Linking risk conferring mutations in NCF4 to functional consequences in Crohn's disease

Gut

Volumn 61, Issue 7, 2012, Pages 1097-

  Somasundaram, R ^a   Deuring, J J ^a   Van Der Woude, C J ^a   Peppelenbosch, M P ^a   Fuhler, Gwenny M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PROTEIN P40; PROTEIN P67; RAC2 PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE;

ALLELE; CROHN DISEASE; GENE; GENE FUNCTION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GRANULOCYTE; HUMAN; INTRACELLULAR SIGNALING; LETTER; NCF4 GENE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SYNTHESIS; RESPIRATORY BURST; SINGLE NUCLEOTIDE POLYMORPHISM;

CROHN DISEASE; GRANULOMATOUS DISEASE, CHRONIC; HUMANS; INFLAMMATORY BOWEL DISEASES; MUTATION, MISSENSE; NADPH OXIDASE; POLYMORPHISM, SINGLE NUCLEOTIDE; RAC GTP-BINDING PROTEINS;

EID: 84861572891     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2011-301344     Document Type: Letter

References (4)

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3. phox and selective defects I neutrophil NADPH oxidase activity. Blood 2009;114:3309-15.
4. Fuhler GM, Drayer AL, Vellenga E. Decreased phosphorylation of protein kinase B and extracellular signal-regulated kinase in neutrophils from patients with myelodysplasia. Blood 2003;101: 1172-80. (Pubitemid 36139393)