Human IRGM induces autophagy to eliminate intracellular mycobacteria

Science

Volumn 313, Issue 5792, 2006, Pages 1438-1441

  Singh, Sudha B ^a   Davis, Alexander S ^a   Taylor, Gregory A ^b,c   Deretic, Vojo ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DURHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIOLOGY; IMMUNOLOGY; PROTEINS;

AUTOPHAGY; IMMUNITY-RELATED P47 GUANOSINE TRIPHOSPHATASES (IRG); MYCOBACTERIUM TUBERCULOSIS;

ENZYME KINETICS;

GUANOSINE TRIPHOSPHATASE; PROTEIN P47;

BACTERIUM; DEFENSE MECHANISM; PATHOGEN; PROTEIN;

ANIMAL CELL; ARTICLE; AUTOPHAGY; BACTERIAL SURVIVAL; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNITY; IMMUNOBLOTTING; LYSOSOME; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; AUTOPHAGY; CELL LINE; CYTOSOL; GTP-BINDING PROTEINS; HELA CELLS; HUMANS; INTERFERON TYPE II; LYSOSOMES; MACROPHAGES; MICE; MICROBIAL VIABILITY; MICROTUBULE-ASSOCIATED PROTEINS; MYCOBACTERIUM BOVIS; PHAGOSOMES; RNA, SMALL INTERFERING; TRANSFECTION; VACUOLES;

CORYNEBACTERINEAE; MURINAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 33748506089     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1129577     Document Type: Article

References (24)

1. C. Bekpen et al., Genome Biol. 6, R92 (2005).
2. G. A. Taylor, C. G. Feng, A. Sher, Nat. Rev. Immunol. 4, 100 (2004).
3. J. D. MacMicking, Curr. Opin. Microbiol. 8, 74 (2005).
4. J. D. MacMicking, G. A. Taylor, J. D. McKinney, Science 302, 654 (2003).
5. S. Martens et al., PLoS Pathog. 1, e24 (2005).
6. C. G. Feng et al., J. Immunol. 172, 1163 (2004).
7. M. G. Gutierrez et al., Cell 119, 753 (2004).
8. T. Shintani, D. J. Klionsky, Science 306, 990 (2004).
9. I. Nakagawa et al., Science 306, 1037 (2004).
10. M. Ogawa et al., Science 307, 727 (2005).
11. C. Paludan et al., Science 307, 593 (2005).
12. C. L. Birmingham, A. C. Smith, M. A. Bakowski, T. Yoshimori, J. H. Brumell, J. Biol. Chem. 281, 11374 (2006).
13. V. Deretic, Trends Immunol. 26, 523 (2005).
14. B. Levine, Cell 120, 159 (2005).
15. V. Deretic, Ed. Autophagy in Immunity and Infection (Wiley-VCH, Weinheim, Germany, 2006).
16. Y. Liu et al., Cell 121, 567 (2005).
17. S. P. Elmore, T. Qian, S. F. Grissom, J. J. Lemasters, FASEB J. 15, 2286 (2001).
18. P. O. Seglen, P. B. Gordon, I. Holen, Semin. Cell Biol. 1, 441 (1990).
19. Y. Kabeya et al., EMBO J. 19, 5720 (2000).
20. X. H. Liang et al., Nature 402, 672 (1999).
21. A. Kihara, Y. Kabeya, Y. Ohsumi, T. Yoshimori, EMBO Rep. 2, 330 (2001).
22. N. Furuya, J. Yu, M. Byfield, S. Pattingre, B. Levine, Autophagy 1, 46 (2005).
23. X. Zeng, J. H. Overmeyer, W. A. Maltese, J. Cell Sci. 119, 259 (2006).
24. We thank T. Ueno and E. Kominami for the LC3 antibody, E. Roberts for experimental input, and G. Timmins for comments. This work was supported by grants from the National Institute of Allergy and Infectious Diseases (AI57831 to G.A.T.; AI45148 and AI42999 to V.D.).