase II construct synthesizes short-hairpin RNA with a quantitative indicator and mediates highly efficient RNAi Nucleic Acids Res. 33 2005 e62
60. H.A. Kim, K. Kim, S.W. Kim, and M. Lee Transcriptional and post-translational regulatory system for hypoxia specific gene expression using the erythropoietin enhancer and the oxygen-dependent degradation domain J. Control. Release 121 2007 218 224 (Pubitemid 47212541)
61. Y.W. Won, M. Lee, H.A. Kim, D.A. Bull, and S.W. Kim Post-translational regulated and hypoxia-responsible VEGF plasmid for efficient secretion J. Control. Release 160 2012 525 531
62. J.M. Brown Exploiting the hypoxic cancer cell: mechanisms and therapeutic strategies Mol. Med. Today 6 2000 157 162 (Pubitemid 30171366)
63. P. Vaupel, F. Kallinowski, and P. Okunieff Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review Cancer Res. 49 1989 6449 6465 (Pubitemid 20008770)
64. H.E. Ryan, M. Poloni, W. McNulty, D. Elson, M. Gassmann, J.M. Arbeit, and R.S. Johnson Hypoxia-inducible factor-1alpha is a positive factor in solid tumor growth Cancer Res. 60 2000 4010 4015 (Pubitemid 30636574)
65. C.W. Chien, S.C. Lin, Y.Y. Lai, B.W. Lin, J.C. Lee, and S.J. Tsai Regulation of CD151 by hypoxia controls cell adhesion and metastasis in colorectal cancer Clin. Cancer Res. 14 2008 8043 8051
66. K. Binley, Z. Askham, L. Martin, H. Spearman, D. Day, S. Kingsman, and S. Naylor Hypoxia-mediated tumour targeting Gene Ther. 10 2003 540 549 (Pubitemid 36432605)
67. R.H. Pin, M. Reinblatt, and Y. Fong Employing tumor hypoxia to enhance oncolytic viral therapy in breast cancer Surgery 136 2004 199 204 (Pubitemid 39037654)
68. R. Hernandez-Alcoceba, M. Pihalja, G. Nunez, and M.F. Clarke Evaluation of a new dual-specificity promoter for selective induction of apoptosis in breast cancer cells Cancer Gene Ther. 8 2001 298 307 (Pubitemid 32480067)
69. Q. Ke, and M. Costa Hypoxia-inducible factor-1 (HIF-1) Mol. Pharmacol. 70 2006 1469 1480
70. X. Sun, M. Vale, X. Jiang, R. Gupta, and G.W. Krissansen Antisense HIF-1alpha prevents acquired tumor resistance to angiostatin gene therapy Cancer Gene Ther. 17 2010 532 540
71. X. Sun, J.R. Kanwar, E. Leung, M. Vale, and G.W. Krissansen Regression of solid tumors by engineered overexpression of von Hippel-Lindau tumor suppressor protein and antisense hypoxia-inducible factor-1alpha Gene Ther. 10 2003 2081 2089 (Pubitemid 37483650)
72. M. Ogura, T. Shibata, J. Yi, J. Liu, R. Qu, H. Harada, and M. Hiraoka A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas Cancer Sci. 96 2005 288 294 (Pubitemid 40895077)
73. M. Hemmings-Mieszczak, G. Dorn, F.J. Natt, J. Hall, and W.L. Wishart Independent combinatorial effect of antisense oligonucleotides and RNAi-mediated specific inhibition of the recombinant rat P2X3 receptor Nucleic Acids Res. 31 2003 2117 2126 (Pubitemid 37442079)
74. S. Matsumoto, M. Miyagishi, H. Akashi, R. Nagai, and K. Taira Analysis of double-stranded RNA-induced apoptosis pathways using interferon-response noninducible small interfering RNA expression vector library J. Biol. Chem. 280 2005 25687 25696 (Pubitemid 40962278)
75. T. Mizuno, M. Nagao, Y. Yamada, M. Narikiyo, M. Ueno, M. Miyagishi, K. Taira, and Y. Nakajima Small interfering RNA expression vector targeting hypoxia-inducible factor 1 alpha inhibits tumor growth in hepatobiliary and pancreatic cancers Cancer Gene Ther. 13 2006 131 140 (Pubitemid 43113414)
76. Y. Takahashi, M. Nishikawa, and Y. Takakura Inhibition of tumor cell growth in the liver by RNA interference-mediated suppression of HIF-1alpha expression in tumor cells and hepatocytes Gene Ther. 15 2008 572 582
77. A.M. Shapiro, J.R. Lakey, E.A. Ryan, G.S. Korbutt, E. Toth, G.L. Warnock, N.M. Kneteman, and R.V. Rajotte Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen N. Engl. J. Med. 343 2000 230 238 (Pubitemid 30490390)
78. C. Ricordi, and T.B. Strom Clinical islet transplantation: advances and immunological challenges Nat. Rev. Immunol. 4 2004 259 268 (Pubitemid 38478661)
79. N. Lifson, K.G. Kramlinger, R.R. Mayrand, and E.J. Lender Blood flow to the rabbit pancreas with special reference to the islets of Langerhans Gastroenterology 79 1980 466 473 (Pubitemid 10056392)
80. P.O. Carlsson, P. Liss, A. Andersson, and L. Jansson Measurements of oxygen tension in native and transplanted rat pancreatic islets Diabetes 47 1998 1027 1032 (Pubitemid 28294543)
81. S. Sezai, S. Sakurabayashi, Y. Yamamoto, T. Morita, M. Hirano, and H. Oka Hepatic arterial and portal venous oxygen content and extraction in liver cirrhosis Liver 13 1993 31 35 (Pubitemid 23122562)
82. A. Pileggi, C. Ricordi, M. Alessiani, and L. Inverardi Factors influencing Islet of Langerhans graft function and monitoring Clin. Chim. Acta 310 2001 3 16 (Pubitemid 32727310)
83. M.D. Menger, J. Yamauchi, and B. Vollmar Revascularization and microcirculation of freely grafted islets of Langerhans World J. Surg. 25 2001 509 515 (Pubitemid 32455206)
84. P.O. Carlsson, F. Palm, A. Andersson, and P. Liss Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site Diabetes 50 2001 489 495 (Pubitemid 32195212)
85. S. Lenzen Oxidative stress: the vulnerable beta-cell Biochem. Soc. Trans. 36 2008 343 347
86. K.E. Dionne, C.K. Colton, and M.L. Yarmush Effect of hypoxia on insulin secretion by isolated rat and canine islets of Langerhans Diabetes 42 1993 12 21 (Pubitemid 23013790)
87. J.A. Emamaullee, R.V. Rajotte, P. Liston, R.G. Korneluk, J.R. Lakey, A.M. Shapiro, and J.F. Elliott XIAP overexpression in human islets prevents early posttransplant apoptosis and reduces the islet mass needed to treat diabetes Diabetes 54 2005 2541 2548 (Pubitemid 41233574)
88. M. Biarnes, M. Montolio, V. Nacher, M. Raurell, J. Soler, and E. Montanya Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia Diabetes 51 2002 66 72 (Pubitemid 34517981)
89. M.O. Hengartner The biochemistry of apoptosis Nature 407 2000 770 776
90. D.R. Green Apoptotic pathways: paper wraps stone blunts scissors Cell 102 2000 1 4
91. J.A. Emamaullee, and A.M. Shapiro Interventional strategies to prevent beta-cell apoptosis in islet transplantation Diabetes 55 2006 1907 1914 (Pubitemid 44509961)
92. S. Puri, D.A. Cano, and M. Hebrok A role for von Hippel-Lindau protein in pancreatic beta-cell function Diabetes 58 2009 433 441
93. J. Cantley, S.T. Grey, P.H. Maxwell, and D.J. Withers The hypoxia response pathway and beta-cell function Diabetes Obes. Metab. 12 Suppl. 2 2010 159 167
94. W. Moritz, F. Meier, D.M. Stroka, M. Giuliani, P. Kugelmeier, P.C. Nett, R. Lehmann, D. Candinas, M. Gassmann, and M. Weber Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression FASEB J. 16 2002 745 747
95. A.E. Greijer, and E. van der Wall The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis J. Clin. Pathol. 57 2004 1009 1014 (Pubitemid 39331346)
96. N. Iwashita, T. Uchida, J.B. Choi, K. Azuma, T. Ogihara, N. Ferrara, H. Gerber, R. Kawamori, M. Inoue, and H. Watada Impaired insulin secretion in vivo but enhanced insulin secretion from isolated islets in pancreatic beta cell-specific vascular endothelial growth factor-A knock-out mice Diabetologia 50 2007 380 389
97. T. Kamba, B.Y. Tam, H. Hashizume, A. Haskell, B. Sennino, M.R. Mancuso, S.M. Norberg, S.M. O'Brien, R.B. Davis, L.C. Gowen, K.D. Anderson, G. Thurston, S. Joho, M.L. Springer, C.J. Kuo, and D.M. McDonald VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature Am. J. Physiol. Heart Circ. Physiol. 290 2006 H560 H576
98. B. Vasir, J.C. Jonas, G.M. Steil, J. Hollister-Lock, W. Hasenkamp, A. Sharma, S. Bonner-Weir, and G.C. Weir Gene expression of VEGF and its receptors Flk-1/KDR and Flt-1 in cultured and transplanted rat islets Transplantation 71 2001 924 935 (Pubitemid 32417355)
99. N. Zhang, A. Richter, J. Suriawinata, S. Harbaran, J. Altomonte, L. Cong, H. Zhang, K. Song, M. Meseck, J. Bromberg, and H. Dong Elevated vascular endothelial growth factor production in islets improves islet graft vascularization Diabetes 53 2004 963 970 (Pubitemid 38436608)
100. Y. Lai, D. Schneider, A. Kidszun, I. Hauck-Schmalenberger, G. Breier, D. Brandhorst, H. Brandhorst, M. Iken, M.D. Brendel, R.G. Bretzel, and T. Linn Vascular endothelial growth factor increases functional beta-cell mass by improvement of angiogenesis of isolated human and murine pancreatic islets Transplantation 79 2005 1530 1536 (Pubitemid 40847584)
101. Z. Mathe, P. Dupraz, C. Rinsch, B. Thorens, D. Bosco, M. Zbinden, P. Morel, T. Berney, and M.S. Pepper Tetracycline-regulated expression of VEGF-A in beta cells induces angiogenesis: improvement of engraftment following transplantation Cell Transplant. 15 2006 621 636 (Pubitemid 44904674)
102. H.Ah. Kim, S. Lee, J.H. Park, B.W. Lee, S.H. Ihm, T.I. Kim, S.W. Kim, K.S. Ko, and M. Lee Enhanced protection of Ins-1 beta cells from apoptosis under hypoxia by delivery of DNA encoding secretion signal peptide-linked exendin-4 J. Drug Target. 17 2009 242 248
103. B.W. Lee, M. Lee, H.Y. Chae, S. Lee, J.G. Kang, C.S. Kim, S.J. Lee, H.J. Yoo, and S.H. Ihm Effect of hypoxia-inducible VEGF gene expression on revascularization and graft function in mouse islet transplantation Transpl. Int. 24 2011 307 314
104. T. Shoshani, A. Faerman, I. Mett, E. Zelin, T. Tenne, S. Gorodin, Y. Moshel, S. Elbaz, A. Budanov, A. Chajut, H. Kalinski, I. Kamer, A. Rozen, O. Mor, E. Keshet, D. Leshkowitz, P. Einat, R. Skaliter, and E. Feinstein Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis Mol. Cell. Biol. 22 2002 2283 2293 (Pubitemid 34224633)
105. L.W. Ellisen, K.D. Ramsayer, C.M. Johannessen, A. Yang, H. Beppu, K. Minda, J.D. Oliner, F. McKeon, and D.A. Haber REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species Mol. Cell 10 2002 995 1005 (Pubitemid 35453821)
106. Z. Wang, M.H. Malone, M.J. Thomenius, F. Zhong, F. Xu, and C.W. Distelhorst Dexamethasone-induced gene 2 (dig2) is a novel pro-survival stress gene induced rapidly by diverse apoptotic signals J. Biol. Chem. 278 2003 27053 27058 (Pubitemid 36876859)
107. R. Panakanti, and R.I. Mahato Bipartite adenoviral vector encoding hHGF and hIL-1Ra for improved human islet transplantation Pharm. Res. 26 2009 587 596
108. J.C. Lopez-Talavera, A. Garcia-Ocana, I. Sipula, K.K. Takane, I. Cozar-Castellano, and A.F. Stewart Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal islet transplant mass required in a glucocorticoid-free rat model of allogeneic portal vein islet transplantation Endocrinol. 145 2004 467 474 (Pubitemid 38183786)
109. J.L. Contreras, G. Bilbao, C.A. Smyth, X.L. Jiang, D.E. Eckhoff, S.M. Jenkins, F.T. Thomas, D.T. Curiel, and J.M. Thomas Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene Transplantation 71 2001 1015 1023 (Pubitemid 32448812)
110. E.M. Carrington, M.D. McKenzie, E. Jansen, M. Myers, S. Fynch, C. Kos, A. Strasser, T.W. Kay, C.L. Scott, and J. Allison Islet beta-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli Diabetes 58 2009 2316 2323
111. A. Plesner, P. Liston, R. Tan, R.G. Korneluk, and C.B. Verchere The X-linked inhibitor of apoptosis protein enhances survival of murine islet allografts Diabetes 54 2005 2533 2540 (Pubitemid 41235478)
112. X. Li, H. Chen, and P.N. Epstein Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species J. Biol. Chem. 279 2004 765 771 (Pubitemid 38044882)
113. D.A. Lepore, T.A. Shinkel, N. Fisicaro, T.B. Mysore, L.E. Johnson, A.J. d'Apice, and P.J. Cowan Enhanced expression of glutathione peroxidase protects islet beta cells from hypoxia-reoxygenation Xenotransplantation 11 2004 53 59 (Pubitemid 38160266)
114. T. Burmester, F. Gerlach, and T. Hankeln Regulation and role of neuroglobin and cytoglobin under hypoxia Adv. Exp. Med. Biol. 618 2007 169 180
115. M. Arakawa, C. Ebato, T. Mita, T. Hirose, R. Kawamori, Y. Fujitani, and H. Watada Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents Biochem. Biophys. Res. Commun. 390 2009 809 814
116. R.N. Faradji, T. Froud, S. Messinger, K. Monroy, A. Pileggi, D. Mineo, T. Tharavanij, A.J. Mendez, C. Ricordi, and R. Alejandro Long-term metabolic and hormonal effects of exenatide on islet transplant recipients with allograft dysfunction Cell transplantation 18 2009 1247 1259
117. Y. Li, T. Hansotia, B. Yusta, F. Ris, P.A. Halban, and D.J. Drucker Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis J. Biol. Chem. 278 2003 471 478 (Pubitemid 36043598)
118. S. Yook, J.H. Jeong, Y.S. Jung, S.W. Hong, B.H. Im, J.W. Seo, J.B. Park, M. Lee, C.H. Ahn, H. Lee, D.Y. Lee, and Y. Byun Molecularly engineered islet cell clusters for diabetes mellitus treatment Cell Transplant. 21 2012 1775 1789
119. J.H. Jeong, S. Yook, Y. Jung, B.H. Im, M. Lee, C.H. Ahn, D.Y. Lee, and Y. Byun Functional enhancement of beta cells in transplanted pancreatic islets by secretion signal peptide-linked exendin-4 gene transduction J. Control. Release 159 2012 368 375
120. H.Ah. Kim, S. Lee, J.H. Park, B.W. Lee, S.H. Ihm, T.I. Kim, S.W. Kim, K.S. Ko, and M. Lee Enhanced protection of Ins-1 beta cells from apoptosis under hypoxia by delivery of DNA encoding secretion signal peptide-linked exendin-4 J. Drug Target. 17 2009 242 248
121. D. Grimm, K.L. Streetz, C.L. Jopling, T.A. Storm, K. Pandey, C.R. Davis, P. Marion, F. Salazar, and M.A. Kay Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways Nature 441 2006 537 541 (Pubitemid 44050158)
122. F. Stegmeier, G. Hu, R.J. Rickles, G.J. Hannon, and S.J. Elledge A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells Proc. Natl. Acad. Sci. U.S.A. 102 2005 13212 13217 (Pubitemid 41325003)
123. D. Kim, J. Hong, H.H. Moon, H.Y. Nam, H. Mok, J.H. Jeong, S.W. Kim, D. Choi, and S.H. Kim Anti-apoptotic cardioprotective effects of SHP-1 gene silencing against ischemia-reperfusion injury: use of deoxycholic acid-modified low molecular weight polyethyleneimine as a cardiac siRNA-carrier J. Control. Release 168 2013 125 134
124. H.A. Kim, T. Rhim, and M. Lee Regulatory systems for hypoxia-inducible gene expression in ischemic heart disease gene therapy Adv. Drug Deliv. Rev. 63 2011 678 687
125. N.A. Mughal, D.A. Russell, S. Ponnambalam, and S. Homer-Vanniasinkam Gene therapy in the treatment of peripheral arterial disease Br. J. Surg. 99 2012 6 15
126. F. Mac Gabhann, B.H. Annex, and A.S. Popel Gene therapy from the perspective of systems biology Curr. Opin. Mol. Ther. 12 2010 570 577
127. F. Mac Gabhann, A.A. Qutub, B.H. Annex, and A.S. Popel Systems biology of pro-angiogenic therapies targeting the VEGF system Wiley Interdiscip. Rev. Syst. Biol. Med. 2 2010 694 707
128. R. Gupta, J. Tongers, and D.W. Losordo Human studies of angiogenic gene therapy Circ. Res. 105 2009 724 736
129. H. Karvinen, and S. Yla-Herttuala New aspects in vascular gene therapy Curr. Opin. Pharmacol. 10 2010 208 211
130. Y. Taniyama, J. Azuma, Y. Kunugiza, K. Iekushi, H. Rakugi, and R. Morishita Therapeutic option of plasmid-DNA based gene transfer Curr. Top. Med. Chem. 12 2012 1630 1637
131. H.C. Kang, M. Lee, and Y.H. Bae Polymeric gene carriers Crit. Rev. Eukaryot. Gene Expr. 15 2005 317 342
132. S. Han, R.I. Mahato, Y.K. Sung, and S.W. Kim Development of biomaterials for gene therapy Mol. Ther. 2 2000 302 317
133. M. Lee, and S.W. Kim Polyethylene glycol-conjugated copolymers for plasmid DNA delivery Pharm. Res. 22 2005 1 10 (Pubitemid 40558140)
134. M.Y. Chen, A. Hoffer, P.F. Morrison, J.F. Hamilton, J. Hughes, K.S. Schlageter, J. Lee, B.R. Kelly, and E.H. Oldfield Surface properties, more than size, limiting convective distribution of virus-sized particles and viruses in the central nervous system J. Neurosurg. 103 2005 311 319 (Pubitemid 43193908)
135. H.M. Blau, and M.L. Springer Gene therapy - a novel form of drug delivery N. Engl. J. Med. 333 1995 1204 1207
136. S. Farokhimanesh, F. Rahbarizadeh, M.J. Rasaee, A. Kamali, and B. Mashkani Hybrid promoters directed tBid gene expression to breast cancer cells by transcriptional targeting Biotechnol. Prog. 26 2010 505 511
137. B.G. Wouters, and M. Koritzinsky Hypoxia signalling through mTOR and the unfolded protein response in cancer Nat. Rev. Cancer 8 2008 851 864
138. Y. Hiwatashi, K. Kanno, C. Takasaki, K. Goryo, T. Sato, S. Torii, K. Sogawa, and K. Yasumoto PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation Exp. Cell Res. 317 2011 2789 2799
139. J. Koditz, J. Nesper, M. Wottawa, D.P. Stiehl, G. Camenisch, C. Franke, J. Myllyharju, R.H. Wenger, and D.M. Katschinski Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor Blood 110 2007 3610 3617 (Pubitemid 350159628)
140. X.W. Song, Q. Li, L. Lin, X.C. Wang, D.F. Li, G.K. Wang, A.J. Ren, Y.R. Wang, Y.W. Qin, W.J. Yuan, and Q. Jing MicroRNAs are dynamically regulated in hypertrophic hearts, and miR-199a is essential for the maintenance of cell size in cardiomyocytes J. Cell. Physiol. 225 2010 437 443
141. J. Krutzfeldt, N. Rajewsky, R. Braich, K.G. Rajeev, T. Tuschl, M. Manoharan, and M. Stoffel Silencing of microRNAs in vivo with 'antagomirs' Nature 438 2005 685 689