-
1
-
-
33846696837
-
Late-neoproterozoic deep-ocean oxygenation and the rise of animal life.
-
Canfield DE, Poulton SW, Narbonne GM. Late-neoproterozoic deep-ocean oxygenation and the rise of animal life. Science 2007, 315:92-95..
-
(2007)
Science
, vol.315
-
-
Canfield, D.E.1
Poulton, S.W.2
Narbonne, G.M.3
-
2
-
-
8844276053
-
Loss of skeletal muscle HIF-1alpha results in altered exercise endurance.
-
Mason SD, Howlett RA, Kim MJ. Loss of skeletal muscle HIF-1alpha results in altered exercise endurance. PLoS Biol 2004, 2:e288..
-
(2004)
PLoS Biol
, vol.2
-
-
Mason, S.D.1
Howlett, R.A.2
Kim, M.J.3
-
4
-
-
38649143118
-
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism.
-
Aragones J, Schneider M, Van Geyte K. Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet 2008, 40:170-180..
-
(2008)
Nat Genet
, vol.40
-
-
Aragones, J.1
Schneider, M.2
Van Geyte, K.3
-
5
-
-
74549142287
-
The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.
-
Zhong L, D'Urso A, Toiber D. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 2010, 140:280-293..
-
(2010)
Cell
, vol.140
-
-
Zhong, L.1
D'Urso, A.2
Toiber, D.3
-
6
-
-
34047264834
-
Von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase.
-
Park SK, Haase VH, Johnson RS. von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase. Int J Oncol 2007, 30:341-348..
-
(2007)
Int J Oncol
, vol.30
-
-
Park, S.K.1
Haase, V.H.2
Johnson, R.S.3
-
7
-
-
65349142586
-
Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones.
-
Wang XL, Suzuki R, Lee K. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metab 2009, 9:428-439..
-
(2009)
Cell Metab
, vol.9
-
-
Wang, X.L.1
Suzuki, R.2
Lee, K.3
-
8
-
-
68949159760
-
HIF 1 alpha induces fibrosis and insulin resistance in white adipose tissue.
-
Halberg N, Khan T, Trujillo ME. HIF 1 alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol 2009, 29:4467-4483..
-
(2009)
Mol Cell Biol
, vol.29
-
-
Halberg, N.1
Khan, T.2
Trujillo, M.E.3
-
9
-
-
61749090485
-
Deletion of the von Hippel-Lindau gene in pancreatic β cells impairs glucose homeostasis in mice.
-
doi:10.1172/JCI26934.
-
Cantley J, Selman C, Shukla D. Deletion of the von Hippel-Lindau gene in pancreatic β cells impairs glucose homeostasis in mice. J Clin Invest 2009, 119:125-135. doi:10.1172/JCI26934.
-
(2009)
J Clin Invest
, vol.119
, pp. 125-135
-
-
Cantley, J.1
Selman, C.2
Shukla, D.3
-
10
-
-
61949412026
-
A role for Von-Hippel Lindau protein in pancreatic β-cell function.
-
Puri S, Cano D, Hebrok M. A role for Von-Hippel Lindau protein in pancreatic β-cell function. Diabetes 2008, 58:433-441..
-
(2008)
Diabetes
, vol.58
-
-
Puri, S.1
Cano, D.2
Hebrok, M.3
-
11
-
-
56549094039
-
PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells.
-
Zehetner J, Danzer C, Collins S. PVHL is a regulator of glucose metabolism and insulin secretion in pancreatic beta cells. Genes Dev 2008, 22:3135-3146..
-
(2008)
Genes Dev
, vol.22
-
-
Zehetner, J.1
Danzer, C.2
Collins, S.3
-
12
-
-
23744439083
-
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes.
-
Gunton JE, Kulkarni RN, Yim S. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 2005, 122:337-349..
-
(2005)
Cell
, vol.122
-
-
Gunton, J.E.1
Kulkarni, R.N.2
Yim, S.3
-
13
-
-
54549089738
-
Hypoxia signalling through mTOR and the unfolded protein response in cancer.
-
Wouters BG, Koritzinsky M. Hypoxia signalling through mTOR and the unfolded protein response in cancer. Nat Rev Cancer 2008, 8:851-864..
-
(2008)
Nat Rev Cancer
, vol.8
-
-
Wouters, B.G.1
Koritzinsky, M.2
-
14
-
-
32444433450
-
Hypoxia-induced energy stress regulates mRNA translation and cell growth.
-
Liu L, Cash TP, Jones RG, Keith B, Thompson CB, Simon MC. Hypoxia-induced energy stress regulates mRNA translation and cell growth. Mol Cell 2006, 21:521-531..
-
(2006)
Mol Cell
, vol.21
-
-
Liu, L.1
Cash, T.P.2
Jones, R.G.3
Keith, B.4
Thompson, C.B.5
Simon, M.C.6
-
15
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation.
-
Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol 1992, 12:5447-5454..
-
(1992)
Mol Cell Biol
, vol.12
-
-
Semenza, G.L.1
Wang, G.L.2
-
16
-
-
31444444162
-
Integration of oxygen signaling at the consensus HRE.
-
Oct 18; (306):
-
Wenger RH, Stiehl DP, Camenisch G. Integration of oxygen signaling at the consensus HRE. Sci STKE 2005, re12.. Oct 18; (306):
-
(2005)
Sci STKE
-
-
Wenger, R.H.1
Stiehl, D.P.2
Camenisch, G.3
-
17
-
-
70450223507
-
Generating specificity and diversity in the transcriptional response to hypoxia.
-
Lendahl U, Lee KL, Yang H, Poellinger L. Generating specificity and diversity in the transcriptional response to hypoxia. Nat Rev Genet 2009, 10:821-832..
-
(2009)
Nat Rev Genet
, vol.10
-
-
Lendahl, U.1
Lee, K.L.2
Yang, H.3
Poellinger, L.4
-
18
-
-
0029051439
-
Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
-
Wang GL, Jiang BH, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995, 92:5510-5514..
-
(1995)
Proc Natl Acad Sci USA
, vol.92
-
-
Wang, G.L.1
Jiang, B.H.2
Rue, E.A.3
Semenza, G.L.4
-
19
-
-
0028935006
-
Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation.
-
Sogawa K, Nakano R, Kobayashi A. Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation. Proc Natl Acad Sci USA 1995, 92:1936-1940..
-
(1995)
Proc Natl Acad Sci USA
, vol.92
-
-
Sogawa, K.1
Nakano, R.2
Kobayashi, A.3
-
20
-
-
0028998310
-
Constitutive function of the basic helix-loop-helix/PAS factor Arnt. Regulation of target promoters via the E box motif.
-
Antonsson C, Arulampalam V, Whitelaw ML, Pettersson S, Poellinger L. Constitutive function of the basic helix-loop-helix/PAS factor Arnt. Regulation of target promoters via the E box motif. J Biol Chem 1995, 270:13968-13972..
-
(1995)
J Biol Chem
, vol.270
-
-
Antonsson, C.1
Arulampalam, V.2
Whitelaw, M.L.3
Pettersson, S.4
Poellinger, L.5
-
21
-
-
0035917808
-
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
-
Jaakkola P, Mole DR, Tian YM. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 2001, 292:468-472..
-
(2001)
Science
, vol.292
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
-
22
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.
-
Maxwell PH, Wiesener MS, Chang GW. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999, 399:271-275..
-
(1999)
Nature
, vol.399
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
-
23
-
-
48649098334
-
PVHL: a multipurpose adaptor protein.
-
Frew IJ, Krek W. pVHL: a multipurpose adaptor protein. Sci Signal 2008, 1:pe30..
-
(2008)
Sci Signal
, vol.1
-
-
Frew, I.J.1
Krek, W.2
-
24
-
-
37549071449
-
Oxygen sensors in context.
-
Ward JP. Oxygen sensors in context. Biochim Biophys Acta 2008, 1777:1-14..
-
(2008)
Biochim Biophys Acta
, vol.1777
-
-
Ward, J.P.1
-
25
-
-
0035157768
-
Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus.
-
Schuit FC, Huypens P, Heimberg H, Pipeleers DG. Glucose sensing in pancreatic beta-cells: a model for the study of other glucose-regulated cells in gut, pancreas, and hypothalamus. Diabetes 2001, 50:1-11..
-
(2001)
Diabetes
, vol.50
-
-
Schuit, F.C.1
Huypens, P.2
Heimberg, H.3
Pipeleers, D.G.4
-
26
-
-
0030810982
-
Metabolic fate of glucose in purified islet cells.
-
Schuit F, De Vos A, Farfari S. Metabolic fate of glucose in purified islet cells. J Biol Chem 1997, 272:18572-18579..
-
(1997)
J Biol Chem
, vol.272
-
-
Schuit, F.1
De Vos, A.2
Farfari, S.3
-
28
-
-
61949476900
-
Intolerant of glucose and gasping for oxygen.
-
Gribble FM. Intolerant of glucose and gasping for oxygen. Nat Med 2009, 15:247-249..
-
(2009)
Nat Med
, vol.15
-
-
Gribble, F.M.1
-
29
-
-
0033919717
-
Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion.
-
Ainscow EK, Zhao C, Rutter GA. Acute overexpression of lactate dehydrogenase-A perturbs beta-cell mitochondrial metabolism and insulin secretion. Diabetes 2000, 49:1149-1155..
-
(2000)
Diabetes
, vol.49
-
-
Ainscow, E.K.1
Zhao, C.2
Rutter, G.A.3
-
30
-
-
0036297974
-
Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets.
-
Nicholls LI, Ainscow EK, Rutter GA. Glucose-stimulated insulin secretion does not require activation of pyruvate dehydrogenase: impact of adenovirus-mediated overexpression of PDH kinase and PDH phosphate phosphatase in pancreatic islets. Biochem Biophys Res Commun 2002, 291:1081-1088..
-
(2002)
Biochem Biophys Res Commun
, vol.291
-
-
Nicholls, L.I.1
Ainscow, E.K.2
Rutter, G.A.3
-
32
-
-
77950344913
-
Oxygen tension regulates pancreatic β-cell differentiation through hypoxia-inducible factor 1α.
-
Heinis M, Simon M-T, Ilc K. Oxygen tension regulates pancreatic β-cell differentiation through hypoxia-inducible factor 1α. Diabetes 2010, 59:662-669..
-
(2010)
Diabetes
, vol.59
-
-
Heinis, M.1
Simon, M.-.T.2
Ilc, K.3
-
33
-
-
27544477748
-
The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing.
-
Kaelin WG. The von Hippel-Lindau protein, HIF hydroxylation, and oxygen sensing. Biochem Biophys Res Commun 2005, 338:627-638..
-
(2005)
Biochem Biophys Res Commun
, vol.338
-
-
Kaelin, W.G.1
-
34
-
-
51649090078
-
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice.
-
Rankin EB, Rha J, Unger TL. Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice. Oncogene 2008, 27:5354-5358..
-
(2008)
Oncogene
, vol.27
-
-
Rankin, E.B.1
Rha, J.2
Unger, T.L.3
-
35
-
-
33745537991
-
The von Hippel-Lindau tumour-suppressor protein interaction with protein kinase C delta.
-
Iturrioz X, Durgan J, Calleja V. The von Hippel-Lindau tumour-suppressor protein interaction with protein kinase C delta. Biochem J 2006, 397:109-120..
-
(2006)
Biochem J
, vol.397
-
-
Iturrioz, X.1
Durgan, J.2
Calleja, V.3
-
36
-
-
0035941291
-
The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C.
-
Okuda H, Saitoh K, Hirai S. The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C. J Biol Chem 2001, 276:43611-43617..
-
(2001)
J Biol Chem
, vol.276
-
-
Okuda, H.1
Saitoh, K.2
Hirai, S.3
-
37
-
-
71649094085
-
The role of hypoxia in development of the mammalian embryo.
-
Dunwoodie SL. The role of hypoxia in development of the mammalian embryo. Dev Cell 2009, 17:755-773..
-
(2009)
Dev Cell
, vol.17
-
-
Dunwoodie, S.L.1
-
38
-
-
27644561755
-
Hypoxia requires notch signaling to maintain the undifferentiated cell state.
-
Gustafsson MV, Zheng X, Pereira T. Hypoxia requires notch signaling to maintain the undifferentiated cell state. Dev Cell 2005, 9:617-628..
-
(2005)
Dev Cell
, vol.9
-
-
Gustafsson, M.V.1
Zheng, X.2
Pereira, T.3
-
39
-
-
34548239264
-
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor.
-
Coleman ML, McDonough MA, Hewitson KS. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J Biol Chem 2007, 282:24027-24038..
-
(2007)
J Biol Chem
, vol.282
-
-
Coleman, M.L.1
McDonough, M.A.2
Hewitson, K.S.3
-
41
-
-
33745109564
-
Von Hippel-Lindau disease and endocrine tumour susceptibility.
-
Woodward ER, Maher ER. Von Hippel-Lindau disease and endocrine tumour susceptibility. Endocr Relat Cancer 2006, 13:415-425..
-
(2006)
Endocr Relat Cancer
, vol.13
-
-
Woodward, E.R.1
Maher, E.R.2
-
42
-
-
20744445650
-
Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma.
-
Raval RR, Lau KW, Tran MG. Contrasting properties of hypoxia-inducible factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-associated renal cell carcinoma. Mol Cell Biol 2005, 25:5675-5686..
-
(2005)
Mol Cell Biol
, vol.25
-
-
Raval, R.R.1
Lau, K.W.2
Tran, M.G.3
-
43
-
-
64549146243
-
Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations.
-
Shen HCJ, Adem A, Ylaya K. Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations. PLoS One 2009, 4:e4897..
-
(2009)
PLoS One
, vol.4
-
-
Shen, H.C.J.1
Adem, A.2
Ylaya, K.3
-
44
-
-
0030847165
-
Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice.
-
Gnarra JR, Ward JM, Porter FD. Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc Natl Acad Sci USA 1997, 94:9102-9107..
-
(1997)
Proc Natl Acad Sci USA
, vol.94
-
-
Gnarra, J.R.1
Ward, J.M.2
Porter, F.D.3
-
45
-
-
0035852668
-
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.
-
Haase VH, Glickman JN, Socolovsky M, Jaenisch R. Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor. Proc Natl Acad Sci USA 2001, 98:1583-1588..
-
(2001)
Proc Natl Acad Sci USA
, vol.98
-
-
Haase, V.H.1
Glickman, J.N.2
Socolovsky, M.3
Jaenisch, R.4
-
46
-
-
33745084564
-
Stabilization of β-catenin impacts pancreas growth.
-
Heiser PW, Lau J, Taketo MM, Herrera PL, Hebrok M. Stabilization of β-catenin impacts pancreas growth. Development 2006, 133:2023-2032..
-
(2006)
Development
, vol.133
-
-
Heiser, P.W.1
Lau, J.2
Taketo, M.M.3
Herrera, P.L.4
Hebrok, M.5
-
47
-
-
0035120134
-
Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site.
-
Carlsson PO, Palm F, Andersson A, Liss P. Markedly decreased oxygen tension in transplanted rat pancreatic islets irrespective of the implantation site. Diabetes 2001, 50:489-495..
-
(2001)
Diabetes
, vol.50
-
-
Carlsson, P.O.1
Palm, F.2
Andersson, A.3
Liss, P.4
-
48
-
-
0024494326
-
Prevention of detrimental effect of cyclosporin A on vascular ingrowth of transplanted pancreatic islets with verapamil.
-
Rooth P, Dawidson I, Lafferty K. Prevention of detrimental effect of cyclosporin A on vascular ingrowth of transplanted pancreatic islets with verapamil. Diabetes 1989, 38(Suppl. 1):202-205..
-
(1989)
Diabetes
, vol.38
, Issue.SUPPL. 1
-
-
Rooth, P.1
Dawidson, I.2
Lafferty, K.3
-
49
-
-
0037665295
-
Role of VEGF-A in vascularization of pancreatic islets.
-
Lammert E, Gu G, McLaughlin M. Role of VEGF-A in vascularization of pancreatic islets. Curr Biol 2003, 13:1070-1074..
-
(2003)
Curr Biol
, vol.13
-
-
Lammert, E.1
Gu, G.2
McLaughlin, M.3
-
50
-
-
33750005328
-
Dynamic production of hypoxia-inducible factor-1alpha in early transplanted islets.
-
Miao G, Ostrowski RP, Mace J. Dynamic production of hypoxia-inducible factor-1alpha in early transplanted islets. Am J Transpl 2006, 6:2636-2643..
-
(2006)
Am J Transpl
, vol.6
-
-
Miao, G.1
Ostrowski, R.P.2
Mace, J.3
-
51
-
-
0035987883
-
Beneficial effects of hyperbaric oxygen therapy on islet transplantation.
-
Juang JH, Hsu BR, Kuo CH, Uengt SW. Beneficial effects of hyperbaric oxygen therapy on islet transplantation. Cell Transpl 2002, 11:95-101..
-
(2002)
Cell Transpl
, vol.11
-
-
Juang, J.H.1
Hsu, B.R.2
Kuo, C.H.3
Uengt, S.W.4
-
52
-
-
33847380696
-
Superiority of small islets in human islet transplantation.
-
Lehmann R, Zuellig RA, Kugelmeier P. Superiority of small islets in human islet transplantation. Diabetes 2007, 56:594-603..
-
(2007)
Diabetes
, vol.56
-
-
Lehmann, R.1
Zuellig, R.A.2
Kugelmeier, P.3
-
53
-
-
40849111440
-
Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection.
-
Marselli L, Thorne J, Ahn YB. Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab 2008, 93:1046-1053..
-
(2008)
J Clin Endocrinol Metab
, vol.93
-
-
Marselli, L.1
Thorne, J.2
Ahn, Y.B.3
-
54
-
-
33846020526
-
A dominant role for glucose in beta cell compensation of insulin resistance.
-
Weir GC, Bonner-Weir S. A dominant role for glucose in beta cell compensation of insulin resistance. J Clin Invest 2007, 117:81-83..
-
(2007)
J Clin Invest
, vol.117
-
-
Weir, G.C.1
Bonner-Weir, S.2
-
55
-
-
33845582804
-
Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes.
-
Li X, Zhang L, Meshinchi S. Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetes. Diabetes 2006, 55:2965-2973..
-
(2006)
Diabetes
, vol.55
-
-
Li, X.1
Zhang, L.2
Meshinchi, S.3
-
56
-
-
34047119110
-
Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation.
-
Hosogai N, Fukuhara A, Oshima K. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 2007, 56:901-911..
-
(2007)
Diabetes
, vol.56
-
-
Hosogai, N.1
Fukuhara, A.2
Oshima, K.3
-
57
-
-
35148854599
-
Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice.
-
Ye J, Gao Z, Yin J, He Q. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 2007, 293:E1118-E1128..
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
-
-
Ye, J.1
Gao, Z.2
Yin, J.3
He, Q.4
-
58
-
-
62749167010
-
Reduced adipose tissue oxygenation in human obesity.
-
Pasarica M, Sereda OR, Redman LM. Reduced adipose tissue oxygenation in human obesity. Diabetes 2009, 58:718-725..
-
(2009)
Diabetes
, vol.58
-
-
Pasarica, M.1
Sereda, O.R.2
Redman, L.M.3
-
59
-
-
21244502161
-
Increased oxygen consumption rates in response to high glucose detected by a novel oxygen biosensor system in non-human primate and human islets.
-
Wang W, Upshaw L, Strong DM, Robertson RP, Reems J. Increased oxygen consumption rates in response to high glucose detected by a novel oxygen biosensor system in non-human primate and human islets. J Endocrinol 2005, 185:445-455..
-
(2005)
J Endocrinol
, vol.185
-
-
Wang, W.1
Upshaw, L.2
Strong, D.M.3
Robertson, R.P.4
Reems, J.5
-
60
-
-
70350310991
-
Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes.
-
Jonas JC, Bensellam M, Duprez J, Elouil H, Guiot Y, Pascal SM. Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes. Diabetes Obes Metab 2009, 11(Suppl. 4):65-81..
-
(2009)
Diabetes Obes Metab
, vol.11
, Issue.SUPPL. 4
-
-
Jonas, J.C.1
Bensellam, M.2
Duprez, J.3
Elouil, H.4
Guiot, Y.5
Pascal, S.M.6
-
61
-
-
77949273359
-
Nocturnal intermittent hypoxia and the development of type 2 diabetes: the Circulatory Risk in Communities Study (CIRCS).
-
Muraki I, Tanigawa T, Yamagishi K. Nocturnal intermittent hypoxia and the development of type 2 diabetes: the Circulatory Risk in Communities Study (CIRCS). Diabetologia 2010, 53:481-488..
-
(2010)
Diabetologia
, vol.53
-
-
Muraki, I.1
Tanigawa, T.2
Yamagishi, K.3
-
62
-
-
24144493814
-
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing.
-
Guzy RD, Hoyos B, Robin E. Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metabolism 2005, 1:401-408..
-
(2005)
Cell Metabolism
, vol.1
-
-
Guzy, R.D.1
Hoyos, B.2
Robin, E.3
-
63
-
-
24144444133
-
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation.
-
Brunelle JK, Bell EL, Quesada NM. Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab 2005, 1:409-414..
-
(2005)
Cell Metab
, vol.1
-
-
Brunelle, J.K.1
Bell, E.L.2
Quesada, N.M.3
-
64
-
-
24144447915
-
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-[alpha] activation.
-
Mansfield KD, Guzy RD, Pan Y. Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-[alpha] activation. Cell Metab 2005, 1:393-399..
-
(2005)
Cell Metab
, vol.1
-
-
Mansfield, K.D.1
Guzy, R.D.2
Pan, Y.3
-
65
-
-
24144467846
-
ROS: really involved in oxygen sensing.
-
Kaelin WG. ROS: really involved in oxygen sensing. Cell Metab 2005, 1:357-358..
-
(2005)
Cell Metab
, vol.1
-
-
Kaelin, W.G.1
-
66
-
-
5644248079
-
Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes.
-
Robertson RP. Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J Biol Chem 2004, 279:42351-42354..
-
(2004)
J Biol Chem
, vol.279
-
-
Robertson, R.P.1
-
67
-
-
45749127802
-
Nitric oxide donor, ({+/-})-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1{alpha} by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation.
-
Park Y-K, Ahn D-R, Oh M. Nitric oxide donor, ({+/-})-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1{alpha} by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation. Mol Pharmacol 2008, 74:236-245..
-
(2008)
Mol Pharmacol
, vol.74
-
-
Park, Y.-.K.1
Ahn, D.-.R.2
Oh, M.3
-
68
-
-
0037444823
-
Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation.
-
Jung Y, Isaacs JS, Lee S, Trepel J, Liu ZG, Neckers L. Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor kappa B activation. Biochem J 2003, 370:1011-1017..
-
(2003)
Biochem J
, vol.370
-
-
Jung, Y.1
Isaacs, J.S.2
Lee, S.3
Trepel, J.4
Liu, Z.G.5
Neckers, L.6
-
69
-
-
0347334750
-
IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis.
-
Jung YJ, Isaacs JS, Lee S, Trepel J, Neckers L. IL-1beta-mediated up-regulation of HIF-1alpha via an NFkappaB/COX-2 pathway identifies HIF-1 as a critical link between inflammation and oncogenesis. FASEB J 2003, 17:2115-2117..
-
(2003)
FASEB J
, vol.17
-
-
Jung, Y.J.1
Isaacs, J.S.2
Lee, S.3
Trepel, J.4
Neckers, L.5
-
70
-
-
0023203183
-
Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets.
-
Sandler S, Andersson A, Hellerstrom C. Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets. Endocrinology 1987, 121:1424-1431..
-
(1987)
Endocrinology
, vol.121
-
-
Sandler, S.1
Andersson, A.2
Hellerstrom, C.3
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