Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1α → hypoxia response element → VEGF cascade differentially regulates vascular response and growth rate in tumors

Cancer Research

Volumn 60, Issue 22, 2000, Pages 6248-6252

  Tsuzuki, Yoshikazu ^a   Fukumura, Dai ^a   Oosthuyse, Bert ^b   Koike, Chieko ^a   Carmeliet, Peter ^b   Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; GROWTH RATE; HYPOXIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR BLOOD FLOW; TUMOR GROWTH;

ANIMALS; CAPILLARY PERMEABILITY; CELL COMMUNICATION; CELL DIVISION; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; GENES, LETHAL; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LEUKOCYTES; LYMPHOKINES; MICE; MICE, KNOCKOUT; MICE, SCID; NEOPLASMS, EXPERIMENTAL; NEOVASCULARIZATION, PATHOLOGIC; NUCLEAR PROTEINS; RESPONSE ELEMENTS; SIGNAL TRANSDUCTION; STEM CELL TRANSPLANTATION; STEM CELLS; STROMAL CELLS; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0033693293     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis
2. Molecular and biological properties of vascular endothelial growth factor
3. Mechanisms of angiogenesis and arteriogenesis
4. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium
5. 2 homeostasis by hypoxia-inducible factor 1
6. Tumor induction of VEGF promoter in stromal cells
7. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice
8. Analysis of the tumor vasculature and metastatic behavior of xenografts of human melanoma cell lines transfected with vascular permeability factor
9. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene
10. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
11. Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
12. Suppression of glioblastoma angiogenicity and tumorigenicity by inhibition of endogenous expression of vascular endothelial growth factor
13. Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: Effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts
14. Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor
15. Quantitation and physiological characterization of angiogenic vessels in mice: Effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment
16. Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody
17. Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: Role of vascular endothelial growth factor
18. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
19. Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice
20. Tumor necrosis factor α-induced leukocyte adhesion in normal and tumor vessels: Effect of tumor type, transplantation site, and host strain
21. Formation of endothelial cell networks
22. Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: A potential role for T cells in angiogenesis
23. VEGF expression by epithelial and stromal cell compartments: Resolving a controversy
24. In vivo detection of human vascular endothelial growth factor promoter activity in transgenic mouse skin
25. Leukocyte-endothelial adhesion and angiogenesis in tumors
26. HIF-1α is required for solid tumor formation and embryonic vascularization
27. Hypoxia-inducible factor-1α is a positive factor in solid tumor growth
28. Angiogenesis in cancer and other diseases: From genes to function to therapy