Functional enhancement of beta cells in transplanted pancreatic islets by secretion signal peptide-linked exendin-4 gene transduction

Journal of Controlled Release

Volumn 159, Issue 3, 2012, Pages 368-375

  Jeong, Jee Heon ^a   Yook, Simmyung ^a   Jung, Yoonsuk ^a   Im, Bok Hyeon ^a   Lee, Minhyung ^b   Ahn, Cheol Hee ^a   Lee, Dong Yun ^b   Byun, Youngro ^a,c  

^a Seoul National University   (South Korea)

^b Hanyang University   (South Korea)

^c Seoul National University   (South Korea)

Author keywords

Beta cell function; Exendin 4 gene; Islet transplantation; Signal peptide

Indexed keywords

ANIMAL MODEL; BETA CELL; CYTOKINES; FUNCTIONAL ENHANCEMENTS; GENE TRANSDUCTION; GLUCOSE-STIMULATED INSULIN SECRETIONS; IN-VIVO; ISLET TRANSPLANTATION; NUDE MICE; PANCREATIC ISLET; POTENTIAL TECHNOLOGIES; SIGNAL PEPTIDE; SURVIVAL RATE; THERAPEUTIC EFFECTS;

BACTERIOPHAGES; CELLS; CURING; CYTOLOGY; ENCODING (SYMBOLS); GENE THERAPY; GLUCOSE; MAMMALS; PHYSIOLOGY;

GENE ENCODING;

EXENDIN 4; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SECRETION; CELL TRANSPLANTATION; CELL VIABILITY; CONTROLLED STUDY; DISEASE MODEL; GENETIC TRANSDUCTION; HUMAN; HYPOXIA; IMMUNOCOMPETENT CELL; IN VIVO STUDY; INSULIN RELEASE; LENTIVIRINAE; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; SURVIVAL RATE;

ANIMALS; APOPTOSIS; CELL HYPOXIA; DIABETES MELLITUS, EXPERIMENTAL; GENETIC VECTORS; GLUCOSE; GRAFT REJECTION; GRAFT SURVIVAL; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS TRANSPLANTATION; LENTIVIRUS; MICE; MICE, NUDE; PEPTIDES; PROTEIN SORTING SIGNALS; TRANSDUCTION, GENETIC; TRANSPLANTATION, HOMOLOGOUS; VENOMS;

EID: 84862776597     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.01.029     Document Type: Article

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