Autophagy 16-like 1 rs2241880 G allele is associated with Crohn's disease in German children

Acta Paediatrica, International Journal of Paediatrics

Volumn 98, Issue 11, 2009, Pages 1835-1840

  Lacher, Martin ^a   Schroepf, Sebastian ^a   Ballauff, Antje ^b   Lohse, Peter ^a   Von Schweinitz, Dietrich ^a   Kappler, Roland ^a   Koletzko, Sibylle ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

ATG16L1; Crohn's disease; Early onset; Inflammatory bowel disease; Rs2241880

Indexed keywords

AUTOPHAGY 16 LIKE 1 PROTEIN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT; ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; AUTOPHAGY; CHILD; CONTROLLED STUDY; CROHN DISEASE; EPISTASIS; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE MUTATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTYPE; GERMANY; HETEROZYGOTE; HUMAN; HUMAN TISSUE; INFANT; INTESTINE BIOPSY; LARGE INTESTINE; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PEDIATRICS; PRESCHOOL CHILD; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; AGE OF ONSET; CARRIER PROTEINS; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; CROHN DISEASE; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; GERMANY; HUMANS; INFANT; LOGISTIC MODELS; MALE; ODDS RATIO; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK ASSESSMENT;

EID: 70350514089     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2009.01438.x     Document Type: Article

References (18)

1. Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH, Rioux JD, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008 40 : 955 962.
2. Hampe J, Franke A, Rosenstiel P, Till A, Teuber M, Huse K, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 2007 39 : 207 211. (Pubitemid 46184351)
3. Prescott NJ, Fisher SA, Franke A, Hampe J, Onnie CM, Soars D, et al. A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. Gastroenterology 2007 132 : 1665 1671.
4. Glas J, Konrad A, Schmechel S, Dambacher J, Seiderer J, Schroff F, et al. The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population. Am J Gastroenterol 2008 103 : 682 691.
5. Klionsky DJ. Crohn's disease, autophagy, and the Paneth cell. N Engl J Med 2009 360 : 1785 1786.
6. Baldassano RN, Bradfield JP, Monos DS, Kim CE, Glessner JT, Casalunovo T, et al. Association of the T300A non-synonymous variant of the ATG16L1 gene with susceptibility to paediatric Crohn's disease. Gut 2007 56 : 1171 1173.
7. van Limbergen J, Russell RK, Nimmo ER, Drummond HE, Smith L, Anderson NH, et al. Autophagy gene ATG16L1 influences susceptibility and disease location but not childhood-onset in Crohn's disease in Northern Europe. Inflamm Bowel Dis 2008 14 : 338 346.
8. Amre DK, Mack DR, Morgan K, Krupoves A, Costea I, Lambrette P, et al. Autophagy gene ATG16L1 but not IRGM is associated with Crohn's disease in Canadian children. Inflamm Bowel Dis 2009 15 : 501 507.
9. Latiano A, Palmieri O, Valvano MR, D'Inca R, Cucchiara S, Riegler G, et al. Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy. World J Gastroenterol 2008 14 : 4643 4651.
10. Patterson M, Cardon L. Replication publication. PLoS Biol 2005 3 : e327.
11. Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, Brant SR, et al. Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 2005 19 (Suppl. A 5 36.
12. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001 29 : e45.
13. R Development Core Team. R: A language and environment for statistical computing. Vienna : R Foundation for Statistical Computing. ISBN 3-900051-07-0. Available at: http://www.R-project.org, 2006.
14. Feller M, Huwiler K, Stephan R, Altpeter E, Shang A, Furrer H, et al. Mycobacterium avium subspecies paratuberculosis and Crohn's disease: a systematic review and meta-analysis. Lancet Infect Dis 2007 7 : 607 613.
15. Xavier RJ, Huett A, Rioux JD. Autophagy as an important process in gut homeostasis and Crohn's disease pathogenesis. Gut 2008 57 : 717 720.
16. Cadwell K, Liu JY, Brown SL, Miyoshi H, Loh J, Lennerz JK, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008 456 : 259 263.
17. Saitoh T, Fujita N, Jang MH, Uematsu A, Yang BG, Satoh T, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1ß production. Nature 2008 456 : 264 268.
18. Peterson N, Guthery S, Denson L, Lee J, Saeed S, Prahalad S, et al. Genetic variants in the autophagy pathway contribute to paediatric Crohn's disease. Gut 2008 57 : 1336 1337.