Immune Control of Tuberculosis by IFN-γ-inducible LRG-47

Science

Volumn 302, Issue 5645, 2003, Pages 654-659

  MacMicking, John D ^a   Taylor, Gregory A ^b,c   McKinney, John D ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c DURHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; CELLS; DISEASE CONTROL; DISEASES;

INTRACELLULAR PATHOGENS;

IMMUNOLOGY;

GAMMA INTERFERON; IGTP PROTEIN; INTERFERON GAMMA INDUCIBLE NITRIC OXIDE SYNTHASE 2; LRG 47 PROTEIN; NITRIC OXIDE SYNTHASE; P47 GUANOSINE TRIPHOSPHATASE IRG 47 PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

IMMUNITY; TUBERCULOSIS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL IMMUNITY; BACTERIAL REPRODUCTION; BACTERICIDAL ACTIVITY; BACTERIUM REPLICATION; CONTROLLED STUDY; IMMUNOREGULATION; MACROPHAGE; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; TUBERCULOSIS; TUBERCULOSIS CONTROL;

ANIMALS; CELLS, CULTURED; COMPUTATIONAL BIOLOGY; DISEASE SUSCEPTIBILITY; FEMALE; GTP PHOSPHOHYDROLASES; GTP-BINDING PROTEINS; HYDROGEN-ION CONCENTRATION; IMMUNITY, NATURAL; INTERFERON TYPE II; MACROPHAGE ACTIVATION; MACROPHAGES; MACROPHAGES, ALVEOLAR; MALE; MICE; MICE, INBRED C57BL; MUTATION; MYCOBACTERIUM TUBERCULOSIS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHAGOSOMES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TUBERCULOSIS;

ANIMALIA; BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 0142240338     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1088063     Document Type: Article

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34. We thank J. Belisle for provision of purified Mtb cell-wall components; R. Steinman for F4/80 anti-body; H. Shio for electron microscopy; D. McMurray for aerosol chamber instruction; P. Giannakis, D. Phelan, R. Rice, and A. Sousa for experimental assistance; and A. Francesconi, A. Muesch, C. Nathan, and members of the Section of Microbial Pathogenesis (Yale University School of Medicine) for helpful discussions. Supported by a Howard Hughes Medical Institute Fellowship of the Life Science Research Foundation (J.D.M.), Veterans Administration Merit Review Grant (G.A.T.), Ellison Medical Foundation, Sequella Global Tuberculosis Foundation, Sinsheimer Fund, Irma T. Hirschl Trust, and NIH RO1 A1051702 (J. D. McKinney).