The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts

Biochemical and Biophysical Research Communications

Volumn 360, Issue 4, 2007, Pages 791-796

  Harada, Hiroshi ^a,b   Kizaka Kondoh, Shinae ^a   Itasaka, Satoshi ^a   Shibuya, Keiko ^a   Morinibu, Akiyo ^a   Shinomiya, Kazumi ^a   Hiraoka, Masahiro ^a,b  

^a KYOTO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Hypoxia; Hypoxia inducible factor 1 (HIF 1); Hypoxia response element (HRE); Optical imaging; Oxygen dependent degradation domain (ODD domain)

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; LUCIFERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER THERAPY; CONTROLLED STUDY; HYPOXIA; LUMINESCENCE; MOLECULAR IMAGING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPORTER GENE; TUMOR GROWTH; TUMOR XENOGRAFT;

BASE SEQUENCE; CELL HYPOXIA; DNA PRIMERS; GENES, REPORTER; HELA CELLS; HUMANS; HYDROLYSIS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; NEOPLASMS; OXYGEN; TRANSPLANTATION, HETEROLOGOUS;

EID: 34447565882     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.06.149     Document Type: Article

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