Molecularly engineered islet cell clusters for diabetes mellitus treatment

Cell Transplantation

Volumn 21, Issue 8, 2012, Pages 1775-1789

  Yook, Simmyung ^a   Jeong, Jee Heon ^a   Jung, Yoon Suk ^a   Hong, Sung Woo ^b   Im, Bok Hyeon ^a   Seo, Jin Won ^a   Park, Jun Beom ^a   Lee, Minhyung ^c   Ahn, Cheol Hee ^a   Lee, Haeshin ^d   Lee, Dong Yun ^c   Byun, Youngro ^a,b  

^a Seoul National University   (South Korea)

^b Seoul National University   (South Korea)

^c Hanyang University   (South Korea)

^d Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

Author keywords

Exendin 4; Islet cell clusters (ICCs); Polyethylene glycol; Transplantation

Indexed keywords

CD40 LIGAND MONOCLONAL ANTIBODY; EXENDIN 4; GLUCOSE; MACROGOL; SIGNAL PEPTIDE; TACROLIMUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CULTURE; CELL ENGINEERING; CELL HYPOXIA; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; GENETIC TRANSDUCTION; GLUCOSE METABOLISM; GRAFT SURVIVAL; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; LOW DRUG DOSE; MALE; NONHUMAN; PANCREAS ISLET CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; RAT; SURVIVAL RATE;

ANIMALS; ANOXIA; ANTIBODIES; APOPTOSIS; CD40 LIGAND; CELL SURVIVAL; CELLS, CULTURED; DIABETES MELLITUS, EXPERIMENTAL; GENETIC ENGINEERING; GLUCOSE; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MICE; MICE, INBRED C57BL; MICE, NUDE; PEPTIDES; POLYETHYLENE GLYCOLS; TACROLIMUS; VENOMS;

MUS;

EID: 84868148341     PISSN: 09636897     EISSN: None     Source Type: Journal    
DOI: 10.3727/096368912X640628     Document Type: Article

References (29)

1. Arakawa, M.; Ebato, C.; Mita, T.; Hirose, T.; Kawamori, R.; Fujitani, Y.; Watada, H. Effects of exendin-4 on glucose tolerance, insulin secretion, and beta-cell proliferation depend on treatment dose, treatment duration and meal contents. Biochem. Biophys. Res. Commun. 390(3):809-814; 2009.
2. Bavamian, S.; Klee, P.; Britan, A.; Populaire, C.; Caille, D.; Cancela, J.; Charollais, A.; Meda, P. Islet-cell-to-cell communication as basis for normal insulin secretion. Diabetes Obes. Metab. 9 Suppl 2:118-132; 2007.
3. Biarnes, M.; Montolio, M.; Nacher, V.; Raurell, M.; Soler, J.; Montanya, E. Beta-cell death and mass in syngeneically transplanted islets exposed to short- and long-term hyperglycemia. Diabetes 51(1):66-72; 2002.
4. Coffey, L. C.; Berman, D. M.; Willman, M. A.; Kenyon, N. S. Immune cell populations in nonhuman primate islets. Cell Transplant. 18(10):1213-1222; 2009.
5. Davalli, A. M.; Scaglia, L.; Zangen, D. H.; Hollister, J.; Bonner-Weir, S.; Weir, G. C. Vulnerability of islets in the immediate posttransplantation period. Dynamic changes in structure and function. Diabetes 45(9):1161-1167; 1996.
6. de Groot, M.; Schuurs, T. A.; van Schilfgaarde, R. Causes of limited survival of microencapsulated pancreatic islet grafts. J. Surg. Res. 121(1):141-150; 2004.
7. De Vos, P.; De Haan, B.; Pater, J.; Van Schilfgaarde, R. Association between capsule diameter, adequacy of encapsulation, and survival of microencapsulated rat islet allografts. Transplantation 62(7):893-899; 1996.
8. de Vos, P.; Spasojevic, M.; Faas, M. M. Treatment of diabetes with encapsulated islets. Adv. Exp. Med. Biol. 670:38-53; 2010.
9. Faradji, R. N.; Froud, T.; Messinger, S.; Monroy, K.; Pileggi, A.; Mineo, D.; Tharavanij, T.; Mendez, A. J.; Ricordi, C.; Alejandro, R. Long-term metabolic and hormonal effects of exenatide on islet transplant recipients with allograft dysfunction. Cell Transplant. 18(10):1247-1259; 2009.
10. Halban, P. A.; Powers, S. L.; George, K. L.; Bonner-Weir, S. Spontaneous reassociation of dispersed adult rat pancreatic islet cells into aggregates with three-dimensional architecture typical of native islets. Diabetes 36(7):783-790; 1987.
11. Halban, P. A.; Wollheim, C. B.; Blondel, B.; Meda, P.; Niesor, E. N.; Mintz, D. H. The possible importance of contact between pancreatic islet cells for the control of insulin release. Endocrinology 111(1):86-94; 1982.
12. Jang, J. Y.; Lee, D. Y.; Park, S. J.; Byun, Y. Immune reactions of lymphocytes and macrophages against PEG-grafted pancreatic islets. Biomaterials 25(17):3663-3669; 2004.
13. Kim, H. A.; Lee, S.; Park, J. H.; Lee, B. W.; Ihm, S. H.; Kim, T. I.; Kim, S. W.; Ko, K. S.; Lee, M. Enhanced protection of Ins-1 beta cells from apoptosis under hypoxia by delivery of DNA encoding secretion signal peptide-linked exendin-4. J. Drug Target. 17(3):242-248; 2009.
14. Konstantinova, I.; Nikolova, G.; Ohara-Imaizumi, M.; Meda, P.; Kucera, T.; Zarbalis, K.; Wurst, W.; Nagamatsu, S.; Lammert, E. EphA-ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell 129(2):359-370; 2007.
15. Korsgren, O.; Sandler, S.; Landstrom, A. S.; Jansson, L.; Andersson, A. Large-scale production of fetal porcine pancreatic isletlike cell clusters. An experimental tool for studies of islet cell differentiation and xenotransplantation. Transplantation 45(3):509-514; 1988.
16. Lacy, P. E.; Kostianovsky, M. Method for the isolation of intact islets of Langerhans from the rat pancreas. Diabetes 16(1):35-39; 1967.
17. Lee, D. Y.; Lee, S.; Nam, J. H.; Byun, Y. Minimization of immunosuppressive therapy after islet transplantation: Combined action of heme oxygenase-1 and PEGylation to islet. Am. J. Transplant. 6(8):1820-1828; 2006.
18. Lehmann, R.; Zuellig, R. A.; Kugelmeier, P.; Baenninger, P. B.; Moritz, W.; Perren, A.; Clavien, P. A.; Weber, M.; Spinas, G. A. Superiority of small islets in human islet transplantation. Diabetes 56(3):594-603; 2007.
19. Li, Y.; Hansotia, T.; Yusta, B.; Ris, F.; Halban, P. A.; Drucker, D. J. Glucagon-like peptide-1 receptor signaling modulates beta cell apoptosis. J. Biol. Chem. 278(1):471-478; 2003.
20. Lim, F.; Sun, A. M. Microencapsulated islets as bioartificial endocrine pancreas. Science 210(4472):908-910; 1980.
21. MacGregor, R. R.; Williams, S. J.; Tong, P. Y.; Kover, K.; Moore, W. V.; Stehno-Bittel, L. Small rat islets are superior to large islets in in vitro function and in transplantation outcomes. Am. J. Physiol. Endocrinol. Metab. 290(5):E771-E779; 2006.
22. Ricordi, C. Quantitative and qualitative standards for islet isolation assessment in humans and large mammals. Pancreas 6(2):242-244; 1991.
23. Ricordi, C.; Strom, T. B. Clinical islet transplantation: Advances and immunological challenges. Nat. Rev. Immunol. 4(4):259-268; 2004.
24. Shapiro, A. M.; Lakey, J. R.; Ryan, E. A.; Korbutt, G. S.; Toth, E.; Warnock, G. L.; Kneteman, N. M.; Rajotte, R. V. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N. Engl. J. Med. 343(4):230-238; 2000.
25. Shapiro, A. M.; Nanji, S. A.; Lakey, J. R. Clinical islet transplant: Current and future directions towards tolerance. Immunol. Rev. 196:219-236; 2003.
26. Shapiro, A. M.; Ricordi, C.; Hering, B. J.; Auchincloss, H.; Lindblad, R.; Robertson, R. P.; Secchi, A.; Brendel, M. D.; Berney, T.; Brennan, D. C.; Cagliero, E.; Alejandro, R.; Ryan, E. A.; DiMercurio, B.; Morel, P.; Polonsky, K. S.; Reems, J. A.; Bretzel, R. G.; Bertuzzi, F.; Froud, T.; Kandaswamy, R.; Sutherland, D. E.; Eisenbarth, G.; Segal, M.; Preiksaitis, J.; Korbutt, G. S.; Barton, F. B.; Viviano, L.; Seyfert-Margolis, V.; Bluestone, J.; Lakey, J. R. International trial of the Edmonton protocol for islet transplantation. N. Engl. J. Med. 355(13):1318-1330; 2006.
27. Taler, S. J.; Textor, S. C.; Canzanello, V. J.; Schwartz, L.; Porayko, M.; Wiesner, R. H.; Krom, R. A. Role of steroid dose in hypertension early after liver transplantation with tacrolimus (FK506) and cyclosporine. Transplantation 62(11):1588-1592; 1996.
28. Tam, S. K.; Dusseault, J.; Polizu, S.; Menard, M.; Halle, J. P.; Yahia, L. Impact of residual contamination on the biofunctional properties of purified alginates used for cell encapsulation. Biomaterials 27(8):1296-1305; 2006.
29. Wee, Y. M.; Lim, D. G.; Kim, Y. H.; Kim, J. H.; Kim, S. C.; Yu, E.; Park, M. O.; Choi, M. Y.; Park, Y. H.; Jang, H. J.; Cho, E. Y.; Cho, M. H.; Han, D. J. Cell surface modification by activated polyethylene glycol prevents allosensitization after islet transplantation. Cell Transplant. 17(10-11):1257-1269; 2008.