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Volumn 57, Issue 10, 2004, Pages 1009-1014

The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

BCL 2 ADENOVIRUS E1B 19 KDA INTERACTING PROTEIN 3; HYPOXIA INDUCIBLE FACTOR 1; INHIBITOR OF APOPTOSIS PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN 2; PROTEIN; PROTEIN BAX; PROTEIN P53; UNCLASSIFIED DRUG;

EID: 4944246547     PISSN: 00219746     EISSN: None     Source Type: Journal    
DOI: 10.1136/jcp.2003.015032     Document Type: Review
Times cited : (665)

References (84)
  • 1
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003;3:721-32.
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 2
    • 0034680102 scopus 로고    scopus 로고
    • Molecular portraits of human breast tumours
    • Perou CM, Sorlie T, Eisen MB, et al. Molecular portraits of human breast tumours. Nature 2000;406:747-52.
    • (2000) Nature , vol.406 , pp. 747-752
    • Perou, C.M.1    Sorlie, T.2    Eisen, M.B.3
  • 3
    • 0004580887 scopus 로고
    • Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells
    • Rice GC, Hoy C, Schimke RT. Transient hypoxia enhances the frequency of dihydrofolate reductase gene amplification in Chinese hamster ovary cells. Proc Natl Acad Sci U S A 1986;83:5978-82.
    • (1986) Proc Natl Acad Sci U S A , vol.83 , pp. 5978-5982
    • Rice, G.C.1    Hoy, C.2    Schimke, R.T.3
  • 4
    • 0010170555 scopus 로고
    • Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells
    • Young SD, Marshall RS, Hill RP. Hypoxia induces DNA overreplication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci U S A 1988;85:9533-7.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 9533-9537
    • Young, S.D.1    Marshall, R.S.2    Hill, R.P.3
  • 5
    • 0032132806 scopus 로고    scopus 로고
    • A new role for hypoxia in tumor progression: Induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs
    • Coquelle A, Toledo F, Stern S, et al. A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs. Mol Cell 1998;2:259-65.
    • (1998) Mol Cell , vol.2 , pp. 259-265
    • Coquelle, A.1    Toledo, F.2    Stern, S.3
  • 6
    • 0029753768 scopus 로고    scopus 로고
    • Genetic instability induced by the tumor microenvironment
    • Reynolds TY, Rockwell S, Glazer PM. Genetic instability induced by the tumor microenvironment. Cancer Res 1996;56:5754-7.
    • (1996) Cancer Res , vol.56 , pp. 5754-5757
    • Reynolds, T.Y.1    Rockwell, S.2    Glazer, P.M.3
  • 7
    • 0032585644 scopus 로고    scopus 로고
    • Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury
    • Saikumar P, Dong Z, Patel Y, et al. Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury. Oncogene 1998;17:3401-15.
    • (1998) Oncogene , vol.17 , pp. 3401-3415
    • Saikumar, P.1    Dong, Z.2    Patel, Y.3
  • 8
    • 0035971220 scopus 로고    scopus 로고
    • Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor-1 by low oxygen tension
    • Aragones J, Jones DR, Martin S, et al. Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor-1 by low oxygen tension. J Biol Chem 2001;276:10548-55.
    • (2001) J Biol Chem , vol.276 , pp. 10548-10555
    • Aragones, J.1    Jones, D.R.2    Martin, S.3
  • 9
    • 0036082689 scopus 로고    scopus 로고
    • Anoxia-induced apoptosis occurs through a mitochondria-dependent pathway in lung epithelial cells
    • Santore MT, McClintock DS, Lee VY, et al. Anoxia-induced apoptosis occurs through a mitochondria-dependent pathway in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 2002;282:L727-34.
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.282
    • Santore, M.T.1    McClintock, D.S.2    Lee, V.Y.3
  • 10
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris AL. Hypoxia - a key regulatory factor in tumour growth. Nat Rev Cancer 2002;2:38-47.
    • (2002) Nat Rev Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 12
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1 alpha or in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
    • Carmeliet P, Dor Y, Herbert JM, et al. Role of HIF-1 alpha or in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 1998;394:485-90.
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1    Dor, Y.2    Herbert, J.M.3
  • 13
    • 0036584585 scopus 로고    scopus 로고
    • Apoptosis in hypoxic human pancreatic islets correlates with HIF-1 alpha expression
    • Moritz W, Meier F, Stroka DM, et al. Apoptosis in hypoxic human pancreatic islets correlates with HIF-1 alpha expression. FASEB J 2002;16:745-7.
    • (2002) FASEB J , vol.16 , pp. 745-747
    • Moritz, W.1    Meier, F.2    Stroka, D.M.3
  • 14
    • 0035418621 scopus 로고    scopus 로고
    • Constitutive expression of hypoxia-inducible factor-1 alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation
    • Akakura N, Kobayashi M, Horiuchi I, et al. Constitutive expression of hypoxia-inducible factor-1 alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res 2001;61:6548-54.
    • (2001) Cancer Res , vol.61 , pp. 6548-6554
    • Akakura, N.1    Kobayashi, M.2    Horiuchi, I.3
  • 15
    • 0033562569 scopus 로고    scopus 로고
    • Defective vascularization of HIF-1 alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death
    • Kotch LE, Iyer NV, Laughner E, et al. Defective vascularization of HIF-1 alpha-null embryos is not associated with VEGF deficiency but with mesenchymal cell death. Dev Biol 1999;209:254-67.
    • (1999) Dev Biol , vol.209 , pp. 254-267
    • Kotch, L.E.1    Iyer, N.V.2    Laughner, E.3
  • 16
    • 15444342958 scopus 로고    scopus 로고
    • Cellular and developmental control of O-2 homeastasis by hypoxia-inducible factor 1 alpha
    • Iyer NV, Kotch LE, Agani F, et al. Cellular and developmental control of O-2 homeastasis by hypoxia-inducible factor 1 alpha. Genes Dev 1998;12:149-62.
    • (1998) Genes Dev , vol.12 , pp. 149-162
    • Iyer, N.V.1    Kotch, L.E.2    Agani, F.3
  • 17
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1 alpha is required for solid tumor formation and embryonic vascularization
    • Ryan HE, Lo J, Johnson RS. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 1998;17:3005-15.
    • (1998) EMBO J , vol.17 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 18
    • 0032403263 scopus 로고    scopus 로고
    • Increased expression of hypoxia inducible factor-1 alpha in rat and human prostate cancer
    • Zhong H, Agani F, Baccala AA, et al. Increased expression of hypoxia inducible factor-1 alpha in rat and human prostate cancer. Cancer Res 1998;58:5280-4.
    • (1998) Cancer Res , vol.58 , pp. 5280-5284
    • Zhong, H.1    Agani, F.2    Baccala, A.A.3
  • 19
    • 0030659531 scopus 로고    scopus 로고
    • V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
    • Jiang BH, Agani F, Passaniti A, et al. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res 1997;57:5328-35.
    • (1997) Cancer Res , vol.57 , pp. 5328-5335
    • Jiang, B.H.1    Agani, F.2    Passaniti, A.3
  • 20
    • 0033566792 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha mediates hypoxia-induced delayed neuronal death that involves p53
    • Halterman MW, Miller CC, Federoff HJ. Hypoxia-inducible factor-1 alpha mediates hypoxia-induced delayed neuronal death that involves p53. J Neurosci 1999;19:6818-24.
    • (1999) J Neurosci , vol.19 , pp. 6818-6824
    • Halterman, M.W.1    Miller, C.C.2    Federoff, H.J.3
  • 21
    • 0028816847 scopus 로고
    • Purification and characterization of hypoxia-inducible factor-1
    • Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor-1. J Biol Chem 1995;270:1230-7.
    • (1995) J Biol Chem , vol.270 , pp. 1230-1237
    • Wang, G.L.1    Semenza, G.L.2
  • 22
    • 0030588298 scopus 로고    scopus 로고
    • Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia
    • Salceda S, Beck I, Caro J. Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia. Arch Biochem Biophys 1996;334:389-94.
    • (1996) Arch Biochem Biophys , vol.334 , pp. 389-394
    • Salceda, S.1    Beck, I.2    Caro, J.3
  • 23
    • 0036710591 scopus 로고    scopus 로고
    • Signal transduction to hypoxia-inducible factor 1
    • Semenza GL. Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol 2002;64:993-8.
    • (2002) Biochem Pharmacol , vol.64 , pp. 993-998
    • Semenza, G.L.1
  • 24
    • 0034676331 scopus 로고    scopus 로고
    • Up-regulation of hypoxia-inducible factors HIF-1 alpha and HIF-2 alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function
    • Krieg M, Haas R, Brauch H, et al. Up-regulation of hypoxia-inducible factors HIF-1 alpha and HIF-2 alpha under normoxic conditions in renal carcinoma cells by von Hippel-Lindau tumor suppressor gene loss of function. Oncogene 2000;19:5435-43.
    • (2000) Oncogene , vol.19 , pp. 5435-5443
    • Krieg, M.1    Haas, R.2    Brauch, H.3
  • 25
    • 17944375360 scopus 로고    scopus 로고
    • C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
    • Epslein ACP, Gleadle JM, McNeill LA, et al. C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001;107:43-54.
    • (2001) Cell , vol.107 , pp. 43-54
    • Epslein, A.C.P.1    Gleadle, J.M.2    McNeill, L.A.3
  • 26
    • 0035917808 scopus 로고    scopus 로고
    • Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O-2-regulated prolyl hydroxylation
    • Jaokkola P, Mole DR, Tian YM, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O-2-regulated prolyl hydroxylation. Science 2001;292:468-72.
    • (2001) Science , vol.292 , pp. 468-472
    • Jaokkola, P.1    Mole, D.R.2    Tian, Y.M.3
  • 27
    • 0035834409 scopus 로고    scopus 로고
    • A conserved family of prolyl-4-hydroxylases that modify HIF
    • Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 2001;294:1337-40.
    • (2001) Science , vol.294 , pp. 1337-1340
    • Bruick, R.K.1    McKnight, S.L.2
  • 28
    • 0033954247 scopus 로고    scopus 로고
    • Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1 alpha
    • Ravi R, Mookerjee B, Bhujwalla ZM, et al. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1 alpha. Genes Dev 2000;14:34-44.
    • (2000) Genes Dev , vol.14 , pp. 34-44
    • Ravi, R.1    Mookerjee, B.2    Bhujwalla, Z.M.3
  • 29
    • 0037016769 scopus 로고    scopus 로고
    • Jab1 interacts directly with HIF-1 alpha and regulates its stability
    • Bae MK, Ahn MY, Jeong JW, et al. Jab1 interacts directly with HIF-1 alpha and regulates its stability. J Biol Chem 2002;277:9-12.
    • (2002) J Biol Chem , vol.277 , pp. 9-12
    • Bae, M.K.1    Ahn, M.Y.2    Jeong, J.W.3
  • 30
    • 0032422032 scopus 로고    scopus 로고
    • The vascular endothelial growth factor mRNA contains an internal ribosome entry site
    • Miller DL, Dibbens JA, Damert A, et al. The vascular endothelial growth factor mRNA contains an internal ribosome entry site. FEBS Lett 1998;434:417-20.
    • (1998) FEBS Lett , vol.434 , pp. 417-420
    • Miller, D.L.1    Dibbens, J.A.2    Damert, A.3
  • 31
    • 0036000028 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia
    • Lang KJ, Kappel A, Goodall GJ. Hypoxia-inducible factor-1 alpha mRNA contains an internal ribosome entry site that allows efficient translation during normoxia and hypoxia. Mol Biol Cell 2002;13:1792-801.
    • (2002) Mol Biol Cell , vol.13 , pp. 1792-1801
    • Lang, K.J.1    Kappel, A.2    Goodall, G.J.3
  • 32
    • 0028891906 scopus 로고
    • The transcription factors Atf-1 and Creb-1 bind constitutively to the hypoxia-inducible factor-1 (Hif-1) DNA recognition site
    • Kvietikova I, Wenger RH, Marti HH, et al. The transcription factors Atf-1 and Creb-1 bind constitutively to the hypoxia-inducible factor-1 (Hif-1) DNA recognition site. Nucleic Acids Res 1995;23:4542-50.
    • (1995) Nucleic Acids Res , vol.23 , pp. 4542-4550
    • Kvietikova, I.1    Wenger, R.H.2    Marti, H.H.3
  • 33
    • 0036710591 scopus 로고    scopus 로고
    • Signal transduction to hypoxia-inducible factor 1
    • Semenza G. Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol 2002;64:993-8.
    • (2002) Biochem Pharmacol , vol.64 , pp. 993-998
    • Semenza, G.1
  • 34
    • 0029783518 scopus 로고    scopus 로고
    • Counting of apoptotic cells: A methodological study in invasive breast cancer
    • Schepop HAM, de Jong JS, van Diest PJ, et al. Counting of apoptotic cells: a methodological study in invasive breast cancer. Mol Pathol 1996;49:M214-17.
    • (1996) Mol Pathol , vol.49
    • Schepop, H.A.M.1    De Jong, J.S.2    Van Diest, P.J.3
  • 35
    • 0036006511 scopus 로고    scopus 로고
    • Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death
    • McClintock DS, Santore MT, Lee VY, et al. Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death. Mol Cell Biol 2002;22:94-104.
    • (2002) Mol Cell Biol , vol.22 , pp. 94-104
    • McClintock, D.S.1    Santore, M.T.2    Lee, V.Y.3
  • 36
    • 0033534446 scopus 로고    scopus 로고
    • Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death
    • Gross A, Yin XM, Wang K, et al. Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem 1999;274:1156-63.
    • (1999) J Biol Chem , vol.274 , pp. 1156-1163
    • Gross, A.1    Yin, X.M.2    Wang, K.3
  • 37
    • 0035957653 scopus 로고    scopus 로고
    • Proapoptotic BAX and BAK: A requisite gateway to mitochondrial dysfunction and death
    • Wei MC, Zong WX, Cheng EH, et al. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001;292:727-30.
    • (2001) Science , vol.292 , pp. 727-730
    • Wei, M.C.1    Zong, W.X.2    Cheng, E.H.3
  • 38
    • 0030715323 scopus 로고    scopus 로고
    • Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
    • Li P, Nijhawan D, Budihardjo I, et al. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997;91:479-89.
    • (1997) Cell , vol.91 , pp. 479-489
    • Li, P.1    Nijhawan, D.2    Budihardjo, I.3
  • 40
    • 0028927607 scopus 로고
    • The Fas death factor
    • Nagata S, Golstein P. The Fas death factor. Science 1995;267:1449-56.
    • (1995) Science , vol.267 , pp. 1449-1456
    • Nagata, S.1    Golstein, P.2
  • 41
    • 0034660874 scopus 로고    scopus 로고
    • Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression
    • Fulda S, Meyer E, Debatin KM. Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression. Cancer Res 2000;60:3947-56.
    • (2000) Cancer Res , vol.60 , pp. 3947-3956
    • Fulda, S.1    Meyer, E.2    Debatin, K.M.3
  • 42
    • 0037072937 scopus 로고    scopus 로고
    • An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12
    • Morishima N, Nakanishi K, Takenouchi H, et al. An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 2002;277:34287-94.
    • (2002) J Biol Chem , vol.277 , pp. 34287-34294
    • Morishima, N.1    Nakanishi, K.2    Takenouchi, H.3
  • 43
    • 0042564805 scopus 로고    scopus 로고
    • ROS-dependent caspase-9 activation in hypoxic cell death
    • Kim JY, Park JH. ROS-dependent caspase-9 activation in hypoxic cell death. FEBS Lett 2003;549:94-8.
    • (2003) FEBS Lett , vol.549 , pp. 94-98
    • Kim, J.Y.1    Park, J.H.2
  • 44
    • 0032411879 scopus 로고    scopus 로고
    • Stress signals for apoptosis: Ceramide and c-Jun kinase
    • Basu S, Kolesnick R. Stress signals for apoptosis: ceramide and c-Jun kinase. Oncogene 1998;17:3277-85.
    • (1998) Oncogene , vol.17 , pp. 3277-3285
    • Basu, S.1    Kolesnick, R.2
  • 45
    • 0034920088 scopus 로고    scopus 로고
    • Activation of c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) is critical for hypoxia-induced apoptosis of human malignant melanoma
    • Kunz M, Ibrahim S, Koczan D, et al. Activation of c-Jun NH2-terminal kinase/stress-activated protein kinase (JNK/SAPK) is critical for hypoxia-induced apoptosis of human malignant melanoma. Cell Growth Differ 2001;12:137-45.
    • (2001) Cell Growth Differ , vol.12 , pp. 137-145
    • Kunz, M.1    Ibrahim, S.2    Koczan, D.3
  • 46
    • 0042845994 scopus 로고    scopus 로고
    • Apoptosis-resistance of hypoxic cells: Multiple factors involved and a role for IAP-2
    • Dong Z, Wang JZ, Yu F, et al. Apoptosis-resistance of hypoxic cells: multiple factors involved and a role for IAP-2. Am J Pathol 2003;163:663-71.
    • (2003) Am J Pathol , vol.163 , pp. 663-671
    • Dong, Z.1    Wang, J.Z.2    Yu, F.3
  • 47
    • 0036606747 scopus 로고    scopus 로고
    • Gene promoter of apoptosis inhibitory protein IAP2: Identification of enhancer elements and activation by severe hypoxia
    • Dong Z, Nishiyama J, Yi XL, et al. Gene promoter of apoptosis inhibitory protein IAP2: identification of enhancer elements and activation by severe hypoxia. Biochem J 2002;364:413-21.
    • (2002) Biochem J , vol.364 , pp. 413-421
    • Dong, Z.1    Nishiyama, J.2    Yi, X.L.3
  • 48
    • 0033160190 scopus 로고    scopus 로고
    • A new internal-ribosome-entry-site motif potentiates XIAP-mediated cytoprotection
    • Holcik M, Lefebvre C, Yeh CL, et al. A new internal-ribosome-entry-site motif potentiates XIAP-mediated cytoprotection. Nat Cell Biol 1999;1:190-2.
    • (1999) Nat Cell Biol , vol.1 , pp. 190-192
    • Holcik, M.1    Lefebvre, C.2    Yeh, C.L.3
  • 49
    • 0035798604 scopus 로고    scopus 로고
    • The von Hippel-Lindau gene product inhibits renal cell apoptosis via Bcl-2-dependent pathways
    • Devarajan P, De Leon M, Talasazan F, et al. The von Hippel-Lindau gene product inhibits renal cell apoptosis via Bcl-2-dependent pathways. J Biol Chem 2001;276:40599-605.
    • (2001) J Biol Chem , vol.276 , pp. 40599-40605
    • Devarajan, P.1    De Leon, M.2    Talasazan, F.3
  • 50
    • 0035933726 scopus 로고    scopus 로고
    • Hypoxia induces the activation of the phosphatidyinositol 3-kinase/Akt cell survival pathway in PC12 protective role in apoptosis
    • Alvarez-Tejado M, Naranjo-Suarez S, Jimenez C, et al. Hypoxia induces the activation of the phosphatidyinositol 3-kinase/Akt cell survival pathway in PC12 protective role in apoptosis. J Biol Chem 2001;276:22368-74.
    • (2001) J Biol Chem , vol.276 , pp. 22368-22374
    • Alvarez-Tejado, M.1    Naranjo-Suarez, S.2    Jimenez, C.3
  • 51
    • 0037118575 scopus 로고    scopus 로고
    • AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival
    • Bacus SS, Altomare DA, Lyass L, et al. AKT2 is frequently upregulated in HER-2/neu-positive breast cancers and may contribute to tumor aggressiveness by enhancing cell survival. Oncogene 2002;21:3532-40.
    • (2002) Oncogene , vol.21 , pp. 3532-3540
    • Bacus, S.S.1    Altomare, D.A.2    Lyass, L.3
  • 52
    • 0035914436 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2 alpha (HIF-2 alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia
    • Brusselmans K, Bono F, Maxwell P, et al. Hypoxia-inducible factor-2 alpha (HIF-2 alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia. J Biol Chem 2001;276:39192-6.
    • (2001) J Biol Chem , vol.276 , pp. 39192-39196
    • Brusselmans, K.1    Bono, F.2    Maxwell, P.3
  • 53
    • 0038529602 scopus 로고    scopus 로고
    • Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function
    • Chen D, Li M, Luo J, et al. Direct interactions between HIF-1 alpha and Mdm2 modulate p53 function. J Biol Chem 2003;278:13595-8.
    • (2003) J Biol Chem , vol.278 , pp. 13595-13598
    • Chen, D.1    Li, M.2    Luo, J.3
  • 54
    • 0036678830 scopus 로고    scopus 로고
    • Two sequence motifs from HIF-1 alpha bind to the DNA-binding site of p53
    • Hansson LO, Friedler A, Freund S, et al. Two sequence motifs from HIF-1 alpha bind to the DNA-binding site of p53. Proc Natl Acad Sci U S A, 2002;99:10305-9.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10305-10309
    • Hansson, L.O.1    Friedler, A.2    Freund, S.3
  • 55
    • 0032568150 scopus 로고    scopus 로고
    • Stabilization of wild-type p53 by hypoxia-inducible factor 1 alpha
    • An WG, Kanekal M, Simon MC, et al. Stabilization of wild-type p53 by hypoxia-inducible factor 1 alpha. Nature 1998;392:405-8.
    • (1998) Nature , vol.392 , pp. 405-408
    • An, W.G.1    Kanekal, M.2    Simon, M.C.3
  • 56
    • 0035884701 scopus 로고    scopus 로고
    • HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors
    • Sowter HM, Ratcliffe PJ, Watson P, et al. HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res 2001;61:6669-73.
    • (2001) Cancer Res , vol.61 , pp. 6669-6673
    • Sowter, H.M.1    Ratcliffe, P.J.2    Watson, P.3
  • 57
    • 0028775458 scopus 로고
    • Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins
    • Boyd JM. Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins. Cell 1994;79:1121.
    • (1994) Cell , vol.79 , pp. 1121
    • Boyd, J.M.1
  • 58
    • 0034255036 scopus 로고    scopus 로고
    • Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
    • Bruick RK. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc Natl Acad Sci U S A, 2000;97:9082-7.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 9082-9087
    • Bruick, R.K.1
  • 59
    • 0043091971 scopus 로고    scopus 로고
    • BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF
    • Kothari S, Cizeau J, McMillan-Ward E, et al. BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF. Oncogene 2003;22:4734-44.
    • (2003) Oncogene , vol.22 , pp. 4734-4744
    • Kothari, S.1    Cizeau, J.2    McMillan-Ward, E.3
  • 60
    • 0033942613 scopus 로고    scopus 로고
    • BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore
    • Vande Velde C, Cizeau J, Dubik D, et al. BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol Cell Biol 2000;20:5454-68.
    • (2000) Mol Cell Biol , vol.20 , pp. 5454-5468
    • Vande Velde, C.1    Cizeau, J.2    Dubik, D.3
  • 61
    • 0344608877 scopus 로고    scopus 로고
    • Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism
    • Chen J, Zhao SJ, Nakada K, et al. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. Am J Pathol 2003;162:1283-91.
    • (2003) Am J Pathol , vol.162 , pp. 1283-1291
    • Chen, J.1    Zhao, S.J.2    Nakada, K.3
  • 62
    • 0036707398 scopus 로고    scopus 로고
    • Is HIF-1 alpha a pro- or an anti-apoptotic protein?
    • Piret JP, Mottet D, Raes M, et al. Is HIF-1 alpha a pro- or an anti-apoptotic protein? Biochem Pharmacol 2002;64:889-92.
    • (2002) Biochem Pharmacol , vol.64 , pp. 889-892
    • Piret, J.P.1    Mottet, D.2    Raes, M.3
  • 63
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    • Graeber TG, Osmanian C, Jacks T, et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours. Nature 1996;379:88-91.
    • (1996) Nature , vol.379 , pp. 88-91
    • Graeber, T.G.1    Osmanian, C.2    Jacks, T.3
  • 64
    • 0033961467 scopus 로고    scopus 로고
    • Interrelationship of proliferation and hypoxia in carcinoma of the cervix
    • Tsang RW, Fyles AW, Milosevic M, et al. Interrelationship of proliferation and hypoxia in carcinoma of the cervix. Int J Radiat Oncol Biol Phys 2000;46:95-9.
    • (2000) Int J Radiat Oncol Biol Phys , vol.46 , pp. 95-99
    • Tsang, R.W.1    Fyles, A.W.2    Milosevic, M.3
  • 65
    • 0030995145 scopus 로고    scopus 로고
    • Proliferation and hypoxia in human squamous cell carcinoma of the cervix: First report of combined immunohistochemical assays
    • Kennedy AS, Raleigh JA, Perez GM, et al. Proliferation and hypoxia in human squamous cell carcinoma of the cervix: first report of combined immunohistochemical assays. Int J Radiat Oncol Biol Phys 1997;37:897-905.
    • (1997) Int J Radiat Oncol Biol Phys , vol.37 , pp. 897-905
    • Kennedy, A.S.1    Raleigh, J.A.2    Perez, G.M.3
  • 66
    • 0028847455 scopus 로고
    • Simultaneous triple staining for hypoxia, proliferation, and DNA content in murine tumours
    • Webster L, Hodgkiss RJ, Wilson GD. Simultaneous triple staining for hypoxia, proliferation, and DNA content in murine tumours. Cytometry 1995;21:344-51.
    • (1995) Cytometry , vol.21 , pp. 344-351
    • Webster, L.1    Hodgkiss, R.J.2    Wilson, G.D.3
  • 67
    • 0029078709 scopus 로고
    • Distribution of hypoxia and proliferation associated markers in spontaneous canine tumors
    • Raleigh JA, Zeman EM, Calkins DP, et al. Distribution of hypoxia and proliferation associated markers in spontaneous canine tumors. Acta Oncol 1995;34:345-9.
    • (1995) Acta Oncol , vol.34 , pp. 345-349
    • Raleigh, J.A.1    Zeman, E.M.2    Calkins, D.P.3
  • 68
    • 0030199968 scopus 로고    scopus 로고
    • The relationship between tumor oxygenation and cell proliferation in human soft tissue sarcomas
    • Nordsmark M, Hoyer M, Keller J, et al. The relationship between tumor oxygenation and cell proliferation in human soft tissue sarcomas. Int J Radiat Oncol Biol Phys 1996;35:701-8.
    • (1996) Int J Radiat Oncol Biol Phys , vol.35 , pp. 701-708
    • Nordsmark, M.1    Hoyer, M.2    Keller, J.3
  • 69
    • 0038523737 scopus 로고    scopus 로고
    • Tumor hypoxia at the micro-regional level: Clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers
    • Bussink J, Kaanders JH, van der Kogel AJ. Tumor hypoxia at the micro-regional level: clinical relevance and predictive value of exogenous and endogenous hypoxic cell markers. Radiother Oncol 2003;67:3-15.
    • (2003) Radiother Oncol , vol.67 , pp. 3-15
    • Bussink, J.1    Kaanders, J.H.2    Van Der Kogel, A.J.3
  • 70
    • 0028860378 scopus 로고
    • Apoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma
    • Levine EL, Renehan A, Gossiel R, et al. Apoptosis, intrinsic radiosensitivity and prediction of radiotherapy response in cervical carcinoma. Radiother Oncol 1995;37:1-9.
    • (1995) Radiother Oncol , vol.37 , pp. 1-9
    • Levine, E.L.1    Renehan, A.2    Gossiel, R.3
  • 71
    • 0033019266 scopus 로고    scopus 로고
    • Tumour proliferation and apoptosis in human uterine cervix carcinoma II: Correlations with clinical outcome
    • Tsang RW, Wong CS, Fyles AW, et al. Tumour proliferation and apoptosis in human uterine cervix carcinoma II: correlations with clinical outcome. Radiother Oncol 1999;50:93-101.
    • (1999) Radiother Oncol , vol.50 , pp. 93-101
    • Tsang, R.W.1    Wong, C.S.2    Fyles, A.W.3
  • 72
    • 0033062346 scopus 로고    scopus 로고
    • A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy or cervical adenocarcinoma
    • Sheridan MT, Cooper RA, West CM. A high ratio of apoptosis to proliferation correlates with improved survival after radiotherapy or cervical adenocarcinoma. Int J Radiat Oncol Biol Phys 1999;44:507-12.
    • (1999) Int J Radiat Oncol Biol Phys , vol.44 , pp. 507-512
    • Sheridan, M.T.1    Cooper, R.A.2    West, C.M.3
  • 73
    • 0029100685 scopus 로고
    • ASTRO research fellowship: Apoptosis as a predictor of tumor response to radiation in stage IB cervical carcinoma
    • American Society for Therapeutic Radiology and Oncology
    • Wheeler JA, Stephens LC, Tornos C, et al. ASTRO research fellowship: apoptosis as a predictor of tumor response to radiation in stage IB cervical carcinoma. American Society for Therapeutic Radiology and Oncology. Int J Radiat Oncol Biol Phys 1995;32:1487-93.
    • (1995) Int J Radiat Oncol Biol Phys , vol.32 , pp. 1487-1493
    • Wheeler, J.A.1    Stephens, L.C.2    Tornos, C.3
  • 74
    • 0033571682 scopus 로고    scopus 로고
    • Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases
    • Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1 alpha in common human cancers and their metastases. Cancer Res 1999;59:5830-5.
    • (1999) Cancer Res , vol.59 , pp. 5830-5835
    • Zhong, H.1    De Marzo, A.M.2    Laughner, E.3
  • 75
    • 0035925072 scopus 로고    scopus 로고
    • Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis
    • Bos R, Zhong H, Hanrahan CF, et al. Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J Natl Cancer Inst 2001;93:309-14.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 309-314
    • Bos, R.1    Zhong, H.2    Hanrahan, C.F.3
  • 76
    • 0037443587 scopus 로고    scopus 로고
    • Levels of hypoxia-inducible factor-1 alpha independently predict prognosis in patients with lymph node negative breast carcinoma
    • Bos R, Van Der Groep, Greijer AE, et al. Levels of hypoxia-inducible factor-1 alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 2003;97:1573-81.
    • (2003) Cancer , vol.97 , pp. 1573-1581
    • Bos, R.1    Van Der Groep2    Greijer, A.E.3
  • 77
    • 0035423048 scopus 로고    scopus 로고
    • Re: Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis
    • Costa A, Coradini D, Carrassi A, et al. Re: Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J Natl Cancer Inst 2001;93:1175-7.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1175-1177
    • Costa, A.1    Coradini, D.2    Carrassi, A.3
  • 78
    • 85016438530 scopus 로고    scopus 로고
    • Response: Levels of hypoxia-inducible factor-1a during breast carcinogenesis
    • Bos R, Van Diest PJ, Van Der Wall E. Response: levels of hypoxia-inducible factor-1a during breast carcinogenesis. J Natl Cancer Inst 2001;93:1177.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1177
    • Bos, R.1    Van Diest, P.J.2    Van Der Wall, E.3
  • 79
    • 0342433777 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer
    • Volm M, Koomagi R. Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Res 2000;20:1527-33.
    • (2000) Anticancer Res , vol.20 , pp. 1527-1533
    • Volm, M.1    Koomagi, R.2
  • 80
    • 0342433777 scopus 로고    scopus 로고
    • Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer
    • Volm M, Koomagi R. Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer. Anticancer Res 2000;20:1527-33.
    • (2000) Anticancer Res , vol.20 , pp. 1527-1533
    • Volm, M.1    Koomagi, R.2
  • 81
    • 0035860147 scopus 로고    scopus 로고
    • Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival
    • Giatromanolaki A, Koukourakis MI, Sivridis E, et al. Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumours and survival. Br J Cancer 2001;85:881-90.
    • (2001) Br J Cancer , vol.85 , pp. 881-890
    • Giatromanolaki, A.1    Koukourakis, M.I.2    Sivridis, E.3
  • 82
    • 0031471135 scopus 로고    scopus 로고
    • Potential role of bcl-2 as a suppressor of tumour angiogenesis in non-small-cell lung cancer
    • Koukourakis MI, Giatromanolaki A, O'Byrne KJ, et al. Potential role of bcl-2 as a suppressor of tumour angiogenesis in non-small-cell lung cancer. Int J Cancer 1997;74:565-70.
    • (1997) Int J Cancer , vol.74 , pp. 565-570
    • Koukourakis, M.I.1    Giatromanolaki, A.2    O'Byrne, K.J.3
  • 83
    • 0038282482 scopus 로고    scopus 로고
    • The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy
    • Unruh A, Ressel A, Mohamed HG, et al. The hypoxia-inducible factor-1 alpha is a negative factor for tumor therapy. Oncogene 2003;22:3213-20.
    • (2003) Oncogene , vol.22 , pp. 3213-3220
    • Unruh, A.1    Ressel, A.2    Mohamed, H.G.3
  • 84
    • 0035300410 scopus 로고    scopus 로고
    • Expression of hypoxia-inducible factor-1 alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
    • Aebrsold DM, Burri P, Beer KT, et al. Expression of hypoxia-inducible factor-1 alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res 2001;61:2911-16.
    • (2001) Cancer Res , vol.61 , pp. 2911-2916
    • Aebrsold, D.M.1    Burri, P.2    Beer, K.T.3


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