Enhanced expression of glutathione peroxidase protects islet β cells from hypoxia-reoxygenation

Xenotransplantation

Volumn 11, Issue 1, 2004, Pages 53-59

  Lepore, Diana A ^a   Shinkel, Trixie A ^a   Fisicaro, Nella ^a   Mysore, Tharun B ^a   Johnson, Lucinda E A ^a   D'Apice, Anthony J F ^a,b   Cowan, Peter J ^a,b  

^a Immunology Research Centre   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Glutathione peroxidase; Islets; NIT 1 cells; Nitric oxide; Reactive oxygen species; Superoxide dismutase; Xenotransplantation

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUCOSE; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; MENADIONE; PEROXYNITRITE; SUPEROXIDE;

ALLOGRAFT; ANIMAL CELL; ARTICLE; CELL LINE; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; GENETIC TRANSFECTION; HYPOXIA; INSULINOMA; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN ISOLATION; REOXYGENATION; TRANSPLANTATION; XENOGRAFT;

ANIMALS; ANOXIA; CELL LINE, TUMOR; CELL SURVIVAL; CYTOPROTECTION; GLUTATHIONE PEROXIDASE; HUMANS; HYDROGEN PEROXIDE; ISLETS OF LANGERHANS; ISOENZYMES; MICE; OXIDANTS; OXYGEN; SUPEROXIDE DISMUTASE; TRANSFECTION; VITAMIN K 3;

EID: 0742271154     PISSN: 0908665X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3089.2004.00082.x     Document Type: Article

References (38)

1. RYAN EA, LAKEY JR, RAJOTTE RV et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 2001; 50: 710.
2. SHAPIRO AM, LAKEY JR, RYAN EA et al. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230,
3. BENNET W, SUNDBERG B, LUNDGREN T et al. Damage to porcine islets of Langerhans after exposure to human blood in vitro, or after intraportal transplantation to cynomologus monkeys: protective effects of sCR1 and heparin. Transplantation 2000; 69: 711.
4. LI C, JACKSON RM. Reactive species mechanisms of cellular hypoxia-reoxygenation injury. Am J Physiol Cell Physiol 2002; 282: C227.
5. PARR EL, BOWEN KM, LAFFERTY KJ. Cellular changes in cultured mouse thyroid glands and islets of Langerhans. Transplantation 1980; 30: 135.
6. GRIFFITH RC, SCHARP DW, HARTMAN BK, BALLINGER WF, LACY PE. A morphologic study of intrahepatic portal-vein islet isografts. Diabetes 1977; 26: 201.
7. CARLSSON PO, LISS P, ANDERSSON A, JANSSON L. Measurements of oxygen tension in native and transplanted rat pancreatic islets. Diabetes 1998; 47: 1027.
8. LEPORE DA. Nitric oxide synthase-independent generation of nitric oxide in muscle ischemia-reperfusion injury. Nitric Oxide 2000; 4: 541.
9. BECKMAN JS, BECKMAN TW, CHEN J, MARSHALL PA, FREEMAN BA. Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990; 87: 1620.
10. LAKEY JR, SUAREZ-PINZON WL, STRYNADKA K et al. Peroxynitrite is a mediator of cytokine-induced destruction of human pancreatic islet beta cells. Lab Invest 2001; 81: 1683.
11. TIEDGE M, LORTZ S, DRINKGERN J, LENZEN S. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 1997; 46: 1733.
12. BENHAMOU PY, MORISCOT C, RICHARD MJ et al. Adenovirus-mediated catalase gene transfer reduces oxidant stress in human, porcine and rat pancreatic islets. Diabetologia 1998; 41: 1093.
13. TIEDGE M, LORTZ S, MUNDAY R, LENZEN S. Complementary action of antioxidant enzymes in the protection of bioengineered insulin-producing R1Nm5F cells against the toxicity of reactive oxygen species. Diabetes 1998; 47: 1578.
14. HAMAGUCHI K, GASKINS HR, LEITER EH. NIT-1, a pancreatic beta-cell line established from a transgenic NOD/Lt mouse. Diabetes 1991; 40: 842.
15. HALLEWELL RA, MASIARZ FR, NAJARIAN RC et al. Human Cu/Zn superoxide dismutase cDNA: isolation of clones synthesising high levels of active or inactive enzyme from an expression library. Nucleic Acids Res 1985; 13: 2017.
16. Moscow JA, MORROW CS, HE R, MULLENBACH GT, COWAN KH. Structure and function of the 5′-flanking sequence of the human cytosolic selenium-dependent glutathione peroxidase gene (hgpx1). J Biol Chem 1992; 267: 5949.
17. MICHIELS C, RAES M, TOUSSAINT O, REMACLE J. Importance of Se-glutathione peroxidase, catalase, and Cu/Zn-SOD for cell survival against oxidative stress. Free Radic Biol Med 1994; 17: 235.
18. ELSTNER EF, HEUPEL A. Inhibition of nitrite formation from hydroxylammoniumchloride: a simple assay for superoxide dismutase. Anal Biochem 1976; 70: 616.
19. PAGLIA DE, VALENTINE WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70: 158.
20. MESTRIL R, CHI SH, SAYEN MR, O'REILLY K, DILLMANN WH. Expression of inducible stress protein 70 in rat heart myogenic cells confers protection against simulated ischemia-induced injury. J Clin Invest 1994; 93: 759.
21. MESTRIL R, GIORDANO FJ, CONDE AG, DILLMANN WH. Adenovirus-mediated gene transfer of a heat shock protein 70 (hsp 70i) protects against simulated ischemia. J Mol Cell Cardiol 1996; 28: 2351.
22. MOSMANN T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Meth 1983; 65: 55.
23. TIEDGE M, LORTZ S, MUNDAY R, LENZEN S. Protection against the co-operative toxicity of nitric oxide and oxygen free radicals by overexpression of antioxidant enzymes in bioengineered insulin-producing RINm5F cells. Diabetologia 1999; 42: 849.
24. ISHIBASHI N, PROKOPENKO O, REUHL KR, MIROCHNITCHENKO O. Inflammatory response and glutathione peroxidase in a model of stroke. J Immunol 2002; 168: 1926.
25. WEISBROT-LEFKOWITZ M, REUHL K, PERRY B et al. Overexpression of human glutathione peroxidase protects transgenic mice against focal cerebral ischemia/reperfusion damage. Brain Res Mol Brain Res 1998; 53: 333.
26. SIES H, SHAROV VS, KLOTZ LO, BRIVIBA K. Glutathione peroxidase protects against peroxynitrite-mediated oxidations. A new function for selenoproteins as peroxynitrite reductase. J Biol Chem 1997; 272: 27812.
27. BECKMAN JS. Oxidative damage and tyrosine nitration from peroxynitrite. Chem Res Toxicol 1996; 9: 836.
28. MURPHY MP, PACKER MA, SCARLETT JL, MARTIN SW. Peroxynitrite: a biologically significant oxidant. Gen Pharmacol 1998; 31: 179.
29. STEPHENS LA, THOMAS HE, KAY TW. Protection of NIT-1 pancreatic beta-cells from immune attack by inhibition of NF-kappaB. J Autoimmun 1997; 10: 293.
30. BECKMAN JS, KOPPENOL WH. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. Am J Physiol 1996; 271: C1424.
31. CHEN Z, OBERLEY TD, HO Y et al. Overexpression of CuZnSOD in coronary vascular cells attenuates myocardial ischemia/reperfusion injury. Free Radic Biol Med 2000; 29: 589.
32. YIN M, WHEELER MD, CONNOR HD et al. Cu/Zn-superoxide dismutase gene attenuates ischemia-reperfusion injury in the rat kidney. J Am Soc Nephrol 2001; 12: 2691.
33. KIM GW, LEWEN A, COPIN J, WATSON BD, CHAN PH. The cytosolic antioxidant, copper/zinc superoxide dismutase, attenuates blood-brain barrier disruption and oxidative cellular injury after photothrombotic cortical ischemia in mice. Neuroscience 2001; 105: 1007.
34. CUZZOCREA S, RILEY DP, CAPUTI AP, SALVEMINI D. Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol Rev 2001; 53: 135.
35. ZWEIER JL, WANG P, SAMOUILOV A, KUPPUSAMY P. Enzyme-independent formation of nitric oxide in biological tissues. Nat Med 1995; 1: 804.
36. SAMOUILOV A, KUPPUSAMY P, ZWEIER JL. Evaluation of the magnitude and rate of nitric oxide production from nitrite in biological systems. Arch Biochem Biophys 1998; 1: 357.
37. ZWEIER JL, SAMOUILOV A, KUPPUSAMY P. Non-enzymatic nitric oxide synthesis in biological systems. Biochim Biophys Acta 1999; 1411: 250.
38. PIGANELLI JD, FLORES SC, CRUZ C et al. A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. Diabetes 2002; 51: 347.