Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy

Inflammatory Bowel Diseases

Volumn 18, Issue 5, 2012, Pages 900-912

  Scharl, Michael ^a,b   Mwinyi, Jessica ^a   Fischbeck, Anne ^a   Leucht, Katharina ^a   Eloranta, Jyrki J ^a,b   Arikkat, Joba ^a   Pesch, Theresa ^a   Kellermeier, Silvia ^a   Mair, Alma ^a   Kullak Ublick, Gerd A ^a,b   Truninger, Kaspar ^c,d   Noreen, Faiza ^d   Regula, Jaroslaw ^e   Gaj, Pawel ^e   Pittet, Valerie ^f   Mueller, Christoph ^g   Hofmann, Claudia ^h   Fried, Michael ^a,b   McCole, Declan F ⁱ   Rogler, Gerhard ^a,b  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c Spital Region Oberaargau   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

^e INSTITUTE OF ONCOLOGY   (Poland)

^f UNIVERSITY OF LAUSANNE   (Switzerland)

^g UNIVERSITY OF BERN   (Switzerland)

^h UNIVERSITY HOSPITAL REGENSBURG   (Germany)

ⁱ UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Crohn's disease; Cytokine secretion; NOD2; PTPN2 polymorphism

Indexed keywords

BACTERIAL ANTIGEN; CASPASE RECRUITMENT DOMAIN PROTEIN 15; GAMMA INTERFERON; INTERLEUKIN 8; LENTIVIRUS VECTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MURAMYL DIPEPTIDE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; TRANSCRIPTION FACTOR T BET; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BACTERIAL CELL WALL; COHORT ANALYSIS; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE RELEASE; DNA POLYMORPHISM; FEMALE; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; HUMAN TISSUE; IMMUNOREGULATION; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; INTESTINE EPITHELIUM CELL; INTRON; MAJOR CLINICAL STUDY; MALE; MONOCYTE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; ULCERATIVE COLITIS;

ACETYLMURAMYL-ALANYL-ISOGLUTAMINE; ADJUVANTS, IMMUNOLOGIC; ADULT; AUTOPHAGY; BLOTTING, WESTERN; CASE-CONTROL STUDIES; CELLS, CULTURED; COHORT STUDIES; COLON; CROHN DISEASE; CYTOKINES; DNA; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENOTYPE; HAPLOTYPES; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; INTERFERON-GAMMA; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; MONOCYTES; NOD2 SIGNALING ADAPTOR PROTEIN; PHOSPHORYLATION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 2; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS; TUMOR MARKERS, BIOLOGICAL;

EID: 84858683881     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21913     Document Type: Article

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