메뉴 건너뛰기




Volumn 22, Issue 1, 2012, Pages 43-61

Autophagy: For better or for worse

Author keywords

Autophagosome; Autophagy; Cell death; Degradation; Vesicle

Indexed keywords

ANIMAL; APOPTOSIS; AUTOPHAGY; CELL AGING; CELL DIFFERENTIATION; CELL TRANSFORMATION; HUMAN; IMMUNITY; IMMUNOLOGY; INTRACELLULAR MEMBRANE; LYSOSOME; METABOLISM; PATHOLOGY; PHAGOSOME; REVIEW; SIGNAL TRANSDUCTION;

EID: 84855500993     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2011.152     Document Type: Review
Times cited : (396)

References (221)
  • 1
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy and metabolism
    • Rabinowitz JD, White E. Autophagy and metabolism. Science 2010; 330:1344-1348.
    • (2010) Science , vol.330 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 2
    • 4544385218 scopus 로고    scopus 로고
    • Autophagy: Many paths to the same end
    • DOI 10.1023/B:MCBI.0000041848.57020.57
    • Cuervo AM. Autophagy: many paths to the same end. Mol Cell Biochem 2004; 263:55-72. (Pubitemid 39256145)
    • (2004) Molecular and Cellular Biochemistry , vol.263 , Issue.1 , pp. 55-72
    • Cuervo, A.M.1
  • 3
    • 79951833039 scopus 로고    scopus 로고
    • Chaperonemediated autophagy at a glance
    • Kaushik S, Bandyopadhyay U, Sridhar S, et al. Chaperonemediated autophagy at a glance. J Cell Sci 2011; 124:495-499.
    • (2011) J Cell Sci , vol.124 , pp. 495-499
    • Kaushik, S.1    Bandyopadhyay, U.2    Sridhar, S.3
  • 4
    • 77957654940 scopus 로고    scopus 로고
    • Autophagic degradation of active caspase-8: A crosstalk mechanism between autophagy and apoptosis
    • Hou W, Han J, Lu C, Goldstein LA, Rabinowich H. Autophagic degradation of active caspase-8: a crosstalk mechanism between autophagy and apoptosis. Autophagy 2010; 6:891-900.
    • (2010) Autophagy , vol.6 , pp. 891-900
    • Hou, W.1    Han, J.2    Lu, C.3    Goldstein, L.A.4    Rabinowich, H.5
  • 5
    • 77955172368 scopus 로고    scopus 로고
    • Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation
    • Gao C, Cao W, Bao L, et al. Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol 2010; 12:781-790.
    • (2010) Nat Cell Biol , vol.12 , pp. 781-790
    • Gao, C.1    Cao, W.2    Bao, L.3
  • 6
    • 65549142204 scopus 로고    scopus 로고
    • A role for ubiquitin in selective autophagy
    • Kirkin V, McEwan DG, Novak I, Dikic I. A role for ubiquitin in selective autophagy. Mol Cell 2009; 34:259-269.
    • (2009) Mol Cell , vol.34 , pp. 259-269
    • Kirkin, V.1    McEwan, D.G.2    Novak, I.3    Dikic, I.4
  • 7
    • 78649348967 scopus 로고    scopus 로고
    • Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress
    • Sengupta S, Peterson TR, Sabatini DM. Regulation of the mTOR complex 1 pathway by nutrients, growth factors, and stress. Mol Cell 2010; 40:310-322.
    • (2010) Mol Cell , vol.40 , pp. 310-322
    • Sengupta, S.1    Peterson, T.R.2    Sabatini, D.M.3
  • 8
    • 65249119430 scopus 로고    scopus 로고
    • Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
    • Hosokawa N, Hara T, Kaizuka T, et al. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 2009; 20:1981-1991.
    • (2009) Mol Biol Cell , vol.20 , pp. 1981-1991
    • Hosokawa, N.1    Hara, T.2    Kaizuka, T.3
  • 9
    • 66449083078 scopus 로고    scopus 로고
    • ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy
    • Ganley IG, Lam du H, Wang J, Ding X, Chen S, Jiang X. ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 2009; 284:12297-12305.
    • (2009) J Biol Chem , vol.284 , pp. 12297-12305
    • Ganley, I.G.1    Lam Du, H.2    Wang, J.3    Ding, X.4    Chen, S.5    Jiang, X.6
  • 10
    • 65249176304 scopus 로고    scopus 로고
    • ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
    • Jung CH, Jun CB, Ro SH, et al. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009; 20:1992-2003.
    • (2009) Mol Biol Cell , vol.20 , pp. 1992-2003
    • Jung, C.H.1    Jun, C.B.2    Ro, S.H.3
  • 11
    • 67549110195 scopus 로고    scopus 로고
    • A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy
    • Mercer CA, Kaliappan A, Dennis PB. A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy. Autophagy 2009; 5:649-662.
    • (2009) Autophagy , vol.5 , pp. 649-662
    • Mercer, C.A.1    Kaliappan, A.2    Dennis, P.B.3
  • 13
    • 77957728513 scopus 로고    scopus 로고
    • The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
    • Di Bartolomeo S, Corazzari M, Nazio F, et al. The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy. J Cell Biol 2010; 191:155-168.
    • (2010) J Cell Biol , vol.191 , pp. 155-168
    • Di Bartolomeo, S.1    Corazzari, M.2    Nazio, F.3
  • 14
    • 33745086418 scopus 로고    scopus 로고
    • Assortment of phosphatidylinositol 3-kinase complexes-Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae
    • DOI 10.1091/mbc.E05-09-0841
    • Obara K, Sekito T, Ohsumi Y. Assortment of phosphati-dylinositol 3-kinase complexes - Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae. Mol Biol Cell 2006; 17:1527-1539. (Pubitemid 44011573)
    • (2006) Molecular Biology of the Cell , vol.17 , Issue.4 , pp. 1527-1539
    • Obara, K.1    Sekito, T.2    Ohsumi, Y.3
  • 15
    • 77950491704 scopus 로고    scopus 로고
    • New insights into the function of Atg9
    • Webber JL, Tooze SA. New insights into the function of Atg9. FEBS Lett 2010; 584:1319-1326.
    • (2010) FEBS Lett , vol.584 , pp. 1319-1326
    • Webber, J.L.1    Tooze, S.A.2
  • 17
    • 79951805767 scopus 로고    scopus 로고
    • Atg1-mediated myosin II activation regulates autophago-some formation during starvation-induced autophagy
    • Tang HW, Wang YB, Wang SL, Wu MH, Lin SY, Chen GC. Atg1-mediated myosin II activation regulates autophago-some formation during starvation-induced autophagy. EMBO J 2011; 30:636-651.
    • (2011) EMBO J , vol.30 , pp. 636-651
    • Tang, H.W.1    Wang, Y.B.2    Wang, S.L.3    Wu, M.H.4    Lin, S.Y.5    Chen, G.C.6
  • 18
    • 79956095420 scopus 로고    scopus 로고
    • Autophagosome formation and molecular mechanism of autophagy
    • Tanida I. Autophagosome formation and molecular mechanism of autophagy. Antioxid Redox Signal 2011; 14:2201-2214.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 2201-2214
    • Tanida, I.1
  • 19
    • 77951237303 scopus 로고    scopus 로고
    • The Beclin 1 interactome
    • He C, Levine B. The Beclin 1 interactome. Curr Opin Cell Biol 2010; 22:140-149.
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 140-149
    • He, C.1    Levine, B.2
  • 20
    • 77953543377 scopus 로고    scopus 로고
    • The Beclin 1-VPS34 complex - At the crossroads of autophagy and beyond
    • Funderburk SF, Wang QJ, Yue Z. The Beclin 1-VPS34 complex - at the crossroads of autophagy and beyond. Trends Cell Biol 2010; 20:355-362.
    • (2010) Trends Cell Biol , vol.20 , pp. 355-362
    • Funderburk, S.F.1    Wang, Q.J.2    Yue, Z.3
  • 21
    • 77953726483 scopus 로고    scopus 로고
    • Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation
    • Polson HE, de Lartigue J, Rigden DJ, et al. Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. Autophagy 2010; 6:506-522.
    • (2010) Autophagy , vol.6 , pp. 506-522
    • Polson, H.E.1    De Lartigue, J.2    Rigden, D.J.3
  • 23
    • 0037166241 scopus 로고    scopus 로고
    • Formation of the 350-kDa Apg12-Apg Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast
    • DOI 10.1074/jbc.M111889200
    • Kuma A, Mizushima N, Ishihara N, Ohsumi Y. Formation of the approximately 350-kDa Apg12-Apg5. Apg16 multimeric complex, mediated by Apg16 oligomerization, is essential for autophagy in yeast. J Biol Chem 2002; 277:18619-18625. (Pubitemid 34952416)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.21 , pp. 18619-18625
    • Kuma, A.1    Mizushima, N.2    Ishihara, N.3    Ohsumi, Y.4
  • 24
    • 43949143804 scopus 로고    scopus 로고
    • The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy
    • Fujita N, Itoh T, Omori H, Fukuda M, Noda T, Yoshimori T. The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy. Mol Biol Cell 2008; 19:2092-2100.
    • (2008) Mol Biol Cell , vol.19 , pp. 2092-2100
    • Fujita, N.1    Itoh, T.2    Omori, H.3    Fukuda, M.4    Noda, T.5    Yoshimori, T.6
  • 25
    • 4344604111 scopus 로고    scopus 로고
    • A receptor-associated protein-phospholipid conjugates
    • DOI 10.1074/jbc.M401461200
    • Tanida I, Sou YS, Ezaki J, Minematsu-Ikeguchi N, Ueno T, Kominami E. HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates. J Biol Chem 2004; 279:36268-36276. (Pubitemid 39128963)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.35 , pp. 36268-36276
    • Tanida, I.1    Sou, Y.-S.2    Ezaki, J.3    Minematsu-Ikeguchi, N.4    Ueno, T.5    Kominami, E.6
  • 27
    • 33645120442 scopus 로고    scopus 로고
    • Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes
    • Kochl R, Hu XW, Chan EY, Tooze SA. Microtubules facilitate autophagosome formation and fusion of autophagosomes with endosomes. Traffic 2006; 7:129-145.
    • (2006) Traffic , vol.7 , pp. 129-145
    • Kochl, R.1    Hu, X.W.2    Chan, E.Y.3    Tooze, S.A.4
  • 28
    • 79953153833 scopus 로고    scopus 로고
    • The late stage of autophagy: Cellular events and molecular regulation
    • Tong J, Yan X, Yu L. The late stage of autophagy: cellular events and molecular regulation. Protein Cell 2010; 1:907-915.
    • (2010) Protein Cell , vol.1 , pp. 907-915
    • Tong, J.1    Yan, X.2    Yu, L.3
  • 29
    • 40449139980 scopus 로고    scopus 로고
    • The itinerary of autophagosomes: From peripheral formation to kiss-and-run fusion with lysosomes
    • DOI 10.1111/j.1600-0854.2008.00701.x
    • Jahreiss L, Menzies FM, Rubinsztein DC. The itinerary of autophagosomes: from peripheral formation to kiss-and-run fusion with lysosomes. Traffic 2008; 9:574-587. (Pubitemid 351351616)
    • (2008) Traffic , vol.9 , Issue.4 , pp. 574-587
    • Jahreiss, L.1    Menzies, F.M.2    Rubinsztein, D.C.3
  • 30
    • 33845407202 scopus 로고    scopus 로고
    • Atg22 recycles amino acids to link the degradative and recycling functions of autophagy
    • DOI 10.1091/mbc.E06-06-0479
    • Yang Z, Huang J, Geng J, Nair U, Klionsky DJ. Atg22 recycles amino acids to link the degradative and recycling functions of autophagy. Mol Biol Cell 2006; 17:5094-5104. (Pubitemid 44907353)
    • (2006) Molecular Biology of the Cell , vol.17 , Issue.12 , pp. 5094-5104
    • Yang, Z.1    Huang, J.2    Geng, J.3    Nair, U.4    Klionsky, D.J.5
  • 31
    • 50249084987 scopus 로고    scopus 로고
    • Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum
    • Axe EL, Walker SA, Manifava M, et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 2008; 182:685-701.
    • (2008) J Cell Biol , vol.182 , pp. 685-701
    • Axe, E.L.1    Walker, S.A.2    Manifava, M.3
  • 32
    • 77952495224 scopus 로고    scopus 로고
    • Mitochondria supply membranes for autophagosome biogenesis during starvation
    • Hailey DW, Rambold AS, Satpute-Krishnan P, et al. Mitochondria supply membranes for autophagosome biogenesis during starvation. Cell 2010; 141:656-667.
    • (2010) Cell , vol.141 , pp. 656-667
    • Hailey, D.W.1    Rambold, A.S.2    Satpute-Krishnan, P.3
  • 33
  • 34
    • 70349641036 scopus 로고    scopus 로고
    • Nuclear membranederived autophagy, a novel process that participates in the presentation of endogenous viral antigens during HSV-1 infection
    • English L, Chemali M, Desjardins M. Nuclear membranederived autophagy, a novel process that participates in the presentation of endogenous viral antigens during HSV-1 infection. Autophagy 2009; 5:1026-1029.
    • (2009) Autophagy , vol.5 , pp. 1026-1029
    • English, L.1    Chemali, M.2    Desjardins, M.3
  • 35
    • 33646800306 scopus 로고    scopus 로고
    • Loss of autophagy in the central nervous system causes neurodegeneration in mice
    • Komatsu M, Waguri S, Chiba T, et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Nature 2006; 441:880-884.
    • (2006) Nature , vol.441 , pp. 880-884
    • Komatsu, M.1    Waguri, S.2    Chiba, T.3
  • 37
    • 33745192802 scopus 로고    scopus 로고
    • Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
    • Hara T, Nakamura K, Matsui M, et al. Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice. Nature 2006; 441:885-889.
    • (2006) Nature , vol.441 , pp. 885-889
    • Hara, T.1    Nakamura, K.2    Matsui, M.3
  • 39
    • 0036345454 scopus 로고    scopus 로고
    • CHIP is associated with Parkin, a gene responsible for familial Parkinson's Disease, and enhances its ubiquitin ligase activity
    • DOI 10.1016/S1097-2765(02)00583-X
    • Imai Y, Soda M, Hatakeyama S, et al. CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity. Mol Cell 2002; 10:55-67. (Pubitemid 34876562)
    • (2002) Molecular Cell , vol.10 , Issue.1 , pp. 55-67
    • Imai, Y.1    Soda, M.2    Hatakeyama, S.3    Akagi, T.4    Hashikawa, T.5    Nakayama, K.-I.6    Takahashi, R.7
  • 40
    • 0346727127 scopus 로고    scopus 로고
    • Protein degradation and protection against misfolded or damaged proteins
    • DOI 10.1038/nature02263
    • Goldberg AL. Protein degradation and protection against misfolded or damaged proteins. Nature 2003; 426:895-899. (Pubitemid 38056882)
    • (2003) Nature , vol.426 , Issue.6968 , pp. 895-899
    • Goldberg, A.L.1
  • 41
    • 60849099049 scopus 로고    scopus 로고
    • A role for NBR1 in autophagosomal degradation of ubiquitinated substrates
    • Kirkin V, Lamark T, Sou YS, et al. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. Mol Cell 2009; 33:505-516.
    • (2009) Mol Cell , vol.33 , pp. 505-516
    • Kirkin, V.1    Lamark, T.2    Sou, Y.S.3
  • 45
    • 0346020435 scopus 로고    scopus 로고
    • The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress
    • DOI 10.1016/S0092-8674(03)00939-5
    • Kawaguchi Y, Kovacs JJ, McLaurin A, Vance JM, Ito A, Yao TP. The deacetylase HDAC6 regulates aggresome formation and cell viability in response to misfolded protein stress. Cell 2003; 115:727-738. (Pubitemid 38030301)
    • (2003) Cell , vol.115 , Issue.6 , pp. 727-738
    • Kawaguchi, Y.1    Kovacs, J.J.2    McLaurin, A.3    Vance, J.M.4    Ito, A.5    Yao, T.-P.6
  • 46
    • 79952319773 scopus 로고    scopus 로고
    • Mitochondria removal by autophagy
    • Wang K, Klionsky DJ. Mitochondria removal by autophagy. Autophagy 2011; 7:297-300.
    • (2011) Autophagy , vol.7 , pp. 297-300
    • Wang, K.1    Klionsky, D.J.2
  • 47
    • 4644273585 scopus 로고    scopus 로고
    • Uth1p is involved in the autophagic degradation of mitochondria
    • DOI 10.1074/jbc.M406960200
    • Kissova I, Deffieu M, Manon S, Camougrand N. Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem 2004; 279:39068-39074. (Pubitemid 39296069)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.37 , pp. 39068-39074
    • Kissova, I.1    Deffieu, M.2    Manon, S.3    Camougrand, N.4
  • 48
    • 34247172582 scopus 로고    scopus 로고
    • Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival
    • DOI 10.1074/jbc.M605940200
    • Tal R, Winter G, Ecker N, Klionsky DJ, Abeliovich H. Aup1p, a yeast mitochondrial protein phosphatase homolog, is required for efficient stationary phase mitophagy and cell survival. J Biol Chem 2007; 282:5617-5624. (Pubitemid 47093789)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.8 , pp. 5617-5624
    • Tal, R.1    Winter, G.2    Ecker, N.3    Klionsky, D.J.4    Abeliovich, H.5
  • 49
    • 37649017266 scopus 로고    scopus 로고
    • NIX is required for programmed mitochondrial clearance during reticulocyte maturation
    • Schweers RL, Zhang J, Randall MS, et al. NIX is required for programmed mitochondrial clearance during reticulocyte maturation. Proc Natl Acad Sci USA 2007; 104:19500-19505.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 19500-19505
    • Schweers, R.L.1    Zhang, J.2    Randall, M.S.3
  • 50
    • 79954577302 scopus 로고    scopus 로고
    • Targeting mitochondrial dysfunction: Role for PINK1 and Parkin in mitochondrial quality control
    • Narendra DP, Youle RJ. Targeting Mitochondrial Dysfunction: Role for PINK1 and Parkin in Mitochondrial Quality Control. Antioxid Redox Signal 2011; 14:1929-1938.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 1929-1938
    • Narendra, D.P.1    Youle, R.J.2
  • 51
    • 75949098487 scopus 로고    scopus 로고
    • PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
    • Vives-Bauza C, Zhou C, Huang Y, et al. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci USA 2010; 107:378-383.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 378-383
    • Vives-Bauza, C.1    Zhou, C.2    Huang, Y.3
  • 52
    • 77957686348 scopus 로고    scopus 로고
    • Uncovering the roles of PINK1 and parkin in mitophagy
    • Matsuda N, Tanaka K. Uncovering the roles of PINK1 and parkin in mitophagy. Autophagy 2010; 6:952-954.
    • (2010) Autophagy , vol.6 , pp. 952-954
    • Matsuda, N.1    Tanaka, K.2
  • 53
    • 56049091236 scopus 로고    scopus 로고
    • PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
    • Kim Y, Park J, Kim S, et al. PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem Biophys Res Commun 2008; 377:975-980.
    • (2008) Biochem Biophys Res Commun , vol.377 , pp. 975-980
    • Kim, Y.1    Park, J.2    Kim, S.3
  • 54
    • 67349239050 scopus 로고    scopus 로고
    • Parkin stabilizes PINK1 through direct interaction
    • Shiba K, Arai T, Sato S, et al. Parkin stabilizes PINK1 through direct interaction. Biochem Biophys Res Commun 2009; 383:331-335.
    • (2009) Biochem Biophys Res Commun , vol.383 , pp. 331-335
    • Shiba, K.1    Arai, T.2    Sato, S.3
  • 55
    • 77952242572 scopus 로고    scopus 로고
    • The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy
    • Michiorri S, Gelmetti V, Giarda E, et al. The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy. Cell Death Differ 2010; 17:962-974.
    • (2010) Cell Death Differ , vol.17 , pp. 962-974
    • Michiorri, S.1    Gelmetti, V.2    Giarda, E.3
  • 56
    • 77956416339 scopus 로고    scopus 로고
    • Autophagy in mammalian development and differentiation
    • Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat Cell Biol 2010; 12:823-830.
    • (2010) Nat Cell Biol , vol.12 , pp. 823-830
    • Mizushima, N.1    Levine, B.2
  • 58
    • 0037705403 scopus 로고    scopus 로고
    • Macroautophagy is required for multicellular development of the social amoeba Dictyostelium discoideum
    • DOI 10.1074/jbc.M212467200
    • Otto GP, Wu MY, Kazgan N, Anderson OR, Kessin RH. Macroautophagy is required for multicellular development of the social amoeba Dictyostelium discoideum. J Biol Chem 2003; 278:17636-17645. (Pubitemid 36799365)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.20 , pp. 17636-17645
    • Otto, G.P.1    Wu, M.Y.2    Kazgan, N.3    Anderson, O.R.4    Kessin, R.H.5
  • 59
    • 0042691506 scopus 로고    scopus 로고
    • Autophagy genes are essential for dauer development and life-span extension in C. elegans
    • DOI 10.1126/science.1087782
    • Melendez A, Talloczy Z, Seaman M, Eskelinen EL, Hall DH, Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science 2003; 301:1387-1391. (Pubitemid 37075816)
    • (2003) Science , vol.301 , Issue.5638 , pp. 1387-1391
    • Melendez, A.1    Talloczy, Z.2    Seaman, M.3    Eskelinen, E.-L.4    Hall, D.H.5    Levine, B.6
  • 61
    • 0036387157 scopus 로고    scopus 로고
    • Steroid regulation of midgut cell death during Drosophila development
    • Lee CY, Cooksey BA, Baehrecke EH. Steroid regulation of midgut cell death during Drosophila development. Dev Biol 2002; 250:101-111.
    • (2002) Dev Biol , vol.250 , pp. 101-111
    • Lee, C.Y.1    Cooksey, B.A.2    Baehrecke, E.H.3
  • 62
    • 36849088609 scopus 로고    scopus 로고
    • Growth Arrest and Autophagy Are Required for Salivary Gland Cell Degradation in Drosophila
    • DOI 10.1016/j.cell.2007.10.048, PII S009286740701402X
    • Berry DL, Baehrecke EH. Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell 2007; 131:1137-1148. (Pubitemid 350235023)
    • (2007) Cell , vol.131 , Issue.6 , pp. 1137-1148
    • Berry, D.L.1    Baehrecke, E.H.2
  • 63
    • 36849021043 scopus 로고    scopus 로고
    • Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila
    • DOI 10.1101/gad.1600707
    • Juhasz G, Erdi B, Sass M, Neufeld TP. Atg7-dependent autophagy promotes neuronal health, stress tolerance, and longevity but is dispensable for metamorphosis in Drosophila. Genes Dev 2007; 21:3061-3066. (Pubitemid 350223523)
    • (2007) Genes and Development , vol.21 , Issue.23 , pp. 3061-3066
    • Juhasz, G.1    Erdi, B.2    Sass, M.3    Neufeld, T.P.4
  • 64
    • 70449727080 scopus 로고    scopus 로고
    • Autophagy promotes synapse development in Drosophila
    • Shen W, Ganetzky B. Autophagy promotes synapse development in Drosophila. J Cell Biol 2009; 187:71-79.
    • (2009) J Cell Biol , vol.187 , pp. 71-79
    • Shen, W.1    Ganetzky, B.2
  • 65
    • 46849115787 scopus 로고    scopus 로고
    • Autophagy is essential for preimplantation development of mouse embryos
    • DOI 10.1126/science.1154822
    • Tsukamoto S, Kuma A, Murakami M, Kishi C, Yamamoto A, Mizushima N. Autophagy is essential for preimplantation development of mouse embryos. Science 2008; 321:117-120. (Pubitemid 351956245)
    • (2008) Science , vol.321 , Issue.5885 , pp. 117-120
    • Tsukamoto, S.1    Kuma, A.2    Murakami, M.3    Kishi, C.4    Yamamoto, A.5    Mizushima, N.6
  • 68
    • 33847404337 scopus 로고    scopus 로고
    • Autophagy Gene-Dependent Clearance of Apoptotic Cells during Embryonic Development
    • DOI 10.1016/j.cell.2006.12.044, PII S009286740700178X
    • Qu X, Zou Z, Sun Q, et al. Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell 2007; 128:931-946. (Pubitemid 46341412)
    • (2007) Cell , vol.128 , Issue.5 , pp. 931-946
    • Qu, X.1    Zou, Z.2    Sun, Q.3    Luby-Phelps, K.4    Cheng, P.5    Hogan, R.N.6    Gilpin, C.7    Levine, B.8
  • 71
    • 34547132328 scopus 로고    scopus 로고
    • Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3
    • DOI 10.1074/jbc.M701194200
    • Marino G, Salvador-Montoliu N, Fueyo A, Knecht E, Mizushima N, Lopez-Otin C. Tissue-specific autophagy alterations and increased tumorigenesis in mice deficient in Atg4C/autophagin-3. J Biol Chem 2007; 282:18573-18583. (Pubitemid 47100226)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.25 , pp. 18573-18583
    • Marino, G.1    Salvador-Montoliu, N.2    Fueyo, A.3    Knecht, E.4    Mizushima, N.5    Lopez-Otin, C.6
  • 72
    • 57549094368 scopus 로고    scopus 로고
    • The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice
    • Sou YS, Waguri S, Iwata J, et al. The Atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice. Mol Biol Cell 2008; 19:4762-4775.
    • (2008) Mol Biol Cell , vol.19 , pp. 4762-4775
    • Sou, Y.S.1    Waguri, S.2    Iwata, J.3
  • 73
    • 73949083594 scopus 로고    scopus 로고
    • Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
    • Saitoh T, Fujita N, Hayashi T, et al. Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response. Proc Natl Acad Sci USA 2009; 106:20842-20846.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20842-20846
    • Saitoh, T.1    Fujita, N.2    Hayashi, T.3
  • 74
    • 56249090667 scopus 로고    scopus 로고
    • Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production
    • Saitoh T, Fujita N, Jang MH, et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 2008; 456:264-268.
    • (2008) Nature , vol.456 , pp. 264-268
    • Saitoh, T.1    Fujita, N.2    Jang, M.H.3
  • 75
    • 51649124519 scopus 로고    scopus 로고
    • Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation
    • Kundu M, Lindsten T, Yang CY, et al. Ulk1 plays a critical role in the autophagic clearance of mitochondria and ribosomes during reticulocyte maturation. Blood 2008; 112:1493-1502.
    • (2008) Blood , vol.112 , pp. 1493-1502
    • Kundu, M.1    Lindsten, T.2    Yang, C.Y.3
  • 77
    • 77953744638 scopus 로고    scopus 로고
    • Nonredundant role of Atg7 in mitochondrial clearance during erythroid development
    • Mortensen M, Simon AK. Nonredundant role of Atg7 in mitochondrial clearance during erythroid development. Autophagy 2010; 6:423-425.
    • (2010) Autophagy , vol.6 , pp. 423-425
    • Mortensen, M.1    Simon, A.K.2
  • 78
    • 64249123646 scopus 로고    scopus 로고
    • Autophagy is essential for mitochondrial clearance in mature T lymphocytes
    • Pua HH, Guo J, Komatsu M, He YW. Autophagy is essential for mitochondrial clearance in mature T lymphocytes. J Immunol 2009; 182:4046-4055.
    • (2009) J Immunol , vol.182 , pp. 4046-4055
    • Pua, H.H.1    Guo, J.2    Komatsu, M.3    He, Y.W.4
  • 79
    • 73449117508 scopus 로고    scopus 로고
    • Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice
    • Baerga R, Zhang Y, Chen PH, Goldman S, Jin S. Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice. Autophagy 2009; 5:1118-1130.
    • (2009) Autophagy , vol.5 , pp. 1118-1130
    • Baerga, R.1    Zhang, Y.2    Chen, P.H.3    Goldman, S.4    Jin, S.5
  • 80
    • 79954583401 scopus 로고    scopus 로고
    • Autophagic degradation of mitochondria in white adipose tissue differentiation
    • Goldman SJ, Zhang Y, Jin S. Autophagic degradation of mitochondria in white adipose tissue differentiation. Antioxid Redox Signal 2011; 14:1971-1978.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 1971-1978
    • Goldman, S.J.1    Zhang, Y.2    Jin, S.3
  • 81
    • 73949124173 scopus 로고    scopus 로고
    • Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis
    • Zhang Y, Goldman S, Baerga R, Zhao Y, Komatsu M, Jin S. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc Natl Acad Sci USA 2009; 106:19860-19865.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 19860-19865
    • Zhang, Y.1    Goldman, S.2    Baerga, R.3    Zhao, Y.4    Komatsu, M.5    Jin, S.6
  • 82
    • 74149087187 scopus 로고    scopus 로고
    • Autophagy impairment inhibits differentiation of glioma stem/progenitor cells
    • Zhao Y, Huang Q, Yang J, et al. Autophagy impairment inhibits differentiation of glioma stem/progenitor cells. Brain Res 2010; 1313:250-258.
    • (2010) Brain Res , vol.1313 , pp. 250-258
    • Zhao, Y.1    Huang, Q.2    Yang, J.3
  • 83
    • 39149111914 scopus 로고    scopus 로고
    • Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells
    • Zeng M, Zhou JN. Roles of autophagy and mTOR signaling in neuronal differentiation of mouse neuroblastoma cells. Cell Signal 2008; 20:659-665.
    • (2008) Cell Signal , vol.20 , pp. 659-665
    • Zeng, M.1    Zhou, J.N.2
  • 84
    • 67649607465 scopus 로고    scopus 로고
    • Autophagy, immunity, and microbial adaptations
    • Deretic V, Levine B. Autophagy, immunity, and microbial adaptations. Cell Host Microbe 2009; 5:527-549.
    • (2009) Cell Host Microbe , vol.5 , pp. 527-549
    • Deretic, V.1    Levine, B.2
  • 86
    • 13244256806 scopus 로고    scopus 로고
    • Escape of intracellular Shigella from autophagy
    • DOI 10.1126/science.1106036
    • Ogawa M, Yoshimori T, Suzuki T, Sagara H, Mizushima N, Sasakawa C. Escape of intracellular Shigella from autophagy. Science 2005; 307:727-731. (Pubitemid 40194643)
    • (2005) Science , vol.307 , Issue.5710 , pp. 727-731
    • Ogawa, M.1    Yoshimori, T.2    Suzuki, T.3    Sagara, H.4    Mizushima, N.5    Sasakawa, C.6
  • 87
    • 10944253145 scopus 로고    scopus 로고
    • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
    • DOI 10.1016/j.cell.2004.11.038, PII S0092867404011067
    • Gutierrez MG, Master SS, Singh SB, Taylor GA, Colombo MI, Deretic V. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 2004; 119:753-766. (Pubitemid 40017683)
    • (2004) Cell , vol.119 , Issue.6 , pp. 753-766
    • Gutierrez, M.G.1    Master, S.S.2    Singh, S.B.3    Taylor, G.A.4    Colombo, M.I.5    Deretic, V.6
  • 88
    • 33744958258 scopus 로고    scopus 로고
    • Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole
    • DOI 10.1074/jbc.M509157200
    • Birmingham CL, Smith AC, Bakowski MA, Yoshimori T, Brumell JH. Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuole. J Biol Chem 2006; 281:11374-11383. (Pubitemid 43855562)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.16 , pp. 11374-11383
    • Birmingham, C.L.1    Smith, A.C.2    Bakowski, M.A.3    Yoshimori, T.4    Brumell, J.H.5
  • 89
    • 47849094901 scopus 로고    scopus 로고
    • Autophagic control of listeria through intracellular innate immune recognition in drosophila
    • Yano T, Mita S, Ohmori H, et al. Autophagic control of listeria through intracellular innate immune recognition in drosophila. Nat Immunol 2008; 9:908-916.
    • (2008) Nat Immunol , vol.9 , pp. 908-916
    • Yano, T.1    Mita, S.2    Ohmori, H.3
  • 90
    • 33748331335 scopus 로고    scopus 로고
    • CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes
    • DOI 10.1172/JCI28796
    • Andrade RM, Wessendarp M, Gubbels MJ, Striepen B, Subauste CS. CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes. J Clin Invest 2006; 116:2366-2377. (Pubitemid 44330135)
    • (2006) Journal of Clinical Investigation , vol.116 , Issue.9 , pp. 2366-2377
    • Andrade, R.M.1    Wessendarp, M.2    Gubbels, M.-J.3    Striepen, B.4    Subauste, C.S.5
  • 91
    • 33644609471 scopus 로고    scopus 로고
    • PKR-dependent autophagic degradation of herpes simplex virus type 1
    • Talloczy Z, Virgin HWt, Levine B. PKR-dependent autophagic degradation of herpes simplex virus type 1. Autophagy 2006; 2:24-29.
    • (2006) Autophagy , vol.2 , pp. 24-29
    • Talloczy, Z.1    Virgin, H.W.T.2    Levine, B.3
  • 93
    • 19344368318 scopus 로고    scopus 로고
    • Autophagy regulates programmed cell death during the plant innate immune response
    • DOI 10.1016/j.cell.2005.03.007, PII S0092867405002400
    • Liu Y, Schiff M, Czymmek K, Talloczy Z, Levine B, Dinesh-Kumar SP. Autophagy regulates programmed cell death during the plant innate immune response. Cell 2005; 121:567-577. (Pubitemid 40720010)
    • (2005) Cell , vol.121 , Issue.4 , pp. 567-577
    • Liu, Y.1    Schiff, M.2    Czymmek, K.3    Talloczy, Z.4    Levine, B.5    Dinesh-Kumar, S.P.6
  • 94
    • 70350450808 scopus 로고    scopus 로고
    • The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria
    • Thurston TL, Ryzhakov G, Bloor S, von Muhlinen N, Randow F. The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat Immunol 2009; 10:1215-1221.
    • (2009) Nat Immunol , vol.10 , pp. 1215-1221
    • Thurston, T.L.1    Ryzhakov, G.2    Bloor, S.3    Von Muhlinen, N.4    Randow, F.5
  • 95
    • 74049126112 scopus 로고    scopus 로고
    • The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway
    • Zheng YT, Shahnazari S, Brech A, Lamark T, Johansen T, Brumell JH. The adaptor protein p62/SQSTM1 targets invading bacteria to the autophagy pathway. J Immunol 2009; 183:5909-5916.
    • (2009) J Immunol , vol.183 , pp. 5909-5916
    • Zheng, Y.T.1    Shahnazari, S.2    Brech, A.3    Lamark, T.4    Johansen, T.5    Brumell, J.H.6
  • 96
    • 73649110275 scopus 로고    scopus 로고
    • Sequestosome-1/p62 is the key intracellular target of innate defense regulator peptide
    • Yu HB, Kielczewska A, Rozek A, et al. Sequestosome-1/p62 is the key intracellular target of innate defense regulator peptide. J Biol Chem 2009; 284:36007-36011.
    • (2009) J Biol Chem , vol.284 , pp. 36007-36011
    • Yu, H.B.1    Kielczewska, A.2    Rozek, A.3
  • 98
    • 67649585835 scopus 로고    scopus 로고
    • Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages
    • Kyei GB, Dinkins C, Davis AS, et al. Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages. J Cell Biol 2009; 186:255-268.
    • (2009) J Cell Biol , vol.186 , pp. 255-268
    • Kyei, G.B.1    Dinkins, C.2    Davis, A.S.3
  • 100
    • 58149095737 scopus 로고    scopus 로고
    • Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11
    • Sinha S, Colbert CL, Becker N, Wei Y, Levine B. Molecular basis of the regulation of Beclin 1-dependent autophagy by the gamma-herpesvirus 68 Bcl-2 homolog M11. Autophagy 2008; 4:989-997.
    • (2008) Autophagy , vol.4 , pp. 989-997
    • Sinha, S.1    Colbert, C.L.2    Becker, N.3    Wei, Y.4    Levine, B.5
  • 101
    • 38049029041 scopus 로고    scopus 로고
    • Human cytomegalovirus controls a new autophagy-dependent cellular antiviral defense mechanism
    • Chaumorcel M, Souquere S, Pierron G, Codogno P, Esclatine A. Human cytomegalovirus controls a new autophagy-dependent cellular antiviral defense mechanism. Autophagy 2008; 4:46-53.
    • (2008) Autophagy , vol.4 , pp. 46-53
    • Chaumorcel, M.1    Souquere, S.2    Pierron, G.3    Codogno, P.4    Esclatine, A.5
  • 102
    • 57749100267 scopus 로고    scopus 로고
    • MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages
    • Shi CS, Kehrl JH. MyD88 and Trif target Beclin 1 to trigger autophagy in macrophages. J Biol Chem 2008; 283:33175-33182.
    • (2008) J Biol Chem , vol.283 , pp. 33175-33182
    • Shi, C.S.1    Kehrl, J.H.2
  • 103
    • 77953858790 scopus 로고    scopus 로고
    • TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy
    • Shi CS, Kehrl JH. TRAF6 and A20 regulate lysine 63-linked ubiquitination of Beclin-1 to control TLR4-induced autophagy. Sci Signal 2010; 3:ra42.
    • (2010) Sci Signal , vol.3
    • Shi, C.S.1    Kehrl, J.H.2
  • 104
    • 73849121209 scopus 로고    scopus 로고
    • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    • Travassos LH, Carneiro LA, Ramjeet M, et al. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 2010; 11:55-62.
    • (2010) Nat Immunol , vol.11 , pp. 55-62
    • Travassos, L.H.1    Carneiro, L.A.2    Ramjeet, M.3
  • 105
    • 34548700401 scopus 로고    scopus 로고
    • T Helper 2 Cytokines Inhibit Autophagic Control of Intracellular Mycobacterium tuberculosis
    • DOI 10.1016/j.immuni.2007.07.022, PII S1074761307004177
    • Harris J, De Haro SA, Master SS, et al. T helper 2 cytokines inhibit autophagic control of intracellular Mycobacterium tuberculosis. Immunity 2007; 27:505-517. (Pubitemid 47418681)
    • (2007) Immunity , vol.27 , Issue.3 , pp. 505-517
    • Harris, J.1    De Haro, S.A.2    Master, S.S.3    Keane, J.4    Roberts, E.A.5    Delgado, M.6    Deretic, V.7
  • 106
    • 62449110463 scopus 로고    scopus 로고
    • Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling
    • Tal MC, Sasai M, Lee HK, Yordy B, Shadel GS, Iwasaki A. Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc Natl Acad Sci USA 2009; 106:2770-2775.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 2770-2775
    • Tal, M.C.1    Sasai, M.2    Lee, H.K.3    Yordy, B.4    Shadel, G.S.5    Iwasaki, A.6
  • 107
    • 79951642032 scopus 로고    scopus 로고
    • Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
    • Nakahira K, Haspel JA, Rathinam VA, et al. Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome. Nat Immunol 2011; 12:222-30.
    • (2011) Nat Immunol , vol.12 , pp. 222-230
    • Nakahira, K.1    Haspel, J.A.2    Rathinam, V.A.3
  • 108
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature 2011; 469:221-225.
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4
  • 109
    • 79953176280 scopus 로고    scopus 로고
    • Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation
    • Harris J, Hartman M, Roche C, et al. Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradation. J Biol Chem 2011; 286:9587-9597.
    • (2011) J Biol Chem , vol.286 , pp. 9587-9597
    • Harris, J.1    Hartman, M.2    Roche, C.3
  • 111
    • 33846461678 scopus 로고    scopus 로고
    • A critical role for the autophagy gene Atg5 in T cell survival and proliferation
    • DOI 10.1084/jem.20061303
    • Pua HH, Dzhagalov I, Chuck M, Mizushima N, He YW. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med 2007; 204:25-31. (Pubitemid 46148752)
    • (2007) Journal of Experimental Medicine , vol.204 , Issue.1 , pp. 25-31
    • Pua, H.H.1    Dzhagalov, I.2    Chuck, M.3    Mizushima, N.4    He, Y.-W.5
  • 112
    • 55949083821 scopus 로고    scopus 로고
    • FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells
    • Bell BD, Leverrier S, Weist BM, et al. FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells. Proc Natl Acad Sci USA 2008; 105:16677-16682.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 16677-16682
    • Bell, B.D.1    Leverrier, S.2    Weist, B.M.3
  • 113
    • 56249135538 scopus 로고    scopus 로고
    • A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
    • Cadwell K, Liu J Y, Brown SL, et al. A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 2008; 456:259-263.
    • (2008) Nature , vol.456 , pp. 259-263
    • Cadwell, K.1    Liu, J.Y.2    Brown, S.L.3
  • 114
    • 77955146917 scopus 로고    scopus 로고
    • Autophagy and adaptive immunity
    • Crotzer VL, Blum JS. Autophagy and adaptive immunity. Immunology 2010; 131:9-17.
    • (2010) Immunology , vol.131 , pp. 9-17
    • Crotzer, V.L.1    Blum, J.S.2
  • 115
    • 67349269904 scopus 로고    scopus 로고
    • Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection
    • English L, Chemali M, Duron J, et al. Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection. Nat Immunol 2009; 10:480-487.
    • (2009) Nat Immunol , vol.10 , pp. 480-487
    • English, L.1    Chemali, M.2    Duron, J.3
  • 116
    • 76949091325 scopus 로고    scopus 로고
    • In vivo requirement for Atg5 in antigen presentation by dendritic cells
    • Lee HK, Mattei LM, Steinberg BE, et al. In vivo requirement for Atg5 in antigen presentation by dendritic cells. Immunity 2010; 32:227-239.
    • (2010) Immunity , vol.32 , pp. 227-239
    • Lee, H.K.1    Mattei, L.M.2    Steinberg, B.E.3
  • 117
    • 67549117101 scopus 로고    scopus 로고
    • Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells
    • Uhl M, Kepp O, Jusforgues-Saklani H, Vicencio JM, Kroemer G, Albert ML. Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells. Cell Death Differ 2009; 16:991-1005.
    • (2009) Cell Death Differ , vol.16 , pp. 991-1005
    • Uhl, M.1    Kepp, O.2    Jusforgues-Saklani, H.3    Vicencio, J.M.4    Kroemer, G.5    Albert, M.L.6
  • 118
    • 33947134377 scopus 로고    scopus 로고
    • Autophagy-dependent viral recognition by plasmacytoid dendritic cells
    • DOI 10.1126/science.1136880
    • Lee HK, Lund JM, Ramanathan B, Mizushima N, Iwasaki A. Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science 2007; 315:1398-1401. (Pubitemid 46399546)
    • (2007) Science , vol.315 , Issue.5817 , pp. 1398-1401
    • Lee, H.K.1    Lund, J.M.2    Ramanathan, B.3    Mizushima, N.4    Iwasaki, A.5
  • 119
    • 52149099867 scopus 로고    scopus 로고
    • Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance
    • Nedjic J, Aichinger M, Emmerich J, Mizushima N, Klein L. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature 2008; 455:396-400.
    • (2008) Nature , vol.455 , pp. 396-400
    • Nedjic, J.1    Aichinger, M.2    Emmerich, J.3    Mizushima, N.4    Klein, L.5
  • 121
    • 57649149333 scopus 로고    scopus 로고
    • Classification of cell death: Recommendations of the Nomenclature Committee on Cell Death 2009
    • Kroemer G, Galluzzi L, Vandenabeele P, et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ 2009; 16:3-11.
    • (2009) Cell Death Differ , vol.16 , pp. 3-11
    • Kroemer, G.1    Galluzzi, L.2    Vandenabeele, P.3
  • 122
    • 77956172813 scopus 로고    scopus 로고
    • Physiological role of autophagy as an intracellular recycling system: With an emphasis on nutrient metabolism
    • Kuma A, Mizushima N. Physiological role of autophagy as an intracellular recycling system: with an emphasis on nutrient metabolism. Semin Cell Dev Biol 2010; 21:683-690.
    • (2010) Semin Cell Dev Biol , vol.21 , pp. 683-690
    • Kuma, A.1    Mizushima, N.2
  • 123
    • 41449109334 scopus 로고    scopus 로고
    • Induction of autophagy during extracellular matrix detachment promotes cell survival
    • DOI 10.1091/mbc.E07-10-1092
    • Fung C, Lock R, Gao S, Salas E, Debnath J. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell 2008; 19:797-806. (Pubitemid 351481798)
    • (2008) Molecular Biology of the Cell , vol.19 , Issue.3 , pp. 797-806
    • Fung, C.1    Lock, R.2    Gao, S.3    Salas, E.4    Debnath, J.5
  • 124
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • DOI 10.1016/j.cell.2004.11.046, PII S009286740401150X
    • Lum JJ, Bauer DE, Kong M, et al. Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 2005; 120:237-248. (Pubitemid 40174766)
    • (2005) Cell , vol.120 , Issue.2 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3    Harris, M.H.4    Li, C.5    Lindsten, T.6    Thompson, C.B.7
  • 125
    • 0842279780 scopus 로고    scopus 로고
    • Caspases function in autophagic programmed cell death in Drosophila
    • DOI 10.1242/dev.00933
    • Martin DN, Baehrecke EH. Caspases function in autophagic programmed cell death in Drosophila. Development 2004; 131:275-284. (Pubitemid 38181368)
    • (2004) Development , vol.131 , Issue.2 , pp. 275-284
    • Martin, D.N.1    Baehrecke, E.H.2
  • 128
    • 77955903343 scopus 로고    scopus 로고
    • Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis
    • Nezis IP, Shravage BV, Sagona AP, et al. Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis. J Cell Biol 2010; 190:523-531.
    • (2010) J Cell Biol , vol.190 , pp. 523-531
    • Nezis, I.P.1    Shravage, B.V.2    Sagona, A.P.3
  • 129
    • 20144381544 scopus 로고    scopus 로고
    • Essential roles of Atg5 and FADD in autophagic cell death: Dissection of autophagic cell death into vacuole formation and cell death
    • Pyo JO, Jang MH, Kwon YK, et al. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem 2005; 280:20722-20729.
    • (2005) J Biol Chem , vol.280 , pp. 20722-20729
    • Pyo, J.O.1    Jang, M.H.2    Kwon, Y.K.3
  • 130
    • 77951249136 scopus 로고    scopus 로고
    • Lysosome dysfunction triggers Atg7-dependent neural apoptosis
    • Walls KC, Ghosh AP, Franklin AV, et al. Lysosome dysfunction triggers Atg7-dependent neural apoptosis. J Biol Chem 2010; 285:10497-10507.
    • (2010) J Biol Chem , vol.285 , pp. 10497-10507
    • Walls, K.C.1    Ghosh, A.P.2    Franklin, A.V.3
  • 131
    • 79958276489 scopus 로고    scopus 로고
    • GX015-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy
    • Heidari N, Hicks MA, Harada H. GX015-070 (obatoclax) overcomes glucocorticoid resistance in acute lymphoblastic leukemia through induction of apoptosis and autophagy. Cell Death Dis 2010; 1:e76.
    • (2010) Cell Death Dis , vol.1
    • Heidari, N.1    Hicks, M.A.2    Harada, H.3
  • 132
    • 77955637249 scopus 로고    scopus 로고
    • ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death
    • Radoshevich L, Murrow L, Chen N, et al. ATG12 conjugation to ATG3 regulates mitochondrial homeostasis and cell death. Cell 2010; 142:590-600.
    • (2010) Cell , vol.142 , pp. 590-600
    • Radoshevich, L.1    Murrow, L.2    Chen, N.3
  • 134
    • 75149171923 scopus 로고    scopus 로고
    • Control of basal autophagy by calpain1 mediated cleavage of ATG5
    • Xia HG, Zhang L, Chen G, et al. Control of basal autophagy by calpain1 mediated cleavage of ATG5. Autophagy 2010; 6:61-66.
    • (2010) Autophagy , vol.6 , pp. 61-66
    • Xia, H.G.1    Zhang, L.2    Chen, G.3
  • 135
    • 78649636176 scopus 로고    scopus 로고
    • Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
    • Wirawan E, Vandewalle L, Kersse K, et al. Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis 2010; 1:e18.
    • (2010) Cell Death Dis , vol.1
    • Wirawan, E.1    Vandewalle, L.2    Kersse, K.3
  • 136
    • 69649090647 scopus 로고    scopus 로고
    • Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis
    • Betin VM, Lane JD. Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. J Cell Sci 2009; 122:2554-2566.
    • (2009) J Cell Sci , vol.122 , pp. 2554-2566
    • Betin, V.M.1    Lane, J.D.2
  • 137
    • 48249092267 scopus 로고    scopus 로고
    • Bcl-2 family members: Dual regulators of apoptosis and autophagy
    • Levine B, Sinha S, Kroemer G. Bcl-2 family members: dual regulators of apoptosis and autophagy. Autophagy 2008; 4:600-606.
    • (2008) Autophagy , vol.4 , pp. 600-606
    • Levine, B.1    Sinha, S.2    Kroemer, G.3
  • 138
    • 34249037565 scopus 로고    scopus 로고
    • L-beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein
    • DOI 10.1074/jbc.M700492200
    • Oberstein A, Jeffrey PD, Shi Y. Crystal structure of the Bcl-XL-Beclin 1 peptide complex: Beclin 1 is a novel BH3-only protein. J Biol Chem 2007; 282:13123-13132. (Pubitemid 47100641)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.17 , pp. 13123-13132
    • Oberstein, A.1    Jeffrey, P.D.2    Shi, Y.3
  • 139
    • 67349232611 scopus 로고    scopus 로고
    • Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function
    • Ciechomska IA, Goemans GC, Skepper JN, Tolkovsky AM. Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function. Oncogene 2009; 28:2128-2141.
    • (2009) Oncogene , vol.28 , pp. 2128-2141
    • Ciechomska, I.A.1    Goemans, G.C.2    Skepper, J.N.3    Tolkovsky, A.M.4
  • 140
    • 79953796695 scopus 로고    scopus 로고
    • Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy
    • Strappazzon F, Vietri-Rudan M, Campello S, et al. Mitochondrial BCL-2 inhibits AMBRA1-induced autophagy. EMBO J 2011; 30:1195-1208.
    • (2011) EMBO J , vol.30 , pp. 1195-1208
    • Strappazzon, F.1    Vietri-Rudan, M.2    Campello, S.3
  • 141
    • 70449529788 scopus 로고    scopus 로고
    • FLIP-mediated autophagy regulation in cell death control
    • Lee JS, Li Q, Lee J Y, et al. FLIP-mediated autophagy regulation in cell death control. Nat Cell Biol 2009; 11:1355-1362.
    • (2009) Nat Cell Biol , vol.11 , pp. 1355-1362
    • Lee, J.S.1    Li, Q.2    Lee, J.Y.3
  • 142
    • 67650270918 scopus 로고    scopus 로고
    • Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL
    • Zalckvar E, Berissi H, Eisenstein M, Kimchi A. Phosphorylation of Beclin 1 by DAP-kinase promotes autophagy by weakening its interactions with Bcl-2 and Bcl-XL. Autophagy 2009; 5:720-722.
    • (2009) Autophagy , vol.5 , pp. 720-722
    • Zalckvar, E.1    Berissi, H.2    Eisenstein, M.3    Kimchi, A.4
  • 143
    • 44949237240 scopus 로고    scopus 로고
    • JNK1-mediated phosphorylation of bcl-2 regulates starvation-induced autophagy
    • DOI 10.1016/j.molcel.2008.06.001, PII S1097276508003894
    • Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 2008; 30:678-688. (Pubitemid 351818252)
    • (2008) Molecular Cell , vol.30 , Issue.6 , pp. 678-688
    • Wei, Y.1    Pattingre, S.2    Sinha, S.3    Bassik, M.4    Levine, B.5
  • 144
    • 78650746461 scopus 로고    scopus 로고
    • Involvement of caspase-9 in autophagy-mediated cell survival pathway
    • Jeong HS, Choi HY, Lee ER, et al. Involvement of caspase-9 in autophagy-mediated cell survival pathway. Biochim Biophys Acta 2011; 1813:80-90.
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 80-90
    • Jeong, H.S.1    Choi, H.Y.2    Lee, E.R.3
  • 145
    • 50249145608 scopus 로고    scopus 로고
    • A dual role of p53 in the control of autophagy
    • Tasdemir E, Chiara Maiuri M, Morselli E, et al. A dual role of p53 in the control of autophagy. Autophagy 2008; 4:810-814.
    • (2008) Autophagy , vol.4 , pp. 810-814
    • Tasdemir, E.1    Chiara Maiuri, M.2    Morselli, E.3
  • 148
    • 65549085701 scopus 로고    scopus 로고
    • Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling
    • Jin Z, Li Y, Pitti R, et al. Cullin3-based polyubiquitination and p62-dependent aggregation of caspase-8 mediate extrinsic apoptosis signaling. Cell 2009; 137:721-735.
    • (2009) Cell , vol.137 , pp. 721-735
    • Jin, Z.1    Li, Y.2    Pitti, R.3
  • 149
    • 33745713171 scopus 로고    scopus 로고
    • Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis
    • Degenhardt K, Mathew R, Beaudoin B, et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006; 10:51-64.
    • (2006) Cancer Cell , vol.10 , pp. 51-64
    • Degenhardt, K.1    Mathew, R.2    Beaudoin, B.3
  • 150
    • 34548434775 scopus 로고    scopus 로고
    • Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages
    • Suzuki T, Franchi L, Toma C, et al. Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog 2007; 3:e111.
    • (2007) PLoS Pathog , vol.3
    • Suzuki, T.1    Franchi, L.2    Toma, C.3
  • 151
    • 37349037902 scopus 로고    scopus 로고
    • Autophagy is required for necrotic cell death in Caenorhabditis elegans
    • DOI 10.1038/sj.cdd.4402231, PII 4402231, Special issue on Tumor stress, cell death and the ensuing immune response
    • Samara C, Syntichaki P, Tavernarakis N. Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death Differ 2008; 15:105-112. (Pubitemid 350286178)
    • (2008) Cell Death and Differentiation , vol.15 , Issue.1 , pp. 105-112
    • Samara, C.1    Syntichaki, P.2    Tavernarakis, N.3
  • 152
    • 77955865105 scopus 로고    scopus 로고
    • Inhibition of PI3k class III-dependent autophagy prevents apoptosis and necrosis by oxidative stress in dopaminergic neuroblastoma cells
    • Castino R, Bellio N, Follo C, Murphy D, Isidoro C. Inhibition of PI3k class III-dependent autophagy prevents apoptosis and necrosis by oxidative stress in dopaminergic neuroblastoma cells. Toxicol Sci 2010; 117:152-162.
    • (2010) Toxicol Sci , vol.117 , pp. 152-162
    • Castino, R.1    Bellio, N.2    Follo, C.3    Murphy, D.4    Isidoro, C.5
  • 154
    • 33645521571 scopus 로고    scopus 로고
    • Autophagic programmed cell death by selective catalase degradation
    • Yu L, Wan F, Dutta S, et al. Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci USA 2006; 103:4952-4957.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4952-4957
    • Yu, L.1    Wan, F.2    Dutta, S.3
  • 156
    • 38049123578 scopus 로고    scopus 로고
    • Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress
    • Ullman E, Fan Y, Stawowczyk M, Chen HM, Yue Z, Zong WX. Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress. Cell Death Differ 2008; 15:422-425.
    • (2008) Cell Death Differ , vol.15 , pp. 422-425
    • Ullman, E.1    Fan, Y.2    Stawowczyk, M.3    Chen, H.M.4    Yue, Z.5    Zong, W.X.6
  • 157
    • 33745864334 scopus 로고    scopus 로고
    • Deficiency in apoptotic effectors Bax and Bak reveals an autophagic cell death pathway initiated by photodamage to the endoplasmic reticulum
    • Buytaert E, Callewaert G, Vandenheede JR, Agostinis P. Deficiency in apoptotic effectors Bax and Bak reveals an autophagic cell death pathway initiated by photodamage to the endoplasmic reticulum. Autophagy 2006; 2:238-240. (Pubitemid 44030895)
    • (2006) Autophagy , vol.2 , Issue.3 , pp. 238-240
    • Buytaert, E.1    Callewaert, G.2    Vandenheede, J.R.3    Agostinis, P.4
  • 158
    • 77951171023 scopus 로고    scopus 로고
    • Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance
    • Bonapace L, Bornhauser BC, Schmitz M, et al. Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance. J Clin Invest 2010; 120:1310-1323.
    • (2010) J Clin Invest , vol.120 , pp. 1310-1323
    • Bonapace, L.1    Bornhauser, B.C.2    Schmitz, M.3
  • 159
    • 0033153320 scopus 로고    scopus 로고
    • The interaction of p62 with RIP links the atypical PKCs to NF-κB activation
    • DOI 10.1093/emboj/18.11.3044
    • Sanz L, Sanchez P, Lallena MJ, Diaz-Meco MT, Moscat J. The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation. EMBO J 1999; 18:3044-3053. (Pubitemid 29255613)
    • (1999) EMBO Journal , vol.18 , Issue.11 , pp. 3044-3053
    • Sanz, L.1    Sanchez, P.2    Lallena, M.-J.3    Diaz-Meco, M.T.4    Moscat, J.5
  • 160
    • 79651473201 scopus 로고    scopus 로고
    • Neutrophil extracellular trap cell death requires both autophagy and superoxide generation
    • Remijsen Q, Berghe TV, Wirawan E, et al. Neutrophil extracellular trap cell death requires both autophagy and superoxide generation. Cell Res 2011; 21:290-304.
    • (2011) Cell Res , vol.21 , pp. 290-304
    • Remijsen, Q.1    Berghe, T.V.2    Wirawan, E.3
  • 162
    • 33846210657 scopus 로고    scopus 로고
    • Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans
    • Jia K, Hart AC, Levine B. Autophagy genes protect against disease caused by polyglutamine expansion proteins in Caenorhabditis elegans. Autophagy 2007; 3:21-25. (Pubitemid 46100705)
    • (2007) Autophagy , vol.3 , Issue.1 , pp. 21-25
    • Jia, K.1    Hart, A.C.2    Levine, B.3
  • 163
    • 0141766912 scopus 로고    scopus 로고
    • Demography of dietary restriction and death in Drosophila
    • DOI 10.1126/science.1086016
    • Mair W, Goymer P, Pletcher SD, Partridge L. Demography of dietary restriction and death in Drosophila. Science 2003; 301:1731-1733. (Pubitemid 37174368)
    • (2003) Science , vol.301 , Issue.5640 , pp. 1731-1733
    • Mair, W.1    Goymer, P.2    Pletcher, S.D.3    Partridge, L.4
  • 164
    • 69449106873 scopus 로고    scopus 로고
    • Autophagy is required for extension of yeast chronological life span by rapamycin
    • Alvers AL, Wood MS, Hu D, Kaywell AC, Dunn WA Jr, Aris JP. Autophagy is required for extension of yeast chronological life span by rapamycin. Autophagy 2009; 5:847-849.
    • (2009) Autophagy , vol.5 , pp. 847-849
    • Alvers, A.L.1    Wood, M.S.2    Hu, D.3    Kaywell, A.C.4    Dunn Jr., W.A.5    Aris, J.P.6
  • 165
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison DE, Strong R, Sharp ZD, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460:392-395.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3
  • 166
    • 77950656808 scopus 로고    scopus 로고
    • Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol
    • Morselli E, Galluzzi L, Kepp O, et al. Autophagy mediates pharmacological lifespan extension by spermidine and resveratrol. Aging 2009; 1:961-970.
    • (2009) Aging , vol.1 , pp. 961-970
    • Morselli, E.1    Galluzzi, L.2    Kepp, O.3
  • 167
    • 3943071801 scopus 로고    scopus 로고
    • Sirtuin activators mimic caloric restriction and delay ageing in metazoans
    • DOI 10.1038/nature02789
    • Wood JG, Rogina B, Lavu S, et al. Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 2004; 430:686-689. (Pubitemid 39061685)
    • (2004) Nature , vol.430 , Issue.7000 , pp. 686-689
    • Wood, J.G.1    Regina, B.2    Lavu, S.3    Hewitz, K.4    Helfand, S.L.5    Tatar, M.6    Sinclair, D.7
  • 170
    • 75149128169 scopus 로고    scopus 로고
    • The life spanprolonging effect of sirtuin-1 is mediated by autophagy
    • Morselli E, Maiuri MC, Markaki M, et al. The life spanprolonging effect of sirtuin-1 is mediated by autophagy. Autophagy 2010; 6:186-188.
    • (2010) Autophagy , vol.6 , pp. 186-188
    • Morselli, E.1    Maiuri, M.C.2    Markaki, M.3
  • 171
    • 70449529855 scopus 로고    scopus 로고
    • Induction of autophagy by spermidine promotes longevity
    • Eisenberg T, Knauer H, Schauer A, et al. Induction of autophagy by spermidine promotes longevity. Nat Cell Biol 2009; 11:1305-1314.
    • (2009) Nat Cell Biol , vol.11 , pp. 1305-1314
    • Eisenberg, T.1    Knauer, H.2    Schauer, A.3
  • 172
    • 38449102148 scopus 로고    scopus 로고
    • Resveratrol induces proapoptotic endoplasmic reticulum stress in human colon cancer cells
    • Park JW, Woo KJ, Lee JT, et al. Resveratrol induces proapoptotic endoplasmic reticulum stress in human colon cancer cells. Oncol Rep 2007; 18:1269-1273.
    • (2007) Oncol Rep , vol.18 , pp. 1269-1273
    • Park, J.W.1    Woo, K.J.2    Lee, J.T.3
  • 173
    • 0029560552 scopus 로고
    • The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes
    • Terman A. The effect of age on formation and elimination of autophagic vacuoles in mouse hepatocytes. Gerontology 1995; 41 Suppl 2:319-326. (Pubitemid 26019927)
    • (1995) Gerontology , vol.41 , Issue.SUPPL. 2 , pp. 319-326
    • Terman, A.1
  • 176
    • 77953699668 scopus 로고    scopus 로고
    • Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer
    • Dalby KN, Tekedereli I, Lopez-Berestein G, Ozpolat B. Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy 2010; 6:322-329.
    • (2010) Autophagy , vol.6 , pp. 322-329
    • Dalby, K.N.1    Tekedereli, I.2    Lopez-Berestein, G.3    Ozpolat, B.4
  • 177
  • 178
    • 79951847989 scopus 로고    scopus 로고
    • Principles and current strategies for targeting autophagy for cancer treatment
    • Amaravadi RK, Lippincott-Schwartz J, Yin XM, et al. Principles and current strategies for targeting autophagy for cancer treatment. Clin Cancer Res 2011; 17:654-666.
    • (2011) Clin Cancer Res , vol.17 , pp. 654-666
    • Amaravadi, R.K.1    Lippincott-Schwartz, J.2    Yin, X.M.3
  • 179
    • 69949106925 scopus 로고    scopus 로고
    • The double-edged sword of autophagy modulation in cancer
    • White E, DiPaola RS. The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 2009; 15:5308-5316.
    • (2009) Clin Cancer Res , vol.15 , pp. 5308-5316
    • White, E.1    DiPaola, R.S.2
  • 181
    • 79952228407 scopus 로고    scopus 로고
    • Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
    • Guo JY, Chen HY, Mathew R, et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev 2011; 25:460-470.
    • (2011) Genes Dev , vol.25 , pp. 460-470
    • Guo, J.Y.1    Chen, H.Y.2    Mathew, R.3
  • 182
    • 79952229430 scopus 로고    scopus 로고
    • Pancreatic cancers require autophagy for tumor growth
    • Yang S, Wang X, Contino G, et al. Pancreatic cancers require autophagy for tumor growth. Genes Dev 2011; 25:717-729.
    • (2011) Genes Dev , vol.25 , pp. 717-729
    • Yang, S.1    Wang, X.2    Contino, G.3
  • 183
    • 77957681100 scopus 로고    scopus 로고
    • ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy
    • Dewaele M, Maes H, Agostinis P. ROS-mediated mechanisms of autophagy stimulation and their relevance in cancer therapy. Autophagy 2010; 6:838-854.
    • (2010) Autophagy , vol.6 , pp. 838-854
    • Dewaele, M.1    Maes, H.2    Agostinis, P.3
  • 185
    • 77953289524 scopus 로고    scopus 로고
    • Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model
    • Li J, Hou N, Faried A, Tsutsumi S, Kuwano H. Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. Eur J Cancer 2010; 46:1900-1909.
    • (2010) Eur J Cancer , vol.46 , pp. 1900-1909
    • Li, J.1    Hou, N.2    Faried, A.3    Tsutsumi, S.4    Kuwano, H.5
  • 186
    • 37649005234 scopus 로고    scopus 로고
    • Autophagy in the pathogenesis of disease
    • Levine B, Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132:27-42.
    • (2008) Cell , vol.132 , pp. 27-42
    • Levine, B.1    Kroemer, G.2
  • 188
    • 33745751085 scopus 로고    scopus 로고
    • Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG
    • Liang C, Feng P, Ku B, et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat Cell Biol 2006; 8:688-699.
    • (2006) Nat Cell Biol , vol.8 , pp. 688-699
    • Liang, C.1    Feng, P.2    Ku, B.3
  • 192
    • 34249274942 scopus 로고    scopus 로고
    • Beclin 1 gene inhibits tumor growth in colon cancer cell lines
    • Koneri K, Goi T, Hirono Y, Katayama K, Yamaguchi A. Beclin 1 gene inhibits tumor growth in colon cancer cell lines. Anticancer Res 2007; 27:1453-1457. (Pubitemid 46807222)
    • (2007) Anticancer Research , vol.27 , Issue.3 B , pp. 1453-1457
    • Koneri, K.1    Goi, T.2    Hirono, Y.3    Katayama, K.4    Yamaguchi, A.5
  • 193
    • 77949324323 scopus 로고    scopus 로고
    • Oncogenic ras-induced down-regulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cells
    • Yoo BH, Wu X, Li Y, et al. Oncogenic ras-induced down-regulation of autophagy mediator Beclin-1 is required for malignant transformation of intestinal epithelial cells. J Biol Chem 2010; 285:5438-5449.
    • (2010) J Biol Chem , vol.285 , pp. 5438-5449
    • Yoo, B.H.1    Wu, X.2    Li, Y.3
  • 195
    • 48249087666 scopus 로고    scopus 로고
    • Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells
    • Akar U, Chaves-Reyez A, Barria M, et al. Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells. Autophagy 2008; 4:669-679.
    • (2008) Autophagy , vol.4 , pp. 669-679
    • Akar, U.1    Chaves-Reyez, A.2    Barria, M.3
  • 197
    • 77953139736 scopus 로고    scopus 로고
    • Fighting disease by selective autophagy of aggregate-prone proteins
    • Knaevelsrud H, Simonsen A. Fighting disease by selective autophagy of aggregate-prone proteins. FEBS Lett 2010; 584:2635-2645.
    • (2010) FEBS Lett , vol.584 , pp. 2635-2645
    • Knaevelsrud, H.1    Simonsen, A.2
  • 198
    • 70350550208 scopus 로고    scopus 로고
    • Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases
    • Spencer B, Potkar R, Trejo M, et al. Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases. J Neurosci 2009; 29:13578-13588.
    • (2009) J Neurosci , vol.29 , pp. 13578-13588
    • Spencer, B.1    Potkar, R.2    Trejo, M.3
  • 202
    • 77954486784 scopus 로고    scopus 로고
    • Laforin, the most common protein mutated in Lafora disease, regulates autophagy
    • Aguado C, Sarkar S, Korolchuk VI, et al. Laforin, the most common protein mutated in Lafora disease, regulates autophagy. Hum Mol Genet 2010; 19:2867-2876.
    • (2010) Hum Mol Genet , vol.19 , pp. 2867-2876
    • Aguado, C.1    Sarkar, S.2    Korolchuk, V.I.3
  • 204
  • 205
    • 77956396747 scopus 로고    scopus 로고
    • Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition
    • Luciani A, Villella VR, Esposito S, et al. Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibition. Nat Cell Biol 2010; 12:863-875.
    • (2010) Nat Cell Biol , vol.12 , pp. 863-875
    • Luciani, A.1    Villella, V.R.2    Esposito, S.3
  • 206
    • 78149319082 scopus 로고    scopus 로고
    • Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration
    • Grumati P, Coletto L, Sabatelli P, et al. Autophagy is defective in collagen VI muscular dystrophies, and its reactivation rescues myofiber degeneration. Nat Med 2010; 16:1313-1320.
    • (2010) Nat Med , vol.16 , pp. 1313-1320
    • Grumati, P.1    Coletto, L.2    Sabatelli, P.3
  • 207
    • 46449126749 scopus 로고    scopus 로고
    • Lysosomal myopathies: An excessive build-up in autopha-gosomes is too much to handle
    • Malicdan MC, Noguchi S, Nonaka I, Saftig P, Nishino I. Lysosomal myopathies: an excessive build-up in autopha-gosomes is too much to handle. Neuromuscul Disord 2008; 18:521-529.
    • (2008) Neuromuscul Disord , vol.18 , pp. 521-529
    • Malicdan, M.C.1    Noguchi, S.2    Nonaka, I.3    Saftig, P.4    Nishino, I.5
  • 211
    • 34147168105 scopus 로고    scopus 로고
    • Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and beclin 1 in mediating autophagy
    • DOI 10.1161/01.RES.0000261924.76669.36
    • Matsui Y, Takagi H, Qu X, et al. Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ Res 2007; 100:914-922. (Pubitemid 46555697)
    • (2007) Circulation Research , vol.100 , Issue.6 , pp. 914-922
    • Matsui, Y.1    Takagi, H.2    Qu, X.3    Abdellatif, M.4    Sakoda, H.5    Asano, T.6    Levine, B.7    Sadoshima, J.8
  • 212
    • 78049498575 scopus 로고    scopus 로고
    • Alpha1-antitrypsin deficiency and autophagy
    • Marciniak SJ, Lomas DA. Alpha1-antitrypsin deficiency and autophagy. N Engl J Med 2010; 363:1863-1864.
    • (2010) N Engl J Med , vol.363 , pp. 1863-1864
    • Marciniak, S.J.1    Lomas, D.A.2
  • 213
    • 77954597127 scopus 로고    scopus 로고
    • An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis
    • Hidvegi T, Ewing M, Hale P, et al. An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis. Science 2010; 329:229-232.
    • (2010) Science , vol.329 , pp. 229-232
    • Hidvegi, T.1    Ewing, M.2    Hale, P.3
  • 214
    • 77955292017 scopus 로고    scopus 로고
    • Role of autophagy in diabetes and mitochondria
    • Jung HS, Lee MS. Role of autophagy in diabetes and mitochondria. Ann N Y Acad Sci 2010; 1201:79-83.
    • (2010) Ann N y Acad Sci , vol.1201 , pp. 79-83
    • Jung, H.S.1    Lee, M.S.2
  • 215
    • 64549101639 scopus 로고    scopus 로고
    • Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability
    • Kang MR, Kim MS, Oh JE, et al. Frameshift mutations of autophagy-related genes ATG2B, ATG5, ATG9B and ATG12 in gastric and colorectal cancers with microsatellite instability. J Pathol 2009; 217:702-706.
    • (2009) J Pathol , vol.217 , pp. 702-706
    • Kang, M.R.1    Kim, M.S.2    Oh, J.E.3
  • 216
    • 77952272127 scopus 로고    scopus 로고
    • Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors
    • Li Z, Chen B, Wu Y, Jin F, Xia Y, Liu X. Genetic and epigenetic silencing of the beclin 1 gene in sporadic breast tumors. BMC Cancer 2010; 10:98.
    • (2010) BMC Cancer , vol.10 , pp. 98
    • Li, Z.1    Chen, B.2    Wu, Y.3    Jin, F.4    Xia, Y.5    Liu, X.6
  • 217
    • 34249825782 scopus 로고    scopus 로고
    • Somatic mutations of BECN1, an autophagy-related gene, in human cancers
    • DOI 10.1111/j.1600-0463.2007.apm-640.x
    • Lee JW, Jeong EG, Lee SH, Yoo NJ. Somatic mutations of BECN1, an autophagy-related gene, in human cancers. APMIS 2007; 115:750-756. (Pubitemid 46854994)
    • (2007) APMIS , vol.115 , Issue.6 , pp. 750-756
    • Lee, J.W.1    Jeong, E.G.2    Lee, S.H.3    Yoo, N.J.4    Lee, S.H.5
  • 219
    • 78449273851 scopus 로고    scopus 로고
    • UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy
    • Knaevelsrud H, Ahlquist T, Merok MA, et al. UVRAG mutations associated with microsatellite unstable colon cancer do not affect autophagy. Autophagy 2010; 6:863-870.
    • (2010) Autophagy , vol.6 , pp. 863-870
    • Knaevelsrud, H.1    Ahlquist, T.2    Merok, M.A.3
  • 220
    • 1242296021 scopus 로고    scopus 로고
    • Manipulation of nonsense mediated decay identifies gene mutations in colon cancer cells with microsatellite instability
    • DOI 10.1038/sj.onc.1207178
    • Ionov Y, Nowak N, Perucho M, Markowitz S, Cowell JK. Manipulation of nonsense mediated decay identifies gene mutations in colon cancer cells with microsatellite instability. Oncogene 2004; 23:639-645. (Pubitemid 38241265)
    • (2004) Oncogene , vol.23 , Issue.3 , pp. 639-645
    • Ionov, Y.1    Nowak, N.2    Perucho, M.3    Markowitz, S.4    Cowell, J.K.5
  • 221
    • 45049083880 scopus 로고    scopus 로고
    • Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability
    • Kim MS, Jeong EG, Ahn CH, Kim SS, Lee SH, Yoo NJ. Frameshift mutation of UVRAG, an autophagy-related gene, in gastric carcinomas with microsatellite instability. Hum Pathol 2008; 39:1059-1063.
    • (2008) Hum Pathol , vol.39 , pp. 1059-1063
    • Kim, M.S.1    Jeong, E.G.2    Ahn, C.H.3    Kim, S.S.4    Lee, S.H.5    Yoo, N.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.