-
1
-
-
84857798954
-
Hospitalisations and surgery in Crohn's disease
-
Bernstein, C.N.; Loftus, E.V., Jr.; Ng, S.C.; Lakatos, P.L.; Moum, B. Hospitalisations and surgery in Crohn's disease. Gut 2012, 61, 622-629.
-
(2012)
Gut
, vol.61
, pp. 622-629
-
-
Bernstein, C.N.1
Loftus Jr., E.V.2
Ng, S.C.3
Lakatos, P.L.4
Moum, B.5
-
2
-
-
53049083199
-
Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease
-
Van Limbergen, J.; Russell, R.K.; Drummond, H.E.; Aldhous, M.C.; Round, N.K.; Nimmo, E.R.; Smith, L.; Gillett, P.M.; McGrogan, P.; Weaver, L.T.; et al. Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology 2008, 135, 1114-1122.
-
(2008)
Gastroenterology
, vol.135
, pp. 1114-1122
-
-
van Limbergen, J.1
Russell, R.K.2
Drummond, H.E.3
Aldhous, M.C.4
Round, N.K.5
Nimmo, E.R.6
Smith, L.7
Gillett, P.M.8
McGrogan, P.9
Weaver, L.T.10
-
3
-
-
77954399830
-
Genetics of childhood-onset inflammatory bowel disease
-
Henderson, P.; van Limbergen, J.; Wilson, D.C.; Satsangi, J.; Russell, R.K. Genetics of childhood-onset inflammatory bowel disease. Inflamm. Bowel Dis. 2011, 17, 346-361.
-
(2011)
Inflamm. Bowel Dis.
, vol.17
, pp. 346-361
-
-
Henderson, P.1
van Limbergen, J.2
Wilson, D.C.3
Satsangi, J.4
Russell, R.K.5
-
4
-
-
5144231035
-
Incidence of juvenile-onset Crohn's disease in Scotland: Association with northern latitude and affluence
-
Armitage, E.L.; Aldhous, M.C.; Anderson, N.; Drummond, H.E.; Riemersma, R.A.; Ghosh, S.; Satsangi, J.; Armitage, E.L.; Aldhous, M.C.; Anderson, N.; et al. Incidence of juvenile-onset Crohn's disease in Scotland: Association with northern latitude and affluence. Gastroenterology 2004, 127, 1051-1057.
-
(2004)
Gastroenterology
, vol.127
, pp. 1051-1057
-
-
Armitage, E.L.1
Aldhous, M.C.2
Anderson, N.3
Drummond, H.E.4
Riemersma, R.A.5
Ghosh, S.6
Satsangi, J.7
Armitage, E.L.8
Aldhous, M.C.9
Anderson, N.10
-
5
-
-
84859443151
-
IBD-what role do Proteobacteria play?
-
Mukhopadhya, I.; Hansen, R.; El-Omar, E.M.; Hold, G.L. IBD-what role do Proteobacteria play? Nat. Rev. Gastroenterol. Hepatol. 2012, 9, 219-230.
-
(2012)
Nat. Rev. Gastroenterol. Hepatol.
, vol.9
, pp. 219-230
-
-
Mukhopadhya, I.1
Hansen, R.2
El-Omar, E.M.3
Hold, G.L.4
-
6
-
-
78649489009
-
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
-
Franke, A.; McGovern, D.P.; Barrett, J.C.; Wang, K.; Radford-Smith, G.L.; Ahmad, T.; Lees, C.W.; Balschun, T.; Lee, J.; Roberts, R.; et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat. Genet. 2010, 42, 1118-1125.
-
(2010)
Nat. Genet.
, vol.42
, pp. 1118-1125
-
-
Franke, A.1
McGovern, D.P.2
Barrett, J.C.3
Wang, K.4
Radford-Smith, G.L.5
Ahmad, T.6
Lees, C.W.7
Balschun, T.8
Lee, J.9
Roberts, R.10
-
7
-
-
80052549284
-
Analysis of E. coli isolated from patients affected by Crohn's disease
-
Raso, T.; Crivellaro, S.; Chirillo, M.G.; Pais, P.; Gaia, E.; Savoia, D. Analysis of E. coli isolated from patients affected by Crohn's disease. Curr. Microbiol. 2011, 63, 131-137.
-
(2011)
Curr. Microbiol.
, vol.63
, pp. 131-137
-
-
Raso, T.1
Crivellaro, S.2
Chirillo, M.G.3
Pais, P.4
Gaia, E.5
Savoia, D.6
-
8
-
-
84859795928
-
Characterization of adherent-invasive E. coli isolated from pediatric patients with inflammatory bowel disease
-
Negroni, A.; Costanzo, M.; Vitali, R.; Superti, F.; Bertuccini, L.; Tinari, A.; Minelli, F.; Di Nardo, G.; Nuti, F.; Pierdomenico, M.; et al. Characterization of adherent-invasive E. coli isolated from pediatric patients with inflammatory bowel disease. Inflamm. Bowel Dis. 2012, 18, 913-924.
-
(2012)
Inflamm. Bowel Dis.
, vol.18
, pp. 913-924
-
-
Negroni, A.1
Costanzo, M.2
Vitali, R.3
Superti, F.4
Bertuccini, L.5
Tinari, A.6
Minelli, F.7
di Nardo, G.8
Nuti, F.9
Pierdomenico, M.10
-
9
-
-
78650100616
-
Ubiquitin: Same molecule, different degradation pathways
-
Clague, M.J.; Urbe, S. Ubiquitin: Same molecule, different degradation pathways. Cell 2010, 143, 682-685.
-
(2010)
Cell
, vol.143
, pp. 682-685
-
-
Clague, M.J.1
Urbe, S.2
-
10
-
-
84855500993
-
Autophagy: For better or for worse
-
Wirawan, E.; Vanden Berghe, T.; Lippens, S.; Agostinis, P.; Vandenabeele, P. Autophagy: For better or for worse. Cell Res. 2012, 22, 43-61.
-
(2012)
Cell Res.
, vol.22
, pp. 43-61
-
-
Wirawan, E.1
vanden Berghe, T.2
Lippens, S.3
Agostinis, P.4
Vandenabeele, P.5
-
11
-
-
78649704325
-
Autophagy and metabolism
-
Rabinowitz, J.D.; White, E. Autophagy and metabolism. Science 2010, 330, 1344-1348.
-
(2010)
Science
, vol.330
, pp. 1344-1348
-
-
Rabinowitz, J.D.1
White, E.2
-
12
-
-
69249227502
-
Lysosome biogenesis and lysosomal membrane proteins: Trafficking meets function
-
Saftig, P.; Klumperman, J. Lysosome biogenesis and lysosomal membrane proteins: Trafficking meets function. Nat. Rev. Mol. Cell Biol. 2009, 10, 623-635.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 623-635
-
-
Saftig, P.1
Klumperman, J.2
-
14
-
-
77952851112
-
Chaperone-assisted degradation: Multiple paths to destruction
-
Kettern, N.; Dreiseidler, M.; Tawo, R.; Hohfeld, J. Chaperone-assisted degradation: Multiple paths to destruction. Biol. Chem. 2010, 391, 481-489.
-
(2010)
Biol. Chem.
, vol.391
, pp. 481-489
-
-
Kettern, N.1
Dreiseidler, M.2
Tawo, R.3
Hohfeld, J.4
-
15
-
-
84859161154
-
Microautophagy: Lesser-known self-eating
-
Li, W.W.; Li, J.; Bao, J.K. Microautophagy: Lesser-known self-eating. Cell Mol. Life Sci. 2012, 69, 1125-1136.
-
(2012)
Cell Mol. Life Sci.
, vol.69
, pp. 1125-1136
-
-
Li, W.W.1
Li, J.2
Bao, J.K.3
-
17
-
-
82755161734
-
Autophagy and disease: Always two sides to a problem
-
Sridhar, S.; Botbol, Y.; Macian, F.; Cuervo, A.M. Autophagy and disease: Always two sides to a problem. J. Pathol. 2012, 226, 255-273.
-
(2012)
J. Pathol.
, vol.226
, pp. 255-273
-
-
Sridhar, S.1
Botbol, Y.2
Macian, F.3
Cuervo, A.M.4
-
18
-
-
77955165003
-
The plasma membrane brings autophagosomes to life
-
Cuervo, A.M. The plasma membrane brings autophagosomes to life. Nat. Cell Biol. 2010, 12, 735-737.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 735-737
-
-
Cuervo, A.M.1
-
19
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine, B.; Kroemer, G. Autophagy in the pathogenesis of disease. Cell 2008, 132, 27-42.
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
20
-
-
67649295476
-
Autophagy: From basic science to clinical application
-
Van Limbergen, J.; Stevens, C.; Nimmo, E.R.; Wilson, D.C.; Satsangi, J. Autophagy: From basic science to clinical application. Mucosal Immunol. 2009, 2, 315-330.
-
(2009)
Mucosal Immunol.
, vol.2
, pp. 315-330
-
-
van Limbergen, J.1
Stevens, C.2
Nimmo, E.R.3
Wilson, D.C.4
Satsangi, J.5
-
21
-
-
79959415069
-
Biogenesis and cargo selectivity of autophagosomes
-
Weidberg, H.; Shvets, E.; Elazar, Z. Biogenesis and cargo selectivity of autophagosomes. Annu. Rev. Biochem. 2011, 80, 125-156.
-
(2011)
Annu. Rev. Biochem.
, vol.80
, pp. 125-156
-
-
Weidberg, H.1
Shvets, E.2
Elazar, Z.3
-
22
-
-
67649607465
-
Autophagy, immunity, and microbial adaptations
-
Deretic, V.; Levine, B. Autophagy, immunity, and microbial adaptations. Cell Host Microbe 2009, 5, 527-549.
-
(2009)
Cell Host Microbe
, vol.5
, pp. 527-549
-
-
Deretic, V.1
Levine, B.2
-
23
-
-
70350509568
-
Structural basis of pattern recognition by innate immune molecules
-
McGreal, E.P. Structural basis of pattern recognition by innate immune molecules. Adv. Exp. Med. Biol. 2009, 653, 139-161.
-
(2009)
Adv. Exp. Med. Biol.
, vol.653
, pp. 139-161
-
-
McGreal, E.P.1
-
24
-
-
73849151394
-
NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
-
Cooney, R.; Baker, J.; Brain, O.; Danis, B.; Pichulik, T.; Allan, P.; Ferguson, D.J.; Campbell, B.J.; Jewell, D.; Simmons, A. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat. Med. 2010, 16, 90-97.
-
(2010)
Nat. Med.
, vol.16
, pp. 90-97
-
-
Cooney, R.1
Baker, J.2
Brain, O.3
Danis, B.4
Pichulik, T.5
Allan, P.6
Ferguson, D.J.7
Campbell, B.J.8
Jewell, D.9
Simmons, A.10
-
25
-
-
67549139899
-
Toll-like receptors in control of immunological autophagy
-
Delgado, M.A.; Deretic, V. Toll-like receptors in control of immunological autophagy. Cell Death Differ. 2009, 16, 976-983.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 976-983
-
-
Delgado, M.A.1
Deretic, V.2
-
26
-
-
78651077774
-
Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling
-
Shin, D.M.; Yuk, J.M.; Lee, H.M.; Lee, S.H.; Son, J.W.; Harding, C.V.; Kim, J.M.; Modlin, R.L.; Jo, E.K. Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling. Cell Microbiol. 2010, 12, 1648-1665.
-
(2010)
Cell Microbiol.
, vol.12
, pp. 1648-1665
-
-
Shin, D.M.1
Yuk, J.M.2
Lee, H.M.3
Lee, S.H.4
Son, J.W.5
Harding, C.V.6
Kim, J.M.7
Modlin, R.L.8
Jo, E.K.9
-
27
-
-
84872140163
-
Antigen processing for MHC class II presentation via autophagy
-
Munz, C. Antigen processing for MHC class II presentation via autophagy. Front. Immunol. 2012, 3, 9.
-
(2012)
Front. Immunol.
, vol.3
, pp. 9
-
-
Munz, C.1
-
28
-
-
67650517556
-
NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets
-
Lamark, T.; Kirkin, V.; Dikic, I.; Johansen, T. NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets. Cell Cycle 2009, 8, 1986-1990.
-
(2009)
Cell Cycle
, vol.8
, pp. 1986-1990
-
-
Lamark, T.1
Kirkin, V.2
Dikic, I.3
Johansen, T.4
-
29
-
-
79960735619
-
Ubiquitination-mediated autophagy against invading bacteria
-
Fujita, N.; Yoshimori, T. Ubiquitination-mediated autophagy against invading bacteria. Curr. Opin. Cell Biol. 2011, 23, 492-497.
-
(2011)
Curr. Opin. Cell Biol.
, vol.23
, pp. 492-497
-
-
Fujita, N.1
Yoshimori, T.2
-
30
-
-
79952348751
-
The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway
-
Cemma, M.; Kim, P.K.; Brumell, J.H. The ubiquitin-binding adaptor proteins p62/SQSTM1 and NDP52 are recruited independently to bacteria-associated microdomains to target Salmonella to the autophagy pathway. Autophagy 2011, 7, 341-345.
-
(2011)
Autophagy
, vol.7
, pp. 341-345
-
-
Cemma, M.1
Kim, P.K.2
Brumell, J.H.3
-
31
-
-
79960804104
-
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth
-
Wild, P.; Farhan, H.; McEwan, D.G.; Wagner, S.; Rogov, V.V.; Brady, N.R.; Richter, B.; Korac, J.; Waidmann, O.; Choudhary, C.; et al. Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth. Science 2011, 333, 228-233.
-
(2011)
Science
, vol.333
, pp. 228-233
-
-
Wild, P.1
Farhan, H.2
McEwan, D.G.3
Wagner, S.4
Rogov, V.V.5
Brady, N.R.6
Richter, B.7
Korac, J.8
Waidmann, O.9
Choudhary, C.10
-
32
-
-
33846627302
-
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
-
Hampe, J.; Franke, A.; Rosenstiel, P.; Till, A.; Teuber, M.; Huse, K.; Albrecht, M.; Mayr, G.; de La Vega, F.M.; Briggs, J.; et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat. Genet. 2007, 39, 207-211.
-
(2007)
Nat. Genet.
, vol.39
, pp. 207-211
-
-
Hampe, J.1
Franke, A.2
Rosenstiel, P.3
Till, A.4
Teuber, M.5
Huse, K.6
Albrecht, M.7
Mayr, G.8
de la Vega, F.M.9
Briggs, J.10
-
33
-
-
85117871859
-
Detailed analysis of ATG16L1 demonstrates gene-wide extent of association with crohn disease susceptibility
-
Van Limbergen, J.; Kabakchiev, B.; Stempak, J.; Schumm, P.; Xu, W.; Henderson, P.; Griffiths, A.; Girardin, S.E.; Philpott, D.; Silverberg, M. Detailed analysis of ATG16L1 demonstrates gene-wide extent of association with crohn disease susceptibility. Gut 2012, 61, A4.
-
(2012)
Gut
, vol.61
-
-
van Limbergen, J.1
Kabakchiev, B.2
Stempak, J.3
Schumm, P.4
Xu, W.5
Henderson, P.6
Griffiths, A.7
Girardin, S.E.8
Philpott, D.9
Silverberg, M.10
-
34
-
-
34247566585
-
A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5
-
Prescott, N.J.; Fisher, S.A.; Franke, A.; Hampe, J.; Onnie, C.M.; Soars, D.; Bagnall, R.; Mirza, M.M.; Sanderson, J.; Forbes, A.; et al. A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. Gastroenterology 2007, 132, 1665-1671.
-
(2007)
Gastroenterology
, vol.132
, pp. 1665-1671
-
-
Prescott, N.J.1
Fisher, S.A.2
Franke, A.3
Hampe, J.4
Onnie, C.M.5
Soars, D.6
Bagnall, R.7
Mirza, M.M.8
Sanderson, J.9
Forbes, A.10
-
35
-
-
34247554965
-
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
-
Rioux, J.D.; Xavier, R.J.; Taylor, K.D.; Silverberg, M.S.; Goyette, P.; Huett, A.; Green, T.; Kuballa, P.; Barmada, M.M.; Datta, L.W.; et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat. Genet. 2007, 39, 596-604.
-
(2007)
Nat. Genet.
, vol.39
, pp. 596-604
-
-
Rioux, J.D.1
Xavier, R.J.2
Taylor, K.D.3
Silverberg, M.S.4
Goyette, P.5
Huett, A.6
Green, T.7
Kuballa, P.8
Barmada, M.M.9
Datta, L.W.10
-
36
-
-
34548163868
-
Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene
-
Cummings, J.R.; Cooney, R.; Pathan, S.; Anderson, C.A.; Barrett, J.C.; Beckly, J.; Geremia, A.; Hancock, L.; Guo, C.; Ahmad, T.; et al. Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene. Inflamm. Bowel Dis. 2007, 13, 941-946.
-
(2007)
Inflamm. Bowel Dis.
, vol.13
, pp. 941-946
-
-
Cummings, J.R.1
Cooney, R.2
Pathan, S.3
Anderson, C.A.4
Barrett, J.C.5
Beckly, J.6
Geremia, A.7
Hancock, L.8
Guo, C.9
Ahmad, T.10
-
37
-
-
34347338690
-
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
-
Parkes, M.; Barrett, J.C.; Prescott, N.J.; Tremelling, M.; Anderson, C.A.; Fisher, S.A.; Roberts, R.G.; Nimmo, E.R.; Cummings, F.R.; Soars, D.; et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat. Genet. 2007, 39, 830-832.
-
(2007)
Nat. Genet.
, vol.39
, pp. 830-832
-
-
Parkes, M.1
Barrett, J.C.2
Prescott, N.J.3
Tremelling, M.4
Anderson, C.A.5
Fisher, S.A.6
Roberts, R.G.7
Nimmo, E.R.8
Cummings, F.R.9
Soars, D.10
-
38
-
-
40949105649
-
ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in The Netherlands
-
Weersma, R.K.; Zhernakova, A.; Nolte, I.M.; Lefebvre, C.; Rioux, J.D.; Mulder, F.; van Dullemen, H.M.; Kleibeuker, J.H.; Wijmenga, C.; Dijkstra, G. ATG16L1 and IL23R are associated with inflammatory bowel diseases but not with celiac disease in The Netherlands. Am. J. Gastroenterol. 2008, 103, 621-627.
-
(2008)
Am. J. Gastroenterol.
, vol.103
, pp. 621-627
-
-
Weersma, R.K.1
Zhernakova, A.2
Nolte, I.M.3
Lefebvre, C.4
Rioux, J.D.5
Mulder, F.6
van Dullemen, H.M.7
Kleibeuker, J.H.8
Wijmenga, C.9
Dijkstra, G.10
-
39
-
-
37249054533
-
A study in three European IBD cohorts confirms that the ATG16L1 c.898A > G (p. Thr300Ala) variant is a susceptibility factor for Crohn's disease
-
Buning, C.; Durmus, T.; Molnar, T.; de Jong, D.J.; Drenth, J.P.; Fiedler, T.; Gentz, E.; Todorov, T.; Haas, V.; Buhner, S.; et al. A study in three European IBD cohorts confirms that the ATG16L1 c.898A > G (p. Thr300Ala) variant is a susceptibility factor for Crohn's disease. J. Crohn's Colitis 2007, 1, 70-76.
-
(2007)
J. Crohn's Colitis
, vol.1
, pp. 70-76
-
-
Buning, C.1
Durmus, T.2
Molnar, T.3
de Jong, D.J.4
Drenth, J.P.5
Fiedler, T.6
Gentz, E.7
Todorov, T.8
Haas, V.9
Buhner, S.10
-
40
-
-
77952307602
-
Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease
-
Cotterill, L.; Payne, D.; Levinson, S.; McLaughlin, J.; Wesley, E.; Feeney, M.; Durbin, H.; Lal, S.; Makin, A.; Campbell, S.; et al. Replication and meta-analysis of 13,000 cases defines the risk for interleukin-23 receptor and autophagy-related 16-like 1 variants in Crohn's disease. Can. J. Gastroenterol. 2010, 24, 297-302.
-
(2010)
Can. J. Gastroenterol.
, vol.24
, pp. 297-302
-
-
Cotterill, L.1
Payne, D.2
Levinson, S.3
McLaughlin, J.4
Wesley, E.5
Feeney, M.6
Durbin, H.7
Lal, S.8
Makin, A.9
Campbell, S.10
-
41
-
-
48349136889
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
-
Barrett, J.C.; Hansoul, S.; Nicolae, D.L.; Cho, J.H.; Duerr, R.H.; Rioux, J.D.; Brant, S.R.; Silverberg, M.S.; Taylor, K.D.; Barmada, M.M.; et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 2008, 40, 955-962.
-
(2008)
Nat. Genet.
, vol.40
, pp. 955-962
-
-
Barrett, J.C.1
Hansoul, S.2
Nicolae, D.L.3
Cho, J.H.4
Duerr, R.H.5
Rioux, J.D.6
Brant, S.R.7
Silverberg, M.S.8
Taylor, K.D.9
Barmada, M.M.10
-
42
-
-
67349176205
-
ATG16L1 T300A polymorphism and Crohn's disease susceptibility: Evidence from 13,022 cases and 17,532 controls
-
Zhang, H.F.; Qiu, L.X.; Chen, Y.; Zhu, W.L.; Mao, C.; Zhu, L.G.; Zheng, M.H.; Wang, Y.; Lei, L.; Shi, J. ATG16L1 T300A polymorphism and Crohn's disease susceptibility: Evidence from 13,022 cases and 17,532 controls. Hum. Genet. 2009, 125, 627-631.
-
(2009)
Hum. Genet.
, vol.125
, pp. 627-631
-
-
Zhang, H.F.1
Qiu, L.X.2
Chen, Y.3
Zhu, W.L.4
Mao, C.5
Zhu, L.G.6
Zheng, M.H.7
Wang, Y.8
Lei, L.9
Shi, J.10
-
43
-
-
34347357508
-
Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients
-
Yamazaki, K.; Onouchi, Y.; Takazoe, M.; Kubo, M.; Nakamura, Y.; Hata, A. Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. J. Hum. Genet. 2007, 52, 575-583.
-
(2007)
J. Hum. Genet.
, vol.52
, pp. 575-583
-
-
Yamazaki, K.1
Onouchi, Y.2
Takazoe, M.3
Kubo, M.4
Nakamura, Y.5
Hata, A.6
-
44
-
-
70449719062
-
Contribution of IL23R but not ATG16L1 to Crohn disease susceptibility in Koreans
-
Yang, S.K.; Park, M.; Lim, J.; Park, S.H.; Ye, B.D.; Lee, I.; Song, K. Contribution of IL23R but not ATG16L1 to Crohn disease susceptibility in Koreans. Inflamm. Bowel Dis. 2009, 15, 1385-1390.
-
(2009)
Inflamm. Bowel Dis.
, vol.15
, pp. 1385-1390
-
-
Yang, S.K.1
Park, M.2
Lim, J.3
Park, S.H.4
Ye, B.D.5
Lee, I.6
Song, K.7
-
45
-
-
63149135832
-
Correlation of the autophagosome gene ATG16L1 polymorphism and inflammatory bowel disease
-
Zhi, J.; Zhi, F.C.; Chen, Z.Y.; Yao, G.P.; Guan, J.; Lin, Y.; Zhang, Y.C. Correlation of the autophagosome gene ATG16L1 polymorphism and inflammatory bowel disease. Nan Fang Yi Ke Da Xue Xue Bao 2008, 28, 649-651.
-
(2008)
Nan Fang Yi Ke Da Xue Xue Bao
, vol.28
, pp. 649-651
-
-
Zhi, J.1
Zhi, F.C.2
Chen, Z.Y.3
Yao, G.P.4
Guan, J.5
Lin, Y.6
Zhang, Y.C.7
-
46
-
-
70350514089
-
Autophagy 16-like 1 rs2241880 G allele is associated with Crohn's disease in German children
-
Lacher, M.; Schroepf, S.; Ballauff, A.; Lohse, P.; von Schweinitz, D.; Kappler, R.; Koletzko, S. Autophagy 16-like 1 rs2241880 G allele is associated with Crohn's disease in German children. Acta Paediatr. 2009, 98, 1835-1840.
-
(2009)
Acta Paediatr.
, vol.98
, pp. 1835-1840
-
-
Lacher, M.1
Schroepf, S.2
Ballauff, A.3
Lohse, P.4
von Schweinitz, D.5
Kappler, R.6
Koletzko, S.7
-
47
-
-
34547211759
-
Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease
-
Baldassano, R.N.; Bradfield, J.P.; Monos, D.S.; Kim, C.E.; Glessner, J.T.; Casalunovo, T.; Frackelton, E.C.; Otieno, F.G.; Kanterakis, S.; Shaner, J.L.; et al. Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease. Gut 2007, 56, 1171-1173.
-
(2007)
Gut
, vol.56
, pp. 1171-1173
-
-
Baldassano, R.N.1
Bradfield, J.P.2
Monos, D.S.3
Kim, C.E.4
Glessner, J.T.5
Casalunovo, T.6
Frackelton, E.C.7
Otieno, F.G.8
Kanterakis, S.9
Shaner, J.L.10
-
48
-
-
41149137717
-
Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohn's disease in Northern Europe
-
Van Limbergen, J.; Russell, R.K.; Nimmo, E.R.; Drummond, H.E.; Smith, L.; Anderson, N.H.; Davies, G.; Gillett, P.M.; McGrogan, P.; Weaver, L.T.; et al. Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohn's disease in Northern Europe. Inflamm. Bowel Dis. 2008, 14, 338-346.
-
(2008)
Inflamm. Bowel Dis.
, vol.14
, pp. 338-346
-
-
van Limbergen, J.1
Russell, R.K.2
Nimmo, E.R.3
Drummond, H.E.4
Smith, L.5
Anderson, N.H.6
Davies, G.7
Gillett, P.M.8
McGrogan, P.9
Weaver, L.T.10
-
49
-
-
77950995288
-
NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease
-
Gazouli, M.; Pachoula, I.; Panayotou, I.; Mantzaris, G.; Chrousos, G.; Anagnou, N.P.; Roma-Giannikou, E. NOD2/CARD15, ATG16L1 and IL23R gene polymorphisms and childhood-onset of Crohn's disease. World J. Gastroenterol. 2010, 16, 1753-1758.
-
(2010)
World J. Gastroenterol.
, vol.16
, pp. 1753-1758
-
-
Gazouli, M.1
Pachoula, I.2
Panayotou, I.3
Mantzaris, G.4
Chrousos, G.5
Anagnou, N.P.6
Roma-Giannikou, E.7
-
50
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Wellcome Trust Case Control Consortium (WTCCC)
-
Wellcome Trust Case Control Consortium (WTCCC). Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007, 447, 661-678.
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
51
-
-
66749106217
-
Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: A meta-analysis approach
-
Palomino-Morales, R.J.; Oliver, J.; Gomez-Garcia, M.; Lopez-Nevot, M.A.; Rodrigo, L.; Nieto, A.; Alizadeh, B.Z.; Martin, J. Association of ATG16L1 and IRGM genes polymorphisms with inflammatory bowel disease: A meta-analysis approach. Genes Immun. 2009, 10, 356-364.
-
(2009)
Genes Immun.
, vol.10
, pp. 356-364
-
-
Palomino-Morales, R.J.1
Oliver, J.2
Gomez-Garcia, M.3
Lopez-Nevot, M.A.4
Rodrigo, L.5
Nieto, A.6
Alizadeh, B.Z.7
Martin, J.8
-
52
-
-
84873740366
-
Associations between genetic variants in the IRGM gene and inflammatory bowel diseases in the Korean population
-
doi:10.1002/ibd.22972
-
Moon, C.M.; Shin, D.J.; Kim, S.W.; Son, N.H.; Park, A.; Park, B.; Jung, E.S.; Kim, E.S.; Hong, S.P.; Kim, T.I.; et al. Associations between genetic variants in the IRGM gene and inflammatory bowel diseases in the Korean population. Inflamm. Bowel Dis. 2012, doi:10.1002/ibd.22972.
-
(2012)
Inflamm. Bowel Dis
-
-
Moon, C.M.1
Shin, D.J.2
Kim, S.W.3
Son, N.H.4
Park, A.5
Park, B.6
Jung, E.S.7
Kim, E.S.8
Hong, S.P.9
Kim, T.I.10
-
53
-
-
63849311248
-
Germline variants of IRGM in childhood-onset Crohn'sdisease
-
Van Limbergen, J.; Russell, R.K.; Nimmo, E.R.; Drummond, H.E.; Davies, G.; Wilson, D.C.; Satsangi, J. Germline variants of IRGM in childhood-onset Crohn'sdisease. Gut 2009, 58, 610-611.
-
(2009)
Gut
, vol.58
, pp. 610-611
-
-
van Limbergen, J.1
Russell, R.K.2
Nimmo, E.R.3
Drummond, H.E.4
Davies, G.5
Wilson, D.C.6
Satsangi, J.7
-
54
-
-
70649113728
-
Common variants at five new loci associated with early-onset inflammatory bowel disease
-
Imielinski, M.; Baldassano, R.N.; Griffiths, A.; Russell, R.K.; Annese, V.; Dubinsky, M.; Kugathasan, S.; Bradfield, J.P.; Walters, T.D.; Sleiman, P.; et al. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat. Genet. 2009, 41, 1335-1340.
-
(2009)
Nat. Genet.
, vol.41
, pp. 1335-1340
-
-
Imielinski, M.1
Baldassano, R.N.2
Griffiths, A.3
Russell, R.K.4
Annese, V.5
Dubinsky, M.6
Kugathasan, S.7
Bradfield, J.P.8
Walters, T.D.9
Sleiman, P.10
-
55
-
-
77949527614
-
Detailed haplotype-tagging study of germline variation of MUC19 in inflammatory bowel disease
-
Phillips, A.M.; Nimmo, E.R.; van Limbergen, J.; Drummond, H.E.; Smith, L.; Satsangi, J. Detailed haplotype-tagging study of germline variation of MUC19 in inflammatory bowel disease. Inflamm. Bowel Dis. 2010, 16, 557-558.
-
(2010)
Inflamm. Bowel Dis.
, vol.16
, pp. 557-558
-
-
Phillips, A.M.1
Nimmo, E.R.2
van Limbergen, J.3
Drummond, H.E.4
Smith, L.5
Satsangi, J.6
-
56
-
-
77952708864
-
Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients
-
Torkvist, L.; Halfvarson, J.; Ong, R.T.; Lordal, M.; Sjoqvist, U.; Bresso, F.; Bjork, J.; Befrits, R.; Lofberg, R.; Blom, J.; et al. Analysis of 39 Crohn's disease risk loci in Swedish inflammatory bowel disease patients. Inflamm. Bowel Dis. 2010, 16, 907-909.
-
(2010)
Inflamm. Bowel Dis.
, vol.16
, pp. 907-909
-
-
Torkvist, L.1
Halfvarson, J.2
Ong, R.T.3
Lordal, M.4
Sjoqvist, U.5
Bresso, F.6
Bjork, J.7
Befrits, R.8
Lofberg, R.9
Blom, J.10
-
57
-
-
84876411425
-
Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA study II)
-
doi:10.1002/ibd.23007
-
Duraes, C.; Machado, J.C.; Portela, F.; Rodrigues, S.; Lago, P.; Cravo, M.; Ministro, P.; Marques, M.; Cremers, I.; Freitas, J.; et al. Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA study II). Inflamm. Bowel Dis. 2012, doi:10.1002/ibd.23007.
-
(2012)
Inflamm. Bowel Dis
-
-
Duraes, C.1
Machado, J.C.2
Portela, F.3
Rodrigues, S.4
Lago, P.5
Cravo, M.6
Ministro, P.7
Marques, M.8
Cremers, I.9
Freitas, J.10
-
58
-
-
62049085384
-
Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort
-
Weersma, R.K.; Stokkers, P.C.; Cleynen, I.; Wolfkamp, S.C.; Henckaerts, L.; Schreiber, S.; Dijkstra, G.; Franke, A.; Nolte, I.M.; Rutgeerts, P.; et al. Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort. Am. J. Gastroenterol. 2009, 104, 630-638.
-
(2009)
Am. J. Gastroenterol.
, vol.104
, pp. 630-638
-
-
Weersma, R.K.1
Stokkers, P.C.2
Cleynen, I.3
Wolfkamp, S.C.4
Henckaerts, L.5
Schreiber, S.6
Dijkstra, G.7
Franke, A.8
Nolte, I.M.9
Rutgeerts, P.10
-
59
-
-
77954333748
-
PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population
-
Morgan, A.R.; Han, D.Y.; Huebner, C.; Lam, W.J.; Fraser, A.G.; Ferguson, L.R. PTPN2 but not PTPN22 is associated with Crohn's disease in a New Zealand population. Tissue Antigens 2010, 76, 119-125.
-
(2010)
Tissue Antigens
, vol.76
, pp. 119-125
-
-
Morgan, A.R.1
Han, D.Y.2
Huebner, C.3
Lam, W.J.4
Fraser, A.G.5
Ferguson, L.R.6
-
60
-
-
77951782697
-
Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children
-
Amre, D.K.; Mack, D.R.; Morgan, K.; Israel, D.; Deslandres, C.; Seidman, E.G.; Lambrette, P.; Costea, I.; Krupoves, A.; Fegury, H.; et al. Susceptibility loci reported in genome-wide association studies are associated with Crohn's disease in Canadian children. Aliment. Pharmacol. Ther. 2010, 31, 1186-1191.
-
(2010)
Aliment. Pharmacol. Ther.
, vol.31
, pp. 1186-1191
-
-
Amre, D.K.1
Mack, D.R.2
Morgan, K.3
Israel, D.4
Deslandres, C.5
Seidman, E.G.6
Lambrette, P.7
Costea, I.8
Krupoves, A.9
Fegury, H.10
-
61
-
-
79955790354
-
Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease
-
Henckaerts, L.; Cleynen, I.; Brinar, M.; John, J.M.; van Steen, K.; Rutgeerts, P.; Vermeire, S. Genetic variation in the autophagy gene ULK1 and risk of Crohn's disease. Inflamm. Bowel Dis. 2011, 17, 1392-1397.
-
(2011)
Inflamm. Bowel Dis.
, vol.17
, pp. 1392-1397
-
-
Henckaerts, L.1
Cleynen, I.2
Brinar, M.3
John, J.M.4
van Steen, K.5
Rutgeerts, P.6
Vermeire, S.7
-
62
-
-
84859759059
-
Association analysis of ULK1 with Crohn's disease in a New Zealand population
-
doi:10.1155/2012/715309
-
Morgan, A.R.; Lam, W.J.; Han, D.Y.; Fraser, A.G.; Ferguson, L.R. Association analysis of ULK1 with Crohn's disease in a New Zealand population. Gastroenterol. Res. Pract. 2012, doi:10.1155/2012/715309.
-
(2012)
Gastroenterol. Res. Pract
-
-
Morgan, A.R.1
Lam, W.J.2
Han, D.Y.3
Fraser, A.G.4
Ferguson, L.R.5
-
63
-
-
51249103405
-
Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort
-
Roberts, R.L.; Hollis-Moffatt, J.E.; Gearry, R.B.; Kennedy, M.A.; Barclay, M.L.; Merriman, T.R. Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort. Genes Immun. 2008, 9, 561-565.
-
(2008)
Genes Immun.
, vol.9
, pp. 561-565
-
-
Roberts, R.L.1
Hollis-Moffatt, J.E.2
Gearry, R.B.3
Kennedy, M.A.4
Barclay, M.L.5
Merriman, T.R.6
-
64
-
-
61949327205
-
rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population
-
Glas, J.; Seiderer, J.; Pasciuto, G.; Tillack, C.; Diegelmann, J.; Pfennig, S.; Konrad, A.; Schmechel, S.; Wetzke, M.; Torok, H.P.; et al. rs224136 on chromosome 10q21.1 and variants in PHOX2B, NCF4, and FAM92B are not major genetic risk factors for susceptibility to Crohn's disease in the German population. Am. J. Gastroenterol. 2009, 104, 665-672.
-
(2009)
Am. J. Gastroenterol.
, vol.104
, pp. 665-672
-
-
Glas, J.1
Seiderer, J.2
Pasciuto, G.3
Tillack, C.4
Diegelmann, J.5
Pfennig, S.6
Konrad, A.7
Schmechel, S.8
Wetzke, M.9
Torok, H.P.10
-
65
-
-
80054025654
-
The role of Atg proteins in autophagosome formation
-
Mizushima, N.; Yoshimori, T.; Ohsumi, Y. The role of Atg proteins in autophagosome formation. Annu. Rev. Cell Dev. Biol. 2011, 27, 107-132.
-
(2011)
Annu. Rev. Cell Dev. Biol.
, vol.27
, pp. 107-132
-
-
Mizushima, N.1
Yoshimori, T.2
Ohsumi, Y.3
-
66
-
-
43949143804
-
The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy
-
Fujita, N.; Itoh, T.; Omori, H.; Fukuda, M.; Noda, T.; Yoshimori, T. The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol. Biol. Cell 2008, 19, 2092-2100.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 2092-2100
-
-
Fujita, N.1
Itoh, T.2
Omori, H.3
Fukuda, M.4
Noda, T.5
Yoshimori, T.6
-
67
-
-
0035911162
-
Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells
-
Mizushima, N.; Yamamoto, A.; Hatano, M.; Kobayashi, Y.; Kabeya, Y.; Suzuki, K.; Tokuhisa, T.; Ohsumi, Y.; Yoshimori, T. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J. Cell Biol. 2001, 152, 657-668.
-
(2001)
J. Cell Biol.
, vol.152
, pp. 657-668
-
-
Mizushima, N.1
Yamamoto, A.2
Hatano, M.3
Kobayashi, Y.4
Kabeya, Y.5
Suzuki, K.6
Tokuhisa, T.7
Ohsumi, Y.8
Yoshimori, T.9
-
68
-
-
50249098491
-
Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation
-
Itoh, T.; Fujita, N.; Kanno, E.; Yamamoto, A.; Yoshimori, T.; Fukuda, M. Golgi-resident small GTPase Rab33B interacts with Atg16L and modulates autophagosome formation. Mol. Biol. Cell 2008, 19, 2916-2925.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 2916-2925
-
-
Itoh, T.1
Fujita, N.2
Kanno, E.3
Yamamoto, A.4
Yoshimori, T.5
Fukuda, M.6
-
69
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
-
Saitoh, T.; Fujita, N.; Jang, M.H.; Uematsu, S.; Yang, B.G.; Satoh, T.; Omori, H.; Noda, T.; Yamamoto, N.; Komatsu, M.; et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008, 456, 264-268.
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
Fujita, N.2
Jang, M.H.3
Uematsu, S.4
Yang, B.G.5
Satoh, T.6
Omori, H.7
Noda, T.8
Yamamoto, N.9
Komatsu, M.10
-
70
-
-
56249135538
-
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
-
Cadwell, K.; Liu, J.Y.; Brown, S.L.; Miyoshi, H.; Loh, J.; Lennerz, J.K.; Kishi, C.; Kc, W.; Carrero, J.A.; Hunt, S.; et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008, 456, 259-263.
-
(2008)
Nature
, vol.456
, pp. 259-263
-
-
Cadwell, K.1
Liu, J.Y.2
Brown, S.L.3
Miyoshi, H.4
Loh, J.5
Lennerz, J.K.6
Kishi, C.7
Kc, W.8
Carrero, J.A.9
Hunt, S.10
-
71
-
-
0038325675
-
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
-
Mizushima, N.; Kuma, A.; Kobayashi, Y.; Yamamoto, A.; Matsubae, M.; Takao, T.; Natsume, T.; Ohsumi, Y.; Yoshimori, T. Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J. Cell Sci. 2003, 116, 1679-1688.
-
(2003)
J. Cell Sci.
, vol.116
, pp. 1679-1688
-
-
Mizushima, N.1
Kuma, A.2
Kobayashi, Y.3
Yamamoto, A.4
Matsubae, M.5
Takao, T.6
Natsume, T.7
Ohsumi, Y.8
Yoshimori, T.9
-
72
-
-
11144245626
-
The role of autophagy during the early neonatal starvation period
-
Kuma, A.; Hatano, M.; Matsui, M.; Yamamoto, A.; Nakaya, H.; Yoshimori, T.; Ohsumi, Y.; Tokuhisa, T.; Mizushima, N. The role of autophagy during the early neonatal starvation period. Nature 2004, 432, 1032-1036.
-
(2004)
Nature
, vol.432
, pp. 1032-1036
-
-
Kuma, A.1
Hatano, M.2
Matsui, M.3
Yamamoto, A.4
Nakaya, H.5
Yoshimori, T.6
Ohsumi, Y.7
Tokuhisa, T.8
Mizushima, N.9
-
73
-
-
35348940762
-
Defensins and Paneth cells in inflammatory bowel disease
-
Shi, J. Defensins and Paneth cells in inflammatory bowel disease. Inflamm. Bowel Dis. 2007, 13, 1284-1292.
-
(2007)
Inflamm. Bowel Dis.
, vol.13
, pp. 1284-1292
-
-
Shi, J.1
-
74
-
-
70350500686
-
NOD-like receptors Pivotal guardians of the immunological integrity of barrier organs
-
Rosenstiel, P.; Schreiber, S. NOD-like receptors Pivotal guardians of the immunological integrity of barrier organs. Adv. Exp. Med. Biol. 2009, 653, 35-47.
-
(2009)
Adv. Exp. Med. Biol.
, vol.653
, pp. 35-47
-
-
Rosenstiel, P.1
Schreiber, S.2
-
75
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot, J.P.; Chamaillard, M.; Zouali, H.; Lesage, S.; Cezard, J.P.; Belaiche, J.; Almer, S.; Tysk, C.; O'Morain, C.A.; Gassull, M.; et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001, 411, 599-603.
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
Chamaillard, M.2
Zouali, H.3
Lesage, S.4
Cezard, J.P.5
Belaiche, J.6
Almer, S.7
Tysk, C.8
O'Morain, C.A.9
Gassull, M.10
-
76
-
-
84859778181
-
Immuno-inhibitory PD-L1 can be induced by a peptidoglycan/NOD2 mediated pathway in primary monocytic cells and is deficient in Crohn's patients with homozygous NOD2 mutations
-
Hewitt, R.E.; Pele, L.C.; Tremelling, M.; Metz, A.; Parkes, M.; Powell, J.J. Immuno-inhibitory PD-L1 can be induced by a peptidoglycan/NOD2 mediated pathway in primary monocytic cells and is deficient in Crohn's patients with homozygous NOD2 mutations. Clin. Immunol. 2012, 143, 162-169.
-
(2012)
Clin. Immunol.
, vol.143
, pp. 162-169
-
-
Hewitt, R.E.1
Pele, L.C.2
Tremelling, M.3
Metz, A.4
Parkes, M.5
Powell, J.J.6
-
77
-
-
84875858095
-
The intermediate filament protein vimentin is a regulator of NOD2 activity
-
International Inflammatory Bowel Disease Genetics Consortium (IIBDGC); Wilson, D.C.; Satsangi, J., doi:10.1136/ gutjnl-2011-301775
-
Stevens, C.; Henderson, P.; Soares, D.; Dogan, B.; Simpson, K.; Barrett, J.C.; International Inflammatory Bowel Disease Genetics Consortium (IIBDGC); Wilson, D.C.; Satsangi, J. The intermediate filament protein vimentin is a regulator of NOD2 activity. Gut 2012, doi:10.1136/ gutjnl-2011-301775.
-
(2012)
Gut
-
-
Stevens, C.1
Henderson, P.2
Soares, D.3
Dogan, B.4
Simpson, K.5
Barrett, J.C.6
-
78
-
-
77955655337
-
Nod-like receptors: Sentinels at host membranes
-
Philpott, D.J.; Girardin, S.E. Nod-like receptors: Sentinels at host membranes. Curr. Opin. Immunol. 2010, 22, 428-434.
-
(2010)
Curr. Opin. Immunol.
, vol.22
, pp. 428-434
-
-
Philpott, D.J.1
Girardin, S.E.2
-
79
-
-
82955249021
-
NOD-like receptors and the innate immune system: Coping with danger, damage and death
-
Kersse, K.; Bertrand, M.J.; Lamkanfi, M.; Vandenabeele, P. NOD-like receptors and the innate immune system: Coping with danger, damage and death. Cytokine Growth Factor Rev. 2011, 22, 257-276.
-
(2011)
Cytokine Growth Factor Rev.
, vol.22
, pp. 257-276
-
-
Kersse, K.1
Bertrand, M.J.2
Lamkanfi, M.3
Vandenabeele, P.4
-
80
-
-
73849121209
-
Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
-
Travassos, L.H.; Carneiro, L.A.; Ramjeet, M.; Hussey, S.; Kim, Y.G.; Magalhaes, J.G.; Yuan, L.; Soares, F.; Chea, E.; Le Bourhis, L.; et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat. Immunol. 2010, 11, 55-62.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 55-62
-
-
Travassos, L.H.1
Carneiro, L.A.2
Ramjeet, M.3
Hussey, S.4
Kim, Y.G.5
Magalhaes, J.G.6
Yuan, L.7
Soares, F.8
Chea, E.9
le Bourhis, L.10
-
81
-
-
77957682295
-
ATG16L1 and NOD2 interact in an autophagy-dependent, anti-bacterial pathway implicated in Crohn's disease pathogenesis
-
Homer, C.R.; Richmond, A.L.; Rebert, N.A.; Achkar, J.P.; McDonald, C. ATG16L1 and NOD2 interact in an autophagy-dependent, anti-bacterial pathway implicated in Crohn's disease pathogenesis. Gastroenterology 2010, 139, 1630-1641.
-
(2010)
Gastroenterology
, vol.139
, pp. 1630-1641
-
-
Homer, C.R.1
Richmond, A.L.2
Rebert, N.A.3
Achkar, J.P.4
McDonald, C.5
-
82
-
-
84864094479
-
A dual role for receptor interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy
-
doi:10.1074/jbc.M111.326835
-
Homer, C.R.; Kabi, A.; Marina-Garc, I.A.N.; Sreekumar, A.; Nesvizhskii, A.I.; Nickerson, K.P.; Chinnaiyan, A.M.; Nunez, G.; McDonald, C. A dual role for receptor interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy. J. Biol. Chem. 2012, doi:10.1074/jbc.M111.326835.
-
(2012)
J. Biol. Chem
-
-
Homer, C.R.1
Kabi, A.2
Marina-Garc, I.A.N.3
Sreekumar, A.4
Nesvizhskii, A.I.5
Nickerson, K.P.6
Chinnaiyan, A.M.7
Nunez, G.8
McDonald, C.9
-
83
-
-
54849421128
-
Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant
-
Kuballa, P.; Huett, A.; Rioux, J.D.; Daly, M.J.; Xavier, R.J. Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS One 2008, 3, e3391.
-
(2008)
PLoS One
, vol.3
-
-
Kuballa, P.1
Huett, A.2
Rioux, J.D.3
Daly, M.J.4
Xavier, R.J.5
-
84
-
-
78449269144
-
Proteomic analysis of clathrin-coated vesicles
-
McPherson, P.S. Proteomic analysis of clathrin-coated vesicles. Proteomics 2010, 10, 4025-4039.
-
(2010)
Proteomics
, vol.10
, pp. 4025-4039
-
-
McPherson, P.S.1
-
85
-
-
77955131007
-
Plasma membrane contributes to the formation of pre-autophagosomal structures
-
Ravikumar, B.; Moreau, K.; Jahreiss, L.; Puri, C.; Rubinsztein, D.C. Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat. Cell Biol. 2010, 12, 747-757.
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 747-757
-
-
Ravikumar, B.1
Moreau, K.2
Jahreiss, L.3
Puri, C.4
Rubinsztein, D.C.5
-
86
-
-
80051550866
-
Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2
-
Plantinga, T.S.; Crisan, T.O.; Oosting, M.; van de Veerdonk, F.L.; de Jong, D.J.; Philpott, D.J.; van der Meer, J.W.; Girardin, S.E.; Joosten, L.A.; Netea, M.G. Crohn's disease-associated ATG16L1 polymorphism modulates pro-inflammatory cytokine responses selectively upon activation of NOD2. Gut 2011, 60, 1229-1235.
-
(2011)
Gut
, vol.60
, pp. 1229-1235
-
-
Plantinga, T.S.1
Crisan, T.O.2
Oosting, M.3
van de Veerdonk, F.L.4
de Jong, D.J.5
Philpott, D.J.6
van der Meer, J.W.7
Girardin, S.E.8
Joosten, L.A.9
Netea, M.G.10
-
87
-
-
79959655886
-
NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease
-
Glubb, D.M.; Gearry, R.B.; Barclay, M.L.; Roberts, R.L.; Pearson, J.; Keenan, J.I.; McKenzie, J.; Bentley, R.W. NOD2 and ATG16L1 polymorphisms affect monocyte responses in Crohn's disease. World J. Gastroenterol. 2011, 17, 2829-2837.
-
(2011)
World J. Gastroenterol.
, vol.17
, pp. 2829-2837
-
-
Glubb, D.M.1
Gearry, R.B.2
Barclay, M.L.3
Roberts, R.L.4
Pearson, J.5
Keenan, J.I.6
McKenzie, J.7
Bentley, R.W.8
-
88
-
-
80053625777
-
Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response
-
Kleinnijenhuis, J.; Oosting, M.; Plantinga, T.S.; van der Meer, J.W.; Joosten, L.A.; Crevel, R.V.; Netea, M.G. Autophagy modulates the Mycobacterium tuberculosis-induced cytokine response. Immunology 2011, 134, 341-348.
-
(2011)
Immunology
, vol.134
, pp. 341-348
-
-
Kleinnijenhuis, J.1
Oosting, M.2
Plantinga, T.S.3
van der Meer, J.W.4
Joosten, L.A.5
Crevel, R.V.6
Netea, M.G.7
-
89
-
-
84863078686
-
Autophagy suppresses interleukin-1beta (IL-1beta) signaling by activation of p62 degradation via lysosomal and proteasomal pathways
-
Lee, J.; Kim, H.R.; Quinley, C.; Kim, J.; Gonzalez-Navajas, J.; Xavier, R.; Raz, E. Autophagy suppresses interleukin-1beta (IL-1beta) signaling by activation of p62 degradation via lysosomal and proteasomal pathways. J. Biol. Chem. 2012, 287, 4033-4040.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 4033-4040
-
-
Lee, J.1
Kim, H.R.2
Quinley, C.3
Kim, J.4
Gonzalez-Navajas, J.5
Xavier, R.6
Raz, E.7
-
90
-
-
84861615385
-
Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse
-
Wildenberg, M.E.; Vos, A.C.; Wolfkamp, S.C.; Duijvestein, M.; Verhaar, A.P.; Te Velde, A.A.; van den Brink, G.R.; Hommes, D.W. Autophagy attenuates the adaptive immune response by destabilizing the immunologic synapse. Gastroenterology 2012, 142, 1493-1503.
-
(2012)
Gastroenterology
, vol.142
, pp. 1493-1503
-
-
Wildenberg, M.E.1
Vos, A.C.2
Wolfkamp, S.C.3
Duijvestein, M.4
Verhaar, A.P.5
Te Velde, A.A.6
van den Brink, G.R.7
Hommes, D.W.8
-
91
-
-
84860223287
-
Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans
-
Raju, D.; Hussey, S.; Ang, M.; Terebiznik, M.R.; Sibony, M.; Galindo-Mata, E.; Gupta, V.; Blanke, S.R.; Delgado, A.; Romero-Gallo, J.; et al. Vacuolating cytotoxin and variants in Atg16L1 that disrupt autophagy promote Helicobacter pylori infection in humans. Gastroenterology 2012, 142, 1160-1171.
-
(2012)
Gastroenterology
, vol.142
, pp. 1160-1171
-
-
Raju, D.1
Hussey, S.2
Ang, M.3
Terebiznik, M.R.4
Sibony, M.5
Galindo-Mata, E.6
Gupta, V.7
Blanke, S.R.8
Delgado, A.9
Romero-Gallo, J.10
-
92
-
-
84859982621
-
Nondegradative role of Atg5-Atg12/ Atg16L1 autophagy protein complex in antiviral activity of interferon gamma
-
Hwang, S.; Maloney, N.S.; Bruinsma, M.W.; Goel, G.; Duan, E.; Zhang, L.; Shrestha, B.; Diamond, M.S.; Dani, A.; Sosnovtsev, S.V.; et al. Nondegradative role of Atg5-Atg12/ Atg16L1 autophagy protein complex in antiviral activity of interferon gamma. Cell Host Microbe 2012, 11, 397-409.
-
(2012)
Cell Host Microbe
, vol.11
, pp. 397-409
-
-
Hwang, S.1
Maloney, N.S.2
Bruinsma, M.W.3
Goel, G.4
Duan, E.5
Zhang, L.6
Shrestha, B.7
Diamond, M.S.8
Dani, A.9
Sosnovtsev, S.V.10
-
93
-
-
33744509713
-
The interferon-inducible p47 (IRG) GTPases in vertebrates: Loss of the cell autonomous resistance mechanism in the human lineage
-
doi:10.1186/gb-2005-6-11-r92
-
Bekpen, C.; Hunn, J.P.; Rohde, C.; Parvanova, I.; Guethlein, L.; Dunn, D.M.; Glowalla, E.; Leptin, M.; Howard, J.C. The interferon-inducible p47 (IRG) GTPases in vertebrates: Loss of the cell autonomous resistance mechanism in the human lineage. Genome Biol. 2005, 6, doi:10.1186/gb-2005-6-11-r92.
-
(2005)
Genome Biol.
, vol.6
-
-
Bekpen, C.1
Hunn, J.P.2
Rohde, C.3
Parvanova, I.4
Guethlein, L.5
Dunn, D.M.6
Glowalla, E.7
Leptin, M.8
Howard, J.C.9
-
94
-
-
79953131751
-
Human IRGM gene to be or not to be
-
Bekpen, C.; Xavier, R.J.; Eichler, E.E. Human IRGM gene to be or not to be. Semin. Immunopathol. 2010, 32, 437-444.
-
(2010)
Semin. Immunopathol.
, vol.32
, pp. 437-444
-
-
Bekpen, C.1
Xavier, R.J.2
Eichler, E.E.3
-
95
-
-
0019751650
-
Induction of interferon by bacterial endotoxin
-
Nagano, Y.; Maehara, N. Induction of interferon by bacterial endotoxin. Methods Enzymol. 1981, 78, 258-261.
-
(1981)
Methods Enzymol.
, vol.78
, pp. 258-261
-
-
Nagano, Y.1
Maehara, N.2
-
96
-
-
0035898464
-
Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection
-
Collazo, C.M.; Yap, G.S.; Sempowski, G.D.; Lusby, K.C.; Tessarollo, L.; Woude, G.F.; Sher, A.; Taylor, G.A. Inactivation of LRG-47 and IRG-47 reveals a family of interferon gamma-inducible genes with essential, pathogen-specific roles in resistance to infection. J. Exp. Med. 2001, 194, 181-188.
-
(2001)
J. Exp. Med.
, vol.194
, pp. 181-188
-
-
Collazo, C.M.1
Yap, G.S.2
Sempowski, G.D.3
Lusby, K.C.4
Tessarollo, L.5
Woude, G.F.6
Sher, A.7
Taylor, G.A.8
-
97
-
-
0032534733
-
Two families of GTPases dominate the complex cellular response to IFN-gamma
-
Boehm, U.; Guethlein, L.; Klamp, T.; Ozbek, K.; Schaub, A.; Futterer, A.; Pfeffer, K.; Howard, J.C. Two families of GTPases dominate the complex cellular response to IFN-gamma. J. Immunol. 1998, 161, 6715-6723.
-
(1998)
J. Immunol.
, vol.161
, pp. 6715-6723
-
-
Boehm, U.1
Guethlein, L.2
Klamp, T.3
Ozbek, K.4
Schaub, A.5
Futterer, A.6
Pfeffer, K.7
Howard, J.C.8
-
98
-
-
0142240338
-
Immune control of tuberculosis by IFN-gamma-inducible LRG-47
-
MacMicking, J.D.; Taylor, G.A.; McKinney, J.D. Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science 2003, 302, 654-659.
-
(2003)
Science
, vol.302
, pp. 654-659
-
-
MacMicking, J.D.1
Taylor, G.A.2
McKinney, J.D.3
-
99
-
-
1142292747
-
Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia
-
Feng, C.G.; Collazo-Custodio, C.M.; Eckhaus, M.; Hieny, S.; Belkaid, Y.; Elkins, K.; Jankovic, D.; Taylor, G.A.; Sher, A. Mice deficient in LRG-47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. J. Immunol. 2004, 172, 1163-1168.
-
(2004)
J. Immunol.
, vol.172
, pp. 1163-1168
-
-
Feng, C.G.1
Collazo-Custodio, C.M.2
Eckhaus, M.3
Hieny, S.4
Belkaid, Y.5
Elkins, K.6
Jankovic, D.7
Taylor, G.A.8
Sher, A.9
-
100
-
-
10944253145
-
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
-
Gutierrez, M.G.; Master, S.S.; Singh, S.B.; Taylor, G.A.; Colombo, M.I.; Deretic, V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 2004, 119, 753-766.
-
(2004)
Cell
, vol.119
, pp. 753-766
-
-
Gutierrez, M.G.1
Master, S.S.2
Singh, S.B.3
Taylor, G.A.4
Colombo, M.I.5
Deretic, V.6
-
101
-
-
33748506089
-
Human IRGM induces autophagy to eliminate intracellular mycobacteria
-
Singh, S.B.; Davis, A.S.; Taylor, G.A.; Deretic, V. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 2006, 313, 1438-1441.
-
(2006)
Science
, vol.313
, pp. 1438-1441
-
-
Singh, S.B.1
Davis, A.S.2
Taylor, G.A.3
Deretic, V.4
-
102
-
-
84855293818
-
IRGM is a common target of RNA viruses that subvert the autophagy network
-
Gregoire, I.P.; Richetta, C.; Meyniel-Schicklin, L.; Borel, S.; Pradezynski, F.; Diaz, O.; Deloire, A.; Azocar, O.; Baguet, J.; Le Breton, M.; et al. IRGM is a common target of RNA viruses that subvert the autophagy network. PLoS Pathog. 2011, 7, e1002422.
-
(2011)
PLoS Pathog.
, vol.7
-
-
Gregoire, I.P.1
Richetta, C.2
Meyniel-Schicklin, L.3
Borel, S.4
Pradezynski, F.5
Diaz, O.6
Deloire, A.7
Azocar, O.8
Baguet, J.9
le Breton, M.10
-
103
-
-
38449116497
-
Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47)
-
Henry, S.C.; Daniell, X.; Indaram, M.; Whitesides, J.F.; Sempowski, G.D.; Howell, D.; Oliver, T.; Taylor, G.A. Impaired macrophage function underscores susceptibility to Salmonella in mice lacking Irgm1 (LRG-47). J. Immunol. 2007, 179, 6963-6972.
-
(2007)
J. Immunol.
, vol.179
, pp. 6963-6972
-
-
Henry, S.C.1
Daniell, X.2
Indaram, M.3
Whitesides, J.F.4
Sempowski, G.D.5
Howell, D.6
Oliver, T.7
Taylor, G.A.8
-
104
-
-
19744378057
-
p47 GTPases regulate Toxoplasma gondii survival in activated macrophages
-
Butcher, B.A.; Greene, R.I.; Henry, S.C.; Annecharico, K.L.; Weinberg, J.B.; Denkers, E.Y.; Sher, A.; Taylor, G.A. p47 GTPases regulate Toxoplasma gondii survival in activated macrophages. Infect. Immun. 2005, 73, 3278-3286.
-
(2005)
Infect. Immun.
, vol.73
, pp. 3278-3286
-
-
Butcher, B.A.1
Greene, R.I.2
Henry, S.C.3
Annecharico, K.L.4
Weinberg, J.B.5
Denkers, E.Y.6
Sher, A.7
Taylor, G.A.8
-
105
-
-
54549089752
-
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death
-
Feng, C.G.; Zheng, L.; Jankovic, D.; Bafica, A.; Cannons, J.L.; Watford, W.T.; Chaussabel, D.; Hieny, S.; Caspar, P.; Schwartzberg, P.L.; et al. The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-gamma-induced cell death. Nat. Immunol. 2008, 9, 1279-1287.
-
(2008)
Nat. Immunol.
, vol.9
, pp. 1279-1287
-
-
Feng, C.G.1
Zheng, L.2
Jankovic, D.3
Bafica, A.4
Cannons, J.L.5
Watford, W.T.6
Chaussabel, D.7
Hieny, S.8
Caspar, P.9
Schwartzberg, P.L.10
-
106
-
-
84861232484
-
Mechanisms of LRRK2-Mediated Neurodegeneration
-
doi:10.1007/s11910-012-0265-8
-
Tsika, E.; Moore, D.J. Mechanisms of LRRK2-Mediated Neurodegeneration. Curr. Neurol. Neurosci. Rep. 2012, doi:10.1007/s11910-012-0265-8.
-
(2012)
Curr. Neurol. Neurosci. Rep
-
-
Tsika, E.1
Moore, D.J.2
-
107
-
-
77953395313
-
Leucine-rich repeat kinase 2 mutations and Parkinson's disease: Three questions
-
Greggio, E.; Cookson, M.R. Leucine-rich repeat kinase 2 mutations and Parkinson's disease: Three questions. ASN Neuro. 2009, 1, e00002.
-
(2009)
ASN Neuro.
, vol.1
-
-
Greggio, E.1
Cookson, M.R.2
-
108
-
-
78649489009
-
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
-
Franke, A.; McGovern, D.P.; Barrett, J.C.; Wang, K.; Radford-Smith, G.L.; Ahmad, T.; Lees, C.W.; Balschun, T.; Lee, J.; Roberts, R.; et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat. Genet. 2010, 42, 1118-1125.
-
(2010)
Nat. Genet.
, vol.42
, pp. 1118-1125
-
-
Franke, A.1
McGovern, D.P.2
Barrett, J.C.3
Wang, K.4
Radford-Smith, G.L.5
Ahmad, T.6
Lees, C.W.7
Balschun, T.8
Lee, J.9
Roberts, R.10
-
109
-
-
41649083587
-
Dynamic and redundant regulation of LRRK2 and LRRK1 expression
-
Biskup, S.; Moore, D.J.; Rea, A.; Lorenz-Deperieux, B.; Coombes, C.E.; Dawson, V.L.; Dawson, T.M.; West, A.B. Dynamic and redundant regulation of LRRK2 and LRRK1 expression. BMC Neurosci. 2007, 8, 102.
-
(2007)
BMC Neurosci.
, vol.8
, pp. 102
-
-
Biskup, S.1
Moore, D.J.2
Rea, A.3
Lorenz-Deperieux, B.4
Coombes, C.E.5
Dawson, V.L.6
Dawson, T.M.7
West, A.B.8
-
110
-
-
79956199220
-
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
-
Hakimi, M.; Selvanantham, T.; Swinton, E.; Padmore, R.F.; Tong, Y.; Kabbach, G.; Venderova, K.; Girardin, S.E.; Bulman, D.E.; Scherzer, C.R.; et al. Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J. Neural. Transm. 2011, 118, 795-808.
-
(2011)
J. Neural. Transm.
, vol.118
, pp. 795-808
-
-
Hakimi, M.1
Selvanantham, T.2
Swinton, E.3
Padmore, R.F.4
Tong, Y.5
Kabbach, G.6
Venderova, K.7
Girardin, S.E.8
Bulman, D.E.9
Scherzer, C.R.10
-
111
-
-
84858002150
-
Molecular pathogenesis of Parkinson's disease: Update
-
Saiki, S.; Sato, S.; Hattori, N. Molecular pathogenesis of Parkinson's disease: Update. J. Neurol. Neurosurg. Psychiatry 2012, 83, 430-436.
-
(2012)
J. Neurol. Neurosurg. Psychiatry
, vol.83
, pp. 430-436
-
-
Saiki, S.1
Sato, S.2
Hattori, N.3
-
112
-
-
20144387207
-
Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: Evidence of a common founder across European populations
-
Kachergus, J.; Mata, I.F.; Hulihan, M.; Taylor, J.P.; Lincoln, S.; Aasly, J.; Gibson, J.M.; Ross, O.A.; Lynch, T.; Wiley, J.; et al. Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: Evidence of a common founder across European populations. Am. J. Hum. Genet. 2005, 76, 672-680.
-
(2005)
Am. J. Hum. Genet.
, vol.76
, pp. 672-680
-
-
Kachergus, J.1
Mata, I.F.2
Hulihan, M.3
Taylor, J.P.4
Lincoln, S.5
Aasly, J.6
Gibson, J.M.7
Ross, O.A.8
Lynch, T.9
Wiley, J.10
-
113
-
-
70549088602
-
Genome-wide association study reveals genetic risk underlying Parkinson's disease
-
Simon-Sanchez, J.; Schulte, C.; Bras, J.M.; Sharma, M.; Gibbs, J.R.; Berg, D.; Paisan-Ruiz, C.; Lichtner, P.; Scholz, S.W.; Hernandez, D.G.; et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nat. Genet. 2009, 41, 1308-1312.
-
(2009)
Nat. Genet.
, vol.41
, pp. 1308-1312
-
-
Simon-Sanchez, J.1
Schulte, C.2
Bras, J.M.3
Sharma, M.4
Gibbs, J.R.5
Berg, D.6
Paisan-Ruiz, C.7
Lichtner, P.8
Scholz, S.W.9
Hernandez, D.G.10
-
114
-
-
70549084415
-
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
-
Satake, W.; Nakabayashi, Y.; Mizuta, I.; Hirota, Y.; Ito, C.; Kubo, M.; Kawaguchi, T.; Tsunoda, T.; Watanabe, M.; Takeda, A.; et al. Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nat. Genet. 2009, 41, 1303-1307.
-
(2009)
Nat. Genet.
, vol.41
, pp. 1303-1307
-
-
Satake, W.1
Nakabayashi, Y.2
Mizuta, I.3
Hirota, Y.4
Ito, C.5
Kubo, M.6
Kawaguchi, T.7
Tsunoda, T.8
Watanabe, M.9
Takeda, A.10
-
115
-
-
79960308079
-
Autophagy deregulation in neurodegenerative diseases Recent advances and future perspectives
-
Cheung, Z.H.; Ip, N.Y. Autophagy deregulation in neurodegenerative diseases Recent advances and future perspectives. J. Neurochem. 2011, 118, 317-325.
-
(2011)
J. Neurochem.
, vol.118
, pp. 317-325
-
-
Cheung, Z.H.1
Ip, N.Y.2
-
116
-
-
70349991886
-
LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
-
Alegre-Abarrategui, J.; Christian, H.; Lufino, M.M.; Mutihac, R.; Venda, L.L.; Ansorge, O.; Wade-Martins, R. LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model. Hum. Mol. Genet. 2009, 18, 4022-4034.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 4022-4034
-
-
Alegre-Abarrategui, J.1
Christian, H.2
Lufino, M.M.3
Mutihac, R.4
Venda, L.L.5
Ansorge, O.6
Wade-Martins, R.7
-
117
-
-
70349574622
-
Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease
-
Higashi, S.; Moore, D.J.; Yamamoto, R.; Minegishi, M.; Sato, K.; Togo, T.; Katsuse, O.; Uchikado, H.; Furukawa, Y.; Hino, H.; et al. Abnormal localization of leucine-rich repeat kinase 2 to the endosomal-lysosomal compartment in lewy body disease. J. Neuropathol. Exp. Neurol. 2009, 68, 994-1005.
-
(2009)
J. Neuropathol. Exp. Neurol.
, vol.68
, pp. 994-1005
-
-
Higashi, S.1
Moore, D.J.2
Yamamoto, R.3
Minegishi, M.4
Sato, K.5
Togo, T.6
Katsuse, O.7
Uchikado, H.8
Furukawa, Y.9
Hino, H.10
-
118
-
-
73449124773
-
Parkinson disease, LRRK2 and the endocytic-autophagic pathway
-
Alegre-Abarrategui, J.; Wade-Martins, R. Parkinson disease, LRRK2 and the endocytic-autophagic pathway. Autophagy 2009, 5, 1208-1210.
-
(2009)
Autophagy
, vol.5
, pp. 1208-1210
-
-
Alegre-Abarrategui, J.1
Wade-Martins, R.2
-
119
-
-
84862907943
-
Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP
-
Gomez-Suaga, P.; Luzon-Toro, B.; Churamani, D.; Zhang, L.; Bloor-Young, D.; Patel, S.; Woodman, P.G.; Churchill, G.C.; Hilfiker, S. Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP. Hum. Mol. Genet. 2012, 21, 511-525.
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 511-525
-
-
Gomez-Suaga, P.1
Luzon-Toro, B.2
Churamani, D.3
Zhang, L.4
Bloor-Young, D.5
Patel, S.6
Woodman, P.G.7
Churchill, G.C.8
Hilfiker, S.9
-
120
-
-
84860510280
-
Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
-
Sanchez-Danes, A.; Richaud-Patin, Y.; Carballo-Carbajal, I.; Jimenez-Delgado, S.; Caig, C.; Mora, S.; Di Guglielmo, C.; Ezquerra, M.; Patel, B.; Giralt, A.; et al. Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease. EMBO Mol. Med. 2012, 4, 380-395.
-
(2012)
EMBO Mol. Med.
, vol.4
, pp. 380-395
-
-
Sanchez-Danes, A.1
Richaud-Patin, Y.2
Carballo-Carbajal, I.3
Jimenez-Delgado, S.4
Caig, C.5
Mora, S.6
di Guglielmo, C.7
Ezquerra, M.8
Patel, B.9
Giralt, A.10
-
121
-
-
77953090478
-
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice
-
Tong, Y.; Yamaguchi, H.; Giaime, E.; Boyle, S.; Kopan, R.; Kelleher, R.J., 3rd; Shen, J. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc. Natl. Acad. Sci. USA 2010, 107, 9879-9884.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 9879-9884
-
-
Tong, Y.1
Yamaguchi, H.2
Giaime, E.3
Boyle, S.4
Kopan, R.5
Kelleher III, R.J.6
Shen, J.7
-
122
-
-
80054933395
-
The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
-
Liu, Z.; Lee, J.; Krummey, S.; Lu, W.; Cai, H.; Lenardo, M.J. The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease. Nat. Immunol. 2011, 12, 1063-1070.
-
(2011)
Nat. Immunol.
, vol.12
, pp. 1063-1070
-
-
Liu, Z.1
Lee, J.2
Krummey, S.3
Lu, W.4
Cai, H.5
Lenardo, M.J.6
-
123
-
-
78149473340
-
LRRK2 is involved in the IFN-gamma response and host response to pathogens
-
Gardet, A.; Benita, Y.; Li, C.; Sands, B.E.; Ballester, I.; Stevens, C.; Korzenik, J.R.; Rioux, J.D.; Daly, M.J.; Xavier, R.J.; et al. LRRK2 is involved in the IFN-gamma response and host response to pathogens. J. Immunol. 2010, 185, 5577-5585.
-
(2010)
J. Immunol.
, vol.185
, pp. 5577-5585
-
-
Gardet, A.1
Benita, Y.2
Li, C.3
Sands, B.E.4
Ballester, I.5
Stevens, C.6
Korzenik, J.R.7
Rioux, J.D.8
Daly, M.J.9
Xavier, R.J.10
-
124
-
-
79952445703
-
The role of bacteria and pattern-recognition receptors in Crohn's disease
-
Man, S.M.; Kaakoush, N.O.; Mitchell, H.M. The role of bacteria and pattern-recognition receptors in Crohn's disease. Nat. Rev. Gastroenterol. Hepatol. 2011, 8, 152-168.
-
(2011)
Nat. Rev. Gastroenterol. Hepatol.
, vol.8
, pp. 152-168
-
-
Man, S.M.1
Kaakoush, N.O.2
Mitchell, H.M.3
-
125
-
-
0035413604
-
Molecular reactions of protein phosphatases Insights from structure and chemistry
-
Jackson, M.D.; Denu, J.M. Molecular reactions of protein phosphatases Insights from structure and chemistry. Chem. Rev. 2001, 101, 2313-2340.
-
(2001)
Chem. Rev.
, vol.101
, pp. 2313-2340
-
-
Jackson, M.D.1
Denu, J.M.2
-
126
-
-
33746729798
-
Myotubularin phosphatases: Policing 3-phosphoinositides
-
Robinson, F.L.; Dixon, J.E. Myotubularin phosphatases: Policing 3-phosphoinositides. Trends Cell Biol. 2006, 16, 403-412.
-
(2006)
Trends Cell Biol.
, vol.16
, pp. 403-412
-
-
Robinson, F.L.1
Dixon, J.E.2
-
127
-
-
77950505030
-
The role of PI3P phosphatases in the regulation of autophagy
-
Vergne, I.; Deretic, V. The role of PI3P phosphatases in the regulation of autophagy. FEBS Lett. 2010, 584, 1313-1318.
-
(2010)
FEBS Lett.
, vol.584
, pp. 1313-1318
-
-
Vergne, I.1
Deretic, V.2
-
128
-
-
44449115788
-
Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae
-
Obara, K.; Noda, T.; Niimi, K.; Ohsumi, Y. Transport of phosphatidylinositol 3-phosphate into the vacuole via autophagic membranes in Saccharomyces cerevisiae. Genes Cells 2008, 13, 537-547.
-
(2008)
Genes Cells
, vol.13
, pp. 537-547
-
-
Obara, K.1
Noda, T.2
Niimi, K.3
Ohsumi, Y.4
-
129
-
-
0035325258
-
FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate
-
Zhao, R.; Qi, Y.; Chen, J.; Zhao, Z.J. FYVE-DSP2, a FYVE domain-containing dual specificity protein phosphatase that dephosphorylates phosphotidylinositol 3-phosphate. Exp. Cell Res. 2001, 265, 329-338.
-
(2001)
Exp. Cell Res.
, vol.265
, pp. 329-338
-
-
Zhao, R.1
Qi, Y.2
Chen, J.3
Zhao, Z.J.4
-
130
-
-
0035899863
-
Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity
-
Walker, D.M.; Urbe, S.; Dove, S.K.; Tenza, D.; Raposo, G.; Clague, M.J. Characterization of MTMR3. an inositol lipid 3-phosphatase with novel substrate specificity. Curr. Biol. 2001, 11, 1600-1605.
-
(2001)
Curr. Biol.
, vol.11
, pp. 1600-1605
-
-
Walker, D.M.1
Urbe, S.2
Dove, S.K.3
Tenza, D.4
Raposo, G.5
Clague, M.J.6
-
131
-
-
77951708056
-
Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy
-
Taguchi-Atarashi, N.; Hamasaki, M.; Matsunaga, K.; Omori, H.; Ktistakis, N.T.; Yoshimori, T.; Noda, T. Modulation of local PtdIns3P levels by the PI phosphatase MTMR3 regulates constitutive autophagy. Traffic 2010, 11, 468-478.
-
(2010)
Traffic
, vol.11
, pp. 468-478
-
-
Taguchi-Atarashi, N.1
Hamasaki, M.2
Matsunaga, K.3
Omori, H.4
Ktistakis, N.T.5
Yoshimori, T.6
Noda, T.7
-
132
-
-
8044257699
-
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
-
Blommaart, E.F.; Krause, U.; Schellens, J.P.; Vreeling-Sindelarova, H.; Meijer, A.J. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur. J. Biochem. 1997, 243, 240-246.
-
(1997)
Eur. J. Biochem.
, vol.243
, pp. 240-246
-
-
Blommaart, E.F.1
Krause, U.2
Schellens, J.P.3
Vreeling-Sindelarova, H.4
Meijer, A.J.5
-
133
-
-
3142583199
-
Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors
-
Dove, S.K.; Piper, R.C.; McEwen, R.K.; Yu, J.W.; King, M.C.; Hughes, D.C.; Thuring, J.; Holmes, A.B.; Cooke, F.T.; Michell, R.H.; et al. Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectors. EMBO J. 2004, 23, 1922-1933.
-
(2004)
EMBO J.
, vol.23
, pp. 1922-1933
-
-
Dove, S.K.1
Piper, R.C.2
McEwen, R.K.3
Yu, J.W.4
King, M.C.5
Hughes, D.C.6
Thuring, J.7
Holmes, A.B.8
Cooke, F.T.9
Michell, R.H.10
-
134
-
-
3342951135
-
Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy
-
Stromhaug, P.E.; Reggiori, F.; Guan, J.; Wang, C.W.; Klionsky, D.J. Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy. Mol. Biol. Cell 2004, 15, 3553-3566.
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 3553-3566
-
-
Stromhaug, P.E.1
Reggiori, F.2
Guan, J.3
Wang, C.W.4
Klionsky, D.J.5
-
135
-
-
33746867157
-
The relevance of the phosphatidylinositolphosphat-binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy
-
Krick, R.; Tolstrup, J.; Appelles, A.; Henke, S.; Thumm, M. The relevance of the phosphatidylinositolphosphat-binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy. FEBS Lett. 2006, 580, 4632-4638.
-
(2006)
FEBS Lett.
, vol.580
, pp. 4632-4638
-
-
Krick, R.1
Tolstrup, J.2
Appelles, A.3
Henke, S.4
Thumm, M.5
-
136
-
-
53549100450
-
Dynamics and function of PtdIns(3)P in autophagy
-
Obara, K.; Ohsumi, Y. Dynamics and function of PtdIns(3)P in autophagy. Autophagy 2008, 4, 952-954.
-
(2008)
Autophagy
, vol.4
, pp. 952-954
-
-
Obara, K.1
Ohsumi, Y.2
-
137
-
-
34548700796
-
Unveiling the roles of autophagy in innate and adaptive immunity
-
Levine, B.; Deretic, V. Unveiling the roles of autophagy in innate and adaptive immunity. Nat. Rev. Immunol. 2007, 7, 767-777.
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 767-777
-
-
Levine, B.1
Deretic, V.2
-
138
-
-
79960929526
-
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese
-
Hu, Z.; Wu, C.; Shi, Y.; Guo, H.; Zhao, X.; Yin, Z.; Yang, L.; Dai, J.; Hu, L.; Tan, W.; et al. A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese. Nat. Genet. 2011, 43, 792-796.
-
(2011)
Nat. Genet.
, vol.43
, pp. 792-796
-
-
Hu, Z.1
Wu, C.2
Shi, Y.3
Guo, H.4
Zhao, X.5
Yin, Z.6
Yang, L.7
Dai, J.8
Hu, L.9
Tan, W.10
-
139
-
-
77951094639
-
Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability
-
Song, S.Y.; Kang, M.R.; Yoo, N.J.; Lee, S.H. Mutational analysis of mononucleotide repeats in dual specificity tyrosine phosphatase genes in gastric and colon carcinomas with microsatellite instability. APMIS 2010, 118, 389-393.
-
(2010)
APMIS
, vol.118
, pp. 389-393
-
-
Song, S.Y.1
Kang, M.R.2
Yoo, N.J.3
Lee, S.H.4
-
140
-
-
80053634368
-
The dynamic nature of autophagy in cancer
-
Kimmelman, A.C. The dynamic nature of autophagy in cancer. Genes Dev. 2011, 25, 1999-2010.
-
(2011)
Genes Dev.
, vol.25
, pp. 1999-2010
-
-
Kimmelman, A.C.1
-
141
-
-
61849135255
-
T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: Lessons from the knockout mouse model and implications in human disease
-
Doody, K.M.; Bourdeau, A.; Tremblay, M.L. T-cell protein tyrosine phosphatase is a key regulator in immune cell signaling: Lessons from the knockout mouse model and implications in human disease. Immunol. Rev. 2009, 228, 325-341.
-
(2009)
Immunol. Rev.
, vol.228
, pp. 325-341
-
-
Doody, K.M.1
Bourdeau, A.2
Tremblay, M.L.3
-
142
-
-
0024359515
-
cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family
-
Cool, D.E.; Tonks, N.K.; Charbonneau, H.; Walsh, K.A.; Fischer, E.H.; Krebs, E.G. cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family. Proc. Natl. Acad. Sci. U. S. A. 1989, 86, 5257-5261.
-
(1989)
Proc. Natl. Acad. Sci. U. S. A.
, vol.86
, pp. 5257-5261
-
-
Cool, D.E.1
Tonks, N.K.2
Charbonneau, H.3
Walsh, K.A.4
Fischer, E.H.5
Krebs, E.G.6
-
143
-
-
1942489307
-
T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease
-
Heinonen, K.M.; Nestel, F.P.; Newell, E.W.; Charette, G.; Seemayer, T.A.; Tremblay, M.L.; Lapp, W.S. T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease. Blood 2004, 103, 3457-3464.
-
(2004)
Blood
, vol.103
, pp. 3457-3464
-
-
Heinonen, K.M.1
Nestel, F.P.2
Newell, E.W.3
Charette, G.4
Seemayer, T.A.5
Tremblay, M.L.6
Lapp, W.S.7
-
144
-
-
70649104669
-
Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase N2
-
Scharl, M.; Paul, G.; Weber, A.; Jung, B.C.; Docherty, M.J.; Hausmann, M.; Rogler, G.; Barrett, K.E.; McCole, D.F. Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase N2. Gastroenterology 2009, 137, 2030-2040.
-
(2009)
Gastroenterology
, vol.137
, pp. 2030-2040
-
-
Scharl, M.1
Paul, G.2
Weber, A.3
Jung, B.C.4
Docherty, M.J.5
Hausmann, M.6
Rogler, G.7
Barrett, K.E.8
McCole, D.F.9
-
145
-
-
78649605952
-
Protein tyrosine phosphatase non-receptor Type 2 regulates IFN-gamma-induced cytokine signaling in THP-1 monocytes
-
Scharl, M.; Hruz, P.; McCole, D.F. Protein tyrosine phosphatase non-receptor Type 2 regulates IFN-gamma-induced cytokine signaling in THP-1 monocytes. Inflamm. Bowel Dis. 2010, 16, 2055-2064.
-
(2010)
Inflamm. Bowel Dis.
, vol.16
, pp. 2055-2064
-
-
Scharl, M.1
Hruz, P.2
McCole, D.F.3
-
146
-
-
78651070199
-
Protein tyrosine phosphatase N2 regulates TNFalpha-induced signalling and cytokine secretion in human intestinal epithelial cells
-
Scharl, M.; McCole, D.F.; Weber, A.; Vavricka, S.R.; Frei, P.; Kellermeier, S.; Pesch, T.; Fried, M.; Rogler, G. Protein tyrosine phosphatase N2 regulates TNFalpha-induced signalling and cytokine secretion in human intestinal epithelial cells. Gut 2011, 60, 189-197.
-
(2011)
Gut
, vol.60
, pp. 189-197
-
-
Scharl, M.1
McCole, D.F.2
Weber, A.3
Vavricka, S.R.4
Frei, P.5
Kellermeier, S.6
Pesch, T.7
Fried, M.8
Rogler, G.9
-
147
-
-
84862194557
-
Protein tyrosine phosphatase nonreceptor type 2 regulates autophagosome formation in human intestinal cells
-
doi:10.1002/ibd.21891
-
Scharl, M.; Wojtal, K.A.; Becker, H.M.; Fischbeck, A.; Frei, P.; Arikkat, J.; Pesch, T.; Kellermeier, S.; Boone, D.L.; Weber, A.; et al. Protein tyrosine phosphatase nonreceptor type 2 regulates autophagosome formation in human intestinal cells. Inflamm. Bowel Dis. 2011, doi:10.1002/ibd.21891.
-
(2011)
Inflamm. Bowel Dis
-
-
Scharl, M.1
Wojtal, K.A.2
Becker, H.M.3
Fischbeck, A.4
Frei, P.5
Arikkat, J.6
Pesch, T.7
Kellermeier, S.8
Boone, D.L.9
Weber, A.10
-
148
-
-
84858683881
-
Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy
-
Scharl, M.; Mwinyi, J.; Fischbeck, A.; Leucht, K.; Eloranta, J.J.; Arikkat, J.; Pesch, T.; Kellermeier, S.; Mair, A.; Kullak-Ublick, G.A.; et al. Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy. Inflamm. Bowel Dis. 2012, 18, 900-912.
-
(2012)
Inflamm. Bowel Dis.
, vol.18
, pp. 900-912
-
-
Scharl, M.1
Mwinyi, J.2
Fischbeck, A.3
Leucht, K.4
Eloranta, J.J.5
Arikkat, J.6
Pesch, T.7
Kellermeier, S.8
Mair, A.9
Kullak-Ublick, G.A.10
-
149
-
-
84857357316
-
NELL1, NCF4, and FAM92B genes are not major susceptibility genes for Crohn's disease in Canadian children and young adults
-
Amre, D.K.; Mack, D.R.; Israel, D.; Krupoves, A.; Costea, I.; Lambrette, P.; Grimard, G.; Dong, J.; Levy, E. NELL1, NCF4, and FAM92B genes are not major susceptibility genes for Crohn's disease in Canadian children and young adults. Inflamm. Bowel Dis. 2012, 18, 529-535.
-
(2012)
Inflamm. Bowel Dis.
, vol.18
, pp. 529-535
-
-
Amre, D.K.1
Mack, D.R.2
Israel, D.3
Krupoves, A.4
Costea, I.5
Lambrette, P.6
Grimard, G.7
Dong, J.8
Levy, E.9
-
150
-
-
33847200398
-
Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding
-
Honbou, K.; Minakami, R.; Yuzawa, S.; Takeya, R.; Suzuki, N.N.; Kamakura, S.; Sumimoto, H.; Inagaki, F. Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding. EMBO J. 2007, 26, 1176-1186.
-
(2007)
EMBO J.
, vol.26
, pp. 1176-1186
-
-
Honbou, K.1
Minakami, R.2
Yuzawa, S.3
Takeya, R.4
Suzuki, N.N.5
Kamakura, S.6
Sumimoto, H.7
Inagaki, F.8
-
151
-
-
33746885455
-
Neutrophils from p40phox-/-mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing
-
Ellson, C.D.; Davidson, K.; Ferguson, G.J.; O'Connor, R.; Stephens, L.R.; Hawkins, P.T. Neutrophils from p40phox-/-mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing. J. Exp. Med. 2006, 203, 1927-1937.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1927-1937
-
-
Ellson, C.D.1
Davidson, K.2
Ferguson, G.J.3
O'Connor, R.4
Stephens, L.R.5
Hawkins, P.T.6
-
152
-
-
34247186472
-
Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
-
Scherz-Shouval, R.; Shvets, E.; Fass, E.; Shorer, H.; Gil, L.; Elazar, Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J. 2007, 26, 1749-1760.
-
(2007)
EMBO J.
, vol.26
, pp. 1749-1760
-
-
Scherz-Shouval, R.1
Shvets, E.2
Fass, E.3
Shorer, H.4
Gil, L.5
Elazar, Z.6
-
153
-
-
84861570833
-
NADPH oxidase complex and IBD candidate gene studies: Identification of a rare variant in NCF2 that results in reduced binding to RAC2
-
Muise, A.M.; Xu, W.; Guo, C.H.; Walters, T.D.; Wolters, V.M.; Fattouh, R.; Lam, G.Y.; Hu, P.; Murchie, R.; Sherlock, M.; et al. NADPH oxidase complex and IBD candidate gene studies: Identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut 2012, 61, 1028-1035.
-
(2012)
Gut
, vol.61
, pp. 1028-1035
-
-
Muise, A.M.1
Xu, W.2
Guo, C.H.3
Walters, T.D.4
Wolters, V.M.5
Fattouh, R.6
Lam, G.Y.7
Hu, P.8
Murchie, R.9
Sherlock, M.10
-
154
-
-
84859620652
-
Clinical and genetic risk factors for perianal Crohn's disease in a population-based cohort
-
Eglinton, T.W.; Roberts, R.; Pearson, J.; Barclay, M.; Merriman, T.R.; Frizelle, F.A.; Gearry, R.B. Clinical and genetic risk factors for perianal Crohn's disease in a population-based cohort. Am. J. Gastroenterol. 2012, 107, 589-596.
-
(2012)
Am. J. Gastroenterol.
, vol.107
, pp. 589-596
-
-
Eglinton, T.W.1
Roberts, R.2
Pearson, J.3
Barclay, M.4
Merriman, T.R.5
Frizelle, F.A.6
Gearry, R.B.7
-
155
-
-
84861572891
-
Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease
-
Somasundaram, R.; Deuring, J.J.; van der Woude, C.J.; Peppelenbosch, M.P.; Fuhler, G.M. Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease. Gut 2012, 61, 1097.
-
(2012)
Gut
, vol.61
, pp. 1097
-
-
Somasundaram, R.1
Deuring, J.J.2
van der Woude, C.J.3
Peppelenbosch, M.P.4
Fuhler, G.M.5
-
156
-
-
84856800302
-
Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: Cross talk, shortcuts, and feedbacks
-
Alers, S.; Loffler, A.S.; Wesselborg, S.; Stork, B. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: Cross talk, shortcuts, and feedbacks. Mol. Cell Biol. 2012, 32, 2-11.
-
(2012)
Mol. Cell Biol.
, vol.32
, pp. 2-11
-
-
Alers, S.1
Loffler, A.S.2
Wesselborg, S.3
Stork, B.4
-
157
-
-
84859911402
-
The incredible ULKs
-
Alers, S.; Loffler, A.S.; Wesselborg, S.; Stork, B. The incredible ULKs. Cell Commun. Signal. 2012, 10, 7.
-
(2012)
Cell Commun. Signal.
, vol.10
, pp. 7
-
-
Alers, S.1
Loffler, A.S.2
Wesselborg, S.3
Stork, B.4
-
158
-
-
73949118739
-
Molecular mechanisms of E. coli pathogenicity
-
Croxen, M.A.; Finlay, B.B. Molecular mechanisms of E. coli pathogenicity. Nat. Rev. Microbiol. 2010, 8, 26-38.
-
(2010)
Nat. Rev. Microbiol.
, vol.8
, pp. 26-38
-
-
Croxen, M.A.1
Finlay, B.B.2
-
159
-
-
0031758230
-
Presence of adherent E. coli strains in ileal mucosa of patients with Crohn's disease
-
Darfeuille-Michaud, A.; Neut, C.; Barnich, N.; Lederman, E.; Di Martino, P.; Desreumaux, P.; Gambiez, L.; Joly, B.; Cortot, A.; Colombel, J.F. Presence of adherent E. coli strains in ileal mucosa of patients with Crohn's disease. Gastroenterology 1998, 115, 1405-1413.
-
(1998)
Gastroenterology
, vol.115
, pp. 1405-1413
-
-
Darfeuille-Michaud, A.1
Neut, C.2
Barnich, N.3
Lederman, E.4
di Martino, P.5
Desreumaux, P.6
Gambiez, L.7
Joly, B.8
Cortot, A.9
Colombel, J.F.10
-
160
-
-
0032768352
-
Invasive ability of an E. coli strain isolated from the ileal mucosa of a patient with Crohn's disease
-
Boudeau, J.; Glasser, A.L.; Masseret, E.; Joly, B.; Darfeuille-Michaud, A. Invasive ability of an E. coli strain isolated from the ileal mucosa of a patient with Crohn's disease. Infect. Immun. 1999, 67, 4499-4509.
-
(1999)
Infect. Immun.
, vol.67
, pp. 4499-4509
-
-
Boudeau, J.1
Glasser, A.L.2
Masseret, E.3
Joly, B.4
Darfeuille-Michaud, A.5
-
161
-
-
79958799781
-
Characterization of E. coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease
-
Sepehri, S.; Khafipour, E.; Bernstein, C.N.; Coombes, B.K.; Pilar, A.V.; Karmali, M.; Ziebell, K.; Krause, D.O. Characterization of E. coli isolated from gut biopsies of newly diagnosed patients with inflammatory bowel disease. Inflamm. Bowel Dis. 2011, 17, 1451-1463.
-
(2011)
Inflamm. Bowel Dis.
, vol.17
, pp. 1451-1463
-
-
Sepehri, S.1
Khafipour, E.2
Bernstein, C.N.3
Coombes, B.K.4
Pilar, A.V.5
Karmali, M.6
Ziebell, K.7
Krause, D.O.8
-
162
-
-
34249886868
-
CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease
-
Barnich, N.; Carvalho, F.A.; Glasser, A.L.; Darcha, C.; Jantscheff, P.; Allez, M.; Peeters, H.; Bommelaer, G.; Desreumaux, P.; Colombel, J.F.; et al. CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J. Clin. Invest. 2007, 117, 1566-1574.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1566-1574
-
-
Barnich, N.1
Carvalho, F.A.2
Glasser, A.L.3
Darcha, C.4
Jantscheff, P.5
Allez, M.6
Peeters, H.7
Bommelaer, G.8
Desreumaux, P.9
Colombel, J.F.10
-
163
-
-
77957195829
-
Abnormally expressed ER stress response chaperone Gp96 in CD favours adherent-invasive E. coli invasion
-
Rolhion, N.; Barnich, N.; Bringer, M.A.; Glasser, A.L.; Ranc, J.; Hebuterne, X.; Hofman, P.; Darfeuille-Michaud, A. Abnormally expressed ER stress response chaperone Gp96 in CD favours adherent-invasive E. coli invasion. Gut 2010, 59, 1355-1362.
-
(2010)
Gut
, vol.59
, pp. 1355-1362
-
-
Rolhion, N.1
Barnich, N.2
Bringer, M.A.3
Glasser, A.L.4
Ranc, J.5
Hebuterne, X.6
Hofman, P.7
Darfeuille-Michaud, A.8
-
164
-
-
77958603351
-
Complete genome sequence of Crohn's disease-associated adherent-invasive E. coli strain LF82
-
Miquel, S.; Peyretaillade, E.; Claret, L.; de Vallee, A.; Dossat, C.; Vacherie, B.; Zineb, E.H.; Segurens, B.; Barbe, V.; Sauvanet, P.; et al. Complete genome sequence of Crohn's disease-associated adherent-invasive E. coli strain LF82. PLoS One 2010, 5, e12714.
-
(2010)
PLoS One
, vol.5
-
-
Miquel, S.1
Peyretaillade, E.2
Claret, L.3
de Vallee, A.4
Dossat, C.5
Vacherie, B.6
Zineb, E.H.7
Segurens, B.8
Barbe, V.9
Sauvanet, P.10
-
165
-
-
79952230127
-
Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae
-
Chassaing, B.; Rolhion, N.; de Vallee, A.; Salim, S.Y.; Prorok-Hamon, M.; Neut, C.; Campbell, B.J.; Soderholm, J.D.; Hugot, J.P.; Colombel, J.F.; et al. Crohn disease-associated adherent-invasive E. coli bacteria target mouse and human Peyer's patches via long polar fimbriae. J. Clin. Invest. 2011, 121, 966-975.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 966-975
-
-
Chassaing, B.1
Rolhion, N.2
de Vallee, A.3
Salim, S.Y.4
Prorok-Hamon, M.5
Neut, C.6
Campbell, B.J.7
Soderholm, J.D.8
Hugot, J.P.9
Colombel, J.F.10
-
166
-
-
77649194674
-
Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly
-
Lapaquette, P.; Glasser, A.L.; Huett, A.; Xavier, R.J.; Darfeuille-Michaud, A. Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cell Microbiol. 2010, 12, 99-113.
-
(2010)
Cell Microbiol.
, vol.12
, pp. 99-113
-
-
Lapaquette, P.1
Glasser, A.L.2
Huett, A.3
Xavier, R.J.4
Darfeuille-Michaud, A.5
-
167
-
-
84861186087
-
Defects in autophagy favour adherent-invasive E. coli persistence within macrophages leading to increased pro-inflammatory response
-
Lapaquette, P.; Bringer, M.A.; Darfeuille-Michaud, A. Defects in autophagy favour adherent-invasive E. coli persistence within macrophages leading to increased pro-inflammatory response. Cell Microbiol. 2012, 14, 791-807.
-
(2012)
Cell Microbiol.
, vol.14
, pp. 791-807
-
-
Lapaquette, P.1
Bringer, M.A.2
Darfeuille-Michaud, A.3
-
168
-
-
79952134938
-
A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease
-
Brest, P.; Lapaquette, P.; Souidi, M.; Lebrigand, K.; Cesaro, A.; Vouret-Craviari, V.; Mari, B.; Barbry, P.; Mosnier, J.F.; Hebuterne, X.; et al. A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nat. Genet. 2011, 43, 242-245.
-
(2011)
Nat. Genet.
, vol.43
, pp. 242-245
-
-
Brest, P.1
Lapaquette, P.2
Souidi, M.3
Lebrigand, K.4
Cesaro, A.5
Vouret-Craviari, V.6
Mari, B.7
Barbry, P.8
Mosnier, J.F.9
Hebuterne, X.10
-
169
-
-
53149144667
-
ATG16L1 T300A shows strong associations with disease subgroups in a large Australian IBD population: Further support for significant disease heterogeneity
-
Fowler, E.V.; Doecke, J.; Simms, L.A.; Zhao, Z.Z.; Webb, P.M.; Hayward, N.K.; Whiteman, D.C.; Florin, T.H.; Montgomery, G.W.; Cavanaugh, J.A.; et al. ATG16L1 T300A shows strong associations with disease subgroups in a large Australian IBD population: Further support for significant disease heterogeneity. Am. J. Gastroenterol. 2008, 103, 2519-2526.
-
(2008)
Am. J. Gastroenterol.
, vol.103
, pp. 2519-2526
-
-
Fowler, E.V.1
Doecke, J.2
Simms, L.A.3
Zhao, Z.Z.4
Webb, P.M.5
Hayward, N.K.6
Whiteman, D.C.7
Florin, T.H.8
Montgomery, G.W.9
Cavanaugh, J.A.10
-
170
-
-
79551587914
-
IL23R, NOD2/CARD15, ATG16L1 and PHOX2B polymorphisms in a group of patients with Crohn's disease and correlation with sub-phenotypes
-
Lauriola, M.; Ugolini, G.; Rivetti, S.; Nani, S.; Rosati, G.; Zanotti, S.; Montroni, I.; Manaresi, A.; Zattoni, D.; Belluzzi, A.; et al. IL23R, NOD2/CARD15, ATG16L1 and PHOX2B polymorphisms in a group of patients with Crohn's disease and correlation with sub-phenotypes. Int. J. Mol. Med. 2011, 27, 469-477.
-
(2011)
Int. J. Mol. Med.
, vol.27
, pp. 469-477
-
-
Lauriola, M.1
Ugolini, G.2
Rivetti, S.3
Nani, S.4
Rosati, G.5
Zanotti, S.6
Montroni, I.7
Manaresi, A.8
Zattoni, D.9
Belluzzi, A.10
-
171
-
-
84857943512
-
Mutations in IRGM are associated with more frequent need for surgery in patients with ileocolonic Crohn's disease
-
Sehgal, R.; Berg, A.; Polinski, J.I.; Hegarty, J.P.; Lin, Z.; McKenna, K.J.; Stewart, D.B.; Poritz, L.S.; Koltun, W.A. Mutations in IRGM are associated with more frequent need for surgery in patients with ileocolonic Crohn's disease. Dis. Colon Rectum 2012, 55, 115-121.
-
(2012)
Dis. Colon Rectum
, vol.55
, pp. 115-121
-
-
Sehgal, R.1
Berg, A.2
Polinski, J.I.3
Hegarty, J.P.4
Lin, Z.5
McKenna, K.J.6
Stewart, D.B.7
Poritz, L.S.8
Koltun, W.A.9
-
172
-
-
77449133968
-
Meta-analysis of the role of granulomas in the recurrence of Crohn disease
-
Simillis, C.; Jacovides, M.; Reese, G.E.; Yamamoto, T.; Tekkis, P.P. Meta-analysis of the role of granulomas in the recurrence of Crohn disease. Dis. Colon Rectum 2010, 53, 177-185.
-
(2010)
Dis. Colon Rectum
, vol.53
, pp. 177-185
-
-
Simillis, C.1
Jacovides, M.2
Reese, G.E.3
Yamamoto, T.4
Tekkis, P.P.5
-
173
-
-
77955227265
-
Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?
-
Wolfkamp, S.C.; Te Velde, A.A.; Weersma, R.K.; Ponsioen, C.Y.; Stokkers, P.C. Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas? Eur. J. Gastroenterol. Hepatol. 2010, 22, 933-937.
-
(2010)
Eur. J. Gastroenterol. Hepatol.
, vol.22
, pp. 933-937
-
-
Wolfkamp, S.C.1
Te Velde, A.A.2
Weersma, R.K.3
Ponsioen, C.Y.4
Stokkers, P.C.5
-
174
-
-
77957322536
-
Granulomas in Crohn's disease: Are newly discovered genetic variants involved?
-
Mazor, Y.; Karban, A.; Nesher, S.; Weiss, B.; Leshinsky-Silver, E.; Levine, A.; Eliakim, R. Granulomas in Crohn's disease: Are newly discovered genetic variants involved? J. Crohn's Colitis 2010, 4, 438-443.
-
(2010)
J. Crohn's Colitis
, vol.4
, pp. 438-443
-
-
Mazor, Y.1
Karban, A.2
Nesher, S.3
Weiss, B.4
Leshinsky-Silver, E.5
Levine, A.6
Eliakim, R.7
-
175
-
-
84855959618
-
Genetic variants in autophagy-related genes and granuloma formation in a cohort of surgically treated Crohn's disease patients
-
Brinar, M.; Vermeire, S.; Cleynen, I.; Lemmens, B.; Sagaert, X.; Henckaerts, L.; van Assche, G.; Geboes, K.; Rutgeerts, P.; de Hertogh, G. Genetic variants in autophagy-related genes and granuloma formation in a cohort of surgically treated Crohn's disease patients. J. Crohn's Colitis 2012, 6, 43-50.
-
(2012)
J. Crohn's Colitis
, vol.6
, pp. 43-50
-
-
Brinar, M.1
Vermeire, S.2
Cleynen, I.3
Lemmens, B.4
Sagaert, X.5
Henckaerts, L.6
van Assche, G.7
Geboes, K.8
Rutgeerts, P.9
de Hertogh, G.10
-
176
-
-
84865046984
-
Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn's disease
-
doi:10.1002/ibd.22884
-
Murdoch, T.B.; Xu, W.; Stempak, J.M.; Landers, C.; Targan, S.R.; Rotter, J.I.; Silverberg, M.S. Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn's disease. Inflamm. Bowel Dis. 2012, doi:10.1002/ibd.22884.
-
(2012)
Inflamm. Bowel Dis
-
-
Murdoch, T.B.1
Xu, W.2
Stempak, J.M.3
Landers, C.4
Targan, S.R.5
Rotter, J.I.6
Silverberg, M.S.7
-
177
-
-
78650099360
-
Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases
-
Frank, D.N.; Robertson, C.E.; Hamm, C.M.; Kpadeh, Z.; Zhang, T.; Chen, H.; Zhu, W.; Sartor, R.B.; Boedeker, E.C.; Harpaz, N.; et al. Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases. Inflamm. Bowel Dis. 2011, 17, 179-184.
-
(2011)
Inflamm. Bowel Dis.
, vol.17
, pp. 179-184
-
-
Frank, D.N.1
Robertson, C.E.2
Hamm, C.M.3
Kpadeh, Z.4
Zhang, T.5
Chen, H.6
Zhu, W.7
Sartor, R.B.8
Boedeker, E.C.9
Harpaz, N.10
|