Gene expression of VEGF and its receptors Flk-1/KDR and Flt-1 in cultured and transplanted rat islets

Transplantation

Volumn 71, Issue 7, 2001, Pages 924-935

  Vasir, Baldev ^a   Jonas, Jean Christophe ^a,b   Steil, Garry M ^a   Hollister Lock, Jennifer ^a   Hasenkamp, Wendy ^a   Sharma, Arun ^a   Bonner Weir, Susan ^a   Weir, Gordon C ^a,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^c JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; ISOPROTEIN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DIABETES MELLITUS; GENE EXPRESSION; GRAFT SURVIVAL; HYPERGLYCEMIA; HYPOXIA; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVASCULARIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TREATMENT OUTCOME;

EID: 0035870769     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-200104150-00018     Document Type: Article

References (61)

1. Relation between blood flow and morphology in islet organ of rat pancreas
2. New perspectives on the microvasculature of islets of Langerhans in the rat
3. Vulnerability of islets in the immediate posttransplantation period: Dynamic changes in structure and function
4. Survival and function of islets during cell culture
5. Effect of hypoxia on insulin secretion by isolated rat and canine islets of Langerhans
6. Angiogenesis and hemodynamics of microvasculature of transplanted islets of Langerhans
7. Mechanisms of angiogenesis
8. The biology of vascular endothelial growth factor
9. Vascular endothelial growth factor (VEGF) and its receptors
10. Regulation of angiogenic growth factor expression by hypoxia, transition metals and chelating agents
11. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin
12. Vulnerability of islets in the immediate posttransplantation period: Dynamic changes in structure and function
13. Effects of hyperglycemia on function of isolated mouse pancreatic islets transplanted under kidney capsule
14. Beneficial influence of glycemic control upon the growth and function of transplanted islets
15. Vascular development and disorders: Molecular analysis and pathogenic insights
16. Hepatocyte growth factor increases urokinase-type plasminogen activator (u-PA) and u-PA receptor expression on Madin-Darby canine kidney epithelial cells
17. Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells
18. Upregulation of urokinase receptor expression on migrating endothelial cells
19. Effects of diabetes and hypoxia on gene markers of angiogenesis (HGF, cMET, uPA and uPAR, TGF-β, TGF-β, bFGF and Vimentin) in cultured and transplanted rat islets
20. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
21. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium
22. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes: Flt-1, but not Flk-1/KDR, is upregulated by hypoxia
23. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1
24. Protein tyrosine kinases expressed in glomeruli and cultured glomerular cells; Flt-1 and VEGF expression in renal mesangial cells
25. Identification and characterization of vascular endothelial growth factor receptor (fit) in bovine retinal pericytes
26. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or chronic hypoxia
27. VEGF, Flk-1 and Flt-1 expression in a rat myocardial infarction model of angiogenesis
28. Distribution of vascular permeability factor (vascular endothelial growth factor) in tumors: Concentration in tumor blood vessels
29. Hypoxia-induced paracrine regulation of vascular endothelial growth factor receptor expression
30. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
31. Homologous up-regulation of KDR/Flk-1 receptor expression by vascular endothelial growth factor in vitro
32. Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: Evidence for a widespread oxygen-sensing mechanism
33. General involvement of hypoxia inducible factor 1 in transcriptional response to hypoxia
34. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
35. In vivo expression of mRNAs encoding hypoxia-inducible factor 1
36. Regulation of hypoxia-inducible factor la is mediated by its oxygen-dependent degradation domain via the ubiquitin-proteasome pathway
37. Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells
38. Interendothelial junctions - Structure, signalling and functional roles
39. Catenin-dependent and independent functions of vascular endothelial cadherin
40. Hypoxia induces vascular endothelial growth factor gene and protein expression in cultured rat islet cells
41. Vascular endothelial growth factor is increased in devascularized rat islets of Langerhans in vitro
42. Function, mass and replication of porcine and rat islets transplanted into diabetic nude mice
43. mRNA profiling of rat islet tumors reveals Nkx 6.1 as a beta-cell-specific homeodomain transcription factor
44. Chronic hyperglycemia triggers loss of pancreatic beta cell differentiation in an animal model of diabetes
45. Differential regulation of vascular endothelial growth factor and its receptor fms-like-tyrosine is mediated by nitric oxide in rat renal mesangial cells
46. Identification of a novel cadherin (vascular endothelial cadherin-2) located at intercellular junctions in endothelial cells
47. cDNA cloning and functional expression of a novel rat kidney organic cation transporter, OCT2
48. Cloning of a rat kidney cDNA that stimulates dibasic and neutral amino acid transport and has sequence similarity to glucosidases
49. Molecular characteristics of Na+ -coupled glucose transporters in adult and embryonic rat kidney
50. Molecular cloning and characterization of NKT, a gene product related to the organic cation transporter family that is almost exclusively expressed in the kidney
51. Developmental expression and regulation of basic fibroblast growth factor and vascular endothelial growth factor in rat decidua and in a decidual cell line
52. Differential expression of vascular endothelial growth factor (vascular permeability factor) forms in rat tissues
53. Role of vascular endothelial-cadherin in vascular morphogenesis
54. Cadherins regulate aggregation of pancreatic beta-cells in vivo
55. Measurement of oxygen tension in native and transplanted rat pancreatic islets
56. Up-regulation of vascular endothelial growth factor in response to glucose deprivation
57. Induction of vascular endothelial growth factor expression by hypoxia and by glucose deficiency in multicell spheroids: Implication for tumor angiogenesis
58. Effects of high glucose on vascular endothelial growth factor expression in vascular smooth muscle cells
59. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm (Banting Lecture 1995)
60. Vascular endothelial growth factor receptor expression during embryogenesis and tissue repair suggests a role in endothelial differentiation and blood vessel growth
61. Transplanted beta cell response to increased metabolic demand. Changes in beta cell replication and mass