-
1
-
-
0002377529
-
2 histography
-
P.W. et al. Vaupel. Germany: Gustav Fischer Verlag
-
2 histography. Vaupel P.W.et al. Tumor Oxygenation. 1995;219-232 Gustav Fischer Verlag, Germany.
-
(1995)
Tumor Oxygenation
, pp. 219-232
-
-
Vaupel, P.W.1
Hockel, M.2
-
2
-
-
0033405294
-
The hypoxic cell: A target for selective cancer therapy - 18th Bruce F. Cain Memorial Award lecture
-
Brown J.M. The hypoxic cell: a target for selective cancer therapy - 18th Bruce F. Cain Memorial Award lecture. Cancer Res. 59:1999;5863-5870.
-
(1999)
Cancer Res.
, vol.59
, pp. 5863-5870
-
-
Brown, J.M.1
-
3
-
-
84960987950
-
Concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy
-
Gray L.H.et al. Concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br. J. Radiol. 26:1953;638-648.
-
(1953)
Br. J. Radiol.
, vol.26
, pp. 638-648
-
-
Gray, L.H.1
-
4
-
-
0029955072
-
Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
-
Nordsmark M.et al. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother. Oncol. 41:1996;31-40.
-
(1996)
Radiother. Oncol.
, vol.41
, pp. 31-40
-
-
Nordsmark, M.1
-
5
-
-
0030742027
-
Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck
-
Brizel D.M.et al. Tumor hypoxia adversely affects the prognosis of carcinoma of the head and neck. Int. J. Radiat. Oncol. Biol. Phys. 38:1997;285-289.
-
(1997)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.38
, pp. 285-289
-
-
Brizel, D.M.1
-
6
-
-
0031716020
-
Oxygenation predicts radiation response and survival in patients with cervix cancer
-
Fyles A.W.et al. Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother. Oncol. 48:1998;149-156.
-
(1998)
Radiother. Oncol.
, vol.48
, pp. 149-156
-
-
Fyles, A.W.1
-
7
-
-
0028603270
-
The influence of microenvironmental factors during cancer therapy
-
Durand R.E. The influence of microenvironmental factors during cancer therapy. In Vivo. 8:1994;691-702.
-
(1994)
In Vivo
, vol.8
, pp. 691-702
-
-
Durand, R.E.1
-
8
-
-
0029775242
-
Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
-
Hockel M.et al. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56:1996;4509-4515.
-
(1996)
Cancer Res.
, vol.56
, pp. 4509-4515
-
-
Hockel, M.1
-
9
-
-
0030022252
-
Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma
-
Brizel D.M.et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 56:1996;941-943.
-
(1996)
Cancer Res.
, vol.56
, pp. 941-943
-
-
Brizel, D.M.1
-
10
-
-
0030025773
-
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
-
Graeber T.G.et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature. 379:1996;88-91.
-
(1996)
Nature
, vol.379
, pp. 88-91
-
-
Graeber, T.G.1
-
11
-
-
0029753768
-
Genetic instability induced by the tumor microenvironment
-
Reynolds T.Y.et al. Genetic instability induced by the tumor microenvironment. Cancer Res. 56:1996;5754-5757.
-
(1996)
Cancer Res.
, vol.56
, pp. 5754-5757
-
-
Reynolds, T.Y.1
-
12
-
-
0031823016
-
The molecular basis of the hypoxia response pathway: Tumour hypoxia as a therapy target
-
Blancher C., Harris A.L. The molecular basis of the hypoxia response pathway: tumour hypoxia as a therapy target. Cancer Metastasis Rev. 17:1998;187-194.
-
(1998)
Cancer Metastasis Rev.
, vol.17
, pp. 187-194
-
-
Blancher, C.1
Harris, A.L.2
-
13
-
-
0015451983
-
Potential bioreductive alkylating agents. 1. Benzoquinone derivatives
-
Lin A.J.et al. Potential bioreductive alkylating agents. 1. Benzoquinone derivatives. J. Med. Chem. 15:1972;1247-1252.
-
(1972)
J. Med. Chem.
, vol.15
, pp. 1247-1252
-
-
Lin, A.J.1
-
14
-
-
0019995383
-
Mitomycin-C as a prototype bioreductive alkylating agent: In vitro studies of metabolism and cytotoxicity
-
Rockwell S.et al. Mitomycin-C as a prototype bioreductive alkylating agent: in vitro studies of metabolism and cytotoxicity. Int. J. Radiat. Oncol. Biol. Phys. 8:1982;753-755.
-
(1982)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.8
, pp. 753-755
-
-
Rockwell, S.1
-
15
-
-
0030028884
-
Hypoxia-specific cytotoxins in cancer therapy
-
Brown J.M., Siim B.G. Hypoxia-specific cytotoxins in cancer therapy. Semin. Radiat. Oncol. 6:1996;22-36.
-
(1996)
Semin. Radiat. Oncol.
, vol.6
, pp. 22-36
-
-
Brown, J.M.1
Siim, B.G.2
-
16
-
-
0027358606
-
Mitomycin C as an adjunct to postoperative radiation therapy in squamous cell carcinoma of the head and neck: Results from two randomized clinical trials
-
Haffty B.G.et al. Mitomycin C as an adjunct to postoperative radiation therapy in squamous cell carcinoma of the head and neck: results from two randomized clinical trials. Int. J. Radiat. Oncol. Biol. Phys. 27:1993;241-250.
-
(1993)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.27
, pp. 241-250
-
-
Haffty, B.G.1
-
17
-
-
0022493495
-
SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells
-
Zeman E.M.et al. SR-4233: a new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int. J. Radiat. Oncol. Biol. Phys. 12:1986;1239-1242.
-
(1986)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.12
, pp. 1239-1242
-
-
Zeman, E.M.1
-
18
-
-
0026802366
-
Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation
-
Wang J.et al. Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation. Cancer Res. 52:1992;4473-4477.
-
(1992)
Cancer Res.
, vol.52
, pp. 4473-4477
-
-
Wang, J.1
-
19
-
-
0001168282
-
Intranuclear metabolism of tirapazamine by matrix-associated reductases
-
(Abstr. 1095)
-
Delahoussaye Y.M.et al. Intranuclear metabolism of tirapazamine by matrix-associated reductases. Proc. Am. Assoc. Cancer Res. 38:1997;163. (Abstr. 1095).
-
(1997)
Proc. Am. Assoc. Cancer Res.
, vol.38
, pp. 163
-
-
Delahoussaye, Y.M.1
-
20
-
-
0025646401
-
Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors
-
Brown J.M., Lemmon M.J. Potentiation by the hypoxic cytotoxin SR 4233 of cell killing produced by fractionated irradiation of mouse tumors. Cancer Res. 50:1990;7745-7749.
-
(1990)
Cancer Res.
, vol.50
, pp. 7745-7749
-
-
Brown, J.M.1
Lemmon, M.J.2
-
21
-
-
84965808588
-
Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin
-
Dorie M.J., Brown J.M. Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233) and cisplatin. Cancer Res. 53:1993;4633-4636.
-
(1993)
Cancer Res.
, vol.53
, pp. 4633-4636
-
-
Dorie, M.J.1
Brown, J.M.2
-
22
-
-
0033063810
-
Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin
-
Kovacs M.S.et al. Cisplatin anti-tumour potentiation by tirapazamine results from a hypoxia-dependent cellular sensitization to cisplatin. Br. J. Cancer. 80:1999;1245-1251.
-
(1999)
Br. J. Cancer
, vol.80
, pp. 1245-1251
-
-
Kovacs, M.S.1
-
23
-
-
0001488812
-
Survival benefit from tirazone (tirapazamine) and cisplatin in advanced non-small cell lung cancer (NSCLC) patients: Final results from the international phase III CATAPULT 1 trial
-
(Abstr. 1749)
-
von Pawel J., von Roemeling R. Survival benefit from tirazone (tirapazamine) and cisplatin in advanced non-small cell lung cancer (NSCLC) patients: Final results from the international phase III CATAPULT 1 trial. Proc. Am. Soc. Clin. Oncol. 17:1998;454a. (Abstr. 1749).
-
(1998)
Proc. Am. Soc. Clin. Oncol.
, vol.17
-
-
Von Pawel, J.1
Von Roemeling, R.2
-
24
-
-
0027220811
-
Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: A new class of bioreductive agent
-
Patterson L.H. Rationale for the use of aliphatic N-oxides of cytotoxic anthraquinones as prodrug DNA binding agents: a new class of bioreductive agent. Cancer Metastasis Rev. 12:1993;119-134.
-
(1993)
Cancer Metastasis Rev.
, vol.12
, pp. 119-134
-
-
Patterson, L.H.1
-
25
-
-
0029054994
-
AQ4N: An alkylaminoanthraquinone N-oxides showing bioreductive potential and positive interaction with radiation in vivo
-
McKeown S.R.et al. AQ4N: an alkylaminoanthraquinone N-oxides showing bioreductive potential and positive interaction with radiation in vivo. Br. J. Cancer. 72:1995;76-81.
-
(1995)
Br. J. Cancer
, vol.72
, pp. 76-81
-
-
McKeown, S.R.1
-
26
-
-
0034024671
-
Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine
-
(in press)
-
Friery O.P.et al. Enhancement of the anti-tumour effect of cyclophosphamide by the bioreductive drugs AQ4N and tirapazamine. Br. J. Cancer. 2000;. (in press).
-
(2000)
Br. J. Cancer
-
-
Friery, O.P.1
-
28
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell P.H.et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 399:1999;271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
-
29
-
-
0028800141
-
Enzyme/prodrug gene therapy: Comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line
-
Trinh Q.T.et al. Enzyme/prodrug gene therapy: comparison of cytosine deaminase/5-fluorocytosine versus thymidine kinase/ganciclovir enzyme/prodrug systems in a human colorectal carcinoma cell line. Cancer Res. 55:1995;4808-4812.
-
(1995)
Cancer Res.
, vol.55
, pp. 4808-4812
-
-
Trinh, Q.T.1
-
30
-
-
0034017489
-
Development of a hypoxia-responsive vector for tumor-specific gene therapy
-
(in press)
-
Shibata T.et al. Development of a hypoxia-responsive vector for tumor-specific gene therapy. Gene Ther. 2000;. (in press).
-
(2000)
Gene Ther.
-
-
Shibata, T.1
-
31
-
-
0032053823
-
The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
-
Brown J.M., Giaccia A.J. The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy. Cancer Res. 58:1998;1408-1416.
-
(1998)
Cancer Res.
, vol.58
, pp. 1408-1416
-
-
Brown, J.M.1
Giaccia, A.J.2
-
32
-
-
0027288316
-
SR 4233 (tirapazamine): A new anticancer drug exploiting hypoxia in solid tumours
-
Brown J.M. SR 4233 (tirapazamine): a new anticancer drug exploiting hypoxia in solid tumours. Br. J. Cancer. 67:1993;1163-1170.
-
(1993)
Br. J. Cancer
, vol.67
, pp. 1163-1170
-
-
Brown, J.M.1
|