VEGF gene delivery to myocardium: Deleterious effects of unregulated expression

Circulation

Volumn 102, Issue 8, 2000, Pages 898-901

  Lee, Randall J ^a,c   Springer, Matthew L ^b   Blanco Bose, William E ^b   Shaw, Robin ^a   Ursell, Philip C ^a   Blau, Helen M ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Cardiac Electrophysiology   (United States)

Author keywords

Angiogenesis; Coronary disease; Genes

Indexed keywords

BETA GALACTOSIDASE; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION; GENE TARGETING; HEART MUSCLE; HEMANGIOMA; IMMUNE DEFICIENCY; MOUSE; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS; VASCULAR TUMOR;

EID: 0034702905     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.102.8.898     Document Type: Article

References (33)

1. Time course of increased cellular proliferation in collateral arteries after administration of vascular endothelial growth factor in a rabbit model of lower limb vascular insufficiency
2. Overexpression of vascular endothelial growth factor in the avian embryo induces hypervascularization and increased vascular permeability without alterations of embryonic pattern formation
3. Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs
4. Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis
5. VEGF improves myocardial blood flow but produces EDRF-mediated hypotension in porcine hearts
6. Gene therapy for myocardial angiogenesis: Initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia
7. Angiogenesis gene therapy: Phase I assessment of direct intramyocardial administration of an adenovirus vector expressing VEGF121 cDNA to individuals with clinically significant severe coronary artery disease
8. Systemic delivery of human growth hormone by injection of genetically engineered myoblasts
9. Systemic delivery of recombinant proteins by genetically modified myoblasts
10. The fate of individual myoblasts after transplantation into muscles of DMD patients
11. Results of a triple blind clinical study of myoblast transplantations without immunosuppressive treatment in young boys with Duchenne muscular dystrophy
12. VEGF gene delivery of muscle: Potential role for vasculogenesis in adults
13. Induction of angiogenesis by implantation of encapsulated primary myoblast expressing vascular endothelial growth factor
14. Soft tissues
15. Safety of direct myocardial administration of an adenovirus vector encoding vascular endothelial growth factor 121
16. Gene therapy via primary myoblasts: Long-term expression of factor IX protein following transplantation in vivo
17. Primary mouse myoblast purification, characterization, and transplantation for cell-mediated gene therapy
18. Effect of intracoronary recombinant human vascular endothelial factor on myocardial perfusion: Evidence for a dose-dependent effect
19. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb
20. Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo
21. Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion
22. Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart
23. Effects of acidic fibroblast growth factor on normal and ischemic myocardium
24. Transplantation of fetal myocardial tissue into the infarcted myocardium of rat: A potential method for repair of infarcted myocardium?
25. Can grafted cardiomyocytes colonize peri-infarct myocardial areas?
26. Survival, integration, and differentiation of cardiomyocyte grafts: A study in normal and injured rat hearts
27. Ex vivo gene transfer into myocardium using replication-defective retrovirus
28. Survival of grafts of genetically modified cardiac myocytes transfected with FITC-labeled oligodeoxynucleotides and the beta-galactosidase gene in the noninfarcted area, but not the myocardial infarcted area
29. Skeletal myoblast transplantation for repair of myocardial necrosis
30. Rapid retroviral delivery of tetracycline-inducible genes in a single autoregulatory cassette
31. Graded transcriptional response to different concentrations of a single transactivator
32. Tetracycline-regulatable factors with distinct dimerization domains allow reversible growth inhibition by p16
33. Tet B or not tet B: Advances in tetracycline-inducible gene expression