Protein tyrosine phosphatase nonreceptor type 2 regulates autophagosome formation in human intestinal cells

Inflammatory Bowel Diseases

Volumn 18, Issue 7, 2012, Pages 1287-1302

  Scharl, Michael ^a,b   Wojtal, Kacper A ^a   Becker, Helen M ^a   Fischbeck, Anne ^a   Frei, Pascal ^a   Arikkat, Joba ^a   Pesch, Theresa ^a   Kellermeier, Silvia ^a   Boone, David L ^c   Weber, Achim ^a   Loessner, Martin J ^d   Vavricka, Stephan R ^a,b,e   Fried, Michael ^a,b   McCole, Declan F ^f   Rogler, Gerhard ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF CHICAGO   (United States)

^d ETH ZURICH   (Switzerland)

^e TRIEMLI HOSPITAL   (Switzerland)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

ATG16L1; Autophagy; Crohn's disease; PTPN2

Indexed keywords

GAMMA INTERFERON; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; TUMOR NECROSIS FACTOR;

ADULT; AGED; APOPTOSIS; ARTICLE; ATG16L1 GENE; AUTOPHAGOSOME; CLINICAL ARTICLE; CONTROLLED STUDY; CROHN DISEASE; ENTERITIS; ENZYME REGULATION; FEMALE; GENE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; INTESTINE BIOPSY; INTESTINE EPITHELIUM CELL; LISTERIA MONOCYTOGENES; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS;

ADULT; AGED; AUTOPHAGY; CARRIER PROTEINS; CASE-CONTROL STUDIES; CELL COMMUNICATION; CELLS, CULTURED; COLON; CROHN DISEASE; CYTOKINES; FEMALE; FIBROBLASTS; HUMANS; IMMUNOENZYME TECHNIQUES; INTESTINES; LISTERIA MONOCYTOGENES; LISTERIOSIS; MALE; MICROSCOPY, FLUORESCENCE; MIDDLE AGED; MUCOUS MEMBRANE; PHOSPHORYLATION; PROGNOSIS; PROSPECTIVE STUDIES; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 2; RNA, SMALL INTERFERING; TOR SERINE-THREONINE KINASES;

EID: 84862194557     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21891     Document Type: Article

References (47)

1. Levine B, Deretic V. Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol. 2007;7:767-777. (Pubitemid 47480305)
2. Ohsumi Y. Molecular dissection of autophagy: two ubiquitin-like systems. Nat Rev Mol Cell Biol. 2001;2:211-216. (Pubitemid 33675746)
3. Mizushima N, Levine B, Cuervo AM, et al. Autophagy fights disease through cellular self-digestion. Nature. 2008;451:1069-1075. (Pubitemid 351317450)
4. Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell. 2008;132:27-42.
5. Birmingham CL, Canadien V, Gouin E, et al. Listeria monocytogenes evades killing by autophagy during colonization of host cells. Autophagy. 2007;3:442-451. (Pubitemid 47293725)
6. Travassos LH, Carneiro LA, Ramjeet M, et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol. 2010;11:55-62.
7. Cooney R, Baker J, Brain O, et al. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med. 2010;16:90-97.
8. Maiuri MC, Zalckvar E, Kimchi A, et al. Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat Rev Mol Cell Biol. 2007;8:741-752. (Pubitemid 47312826)
9. Jia L, Dourmashkin RR, Allen PD, et al. Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells. Br J Haematol. 1997;98:673-685. (Pubitemid 27386551)
10. Cheng Y, Qiu F, Tashiro S, et al. ERK and JNK mediate TNFalphainduced p53 activation in apoptotic and autophagic L929 cell death. Biochem Biophys Res Commun. 2008;376:483-488.
11. Ravikumar B, Vacher C, Berger Z, et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet. 2004;36:585-595. (Pubitemid 38715985)
12. Yu L, McPhee CK, Zheng L, et al. Termination of autophagy and reformation of lysosomes regulated by mTOR. Nature. 2010;465:942-946.
13. Hanada T, Noda NN, Satomi Y, et al. The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem. 2007;282:37298-37302.
14. Podolsky DK. Inflammatory bowel disease. N Engl J Med. 2002;347:417-429. (Pubitemid 34851835)
15. The Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 2007;447:661-678.
16. Hampe J, Franke A, Rosenstiel P, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet. 2007;39:207-211. (Pubitemid 46184351)
17. Rioux JD, Xavier RJ, Taylor KD, et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet. 2007;39:596-604. (Pubitemid 46676115)
18. Di Sabatino A, Ciccocioppo R, Luinetti O, et al. Increased enterocyte apoptosis in inflamed areas of Crohn's disease. Dis Colon Rectum. 2003;46:1498-1507. (Pubitemid 37429731)
19. Gitter AH, Bendfeldt K, Schulzke JD, et al. Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis. FASEB J. 2000;14:1749-1753.
20. Abreu-Martin MT, Vidrich A, Lynch DH, et al. Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNFalpha and ligation of Fas antigen. J Immunol. 1995;155:4147-4154.
21. Fuss IJ, Neurath M, Boirivant M, et al. Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5. J Immunol. 1996;157:1261-1270. (Pubitemid 126449643)
22. Reinecker HC, Steffen M, Witthoeft T, et al. Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. Clin Exp Immunol. 1993;94:174-181. (Pubitemid 23308385)
23. Tiganis T, Bennett AM, Ravichandran KS, et al. Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase. Mol Cell Biol. 1998;18:1622-1634. (Pubitemid 28100928)
24. Scharl M, Rudenko I, McCole DF. Loss of protein tyrosine phosphatase N2 potentiates epidermal growth factor suppression of intestinal epithelial chloride secretion. Am J Physiol Gastrointest Liver Physiol. 2010;299:G935-945.
25. Scharl M, Paul G, Weber A, et al. Protection of epithelial barrier function by the Crohn's disease associated gene protein tyrosine phosphatase n2. Gastroenterology. 2009;137:2030-2040 e2035.
26. Scharl M, McCole DF, Weber A, et al. Protein tyrosine phosphatase N2 regulates TNFalpha-induced signalling and cytokine secretion in human intestinal epithelial cells. Gut. 2011;60:189-197.
27. You-Ten KE, Muise ES, Itie A, et al. Impaired bone marrow microenvironment and immune function in T cell protein tyrosine phosphatase-deficient mice. J Exp Med. 1997;186:683-693. (Pubitemid 27381533)
28. Hassan SW, Doody KM, Hardy S, et al. Increased susceptibility to dextran sulfate sodium induced colitis in the T cell protein tyrosine phosphatase heterozygous mouse. PLoS One. 2010;5:e8868.
29. Dell'Era S, Buchrieser C, Couve E, et al. Listeria monocytogenes L-forms respond to cell wall deficiency by modifying gene expression and the mode of division. Mol Microbiol. 2009;73:306-322.
30. Galbaugh T, Cerrito MG, Jose CC, et al. EGF-induced activation of Akt results in mTOR-dependent p70S6 kinase phosphorylation and inhibition of HC11 cell lactogenic differentiation. BMC Cell Biol. 2006;7:34.
31. Klionsky DJ, Abeliovich H, Agostinis P, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008;4:151-175.
32. Fish SM, Proujansky R, Reenstra WW. Synergistic effects of interferon gamma and tumour necrosis factor alpha on T84 cell function. Gut. 1999;45:191-198. (Pubitemid 29333767)
33. Lippke JA, Gu, Y, Sarnecki C, et al. Identification and characterization of CPP32/Mch2 homolog 1, a novel cysteine protease similar to CPP32. J Biol Chem. 1996;271:1825-1828.
34. Fernandes-Alnemri T, Litwack G, Alnemri GS. CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem. 1994;269:30761-30764. (Pubitemid 24377553)
35. Noda T, Ohsumi Y. Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J Biol Chem. 1998;273:3963-3966. (Pubitemid 28103257)
36. Bjorkoy G, Lamark T, Brech A, et al. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin- induced cell death. J Cell Biol. 2005;171:603-614. (Pubitemid 41668720)
37. Cadwell K, Patel KK, Maloney NS, et al. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell. 2010;141:1135-1145.
38. Cadwell K, Liu JY, Brown SL, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature. 2008;456:259-263.
39. Singh SB, Davis AS, Taylor GA, et al. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science. 2006;313:1438-1441. (Pubitemid 44360272)
40. Saitoh TN, Fujita M, Jang H, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature. 2008;456:264-268.
41. Eisenberger-Lerner A, Bialik S, Simon HU, et al. Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ. 2009;16:966-975.
42. Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene. 2004;23:2891-2906. (Pubitemid 38638851)
43. Yousefi S, Perozzo R, Schmid I, et al. Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis. Nat Cell Biol. 2006;8:1124-1132. (Pubitemid 44473608)
44. Cadwell K, Patel KK, Komatsu M, et al. A common role for Atg16L1, Atg5, and Atg7 in small intestinal Paneth cells and Crohn's disease. Autophagy. 2009;5:250-252.
45. Iwamoto M, Koji T, Makiyama K, et al. Apoptosis of crypt epithelial cells in ulcerative colitis. J Pathol. 1996;180:152-159. (Pubitemid 26370180)
46. Bruewer M, Luegering A, Kucharzik T, et al. Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol. 2003;171:6164-6172. (Pubitemid 37467239)
47. Moore F, Colli ML, Cnop M, et al. PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis. Diabetes. 2009;58:1283-1291.