Enhanced protection of Ins-1 β cells from apoptosis under hypoxia by delivery of DNA encoding secretion signal peptide-linked exendin-4 Exendin-4

Journal of Drug Targeting

Volumn 17, Issue 3, 2009, Pages 242-248

  Ah Kim, Hyun ^a   Lee, Suyeon ^a   Park, Jeong Hyun ^b   Lee, Sanghyun ^a   Lee, Byung Wan ^c   Hee Ihm, Sung ^c   Kim, Tae Il ^d   Wan Kim, Sung ^a,d   Soo Ko, Kyung ^b   Lee, Minhyung ^a  

^a Hanyang University   (South Korea)

^b Inje University   (South Korea)

^c Hallym University   (South Korea)

^d UNIVERSITY OF UTAH   (United States)

Author keywords

Apoptosis; Cytoprotection; Exendin 4; Glucagon like peptide 1; Hypoxia; Signal peptide

Indexed keywords

COMPLEMENTARY DNA; EXENDIN 4; POLYAMIDOAMINE; POLYETHYLENEIMINE; SIGNAL PEPTIDE; BIOMATERIAL; CASPASE 3; DNA; PAMAM STARBURST; PEPTIDE; POLYAMINE; VENOM;

APOPTOSIS; ARTICLE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION SYSTEM; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA; PRIORITY JOURNAL; PROTEIN SECRETION; ANOXIA; CELL CULTURE; CELL SURVIVAL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; GENE VECTOR; GENETICS; METABOLISM; METHODOLOGY; PANCREAS ISLET BETA CELL; SYNTHESIS;

ANOXIA; APOPTOSIS; BIOCOMPATIBLE MATERIALS; CASPASE 3; CELL SURVIVAL; CELLS, CULTURED; DNA; GENETIC VECTORS; HUMANS; INSULIN-SECRETING CELLS; PEPTIDES; POLYAMINES; POLYETHYLENEIMINE; PROTEIN SORTING SIGNALS; TRANSFECTION; VENOMS;

EID: 70149118782     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860902718664     Document Type: Article

References (33)

1. Chae HY, Lee BW, Oh SH, Ahn YR, Chung JH, Min YK, Lee MS, Lee MK, Kim KW.(2005). Effective glycemic control achieved by transplanting non-viral cationic liposome-mediated VEGFtransfected islets in streptozotocin-induced diabetic mice. Exp Mol Med, 37, 513-523.
2. Cheng K, Fraga D, Zhang C, Kotb M, Gaber AO, Guntaka RV, Mahato RI.(2004). Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets. Gene Ther, 11, 1105-1116. (Pubitemid 39117306)
3. Choi JS, Ko KS, Park JS, Kim YH, Kim SW, Lee M.(2006). Dexamethasone conjugated poly(amidoamine) dendrimer as a gene carrier for efficient nuclear translocation. Int J Pharm, 320, 171-178.
4. Choi S, Oh S, Lee M, Kim SW.(2005). Glucagon-like peptide-1 plasmid construction and delivery for the treatment of type 2 diabetes. Mol Ther, 12, 885-891.
5. Contreras JL, Bilbao G, Smyth C, Eckhoff DE, Xiang XL, Jenkins S, Cartner S, Curiel DT, Thomas FT, Thomas JM.(2001a). Gene transfer of the Bcl-2 gene confers cytoprotection to isolated adult porcine pancreatic islets exposed to xenoreactive antibodies and complement. Surgery, 130, 166-174.
6. Contreras JL, Bilbao G, Smyth CA, Jiang XL, Eckhoff DE, Jenkins SM, Thomas FT, Curiel DT, Thomas JM.(2001b). Cytoprotection of pancreatic islets before and soon after transplantation by gene transfer of the anti-apoptotic Bcl-2 gene. Transplantation, 71, 1015-1023. (Pubitemid 32448812)
7. D'Amico E, Hui H, Khoury N, Di Mario U, Perfetti R.(2005). Pancreatic beta-cells expressing GLP-1 are resistant to the toxic effects of immunosuppressive drugs. J Mol Endocrinol, 34, 377-390.
8. Dionne KE, Colton CK, Yarmush ML.(1989). Effect of oxygen on isolated pancreatic tissue. ASAIO Trans, 35, 739-741.
9. Emamaullee J, Liston P, Korneluk RG, Shapiro AM, Elliott JF.(2005). XIAP overexpression in islet beta-cells enhances engraftmentand minimizes hypoxia-reperfusion injury. Am J Transplant, 5, 1297-1305.
10. Gorden DL, Mandriota SJ, Montesano R, Orci L, Pepper MS.(1997). Vascular endothelial growth factor is increased in devascularized rat islets of Langerhans in vitro. Transplantation, 63, 436-443.
11. Holst JJ.(1994). Glucagonlike peptide 1: A newly discovered gastrointestinal hormone. Gastroenterology, 107, 1848-1855.
12. Kim HA, Lee BW, Kang D, Kim JH, Ihm SH, Lee M.(2009). Delivery of hypoxia inducible VEGF gene to rat islets using polyethylenimine. J Drug Target, 17(1), 1-9.
13. Kumar M, Hunag Y, Glinka Y, Prud'homme GJ, Wang Q.(2007). Gene therapy of diabetes using a novel GLP-1/IgG1-Fc fusion construct normalizes glucose levels in db/db mice. Gene Ther, 14, 162-172.
14. Lai Y, Schneider D, Kidszun A, Hauck-Schmalenberger I, Breier G, Brandhorst D, Brandhorst H, Iken M, Brendel MD, Bretzel RG, Linn T.(2005). Vascular endothelial growth factor increases functional beta-cell mass by improvement of angiogenesis of isolated human and murine pancreatic islets. Transplantation, 79, 1530-1536.
15. Lee M, Rentz J, Han SO, Bull DA, Kim SW.(2003). Water-soluble lipopolymer as an efficient carrier for gene delivery to myocardium. Gene Ther, 10, 585-593. (Pubitemid 36432610)
16. Lee RJ, Springer ML, Blanco-Bose WE, Shaw R, Ursell PC, Blau HM. (2000). VEGF gene delivery to myocardium: deleterious effects of unregulated expression. Circulation, 102, 898-901.
17. Liu MJ, Shin S, Li N, Shigihara T, Lee YS, Yoon JW, Jun HS.(2007). Prolonged remission of diabetes by regeneration of beta cells in diabetic mice treated with recombinant adenoviral vector expressing glucagon-like peptide-1. Mol Ther, 15, 86-93.
18. Liu Y, Rabinovitch A, Suarez-Pinzon W, Muhkerjee B, Brownlee M, Edelstein D, Federoff HJ.(1996). Expression of the bcl-2 gene from a defective HSV-1 amplicon vector protects pancreatic beta-cells from apoptosis. Hum Gene Ther, 7, 1719-1726.
19. Moritz W, Meier F, Stroka DM, Giuliani M, Kugelmeier P, Nett PC, Lehmann R, Candinas D, Gassmann M, Weber M.(2002). Apoptosis in hypoxic human pancreatic islets correlates with HIF-1alpha expression. FASEB J, 16, 745-747.
20. Narang AS, Cheng K, Henry J, Zhang C, Sabek O, Fraga D, Kotb M, Gaber AO, Mahato RI.(2004). Vascular endothelial growth factor gene delivery for revascularization in transplanted human islets. Pharm Res, 21, 15-25. (Pubitemid 38122287)
21. Nauck MA, Sauerwald A, Ritzel R, Holst JJ, Schmiegel W.(1998). Influence of glucagon-like peptide 1 on fasting glycemia in type 2 diabetic patients treated with insulin after sulfonylurea secondary failure. Diabetes Care, 21, 1925-1931.
22. Oh S, Lee M, Ko KS, Choi S, Kim SW.(2003). GLP-1 gene delivery for the treatment of type 2 diabetes. Mol Ther, 7, 478-483.
23. Parsons GB, Souza DW, Wu H, Yu D, Wadsworth SG, Gregory RJ, Armentano D.(2007). Ectopic expression of glucagon-like peptide 1 for gene therapy of type II diabetes. Gene Ther, 14, 38-48.
24. Perfetti R, Merkel P.(2000). Glucagon-like peptide-1: A major regulator of pancreatic beta-cell function. Eur J Endocrinol, 143, 717-725.
25. Rachman J, Barrow BA, Levy JC, Turner RC.(1997). Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM. Diabetologia, 40, 205-211.
26. Schrezenmeir J, Gero L, Laue C, Kirchgessner J, Muller A, Huls A, Passmann R, Hahn HJ, Kunz L, Mueller-Klieser W, et al.(1992). The role of oxygen supply in islet transplantation. Transplant Proc, 24, 2925-2929.
27. Soltani N, Kumar M, Glinka Y, Prud'homme GJ, Wang Q.(2007). In vivo expression of GLP-1/IgG-Fc fusion protein enhances betacell mass and protects against streptozotocin-induced diabetes. Gene Ther, 14, 981-988.
28. Springer ML, Chen AS, Kraft PE, Bednarski M, Blau HM.(1998). VEGF gene delivery to muscle: potential role for vasculogenesis in adults. Mol Cell, 2, 549-558.
29. Szayna M, Doyle ME, Betkey JA, Holloway HW, Spencer RG, Greig NH, Egan JM.(2000). Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats. Endocrinology, 141, 1936-1941.
30. Tillmar L, Welsh N.(2002). Hypoxia may increase rat insulin mRNA levels by promoting binding of the polypyrimidine tract-binding protein (PTB) to the pyrimidine-rich insulin mRNA 3'-untranslated region. Mol Med, 8, 263-272.
31. Urusova IA, Farilla L, Hui H, D'Amico E, Perfetti R.(2004). GLP-1 inhibition of pancreatic islet cell apoptosis. Trends Endocrinol Metab, 15, 27-33.
32. Vasir B, Aiello LP, Yoon KH, Quickel RR, Bonner-Weir S, Weir GC.(1998). Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells. Diabetes, 47, 1894-1903.
33. Vilsboll T, Krarup T, Deacon CF, Madsbad S, Holst JJ.(2001). Reduced postprandial concentrations of intact biologically active glucagon- like peptide 1 in type 2 diabetic patients. Diabetes, 50, 609-613.