T-cell protein tyrosine phosphatase deletion results in progressive systemic inflammatory disease

Blood

Volumn 103, Issue 9, 2004, Pages 3457-3464

  Heinonen, Krista M ^b   Nestel, Frederick P ^b   Newell, Evan W ^b   Charette, Gabrielle ^b   Seemayer, Thomas A ^b   Tremblay, Michel L ^a   Lapp, Wayne S ^a  

^a 3655 Prom Sir W O McIntyre Med B   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12; NITRIC OXIDE; PROTEIN TYROSINE KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE COURSE; GASTRITIS; GENE CONTROL; GENE DELETION; HYPERSENSITIVITY; IMMUNE RESPONSE; INFLAMMATORY DISEASE; MOUSE; MYOCARDITIS; NEPHRITIS; NONHUMAN; PRIORITY JOURNAL; SIALOADENITIS; SIGNAL TRANSDUCTION;

EID: 1942489307     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-09-3153     Document Type: Article

References (45)

1. You-Ten KE, Muise ES, Itié A, et al. Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice. J Exp Med. 1997;186:683-693.
2. Simoncic PD, Lee-Loy A, Barber DL, Tremblay ML, McGlade CJ. The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3. Curr Biol. 2002;12:446-453.
3. ten Hoeve J, de Jesus Ibarra-Sanchez M, Fu Y, et al. Identification of a nuclear Statl protein tyrosine phosphatase. Mol Cell Biol. 2002;22:5662-5668.
4. Aoki N, Matsuda T. A nuclear protein tyrosine phosphatase TC-PTP is a potential negative regulator of the PRL-mediated signaling pathway: dephosphorylation and deactivation of signal transducer and activator of transcription 5a and 5b by TC-PTP in nucleus. Mol Endocrinol. 2002;16:58-69.
5. Yamamoto T, Sekine Y, Kashima K, et al. The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation. Biochem Biophys Res Commun. 2002;297:811-817.
6. Ibarra-Sanchez MJ, Simoncic PD, Nestel FR, Duplay P, Lapp WS, Tremblay ML. The T-cell protein tyrosine phosphatase. Semin Immunol. 2000;12:379-386.
7. Tracey KJ, Wei H, Manogue KR, et al. Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation. J Exp Med. 1988;167:1211-1227.
8. Tracey KJ, Fong Y, Hesse DG, et al. Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia. Nature. 1987;330:662-664.
9. Ashkenazi A, Marsters SA, Capon DJ, et al. Protection against endotoxic shock by a tumor necrosis factor receptor immunoadhesin. Proc Natl Acad Sci U S A. 1991;88:10535-10539.
10. Nestel FP, Price KS, Seemayer TA, Lapp WS. Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor alpha during graft-versus-host disease. J Exp Med. 1992;175:405-413.
11. Kichian K, Nestel FP, Kim D, Ponka P, Lapp WS. IL-12 p40 messenger RNA expression in target organs during acute graft-versus-host disease: possible involvement of IFN-gamma. J Immunol. 1996;157:2851-2856.
12. Price KS, Nestel FP, Lapp WS. Progressive accu mulation of bacterial lipopolysaccharide in vivo during murine acute graft-versus-host disease. Scand J Immunol. 1997;45:294-300.
13. Nestel FP, Greene RN, Kichian K, Ponka P, Lapp WS. Activation of macrophage cytostatic effector mechanisms during acute graft-versus-host disease: release of intracellular iron and nitric oxide-mediated cytostasis. Blood. 2000;96:1836-1843.
14. Mannel DN, Moore RN, Mergenhagen SE. Macrophages as a source of tumoricidal activity (tumor-necrotizing factor). Infect Immun. 1980;30:523-530
15. Gifford GE, Lohmann-Matthes ML. Gamma interferon priming of mouse and human macrophages for induction of tumor necrosis factor production by bacterial lipopolysaccharide. J Natl Cancer Inst. 1987;78:121-124
16. Stuehr DJ, Marletta MA. Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma. J Immunol. 1987;139:518-525.
17. Ding AH, Nathan CF, Stuehr DJ. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse pedtoneal macrophages: comparison of activating cytokines and evidence for independent production. J Immunol. 1988;141:2407-2412.
18. Garside P, Hutton AK, Severn A, Liew FY, Mowat AM. Nitric oxide mediates intestinal pathology in graft-vs.-host disease. Eur J Immunol. 1992;22:2141-2145.
19. Liu JS, Zhao ML, Brosnan CF, Lee SC. Expression of inducible nitric oxide synthase and nitrotyrosine in multiple sclerosis lesions. Am J Pathol. 2001;158:2057-2066.
20. Bobe P, Benihoud K, Grandjon D, Opolon P, Pritchard LL, Huchet R. Nitric oxide mediation of active immunosuppression associated with graft-versus-host reaction. Blood. 1999;94:1028-1037.
21. Dalton DK, Haynes L, Chu CQ, Swain SL, Wittmer S. Interferon gamma eliminates responding CD4 T cells during mycobacterial infection by inducing apoptosis of activated CD4 T cells. J Exp Med. 2000;192:117-122.
22. Angulo I, de las Heras FG, Garcia-Bustos JF, Gargallo D, Munoz-Fernandez MA, Fresno M. Nitric oxide-producing CD11 b(+)Ly-6G(Gr-1)(+)CD31(ER-MP12)(+) cells in the spleen of cyclophosphamide-treated mice: implications for T-cell responses in immunosuppressed mice. Blood. 2000;95:212-220.
23. McCormack JM, Leenen PJ, Walker WS. Macrophage progenitors from mouse bone marrow and spleen differ in their expression of the Ly-6C differentiation antigen. J Immunol. 1993;151:6389-6398.
24. Schoenhaut DS, Chua AO, Wolitzky AG, et al. Cloning and expression of murine IL-12. J Immunol. 1992;148:3433-3440.
25. Dupuis M, De Jesus Ibarra-Sanchez M, Tremblay ML, Duplay P. Gr-1 + myeloid cells lacking T cell protein tyrosine phosphatase inhibit lymphocyte proliferation by an IFN-gamma- and nitric oxide-dependent mechanism. J Immunol. 2003;171:726-732.
26. Bogdan C. Nitric oxide and the immune response. Nat Immunol. 2001;2:907-916.
27. Howard JG. Increased sensitivity to bacterial endotoxin of F-1 hybrid mice undergoing graft-versus-host reaction. Nature. 1961;190:1122.
28. Katschinski T, Galanos C, Coumbos A, Freudenberg MA. Gamma interferon mediates Propionibacterium acnes-induced hypersensitivity to lipopolysaccharide in mice. Infect Immun. 1992;60:1994-2001.
29. Dinges MM, Schlievert PM. Role of T cells and gamma interferon during induction of hypersensitivity to lipopolysacchadde by toxic shock syndrome toxin 1 in mice. Infect Immun. 2001;69:1256-1264.
30. Read TE, Harris HW, Grunfeld C, et al. Chylomicrons enhance endotoxin secretion in bile. Infect Immun. 1993;61:3496-3502.
31. Ibarra-Sanchez MJ, Wagner J, Ong MT, Lampron C, Tremblay ML. Murine embryonic fibroblasts lacking TC-PTP display delayed G1 phase through defective NF-kappaB activation. Oncogene. 2001;20:4728-4739.
32. Cooke KR, Gerbitz A, Crawford JM, et al. LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation. J Clin Invest. 2001;107:1581-1589.
33. Cooke KR, Olkiewicz K, Erickson N, Ferrara JL. The role of endotoxin and the innate immune response in the pathophysiology of acute graft versus host disease. J Endotoxin Res. 2002;8:441-448.
34. Teshima T, Ordemann R, Reddy P, et al. Acute graft-versus-host disease does not require alloantigen expression on host epithelium. Nat Med. 2002;8:575-581.
35. Leonard WJ. Cytokines and immunodeficiency diseases. Nat Rev Immunol. 2001;1:200-208.
36. O'Shea JJ, Gadina M, Schreiber RD. Cytokine signaling in 2002: new surprises in the Jak/Stat pathway. Cell. 2002;109(suppl):S121-S131.
37. Okamura H, Tsutsi H, Komatsu T, et al. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature. 1995;378:88-91.
38. Dieli F, Sireci G, Russo D, et al. Resistance of natural killer T cell-deficient mice to systemic Shwartzman reaction. J Exp Med. 2000;192:1645-1652.
39. Ramarathinam L, Niesel DW, Klimpel GR. Salmonella typhimurium induces IFN-gamma production in murine splenocytes: role of natural killer cells and macrophages. J Immunol. 1993;150:3973-3981.
40. Alexander WS, Starr R, Fenner JE, et al. SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell. 1999;98:597-608.
41. Yasukawa H, Misawa H, Sakamoto H, et al. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 1999;18:1309-1320.
42. Starr R, Willson TA, Viney EM, et al. A family of cytokine-inducible inhibitors of signalling. Nature. 1997;387:917-921.
43. Wee C, Muise ES, Coquelet O, et al. Promoter analysis of the murine T-cell protein tyrosine phosphatase gene. Gene. 1999;237:351-360.
44. Elchebly M, Payette P, Michaliszyn E, et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science. 1999;283:1544-1548.
45. Johnson TO. Ermolieff J, Jirousek MR. Protein tyrosine phosphatase 1B inhibitors for diabetes. Nat Rev Drug Discov. 2002;1:696-709.