-
1
-
-
34848850085
-
The genetics of inflammatory bowel disease
-
Cho JH, Weaver CT. The genetics of inflammatory bowel disease. Gastroenterology 2007;133:1327-39.
-
(2007)
Gastroenterology
, vol.133
, pp. 1327-1339
-
-
Cho, J.H.1
Weaver, C.T.2
-
2
-
-
34547176642
-
Unravelling the pathogenesis of inflammatory bowel disease
-
Xavier RJ, Podolsky DK. Unravelling the pathogenesis of inflammatory bowel disease. Nature 2007;448:427-34.
-
(2007)
Nature
, vol.448
, pp. 427-434
-
-
Xavier, R.J.1
Podolsky, D.K.2
-
3
-
-
33745775434
-
Mechanisms of disease: Pathogenesis of Crohn's disease and ulcerative colitis
-
Sartor RB. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 2006;3:390-407.
-
(2006)
Nat Clin Pract Gastroenterol Hepatol
, vol.3
, pp. 390-407
-
-
Sartor, R.B.1
-
4
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
-
Ogura Y, Bonen DK, Inohara N et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001;411:603-6.
-
(2001)
Nature
, vol.411
, pp. 603-606
-
-
Ogura, Y.1
Bonen, D.K.2
Inohara, N.3
-
5
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot JP, Chamaillard M, Zouali H et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001;411:599-603.
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
Chamaillard, M.2
Zouali, H.3
-
6
-
-
33845340501
-
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
-
Duerr RH, Taylor KD, Brant SR et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006;314:1461-3.
-
(2006)
Science
, vol.314
, pp. 1461-1463
-
-
Duerr, R.H.1
Taylor, K.D.2
Brant, S.R.3
-
7
-
-
34247554965
-
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
-
Rioux JD, Xavier RJ, Taylor KD et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet 2007;39:596-604.
-
(2007)
Nat Genet
, vol.39
, pp. 596-604
-
-
Rioux, J.D.1
Xavier, R.J.2
Taylor, K.D.3
-
8
-
-
33846627302
-
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
-
Hampe J, Franke A, Rosenstiel P et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 2007;39:207-11.
-
(2007)
Nat Genet
, vol.39
, pp. 207-211
-
-
Hampe, J.1
Franke, A.2
Rosenstiel, P.3
-
9
-
-
37249034766
-
Systematic association mapping identifies NELL1 as a novel IBD disease gene
-
Franke A, Hampe J, Rosenstiel P et al. Systematic association mapping identifies NELL1 as a novel IBD disease gene. PLoS ONE 2007;2:e691.
-
(2007)
PLoS ONE
, vol.2
-
-
Franke, A.1
Hampe, J.2
Rosenstiel, P.3
-
10
-
-
34347338690
-
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
-
Parkes M, Barrett JC, Prescott NJ et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 2007;39:830-2.
-
(2007)
Nat Genet
, vol.39
, pp. 830-832
-
-
Parkes, M.1
Barrett, J.C.2
Prescott, N.J.3
-
11
-
-
84969213492
-
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
-
Wellcome Trust Case Control Consortium
-
Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661-78.
-
(2007)
Nature
, vol.447
, pp. 661-678
-
-
-
12
-
-
33846036986
-
IL-23: A master regulator in Crohn disease
-
Neurath MF. IL-23: a master regulator in Crohn disease. Nat Med 2007;13:26-8.
-
(2007)
Nat Med
, vol.13
, pp. 26-28
-
-
Neurath, M.F.1
-
13
-
-
42449084096
-
Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): Upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD
-
Seiderer J, Elben I, Diegelmann J et al. Role of the novel Th17 cytokine IL-17F in inflammatory bowel disease (IBD): upregulated colonic IL-17F expression in active Crohn's disease and analysis of the IL17F p.His161Arg polymorphism in IBD. Inflamm Bowel Dis 2008;14:437-45.
-
(2008)
Inflamm Bowel Dis
, vol.14
, pp. 437-445
-
-
Seiderer, J.1
Elben, I.2
Diegelmann, J.3
-
14
-
-
33645829078
-
IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration
-
Brand S, Beigel F, Olszak T et al. IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. Am J Physiol Gastrointest Liver Physiol 2006;290:G827-38.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Brand, S.1
Beigel, F.2
Olszak, T.3
-
15
-
-
39649121919
-
Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status
-
Schmechel S, Konrad A, Diegelmann J et al. Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status. Inflamm Bowel Dis 2008;14:204-12.
-
(2008)
Inflamm Bowel Dis
, vol.14
, pp. 204-212
-
-
Schmechel, S.1
Konrad, A.2
Diegelmann, J.3
-
16
-
-
61949124982
-
The novel IL-10 related cytokine IL-26 is increased in active inflammatory bowel disease and intestinal epithelial cells express the functional IL-26 receptor complex (abstract)
-
Dambacher J, Beigel F, Golluscio R et al. The novel IL-10 related cytokine IL-26 is increased in active inflammatory bowel disease and intestinal epithelial cells express the functional IL-26 receptor complex (abstract). Gastroenterology 2006;130:A696.
-
(2006)
Gastroenterology
, vol.130
-
-
Dambacher, J.1
Beigel, F.2
Golluscio, R.3
-
17
-
-
33645005339
-
Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells
-
Brand S, Olszak T, Beigel F et al. Cell differentiation dependent expressed CCR6 mediates ERK-1/2, SAPK/JNK, and Akt signaling resulting in proliferation and migration of colorectal cancer cells. J Cell Biochem 2006;97:709-23.
-
(2006)
J Cell Biochem
, vol.97
, pp. 709-723
-
-
Brand, S.1
Olszak, T.2
Beigel, F.3
-
18
-
-
68849124464
-
-
Dambacher J, Beigel F, Zitzmann K et al. The role of the novel Th17 cytokine IL-26 in intestinal inflammation. Gut 2008 May 15 [Epub ahead of print]. doi:10.1136/gut.2007.130112.
-
Dambacher J, Beigel F, Zitzmann K et al. The role of the novel Th17 cytokine IL-26 in intestinal inflammation. Gut 2008 May 15 [Epub ahead of print]. doi:10.1136/gut.2007.130112.
-
-
-
-
19
-
-
34548163868
-
Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene
-
Cummings JR, Cooney R, Pathan S et al. Confirmation of the role of ATG16L1 as a Crohn's disease susceptibility gene. Inflamm Bowel Dis 2007;13:941-6.
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 941-946
-
-
Cummings, J.R.1
Cooney, R.2
Pathan, S.3
-
20
-
-
34247566585
-
A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5
-
Prescott NJ, Fisher SA, Franke A et al. A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5. Gastroenterology 2007;132:1665-71.
-
(2007)
Gastroenterology
, vol.132
, pp. 1665-1671
-
-
Prescott, N.J.1
Fisher, S.A.2
Franke, A.3
-
21
-
-
40949112379
-
The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population
-
Glas J, Konrad A, Schmechel S et al. The ATG16L1 gene variants rs2241879 and rs2241880 (T300A) are strongly associated with susceptibility to Crohn's disease in the German population. Am J Gastroenterol 2008;103:682-91.
-
(2008)
Am J Gastroenterol
, vol.103
, pp. 682-691
-
-
Glas, J.1
Konrad, A.2
Schmechel, S.3
-
22
-
-
33746885455
-
Neutrophils from p40phox-/-mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing
-
Ellson CD, Davidson K, Ferguson GJ et al. Neutrophils from p40phox-/-mice exhibit severe defects in NADPH oxidase regulation and oxidant-dependent bacterial killing. J Exp Med 2006;203:1927-37.
-
(2006)
J Exp Med
, vol.203
, pp. 1927-1937
-
-
Ellson, C.D.1
Davidson, K.2
Ferguson, G.J.3
-
23
-
-
18244375249
-
Egr-2 and Egr-3 are negative regulators of T cell activation
-
Safford M, Collins S, Lutz MA et al. Egr-2 and Egr-3 are negative regulators of T cell activation. Nat Immunol 2005;6:472-80.
-
(2005)
Nat Immunol
, vol.6
, pp. 472-480
-
-
Safford, M.1
Collins, S.2
Lutz, M.A.3
-
24
-
-
34547195800
-
Transcriptional regulation of TLX2 and impaired intestinal innervation: Possible role of the PHOX2A and PHOX2B genes
-
Borghini S, Di Duca M, Santamaria G et al. Transcriptional regulation of TLX2 and impaired intestinal innervation: possible role of the PHOX2A and PHOX2B genes. Eur J Hum Genet 2007;15:848-55.
-
(2007)
Eur J Hum Genet
, vol.15
, pp. 848-855
-
-
Borghini, S.1
Di Duca, M.2
Santamaria, G.3
-
25
-
-
27444436558
-
A novel 17 bp deletion in the PHOX2B gene causes congenital central hypoventilation syndrome with total aganglionosis of the small and large intestine
-
Holzinger A, Mittal RA, Kachel W et al. A novel 17 bp deletion in the PHOX2B gene causes congenital central hypoventilation syndrome with total aganglionosis of the small and large intestine. Am J Med Genet A 2005;139:50-1.
-
(2005)
Am J Med Genet A
, vol.139
, pp. 50-51
-
-
Holzinger, A.1
Mittal, R.A.2
Kachel, W.3
-
26
-
-
0033609337
-
The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
-
Pattyn A, Morin X, Cremer H et al. The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. Nature 1999;399:366-70.
-
(1999)
Nature
, vol.399
, pp. 366-370
-
-
Pattyn, A.1
Morin, X.2
Cremer, H.3
-
27
-
-
0024810567
-
Classification of inflammatory bowel disease
-
discussion 16-9
-
Lennard-Jones JE. Classification of inflammatory bowel disease. Scand J Gastroenterol Suppl 1989;170:2-6; discussion 16-9.
-
(1989)
Scand J Gastroenterol Suppl
, vol.170
, pp. 2-6
-
-
Lennard-Jones, J.E.1
-
28
-
-
84894353884
-
-
Silverberg MS, S atsangi J, Ahmad T et al. Toward an integrated clinical, molecular and serological classiffication of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 2005;19 (Suppl A):5-36.
-
Silverberg MS, S atsangi J, Ahmad T et al. Toward an integrated clinical, molecular and serological classiffication of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Can J Gastroenterol 2005;19 (Suppl A):5-36.
-
-
-
-
29
-
-
39649106413
-
rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: Combined analysis of IL23R, CARD15, and OCTN1/2 variants
-
Glas J, Seiderer J, Wetzke M et al. rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants. PLoS ONE 2007;2:e819.
-
(2007)
PLoS ONE
, vol.2
-
-
Glas, J.1
Seiderer, J.2
Wetzke, M.3
-
30
-
-
33748654515
-
Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral E stulas, and frequent need for surgical intervention with high risk of re-stenosis
-
Seiderer J, Schnitzler F, Brand S et al. Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral E stulas, and frequent need for surgical intervention with high risk of re-stenosis. Scand J Gastroenterol 2006;41:1421-32.
-
(2006)
Scand J Gastroenterol
, vol.41
, pp. 1421-1432
-
-
Seiderer, J.1
Schnitzler, F.2
Brand, S.3
-
31
-
-
33751561942
-
Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: Results of a prospective study
-
Seiderer J, Brand S, Herrmann KA et al. Predictive value of the CARD15 variant 1007fs for the diagnosis of intestinal stenoses and the need for surgery in Crohn's disease in clinical practice: results of a prospective study. Inflamm Bowel Dis 2006;12:1114-21.
-
(2006)
Inflamm Bowel Dis
, vol.12
, pp. 1114-1121
-
-
Seiderer, J.1
Brand, S.2
Herrmann, K.A.3
-
32
-
-
33645457756
-
Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease
-
Schnitzler F, Brand S, Staudinger T et al. Eight novel CARD15 variants detected by DNA sequence analysis of the CARD15 gene in 111 patients with inflammatory bowel disease. Immunogenetics 2006;58:99-106.
-
(2006)
Immunogenetics
, vol.58
, pp. 99-106
-
-
Schnitzler, F.1
Brand, S.2
Staudinger, T.3
-
33
-
-
22044432709
-
The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease
-
Brand S, Staudinger T, Schnitzler F et al. The role of Toll-like receptor 4 Asp299Gly and Thr399Ile polymorphisms and CARD15/NOD2 mutations in the susceptibility and phenotype of Crohn's disease. Inflamm Bowel Dis 2005;11:645-52.
-
(2005)
Inflamm Bowel Dis
, vol.11
, pp. 645-652
-
-
Brand, S.1
Staudinger, T.2
Schnitzler, F.3
-
34
-
-
12244297799
-
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
-
Niess JH, Brand S, Gu X et al. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 2005;307:254-8.
-
(2005)
Science
, vol.307
, pp. 254-258
-
-
Niess, J.H.1
Brand, S.2
Gu, X.3
-
35
-
-
33644862062
-
Increased expression of the chemokine fractalkine in Crohn's disease and association of the fractalkine receptor T280 M polymorphism with a fibrostenosing disease phenotype
-
Brand S, Hofbauer K, Dambacher J et al. Increased expression of the chemokine fractalkine in Crohn's disease and association of the fractalkine receptor T280 M polymorphism with a fibrostenosing disease phenotype. Am J Gastroenterol 2006;101:99-106.
-
(2006)
Am J Gastroenterol
, vol.101
, pp. 99-106
-
-
Brand, S.1
Hofbauer, K.2
Dambacher, J.3
-
36
-
-
0141835046
-
Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells
-
Becker C, Wirtz S, Blessing M et al. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest 2003;112:693-706.
-
(2003)
J Clin Invest
, vol.112
, pp. 693-706
-
-
Becker, C.1
Wirtz, S.2
Blessing, M.3
-
37
-
-
21344449654
-
Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease
-
Török HP, Glas J, Tonenchi L et al. Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease. Gut 2005;54:1421-7.
-
(2005)
Gut
, vol.54
, pp. 1421-1427
-
-
Török, H.P.1
Glas, J.2
Tonenchi, L.3
-
38
-
-
33846171221
-
Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease
-
Dambacher J, Staudinger T, Seiderer J et al. Macrophage migration inhibitory factor (MIF) -173G/C promoter polymorphism influences upper gastrointestinal tract involvement and disease activity in patients with Crohn's disease. Inflamm Bowel Dis 2007;13:71-82.
-
(2007)
Inflamm Bowel Dis
, vol.13
, pp. 71-82
-
-
Dambacher, J.1
Staudinger, T.2
Seiderer, J.3
-
39
-
-
40849100426
-
Genotype-phenotype analysis of the CXCL16 p.Ala181Val polymorphism in inflammatory bowel disease
-
Seiderer J, Dambacher J, Leistner D et al. Genotype-phenotype analysis of the CXCL16 p.Ala181Val polymorphism in inflammatory bowel disease. Clin Immunol 2008;127:49-55.
-
(2008)
Clin Immunol
, vol.127
, pp. 49-55
-
-
Seiderer, J.1
Dambacher, J.2
Leistner, D.3
-
40
-
-
48349136889
-
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
-
Barrett JC, Hansoul S, Nicolae DL et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008;40:955-62.
-
(2008)
Nat Genet
, vol.40
, pp. 955-962
-
-
Barrett, J.C.1
Hansoul, S.2
Nicolae, D.L.3
-
41
-
-
34247579326
-
Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4
-
Libioulle C, Louis E, Hansoul S et al. Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet 2007;3:e58.
-
(2007)
PLoS Genet
, vol.3
-
-
Libioulle, C.1
Louis, E.2
Hansoul, S.3
-
42
-
-
51249103405
-
Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort
-
Roberts RL, Hollis-Moffatt JE, Gearry RB et al. Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort. Genes Immun 2008;9:561-5.
-
(2008)
Genes Immun
, vol.9
, pp. 561-565
-
-
Roberts, R.L.1
Hollis-Moffatt, J.E.2
Gearry, R.B.3
-
43
-
-
2442519456
-
Genetic variation in DLG5 is associated with inflammatory bowel disease
-
Stoll M, Corneliussen B, Costello CM et al. Genetic variation in DLG5 is associated with inflammatory bowel disease. Nat Genet 2004;36:476-80.
-
(2004)
Nat Genet
, vol.36
, pp. 476-480
-
-
Stoll, M.1
Corneliussen, B.2
Costello, C.M.3
-
44
-
-
38349113447
-
Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts
-
Browning BL, Annese V, Barclay ML et al. Gender-stratified analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian cohorts. J Med Genet 2008;45:36-42.
-
(2008)
J Med Genet
, vol.45
, pp. 36-42
-
-
Browning, B.L.1
Annese, V.2
Barclay, M.L.3
-
45
-
-
34347357508
-
Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients
-
Yamazaki K, Onouchi Y, Takazoe M et al. Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. J Hum Genet 2007;52:575-83.
-
(2007)
J Hum Genet
, vol.52
, pp. 575-583
-
-
Yamazaki, K.1
Onouchi, Y.2
Takazoe, M.3
-
46
-
-
0036306951
-
Lack of common NOD2 variants in Japanese patients with Crohn's disease
-
Inoue N, Tamura K, Kinouchi Y et al. Lack of common NOD2 variants in Japanese patients with Crohn's disease. Gastroenterology 2002;123:86-91.
-
(2002)
Gastroenterology
, vol.123
, pp. 86-91
-
-
Inoue, N.1
Tamura, K.2
Kinouchi, Y.3
|