Immuno-inhibitory PD-L1 can be induced by a Peptidoglycan/NOD2 mediated pathway in primary monocytic cells and is deficient in Crohn's patients with homozygous NOD2 mutations.

Clinical Immunology

Volumn 143, Issue 2, 2012, Pages 162-169

  Hewitt, Rachel E ^a   Pele, Laetitia C ^a   Tremelling, Mark ^b   Metz, Andrew ^b   Parkes, Miles ^b   Powell, Jonathan J ^a  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

CD14; Crohn's disease; NOD2; PD L1; Peptidoglycan; TLR2

Indexed keywords

B7 ANTIGEN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CD14 ANTIGEN; CD86 ANTIGEN; LIPOPOLYSACCHARIDE; MURAMYL DIPEPTIDE; PD L1 PROTEIN; PEPTIDOGLYCAN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CD8+ T LYMPHOCYTE; CELL SURFACE; CONTROLLED STUDY; CROHN DISEASE; FEMALE; FRAMESHIFT MUTATION; GENE MUTATION; HUMAN; IMMUNOLOGICAL TOLERANCE; MALE; MONOCYTE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; WILD TYPE;

ANTIGENS, CD274; CROHN DISEASE; ESCHERICHIA COLI; FEMALE; GENE EXPRESSION; HUMANS; LIPOPOLYSACCHARIDES; MALE; MONOCYTES; MUTATION; NOD2 SIGNALING ADAPTOR PROTEIN; PEPTIDOGLYCAN; STAPHYLOCOCCUS AUREUS;

EID: 84859778181     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2012.01.016     Document Type: Article

References (43)

1. Chamaillard M., Hashimoto M., Horie Y., Masumoto J., Qiu S., Saab L., et al. An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat. Immunol. Jul 2003, 4(7):702-707.
2. Girardin S.E., Boneca I.G., Carneiro L.A., Antignac A., Jehanno M., Viala J., et al. Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan. Science 2003, 300(5625):1584-1587.
3. Girardin S.E., Boneca I.G., Viala J., Chamaillard M., Labigne A., Thomas G., et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 2003, 278(11):8869-8872.
4. Inohara N., Ogura Y., Fontalba A., Gutierrez O., Pons F., Crespo J., et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J. Biol. Chem. 2003, 278(8):5509-5512.
5. Hedl M., Li J., Cho J.H., Abraham C. Chronic stimulation of Nod2 mediates tolerance to bacterial products. Proc. Natl. Acad. Sci. U. S. A. 2007, 104(49):19440-19445.
6. Yang Z., Fuss I.J., Watanabe T., Asano N., Davey M.P., Rosenbaum J.T., et al. NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction. Gastroenterology Nov 2007, 133(5):1510-1521.
7. Chau T.A., McCully M.L., Brintnell W., An G., Kasper K.J., Vines E.D., et al. Tolllike receptor 2 ligands on the staphylococcal cell wall downregulate superantigen-induced T cell activation and prevent toxic shock syndrome. Nat. Med. Jun 2009, 15(6):641-648.
8. Du Z., Kelly E., Mecklenbrauker I., Agle L., Herrero C., Paik P., et al. Selective regulation of IL-10 signaling and function by zymosan. J. Immunol. 2006, 176(8):4785-4792.
9. Smythies L.E., Sellers M., Clements R.H., Mosteller-Barnum M., Meng G., Benjamin W.H., et al. Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity. J. Clin. Invest. Jan 2005, 115(1):66-75.
10. Watanabe T., Asano N., Murray P.J., Ozato K., Tailor P., Fuss I.J., et al. Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J. Clin. Invest. Feb 2008, 118(2):545-559.
11. Reynoso E.D., Elpek K.G., Francisco L., Bronson R., Bellemare-Pelletier A., Sharpe A.H., et al. Intestinal tolerance is converted to autoimmune enteritis upon PD-1 ligand blockade. J. Immunol. 2009, 182(4):2102-2112.
12. Yamazaki T., Akiba H., Iwai H., Matsuda H., Aoki M., Tanno Y., et al. Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 2002, 169(10):5538-5545.
13. Liu J., Hamrouni A., Wolowiec D., Coiteux V., Kuliczkowski K., Hetuin D., et al. Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway. Blood 2007, 110(1):296-304.
14. Evans S.M., Ashwood P., Warley A., Berisha F., Thompson R.P., Powell J.J. The role of dietary microparticles and calcium in apoptosis and interleukin-1beta release of intestinal macrophages. Gastroenterology Nov 2002, 123(5):1543-1553.
15. Uray I.P., Connelly J.H., Thomazy V., Shipley G.L., Vaughn W.K., Frazier O.H., et al. Left ventricular unloading alters receptor tyrosine kinase expression in the failing human heart. J. Heart Lung Transplant. Jul 2002, 21(7):771-782.
16. Wolf K., Schulz C., Riegger G.A., Pfeifer M. Tumour necrosis factor-alpha induced CD70 and interleukin-7R mRNA expression in BEAS-2B cells. Eur. Respir. J. Aug 2002, 20(2):369-375.
17. Rushworth S.A., Ogborne R.M., Charalambos C.A., O'Connell M.A. Role of protein kinase C delta in curcumin-induced antioxidant response elementmediated gene expression in human monocytes. Biochem. Biophys. Res. Commun. 2006, 341(4):1007-1016.
18. Carreno B.M., Collins M. The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu. Rev. Immunol. 2002, 20:29-53.
19. Chambers C.A. The expanding world of co-stimulation: the two-signal model revisited. Trends Immunol. Apr 2001, 22(4):217-223.
20. Pulko V., Liu X., Krco C.J., Harris K.J., Frigola X., Kwon E.D., et al. TLR3-stimulated dendritic cells up-regulate B7-H1 expression and influence the magnitude of CD8 T cell responses to tumor vaccination. J. Immunol. 2009, 183(6):3634-3641.
21. Travassos L.H., Girardin S.E., Philpott D.J., Blanot D., Nahori M.A., Werts C., et al. Toll-like receptor 2-dependent bacterial sensing does not occur via peptidoglycan recognition. EMBO Rep. Oct 2004, 5(10):1000-1006.
22. Martinon F., Agostini L., Meylan E., Tschopp J. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr. Biol. 2004, 14(21):1929-1934.
23. Hsu L.C., Ali S.R., McGillivray S., Tseng P.H., Mariathasan S., Humke E.W., et al. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc. Natl. Acad. Sci. U. S. A. 2008, 105(22):7803-7808.
24. Papadimitraki E.D., Bertsias G.K., Boumpas D.T. Toll like receptors and autoimmunity: a critical appraisal. J. Autoimmun. Dec 2007, 29(4):310-318.
25. Round J.L., O'Connell R.M., Mazmanian S.K. Coordination of tolerogenic immune responses by the commensal microbiota. J. Autoimmun. 2010 May, 34(3):J220-J225.
26. Dinesh R.K., Hahn B.H., Singh R.P. PD-1, gender, and autoimmunity. Autoimmun. Rev. 2010 Jun, 9(8):583-587.
27. Keir M.E., Butte M.J., Freeman G.J., Sharpe A.H. PD-1 and its ligands in tolerance and immunity. Annu. Rev. Immunol. 2008, 26:677-704.
28. Dziarski R., Gupta D. Staphylococcus aureus peptidoglycan is a toll-like receptor 2 activator: a reevaluation. Infect. Immun. Aug 2005, 73(8):5212-5216.
29. Asong J., Wolfert M.A., Maiti K.K., Miller D., Boons G.J. Binding and Cellular Activation Studies Reveal That Toll-like Receptor 2 Can Differentially Recognize Peptidoglycan from Gram-positive and Gram-negative Bacteria. J. Biol. Chem. 2009, 284(13):8643-8653.
30. Iyer J.K., Coggeshall K.M. Cutting edge: primary innate immune cells respond efficiently to polymeric peptidoglycan, but not to peptidoglycan monomers. J. Immunol. 2011 Apr 1, 186(7):3841-3845.
31. Herskovits A.A., Auerbuch V., Portnoy D.A. Bacterial ligands generated in a phagosome are targets of the cytosolic innate immune system. PLoS Pathog. Mar 2007, 3(3):e51.
32. Pandey A.K., Yang Y., Jiang Z., Fortune S.M., Coulombe F., Behr M.A., et al. NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis. PLoS Pathog. Jul 2009, 5(7):e1000500.
33. Schreiner B., Mitsdoerffer M., Kieseier B.C., Chen L., Hartung H.P., Weller M., et al. Interferon-beta enhances monocyte and dendritic cell expression of B7-H1 (PD-L1), a strong inhibitor of autologous T-cell activation: relevance for the immune modulatory effect in multiple sclerosis. J. Neuroimmunol. Oct 2004, 155(1-2):172-182.
34. D'Souza M., et al. Programmed death 1 expression on HIV-specific CD4+ T cells is driven by viral replication and associated with T cell dysfunction. J Immunol. 2007, 179:1979-1987.
35. Zhang J.Y., et al. PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors. Blood. 2007, 109:4671-4678.
36. Said E.A., et al. Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat Med. 2010, 16:452-459.
37. Becker C., et al. Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cells. J Clin Invest. 2003, 112:693-706.
38. Klasen I.S., et al. The presence of peptidoglycan-polysaccharide complexes in the bowel wall and the cellular responses to these complexes in Crohn's disease. Clin Immunol Immunopathol. 1994, 71:303-308.
39. Macpherson A.J., et al. Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol. 2004, 4:478-485.
40. Carambia A., et al. CD4 T cells in hepatic immune tolerance. J Autoimmun. 2010, 34:23-28.
41. Tiegs G., et al. Immune tolerance: what is unique about the liver. J Autoimmun. 2010, 34:1-6.
42. Castellaneta A., et al. NOD2 ligation subverts IFN-alpha production by liver plasmacytoid dendritic cells and inhibits their T Cell Allostimulatory activity via B7-H1 up-regulation. J Immunol. 2009, 183:6922-6932.
43. Wolfle S.J., et al. PD-L1 expression on tolerogenic APCs is controlled by STAT-3. Eur J Immunol. 2011, 41:413-424.