Hypoxia-inducible vascular endothelial growth factor gene therapy using the oxygen-dependent degradation domain in myocardial ischemia

Pharmaceutical Research

Volumn 27, Issue 10, 2010, Pages 2075-2084

  Kim, Hyun Ah ^a   Lim, Soyeon ^b   Moon, Hyung Ho ^b   Kim, Sung Wan ^a,c   Hwang, Ki Chul ^b   Lee, Minhyung ^a   Kim, Sun Hwa ^b   Choi, Donghoon ^b  

^a Hanyang University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

gene therapy; hypoxia inducible expression; ischemic myocardium; oxygen dependent degradation domain; vascular endothelial growth factor

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CARRIER PROTEIN; LUCIFERASE; OXYGEN DEPENDENT DEGRADATION DOMAIN PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPRESSION VECTOR; GENE EXPRESSION; GENETIC TRANSFECTION; HEART INFARCTION SIZE; HEART MUSCLE FIBROSIS; HEART MUSCLE ISCHEMIA; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROVASCULATURE; NEOVASCULARIZATION (PATHOLOGY); NICK END LABELING; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN SYNTHESIS; RAT;

ANIMALS; ANOXIA; APOPTOSIS; CELL LINE; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; ERYTHROPOIETIN; GENE THERAPY; GENETIC VECTORS; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; LUCIFERASES; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIUM; OXYGEN; PLASMIDS; PROTEIN STABILITY; RATS; RATS, SPRAGUE-DAWLEY; SIMIAN VIRUS 40; TRANSFECTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 77957347050     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0206-7     Document Type: Article

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