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Volumn 4 JUN, Issue , 2013, Pages

Connexin diversity in the heart: Insights from transgenic mouse models

Author keywords

Arrhythmias; Cardiac; Conduction; Connexins; Gap junctions; Mouse models

Indexed keywords

CONNEXIN 30.2; CONNEXIN 37; CONNEXIN 40; CONNEXIN 43; CONNEXIN 45; CONNEXIN 46; GAP JUNCTION PROTEIN; UNCLASSIFIED DRUG;

EID: 84881646732     PISSN: None     EISSN: 16639812     Source Type: Journal    
DOI: 10.3389/fphar.2013.00081     Document Type: Review
Times cited : (56)

References (201)
  • 1
    • 79551514806 scopus 로고    scopus 로고
    • Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice
    • doi: 10.1172/JCI44350
    • Aanhaanen, W. T., Boukens, B. J., Sizarov, A., Wakker, V., De Gier-De Vries, C., Van Ginneken, A. C., et al. (2011). Defective Tbx2-dependent patterning of the atrioventricular canal myocardium causes accessory pathway formation in mice. J. Clin. Invest. 121, 534-544. doi: 10.1172/JCI44350.
    • (2011) J. Clin. Invest. , vol.121 , pp. 534-544
    • Aanhaanen, W.T.1    Boukens, B.J.2    Sizarov, A.3    Wakker, V.4    De Gier-De Vries, C.5    Van Ginneken, A.C.6
  • 2
    • 84866863248 scopus 로고    scopus 로고
    • The noncanonical functions of Cx43 in the heart
    • doi: 10.1007/s00232-012-9466-y
    • Agullo-Pascual, E., and Delmar, M. (2012). The noncanonical functions of Cx43 in the heart. J. Membr. Biol. 245, 477-482. doi: 10.1007/s00232-012-9466-y.
    • (2012) J. Membr. Biol. , vol.245 , pp. 477-482
    • Agullo-Pascual, E.1    Delmar, M.2
  • 3
    • 9144245551 scopus 로고    scopus 로고
    • Replacement of connexin40 by connexin45 in the mouse: impact on cardiac electrical conduction
    • doi: 10.1161/01.RES.0000108261.67979.2A
    • Alcoléa, S., Jarry-Guichard, T., De Bakker, J., Gonzalez, D., Lamers, W., Coppen, S., et al. (2004). Replacement of connexin40 by connexin45 in the mouse: impact on cardiac electrical conduction. Circ. Res. 94, 100-109. doi: 10.1161/01.RES.0000108261.67979.2A.
    • (2004) Circ. Res. , vol.94 , pp. 100-109
    • Alcoléa, S.1    Jarry-Guichard, T.2    De Bakker, J.3    Gonzalez, D.4    Lamers, W.5    Coppen, S.6
  • 4
    • 18244411722 scopus 로고    scopus 로고
    • Downregulation of connexin 45 gene products during mouse heart development
    • doi: 10.1161/01.RES.84.12.1365
    • Alcolea, S., Theveniau-Ruissy, M., Jarry-Guichard, T., Marics, I., Tzouanacou, E., Chauvin, J. P., et al. (1999). Downregulation of connexin 45 gene products during mouse heart development. Circ. Res. 84, 1365-1379. doi: 10.1161/01.RES.84.12.1365.
    • (1999) Circ. Res. , vol.84 , pp. 1365-1379
    • Alcolea, S.1    Theveniau-Ruissy, M.2    Jarry-Guichard, T.3    Marics, I.4    Tzouanacou, E.5    Chauvin, J.P.6
  • 5
    • 84863543347 scopus 로고    scopus 로고
    • TBX5 drives Scn5a expression to regulate cardiac conduction system function
    • doi: 10.1172/JCI62617
    • Arnolds, D. E., Liu, F., Fahrenbach, J. P., Kim, G. H., Schillinger, K. J., Smemo, S., et al. (2012). TBX5 drives Scn5a expression to regulate cardiac conduction system function. J. Clin. Invest. 122, 2509-2518. doi: 10.1172/JCI62617.
    • (2012) J. Clin. Invest. , vol.122 , pp. 2509-2518
    • Arnolds, D.E.1    Liu, F.2    Fahrenbach, J.P.3    Kim, G.H.4    Schillinger, K.J.5    Smemo, S.6
  • 6
    • 26844537322 scopus 로고    scopus 로고
    • Altered right atrial excitation and propagation in connexin40 knockout mice
    • doi: 10.1161/CIRCULATIONAHA.104.527325
    • Bagwe, S., Berenfeld, O., Vaidya, D., Morley, G. E., and Jalife, J. (2005). Altered right atrial excitation and propagation in connexin40 knockout mice. Circulation 112, 2245-2253. doi: 10.1161/CIRCULATIONAHA.104.527325.
    • (2005) Circulation , vol.112 , pp. 2245-2253
    • Bagwe, S.1    Berenfeld, O.2    Vaidya, D.3    Morley, G.E.4    Jalife, J.5
  • 7
    • 44949102430 scopus 로고    scopus 로고
    • Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system
    • doi: 10.1161/CIRCRESAHA.107.169565
    • Bakker, M. L., Boukens, B. J., Mommersteeg, M. T., Brons, J. F., Wakker, V., Moorman, A. F., et al. (2008). Transcription factor Tbx3 is required for the specification of the atrioventricular conduction system. Circ. Res. 102, 1340-1349. doi: 10.1161/CIRCRESAHA.107.169565.
    • (2008) Circ. Res. , vol.102 , pp. 1340-1349
    • Bakker, M.L.1    Boukens, B.J.2    Mommersteeg, M.T.3    Brons, J.F.4    Wakker, V.5    Moorman, A.F.6
  • 8
    • 84455210215 scopus 로고    scopus 로고
    • Residual Cx45 and its relationship to Cx43 in murine ventricular myocardium
    • doi: 10.4161/chan.5.6.18523
    • Bao, M., Kanter, E. M., Huang, R. Y., Maxeiner, S., Frank, M., Zhang, Y., et al. (2011). Residual Cx45 and its relationship to Cx43 in murine ventricular myocardium. Channels (Austin) 5, 489-499. doi: 10.4161/chan.5.6.18523.
    • (2011) Channels (Austin) , vol.5 , pp. 489-499
    • Bao, M.1    Kanter, E.M.2    Huang, R.Y.3    Maxeiner, S.4    Frank, M.5    Zhang, Y.6
  • 9
    • 0032555956 scopus 로고    scopus 로고
    • Rapid turnover of connexin43 in the adult rat heart
    • doi: 10.1161/01.RES.83.6.629
    • Beardslee, M. A., Laing, J. G., Beyer, E. C., and Saffitz, J. E. (1998). Rapid turnover of connexin43 in the adult rat heart. Circ. Res. 83, 629-635. doi: 10.1161/01.RES.83.6.629.
    • (1998) Circ. Res. , vol.83 , pp. 629-635
    • Beardslee, M.A.1    Laing, J.G.2    Beyer, E.C.3    Saffitz, J.E.4
  • 10
    • 3342896391 scopus 로고    scopus 로고
    • Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice
    • doi: 10.1161/01.RES.0000134923.05174.2f
    • Beauchamp, P., Choby, C., Desplantez, T., De Peyer, K., Green, K., Yamada, K. A., et al. (2004). Electrical propagation in synthetic ventricular myocyte strands from germline connexin43 knockout mice. Circ. Res. 95, 170-178. doi: 10.1161/01.RES.0000134923.05174.2f.
    • (2004) Circ. Res. , vol.95 , pp. 170-178
    • Beauchamp, P.1    Choby, C.2    Desplantez, T.3    De Peyer, K.4    Green, K.5    Yamada, K.A.6
  • 11
    • 33751318437 scopus 로고    scopus 로고
    • Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes
    • doi: 10.1161/01.RES.0000250607.34498.b4
    • Beauchamp, P., Yamada, K. A., Baertschi, A. J., Green, K., Kanter, E. M., Saffitz, J. E., et al. (2006). Relative contributions of connexins 40 and 43 to atrial impulse propagation in synthetic strands of neonatal and fetal murine cardiomyocytes. Circ. Res. 99, 1216-1224. doi: 10.1161/01.RES.0000250607.34498.b4.
    • (2006) Circ. Res. , vol.99 , pp. 1216-1224
    • Beauchamp, P.1    Yamada, K.A.2    Baertschi, A.J.3    Green, K.4    Kanter, E.M.5    Saffitz, J.E.6
  • 12
    • 0035750833 scopus 로고    scopus 로고
    • Identification and functional expression of HCx31.9, a novel gap junction gene
    • doi: 10.3109/15419060109080719
    • Belluardo, N., White, T. W., Srinivas, M., Trovato-Salinaro, A., Ripps, H., Mudo, G., et al. (2001). Identification and functional expression of HCx31.9, a novel gap junction gene. Cell Commun. Adhes. 8, 173-178. doi: 10.3109/15419060109080719.
    • (2001) Cell Commun. Adhes. , vol.8 , pp. 173-178
    • Belluardo, N.1    White, T.W.2    Srinivas, M.3    Trovato-Salinaro, A.4    Ripps, H.5    Mudo, G.6
  • 13
    • 1842813431 scopus 로고    scopus 로고
    • Spontaneous and inducible ventricular arrhythmias after myocardial infarction in mice
    • doi: 10.1016/S1054-8807(03)00152-2
    • Betsuyaku, T., Kanno, S., Lerner, D. L., Schuessler, R. B., Saffitz, J. E., and Yamada, K. A. (2004). Spontaneous and inducible ventricular arrhythmias after myocardial infarction in mice. Cardiovasc. Pathol. 13, 156-164. doi: 10.1016/S1054-8807(03)00152-2.
    • (2004) Cardiovasc. Pathol. , vol.13 , pp. 156-164
    • Betsuyaku, T.1    Kanno, S.2    Lerner, D.L.3    Schuessler, R.B.4    Saffitz, J.E.5    Yamada, K.A.6
  • 14
    • 0036487237 scopus 로고    scopus 로고
    • Cardiac structure and function in young and senescent mice heterozygous for a connexin43 null mutation
    • doi: 10.1006/jmcc.2001.1499
    • Betsuyaku, T., Kovacs, A., Saffitz, J. E., and Yamada, K. A. (2002). Cardiac structure and function in young and senescent mice heterozygous for a connexin43 null mutation. J. Mol. Cell. Cardiol. 34, 175-184. doi: 10.1006/jmcc.2001.1499.
    • (2002) J. Mol. Cell. Cardiol. , vol.34 , pp. 175-184
    • Betsuyaku, T.1    Kovacs, A.2    Saffitz, J.E.3    Yamada, K.A.4
  • 15
    • 33644807768 scopus 로고    scopus 로고
    • Overexpression of cardiac connexin45 increases susceptibility to ventricular tachyarrhythmias in vivo
    • doi: 10.1152/ajpheart.01308.2004
    • Betsuyaku, T., Nnebe, N. S., Sundset, R., Patibandla, S., Krueger, C. M., and Yamada, K. A. (2006). Overexpression of cardiac connexin45 increases susceptibility to ventricular tachyarrhythmias in vivo. Am. J. Physiol. Heart Circ. Physiol. 290, H163-H171. doi: 10.1152/ajpheart.01308.2004.
    • (2006) Am. J. Physiol. Heart Circ. Physiol. , vol.290
    • Betsuyaku, T.1    Nnebe, N.S.2    Sundset, R.3    Patibandla, S.4    Krueger, C.M.5    Yamada, K.A.6
  • 16
    • 0033710745 scopus 로고    scopus 로고
    • A targeted disruption in connexin40 leads to distinct atrioventricular conduction defects
    • doi: 10.1023/A:1009800328836
    • Bevilacqua, L. M., Simon, A. M., Maguire, C. T., Gehrmann, J., Wakimoto, H., Paul, D. L., et al. (2000). A targeted disruption in connexin40 leads to distinct atrioventricular conduction defects. J. Interv. Card. Electrophysiol. 4, 459-467. doi: 10.1023/A:1009800328836.
    • (2000) J. Interv. Card. Electrophysiol. , vol.4 , pp. 459-467
    • Bevilacqua, L.M.1    Simon, A.M.2    Maguire, C.T.3    Gehrmann, J.4    Wakimoto, H.5    Paul, D.L.6
  • 17
    • 21744434924 scopus 로고    scopus 로고
    • Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning
    • doi: 10.1016/j.cardiores.2005.04.014
    • Boengler, K., Dodoni, G., Rodriguez-Sinovas, A., Cabestrero, A., Ruiz-Meana, M., Gres, P., et al. (2005). Connexin 43 in cardiomyocyte mitochondria and its increase by ischemic preconditioning. Cardiovasc. Res. 67, 234-244. doi: 10.1016/j.cardiores.2005.04.014.
    • (2005) Cardiovasc. Res. , vol.67 , pp. 234-244
    • Boengler, K.1    Dodoni, G.2    Rodriguez-Sinovas, A.3    Cabestrero, A.4    Ruiz-Meana, M.5    Gres, P.6
  • 18
    • 84864390257 scopus 로고    scopus 로고
    • Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption
    • doi: 10.1111/j.1582-4934.2011.01516.x
    • Boengler, K., Ruiz-Meana, M., Gent, S., Ungefug, E., Soetkamp, D., Miro-Casas, E., et al. (2012). Mitochondrial connexin 43 impacts on respiratory complex I activity and mitochondrial oxygen consumption. J. Cell. Mol. Med. 16, 1649-1655. doi: 10.1111/j.1582-4934.2011.01516.x.
    • (2012) J. Cell. Mol. Med. , vol.16 , pp. 1649-1655
    • Boengler, K.1    Ruiz-Meana, M.2    Gent, S.3    Ungefug, E.4    Soetkamp, D.5    Miro-Casas, E.6
  • 19
    • 62249090215 scopus 로고    scopus 로고
    • Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria
    • doi: 10.1007/s00395-009-0007-5
    • Boengler, K., Stahlhofen, S., Van De Sand, A., Gres, P., Ruiz-Meana, M., Garcia-Dorado, D., et al. (2009). Presence of connexin 43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria. Basic Res. Cardiol. 104, 141-147. doi: 10.1007/s00395-009-0007-5.
    • (2009) Basic Res. Cardiol. , vol.104 , pp. 141-147
    • Boengler, K.1    Stahlhofen, S.2    Van De Sand, A.3    Gres, P.4    Ruiz-Meana, M.5    Garcia-Dorado, D.6
  • 20
    • 33745458793 scopus 로고    scopus 로고
    • Properties of mouse connexin 30.2 and human connexin 31. 9 hemichannels: implications for atrioventricular conduction in the heart
    • doi: 10.1073/pnas.0603372103
    • Bukauskas, F. F., Kreuzberg, M. M., Rackauskas, M., Bukauskiene, A., Bennett, M. V., Verselis, V. K., et al. (2006). Properties of mouse connexin 30.2 and human connexin 31.9 hemichannels: implications for atrioventricular conduction in the heart. Proc. Natl. Acad. Sci. U.S.A. 103, 9726-9731. doi: 10.1073/pnas.0603372103.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 9726-9731
    • Bukauskas, F.F.1    Kreuzberg, M.M.2    Rackauskas, M.3    Bukauskiene, A.4    Bennett, M.V.5    Verselis, V.K.6
  • 21
    • 64749110218 scopus 로고    scopus 로고
    • Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker
    • doi: 10.1161/CIRCULATIONAHA.108.804369
    • Chandler, N. J., Greener, I. D., Tellez, J. O., Inada, S., Musa, H., Molenaar, P., et al. (2009). Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker. Circulation 119, 1562-1575. doi: 10.1161/CIRCULATIONAHA.108.804369.
    • (2009) Circulation , vol.119 , pp. 1562-1575
    • Chandler, N.J.1    Greener, I.D.2    Tellez, J.O.3    Inada, S.4    Musa, H.5    Molenaar, P.6
  • 22
    • 77957066568 scopus 로고    scopus 로고
    • Cardiac conduction is required to preserve cardiac chamber morphology
    • doi: 10.1073/pnas.0909432107
    • Chi, N. C., Bussen, M., Brand-Arzamendi, K., Ding, C., Olgin, J. E., Shaw, R. M., et al. (2010). Cardiac conduction is required to preserve cardiac chamber morphology. Proc. Natl. Acad. Sci. U.S.A. 107, 14662-14667. doi: 10.1073/pnas.0909432107.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 14662-14667
    • Chi, N.C.1    Bussen, M.2    Brand-Arzamendi, K.3    Ding, C.4    Olgin, J.E.5    Shaw, R.M.6
  • 23
    • 1842561719 scopus 로고    scopus 로고
    • T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers
    • doi: 10.1002/dvdy.10487
    • Christoffels, V. M., Hoogaars, W. M., Tessari, A., Clout, D. E., Moorman, A. F., and Campione, M. (2004). T-box transcription factor Tbx2 represses differentiation and formation of the cardiac chambers. Dev. Dyn. 229, 763-770. doi: 10.1002/dvdy.10487.
    • (2004) Dev. Dyn. , vol.229 , pp. 763-770
    • Christoffels, V.M.1    Hoogaars, W.M.2    Tessari, A.3    Clout, D.E.4    Moorman, A.F.5    Campione, M.6
  • 24
    • 0032498522 scopus 로고    scopus 로고
    • Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart
    • doi: 10.1161/01.RES.82.2.232
    • Coppen, S. R., Dupont, E., Rothery, S., and Severs, N. J. (1998). Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart. Circ. Res. 82, 232-243. doi: 10.1161/01.RES.82.2.232.
    • (1998) Circ. Res. , vol.82 , pp. 232-243
    • Coppen, S.R.1    Dupont, E.2    Rothery, S.3    Severs, N.J.4
  • 25
    • 0035045165 scopus 로고    scopus 로고
    • Connexin45 is the first connexin to be expressed in the central conduction system of the mouse heart
    • Coppen, S. R., Gourdie, R. G., and Severs, N. J. (2001). Connexin45 is the first connexin to be expressed in the central conduction system of the mouse heart. Exp. Clin. Cardiol. 6, 17-23.
    • (2001) Exp. Clin. Cardiol. , vol.6 , pp. 17-23
    • Coppen, S.R.1    Gourdie, R.G.2    Severs, N.J.3
  • 26
    • 0037286898 scopus 로고    scopus 로고
    • Comparison of connexin expression patterns in the developing mouse heart and human foetal heart
    • doi: 10.1023/A:1021150014764
    • Coppen, S. R., Kaba, R. A., Halliday, D., Dupont, E., Skepper, J. N., Elneil, S., et al. (2003). Comparison of connexin expression patterns in the developing mouse heart and human foetal heart. Mol. Cell. Biochem. 242, 121-127. doi: 10.1023/A:1021150014764.
    • (2003) Mol. Cell. Biochem. , vol.242 , pp. 121-127
    • Coppen, S.R.1    Kaba, R.A.2    Halliday, D.3    Dupont, E.4    Skepper, J.N.5    Elneil, S.6
  • 27
    • 0033041407 scopus 로고    scopus 로고
    • Connexin45 (alpha 6) expression delineates an extended conduction system in the embryonic and mature rodent heart
    • Coppen, S. R., Severs, N. J., and Gourdie, R. G. (1999). Connexin45 (alpha 6) expression delineates an extended conduction system in the embryonic and mature rodent heart. Dev. Genet. 24, 82-90.
    • (1999) Dev. Genet. , vol.24 , pp. 82-90
    • Coppen, S.R.1    Severs, N.J.2    Gourdie, R.G.3
  • 28
    • 0035195813 scopus 로고    scopus 로고
    • Heterotypic gap junction channel formation between heteromeric and homomeric Cx40 and Cx43 connexons
    • Cottrell, G. T., and Burt, J. M. (2001). Heterotypic gap junction channel formation between heteromeric and homomeric Cx40 and Cx43 connexons. Am. J. Physiol. Cell Physiol. 281, C1559-C1567.
    • (2001) Am. J. Physiol. Cell Physiol. , vol.281
    • Cottrell, G.T.1    Burt, J.M.2
  • 29
    • 0028816743 scopus 로고
    • Expression of gap junction genes, connexin40 and connexin43, during fetal mouse development
    • doi: 10.1007/BF00187825
    • Dahl, E., Winterhager, E., Traub, O., and Willecke, K. (1995). Expression of gap junction genes, connexin40 and connexin43, during fetal mouse development. Anat. Embryol. 191, 267-278. doi: 10.1007/BF00187825.
    • (1995) Anat. Embryol. , vol.191 , pp. 267-278
    • Dahl, E.1    Winterhager, E.2    Traub, O.3    Willecke, K.4
  • 30
    • 8844286738 scopus 로고    scopus 로고
    • Modulation of cardiac gap junction expression and arrhythmic susceptibility
    • doi: 10.1161/01.RES.0000148664.33695.2a
    • Danik, S. B., Liu, F., Zhang, J., Suk, H. J., Morley, G. E., Fishman, G. I., et al. (2004). Modulation of cardiac gap junction expression and arrhythmic susceptibility. Circ. Res. 95, 1035-1041. doi: 10.1161/01.RES.0000148664.33695.2a.
    • (2004) Circ. Res. , vol.95 , pp. 1035-1041
    • Danik, S.B.1    Liu, F.2    Zhang, J.3    Suk, H.J.4    Morley, G.E.5    Fishman, G.I.6
  • 31
    • 42049119846 scopus 로고    scopus 로고
    • Electrical remodeling contributes to complex tachyarrhythmias in connexin43-deficient mouse hearts
    • doi: 10.1096/fj.07-8974com
    • Danik, S. B., Rosner, G., Lader, J., Gutstein, D. E., Fishman, G. I., and Morley, G. E. (2008). Electrical remodeling contributes to complex tachyarrhythmias in connexin43-deficient mouse hearts. FASEB J. 22, 1204-1212. doi: 10.1096/fj.07-8974com.
    • (2008) FASEB J , vol.22 , pp. 1204-1212
    • Danik, S.B.1    Rosner, G.2    Lader, J.3    Gutstein, D.E.4    Fishman, G.I.5    Morley, G.E.6
  • 32
    • 0028024953 scopus 로고
    • Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties
    • doi: 10.1016/0735-1097(94)90879-6
    • Davis, L. M., Kanter, H. L., Beyer, E. C., and Saffitz, J. E. (1994). Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction properties. J. Am. Coll. Cardiol. 24, 1124-1132. doi: 10.1016/0735-1097(94)90879-6.
    • (1994) J. Am. Coll. Cardiol. , vol.24 , pp. 1124-1132
    • Davis, L.M.1    Kanter, H.L.2    Beyer, E.C.3    Saffitz, J.E.4
  • 33
    • 0028860713 scopus 로고
    • Gap junction protein phenotypes of the human heart and conduction system
    • doi: 10.1111/j.1540-8167.1995.tb00357.x
    • Davis, L. M., Rodefeld, M. E., Green, K., Beyer, E. C., and Saffitz, J. E. (1995). Gap junction protein phenotypes of the human heart and conduction system. J. Cardiovasc. Electrophysiol. 6, 813-822. doi: 10.1111/j.1540-8167.1995.tb00357.x.
    • (1995) J. Cardiovasc. Electrophysiol. , vol.6 , pp. 813-822
    • Davis, L.M.1    Rodefeld, M.E.2    Green, K.3    Beyer, E.C.4    Saffitz, J.E.5
  • 34
    • 1942438686 scopus 로고    scopus 로고
    • Acute ischemia-induced gap junctional uncoupling and arrhythmogenesis
    • doi: 10.1016/j.cardiores.2004.01.033
    • De Groot, J. R., and Coronel, R. (2004). Acute ischemia-induced gap junctional uncoupling and arrhythmogenesis. Cardiovasc. Res. 62, 323-334. doi: 10.1016/j.cardiores.2004.01.033.
    • (2004) Cardiovasc. Res. , vol.62 , pp. 323-334
    • De Groot, J.R.1    Coronel, R.2
  • 35
    • 0030792079 scopus 로고    scopus 로고
    • Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular system
    • doi: 10.1161/01.RES.81.3.423
    • Delorme, B., Dahl, E., Jarry-Guichard, T., Briand, J. P., Willecke, K., Gros, D., et al. (1997). Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular system. Circ. Res. 81, 423-437. doi: 10.1161/01.RES.81.3.423.
    • (1997) Circ. Res. , vol.81 , pp. 423-437
    • Delorme, B.1    Dahl, E.2    Jarry-Guichard, T.3    Briand, J.P.4    Willecke, K.5    Gros, D.6
  • 36
    • 0028829253 scopus 로고
    • Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction system
    • doi: 10.1002/aja.1002040403
    • Delorme, B., Dahl, E., Jarry-Guichard, T., Marics, I., Briand, J. P., Willecke, K., et al. (1995). Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction system. Dev. Dyn. 204, 358-371. doi: 10.1002/aja.1002040403.
    • (1995) Dev. Dyn. , vol.204 , pp. 358-371
    • Delorme, B.1    Dahl, E.2    Jarry-Guichard, T.3    Marics, I.4    Briand, J.P.5    Willecke, K.6
  • 37
    • 84859897711 scopus 로고    scopus 로고
    • Cardiac connexins, mutations and arrhythmias
    • doi: 10.1097/HCO.0b013e328352220e
    • Delmar, M., and Makita, N. (2012). Cardiac connexins, mutations and arrhythmias. Curr. Opin. Cardiol. 27, 236-241. doi: 10.1097/HCO.0b013e328352220e.
    • (2012) Curr. Opin. Cardiol. , vol.27 , pp. 236-241
    • Delmar, M.1    Makita, N.2
  • 38
    • 0014478026 scopus 로고
    • A study on the healing-over of myocardial cells of toads
    • doi: 10.1161/01.RES.24.3.475
    • de Mello, W. C., Motta, G. E., and Chapeau, M. (1969). A study on the healing-over of myocardial cells of toads. Circ. Res. 24, 475-487. doi: 10.1161/01.RES.24.3.475.
    • (1969) Circ. Res. , vol.24 , pp. 475-487
    • de Mello, W.C.1    Motta, G.E.2    Chapeau, M.3
  • 39
    • 3442896550 scopus 로고    scopus 로고
    • Cardiac connexins Cx43 and Cx45: formation of diverse gap junction channels with diverse electrical properties
    • doi: 10.1007/s00424-004-1250-0
    • Desplantez, T., Halliday, D., Dupont, E., and Weingart, R. (2004). Cardiac connexins Cx43 and Cx45: formation of diverse gap junction channels with diverse electrical properties. Pflugers Arch. 448, 363-375. doi: 10.1007/s00424-004-1250-0.
    • (2004) Pflugers Arch , vol.448 , pp. 363-375
    • Desplantez, T.1    Halliday, D.2    Dupont, E.3    Weingart, R.4
  • 40
    • 84859018881 scopus 로고    scopus 로고
    • Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current
    • doi: 10.1093/cvr/cvs025
    • Desplantez, T., McCain, M. L., Beauchamp, P., Rigoli, G., Rothen-Rutishauser, B., Parker, K. K., et al. (2012). Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current. Cardiovasc. Res. 94, 58-65. doi: 10.1093/cvr/cvs025.
    • (2012) Cardiovasc. Res. , vol.94 , pp. 58-65
    • Desplantez, T.1    McCain, M.L.2    Beauchamp, P.3    Rigoli, G.4    Rothen-Rutishauser, B.5    Parker, K.K.6
  • 41
    • 79953705138 scopus 로고    scopus 로고
    • Pharmacological modulation of connexin-formed channels in cardiac pathophysiology
    • doi: 10.1111/j.1476-5381.2011.01244.x
    • De Vuyst, E., Boengler, K., Antoons, G., Sipido, K. R., Schulz, R., and Leybaert, L. (2011). Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br. J. Pharmacol. 163, 469-483. doi: 10.1111/j.1476-5381.2011.01244.x.
    • (2011) Br. J. Pharmacol. , vol.163 , pp. 469-483
    • De Vuyst, E.1    Boengler, K.2    Antoons, G.3    Sipido, K.R.4    Schulz, R.5    Leybaert, L.6
  • 42
    • 0141590655 scopus 로고    scopus 로고
    • Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion
    • de Wit, C., Roos, F., Bolz, S. S., and Pohl, U. (2003). Lack of vascular connexin 40 is associated with hypertension and irregular arteriolar vasomotion. Physiol. Genomics 13, 169-177.
    • (2003) Physiol. Genomics , vol.13 , pp. 169-177
    • de Wit, C.1    Roos, F.2    Bolz, S.S.3    Pohl, U.4
  • 43
    • 33744455507 scopus 로고    scopus 로고
    • Cardiac ischemia and uncoupling: gap junctions in ischemia and infarction
    • doi: 10.1159/000092570
    • Dhein, S. (2006). Cardiac ischemia and uncoupling: gap junctions in ischemia and infarction. Adv. Cardiol. 42, 198-212. doi: 10.1159/000092570.
    • (2006) Adv. Cardiol. , vol.42 , pp. 198-212
    • Dhein, S.1
  • 44
    • 72049133465 scopus 로고    scopus 로고
    • Cx30 in the sinus node of murine heart: just one connexin more, or more Evidence for a construction principle?
    • doi: 10.1093/cvr/cvp351
    • Dhein, S. (2010). Cx30 in the sinus node of murine heart: just one connexin more, or more. Evidence for a construction principle? Cardiovasc. Res. 85, 7-8. doi: 10.1093/cvr/cvp351.
    • (2010) Cardiovasc. Res. , vol.85 , pp. 7-8
    • Dhein, S.1
  • 45
    • 38849142479 scopus 로고    scopus 로고
    • The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans
    • doi: 10.1093/hmg/ddm329
    • Dobrowolski, R., Sasse, P., Schrickel, J. W., Watkins, M., Kim, J. S., Rackauskas, M., et al. (2008). The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans. Hum. Mol. Genet. 17, 539-554. doi: 10.1093/hmg/ddm329.
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 539-554
    • Dobrowolski, R.1    Sasse, P.2    Schrickel, J.W.3    Watkins, M.4    Kim, J.S.5    Rackauskas, M.6
  • 46
    • 58149092631 scopus 로고    scopus 로고
    • Connexin-caused genetic diseases and corresponding mouse models
    • doi: 10.1089/ars.2008.2128
    • Dobrowolski, R., and Willecke, K. (2009). Connexin-caused genetic diseases and corresponding mouse models. Antioxid. Redox Signal. 11, 283-295. doi: 10.1089/ars.2008.2128.
    • (2009) Antioxid. Redox Signal. , vol.11 , pp. 283-295
    • Dobrowolski, R.1    Willecke, K.2
  • 47
    • 84864479765 scopus 로고    scopus 로고
    • The molecular mechanisms of gap junction remodeling
    • doi: 10.1016/j.hrthm.2011.11.048
    • Duffy, H. S. (2012). The molecular mechanisms of gap junction remodeling. Heart Rhythm 9, 1331-1334. doi: 10.1016/j.hrthm.2011.11.048.
    • (2012) Heart Rhythm , vol.9 , pp. 1331-1334
    • Duffy, H.S.1
  • 48
    • 1042291189 scopus 로고    scopus 로고
    • Regulation of connexin43 protein complexes by intracellular acidification
    • doi: 10.1161/01.RES.0000113924.06926.11
    • Duffy, H. S., Ashton, A. W., O'donnell, P., Coombs, W., Taffet, S. M., Delmar, M., et al. (2004). Regulation of connexin43 protein complexes by intracellular acidification. Circ. Res. 94, 215-222. doi: 10.1161/01.RES.0000113924.06926.11.
    • (2004) Circ. Res. , vol.94 , pp. 215-222
    • Duffy, H.S.1    Ashton, A.W.2    O'donnell, P.3    Coombs, W.4    Taffet, S.M.5    Delmar, M.6
  • 49
    • 0034975483 scopus 로고    scopus 로고
    • Altered connexin expression in human congestive heart failure
    • doi: 10.1006/jmcc.2000.1308
    • Dupont, E., Matsushita, T., Kaba, R. A., Vozzi, C., Coppen, S. R., Khan, N., et al. (2001). Altered connexin expression in human congestive heart failure. J. Mol. Cell. Cardiol. 33, 359-371. doi: 10.1006/jmcc.2000.1308.
    • (2001) J. Mol. Cell. Cardiol. , vol.33 , pp. 359-371
    • Dupont, E.1    Matsushita, T.2    Kaba, R.A.3    Vozzi, C.4    Coppen, S.R.5    Khan, N.6
  • 51
    • 33751202968 scopus 로고    scopus 로고
    • Cardiomyocyte-restricted deletion of connexin43 during mouse development
    • doi: 10.1016/j.yjmcc.2006.07.017
    • Eckardt, D., Kirchhoff, S., Kim, J. S., Degen, J., Theis, M., Ott, T., et al. (2006). Cardiomyocyte-restricted deletion of connexin43 during mouse development. J. Mol. Cell. Cardiol. 41, 963-971. doi: 10.1016/j.yjmcc.2006.07.017.
    • (2006) J. Mol. Cell. Cardiol. , vol.41 , pp. 963-971
    • Eckardt, D.1    Kirchhoff, S.2    Kim, J.S.3    Degen, J.4    Theis, M.5    Ott, T.6
  • 52
    • 0347635339 scopus 로고    scopus 로고
    • Functional role of connexin43 gap junction channels in adult mouse heart assessed by inducible gene deletion
    • doi: 10.1016/j.yjmcc.2003.10.006
    • Eckardt, D., Theis, M., Degen, J., Ott, T., van Rijen, H. V., Kirchhoff, S., et al. (2004). Functional role of connexin43 gap junction channels in adult mouse heart assessed by inducible gene deletion. J. Mol. Cell. Cardiol. 36, 101-110. doi: 10.1016/j.yjmcc.2003.10.006.
    • (2004) J. Mol. Cell. Cardiol. , vol.36 , pp. 101-110
    • Eckardt, D.1    Theis, M.2    Degen, J.3    Ott, T.4    van Rijen, H.V.5    Kirchhoff, S.6
  • 53
    • 0034859346 scopus 로고    scopus 로고
    • Heterotypic docking of Cx43 and Cx45 connexons blocks fast voltage gating of Cx43
    • doi: 10.1016/S0006-3495(01)75796-7
    • Elenes, S., Martinez, A. D., Delmar, M., Beyer, E. C., and Moreno, A. P. (2001). Heterotypic docking of Cx43 and Cx45 connexons blocks fast voltage gating of Cx43. Biophys. J. 81, 1406-1418. doi: 10.1016/S0006-3495(01)75796-7.
    • (2001) Biophys. J. , vol.81 , pp. 1406-1418
    • Elenes, S.1    Martinez, A.D.2    Delmar, M.3    Beyer, E.C.4    Moreno, A.P.5
  • 54
    • 0032992532 scopus 로고    scopus 로고
    • Junctional communication between isolated pairs of canine atrial cells is mediated by homogeneous and heterogeneous gap junction channels
    • doi: 10.1111/j.1540-8167.1999.tb01270.x
    • Elenes, S., Rubart, M., and Moreno, A. P. (1999). Junctional communication between isolated pairs of canine atrial cells is mediated by homogeneous and heterogeneous gap junction channels. J. Cardiovasc. Electrophysiol. 10, 990-1004. doi: 10.1111/j.1540-8167.1999.tb01270.x.
    • (1999) J. Cardiovasc. Electrophysiol. , vol.10 , pp. 990-1004
    • Elenes, S.1    Rubart, M.2    Moreno, A.P.3
  • 55
    • 0028915946 scopus 로고
    • Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells
    • doi: 10.1083/jcb.129.3.805
    • Elfgang, C., Eckert, R., Lichtenberg-Frate, H., Butterweck, A., Traub, O., Klein, R. A., et al. (1995). Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells. J. Cell Biol. 129, 805-817. doi: 10.1083/jcb.129.3.805.
    • (1995) J. Cell Biol. , vol.129 , pp. 805-817
    • Elfgang, C.1    Eckert, R.2    Lichtenberg-Frate, H.3    Butterweck, A.4    Traub, O.5    Klein, R.A.6
  • 56
    • 0034877413 scopus 로고    scopus 로고
    • High resolution optical mapping reveals conduction slowing in connexin43 deficient mice
    • doi: 10.1016/S0008-6363(01)00341-8
    • Eloff, B. C., Lerner, D. L., Yamada, K. A., Schuessler, R. B., Saffitz, J. E., and Rosenbaum, D. S. (2001). High resolution optical mapping reveals conduction slowing in connexin43 deficient mice. Cardiovasc. Res. 51, 681-690. doi: 10.1016/S0008-6363(01)00341-8.
    • (2001) Cardiovasc. Res. , vol.51 , pp. 681-690
    • Eloff, B.C.1    Lerner, D.L.2    Yamada, K.A.3    Schuessler, R.B.4    Saffitz, J.E.5    Rosenbaum, D.S.6
  • 57
    • 84866729771 scopus 로고    scopus 로고
    • Manipulating connexin communication channels: use of peptidomimetics and the translational outputs
    • doi: 10.1007/s00232-012-9488-5
    • Evans, W. H., Bultynck, G., and Leybaert, L. (2012). Manipulating connexin communication channels: use of peptidomimetics and the translational outputs. J. Membr. Biol. 245, 437-449. doi: 10.1007/s00232-012-9488-5.
    • (2012) J. Membr. Biol. , vol.245 , pp. 437-449
    • Evans, W.H.1    Bultynck, G.2    Leybaert, L.3
  • 58
    • 0030972376 scopus 로고    scopus 로고
    • Heart and neural tube defects in transgenic mice overexpressing the Cx43 gap junction gene
    • Ewart, J. L., Cohen, M. F., Meyer, R. A., Huang, G. Y., Wessels, A., Gourdie, R. G., et al. (1997). Heart and neural tube defects in transgenic mice overexpressing the Cx43 gap junction gene. Development 124, 1281-1292.
    • (1997) Development , vol.124 , pp. 1281-1292
    • Ewart, J.L.1    Cohen, M.F.2    Meyer, R.A.3    Huang, G.Y.4    Wessels, A.5    Gourdie, R.G.6
  • 59
    • 0037089088 scopus 로고    scopus 로고
    • Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart
    • Ferreira-Cornwell, M. C., Luo, Y., Narula, N., Lenox, J. M., Lieberman, M., and Radice, G. L. (2002). Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart. J. Cell. Sci. 115, 1623-1634.
    • (2002) J. Cell. Sci. , vol.115 , pp. 1623-1634
    • Ferreira-Cornwell, M.C.1    Luo, Y.2    Narula, N.3    Lenox, J.M.4    Lieberman, M.5    Radice, G.L.6
  • 60
    • 27644536275 scopus 로고    scopus 로고
    • A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia
    • doi: 10.1242/dev.02011
    • Flenniken, A. M., Osborne, L. R., Anderson, N., Ciliberti, N., Fleming, C., Gittens, J. E., et al. (2005). A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia. Development 132, 4375-4386. doi: 10.1242/dev.02011.
    • (2005) Development , vol.132 , pp. 4375-4386
    • Flenniken, A.M.1    Osborne, L.R.2    Anderson, N.3    Ciliberti, N.4    Fleming, C.5    Gittens, J.E.6
  • 61
    • 33749385706 scopus 로고    scopus 로고
    • Primordial germ cell deficiency in the connexin 43 knockout mouse arises from apoptosis associated with abnormal p53 activation
    • doi: 10.1242/dev.02506
    • Francis, R. J., and Lo, C. W. (2006). Primordial germ cell deficiency in the connexin 43 knockout mouse arises from apoptosis associated with abnormal p53 activation. Development 133, 3451-3460. doi: 10.1242/dev.02506.
    • (2006) Development , vol.133 , pp. 3451-3460
    • Francis, R.J.1    Lo, C.W.2
  • 62
    • 77957875852 scopus 로고    scopus 로고
    • Neuronal connexin-36 can functionally replace connexin-45 in mouse retina but not in the developing heart
    • doi: 10.1242/jcs.068668
    • Frank, M., Eiberger, B., Janssen-Bienhold, U., De Sevilla Muller, L. P., Tjarks, A., Kim, J. S., et al. (2010). Neuronal connexin-36 can functionally replace connexin-45 in mouse retina but not in the developing heart. J. Cell Sci. 123, 3605-3615. doi: 10.1242/jcs.068668.
    • (2010) J. Cell Sci. , vol.123 , pp. 3605-3615
    • Frank, M.1    Eiberger, B.2    Janssen-Bienhold, U.3    De Sevilla Muller, L.P.4    Tjarks, A.5    Kim, J.S.6
  • 63
    • 84871559494 scopus 로고    scopus 로고
    • Connexin45 provides optimal atrioventricular nodal conduction in the adult mouse heart
    • doi: 10.1161/CIRCRESAHA.112.270561
    • Frank, M., Wirth, A., Andrie, R. P., Kreuzberg, M. M., Dobrowolski, R., Seifert, G., et al. (2012). Connexin45 provides optimal atrioventricular nodal conduction in the adult mouse heart. Circ. Res. 111, 1528-1538. doi: 10.1161/CIRCRESAHA.112.270561.
    • (2012) Circ. Res. , vol.111 , pp. 1528-1538
    • Frank, M.1    Wirth, A.2    Andrie, R.P.3    Kreuzberg, M.M.4    Dobrowolski, R.5    Seifert, G.6
  • 64
    • 22544475951 scopus 로고    scopus 로고
    • Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy
    • doi: 10.1016/j.cardiores.2005.04.004
    • Gard, J. J., Yamada, K., Green, K. G., Eloff, B. C., Rosenbaum, D. S., Wang, X., et al. (2005). Remodeling of gap junctions and slow conduction in a mouse model of desmin-related cardiomyopathy. Cardiovasc. Res. 67, 539-547. doi: 10.1016/j.cardiores.2005.04.004.
    • (2005) Cardiovasc. Res. , vol.67 , pp. 539-547
    • Gard, J.J.1    Yamada, K.2    Green, K.G.3    Eloff, B.C.4    Rosenbaum, D.S.5    Wang, X.6
  • 65
    • 40849094209 scopus 로고    scopus 로고
    • Cx30.2 can form heteromeric gap junction channels with other cardiac connexins
    • doi: 10.1016/j.bbrc.2008.02.040
    • Gemel, J., Lin, X., Collins, R., Veenstra, R. D., and Beyer, E. C. (2008). Cx30.2 can form heteromeric gap junction channels with other cardiac connexins. Biochem. Biophys. Res. Commun. 369, 388-394. doi: 10.1016/j.bbrc.2008.02.040.
    • (2008) Biochem. Biophys. Res. Commun. , vol.369 , pp. 388-394
    • Gemel, J.1    Lin, X.2    Collins, R.3    Veenstra, R.D.4    Beyer, E.C.5
  • 66
    • 77955457622 scopus 로고    scopus 로고
    • Functional anatomy of the murine sinus node: high-resolution optical mapping of ankyrin-B heterozygous mice
    • doi: 10.1152/ajpheart.00756.2009
    • Glukhov, A. V., Fedorov, V. V., Anderson, M. E., Mohler, P. J., and Efimov, I. R. (2010). Functional anatomy of the murine sinus node: high-resolution optical mapping of ankyrin-B heterozygous mice. Am. J. Physiol. Heart Circ. Physiol. 299, H482-H491. doi: 10.1152/ajpheart.00756.2009.
    • (2010) Am. J. Physiol. Heart Circ. Physiol. , vol.299
    • Glukhov, A.V.1    Fedorov, V.V.2    Anderson, M.E.3    Mohler, P.J.4    Efimov, I.R.5
  • 67
    • 84862760898 scopus 로고    scopus 로고
    • Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study
    • doi: 10.1093/eurheartj/ehr472
    • Gomes, J., Finlay, M., Ahmed, A. K., Ciaccio, E. J., Asimaki, A., Saffitz, J. E., et al. (2012). Electrophysiological abnormalities precede overt structural changes in arrhythmogenic right ventricular cardiomyopathy due to mutations in desmoplakin-A combined murine and human study. Eur. Heart J. 33, 1942-1953. doi: 10.1093/eurheartj/ehr472.
    • (2012) Eur. Heart J. , vol.33 , pp. 1942-1953
    • Gomes, J.1    Finlay, M.2    Ahmed, A.K.3    Ciaccio, E.J.4    Asimaki, A.5    Saffitz, J.E.6
  • 68
    • 34249050091 scopus 로고    scopus 로고
    • Molecular basis of voltage dependence of connexin channels: an integrative appraisal
    • doi: 10.1016/j.pbiomolbio.2007.03.007
    • Gonzalez, D., Gomez-Hernandez, J. M., and Barrio, L. C. (2007). Molecular basis of voltage dependence of connexin channels: an integrative appraisal. Prog. Biophys. Mol. Biol. 94, 66-106. doi: 10.1016/j.pbiomolbio.2007.03.007.
    • (2007) Prog. Biophys. Mol. Biol. , vol.94 , pp. 66-106
    • Gonzalez, D.1    Gomez-Hernandez, J.M.2    Barrio, L.C.3
  • 69
    • 0025828788 scopus 로고
    • Gap junction distribution in adult mammalian myocardium revealed by an anti-peptide antibody and laser scanning confocal microscopy
    • Gourdie, R. G., Green, C. R., and Severs, N. J. (1991). Gap junction distribution in adult mammalian myocardium revealed by an anti-peptide antibody and laser scanning confocal microscopy. J. Cell Sci. 99, 41-55.
    • (1991) J. Cell Sci. , vol.99 , pp. 41-55
    • Gourdie, R.G.1    Green, C.R.2    Severs, N.J.3
  • 70
    • 79952069424 scopus 로고    scopus 로고
    • Molecular architecture of the human specialised atrioventricular conduction axis
    • doi: 10.1016/j.yjmcc.2010.12.017
    • Greener, I. D., Monfredi, O., Inada, S., Chandler, N. J., Tellez, J. O., Atkinson, A., et al. (2011). Molecular architecture of the human specialised atrioventricular conduction axis. J. Mol. Cell. Cardiol. 50, 642-651. doi: 10.1016/j.yjmcc.2010.12.017.
    • (2011) J. Mol. Cell. Cardiol. , vol.50 , pp. 642-651
    • Greener, I.D.1    Monfredi, O.2    Inada, S.3    Chandler, N.J.4    Tellez, J.O.5    Atkinson, A.6
  • 71
    • 48449085946 scopus 로고    scopus 로고
    • Coexpression of connexin 45 with connexin 43 decreases gap junction size
    • doi: 10.1080/15419060802013943
    • Grikscheit, K., Thomas, N., Bruce, A. F., Rothery, S., Chan, J., Severs, N. J., et al. (2008). Coexpression of connexin 45 with connexin 43 decreases gap junction size. Cell Commun. Adhes. 15, 185-193. doi: 10.1080/15419060802013943.
    • (2008) Cell Commun. Adhes. , vol.15 , pp. 185-193
    • Grikscheit, K.1    Thomas, N.2    Bruce, A.F.3    Rothery, S.4    Chan, J.5    Severs, N.J.6
  • 72
    • 72049094841 scopus 로고    scopus 로고
    • Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rate
    • doi: 10.1093/cvr/cvp280
    • Gros, D., Theveniau-Ruissy, M., Bernard, M., Calmels, T., Kober, F., Sohl, G., et al. (2010). Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rate. Cardiovasc. Res. 85, 45-55. doi: 10.1093/cvr/cvp280.
    • (2010) Cardiovasc. Res. , vol.85 , pp. 45-55
    • Gros, D.1    Theveniau-Ruissy, M.2    Bernard, M.3    Calmels, T.4    Kober, F.5    Sohl, G.6
  • 73
    • 0030248881 scopus 로고    scopus 로고
    • Connexins in mammalian heart function
    • doi: 10.1002/bies.950180907
    • Gros, D. B., and Jongsma, H. J. (1996). Connexins in mammalian heart function. Bioessays 18, 719-730. doi: 10.1002/bies.950180907.
    • (1996) Bioessays , vol.18 , pp. 719-730
    • Gros, D.B.1    Jongsma, H.J.2
  • 74
    • 0043026950 scopus 로고    scopus 로고
    • High incidence of cardiac malformations in connexin40-deficient mice
    • doi: 10.1161/01.RES.0000084852.65396.70
    • Gu, H., Smith, F. C., Taffet, S. M., and Delmar, M. (2003). High incidence of cardiac malformations in connexin40-deficient mice. Circ. Res. 93, 201-206. doi: 10.1161/01.RES.0000084852.65396.70.
    • (2003) Circ. Res. , vol.93 , pp. 201-206
    • Gu, H.1    Smith, F.C.2    Taffet, S.M.3    Delmar, M.4
  • 75
    • 33747031207 scopus 로고    scopus 로고
    • Effects of the gap junction modifier rotigaptide (ZP123) on atrial conduction and vulnerability to atrial fibrillation
    • doi: 10.1161/CIRCULATIONAHA.105.606251
    • Guerra, J. M., Everett, T. H. T., Lee, K. W., Wilson, E., and Olgin, J. E. (2006). Effects of the gap junction modifier rotigaptide (ZP123) on atrial conduction and vulnerability to atrial fibrillation. Circulation 114, 110-118. doi: 10.1161/CIRCULATIONAHA.105.606251.
    • (2006) Circulation , vol.114 , pp. 110-118
    • Guerra, J.M.1    Everett, T.H.T.2    Lee, K.W.3    Wilson, E.4    Olgin, J.E.5
  • 76
    • 0030983063 scopus 로고    scopus 로고
    • Slow ventricular conduction in mice heterozygous for a connexin43 null mutation
    • doi: 10.1172/JCI119367
    • Guerrero, P. A., Schuessler, R. B., Davis, L. M., Beyer, E. C., Johnson, C. M., Yamada, K. A., et al. (1997). Slow ventricular conduction in mice heterozygous for a connexin43 null mutation. J. Clin. Invest. 99, 1991-1998. doi: 10.1172/JCI119367.
    • (1997) J. Clin. Invest. , vol.99 , pp. 1991-1998
    • Guerrero, P.A.1    Schuessler, R.B.2    Davis, L.M.3    Beyer, E.C.4    Johnson, C.M.5    Yamada, K.A.6
  • 78
    • 0037348756 scopus 로고    scopus 로고
    • The organization of adherens junctions and desmosomes at the cardiac intercalated disc is independent of gap junctions
    • doi: 10.1242/jcs.00258
    • Gutstein, D. E., Liu, F. Y., Meyers, M. B., Choo, A., and Fishman, G. I. (2003). The organization of adherens junctions and desmosomes at the cardiac intercalated disc is independent of gap junctions. J. Cell. Sci. 116, 875-885. doi: 10.1242/jcs.00258.
    • (2003) J. Cell. Sci. , vol.116 , pp. 875-885
    • Gutstein, D.E.1    Liu, F.Y.2    Meyers, M.B.3    Choo, A.4    Fishman, G.I.5
  • 79
    • 0035895649 scopus 로고    scopus 로고
    • Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43
    • doi: 10.1161/01.RES.88.3.333
    • Gutstein, D. E., Morley, G. E., Tamaddon, H., Vaidya, D., Schneider, M. D., Chen, J., et al. (2001a). Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43. Circ. Res. 88, 333-339. doi: 10.1161/01.RES.88.3.333.
    • (2001) Circ. Res. , vol.88 , pp. 333-339
    • Gutstein, D.E.1    Morley, G.E.2    Tamaddon, H.3    Vaidya, D.4    Schneider, M.D.5    Chen, J.6
  • 80
    • 0035806899 scopus 로고    scopus 로고
    • Heterogeneous expression of gap junction channels in the heart leads to conduction defects and ventricular dysfunction
    • doi: 10.1161/hc3601.093990
    • Gutstein, D. E., Morley, G. E., Vaidya, D., Liu, F., Chen, F. L., Stuhlmann, H., et al. (2001b). Heterogeneous expression of gap junction channels in the heart leads to conduction defects and ventricular dysfunction. Circulation 104, 1194-1199. doi: 10.1161/hc3601.093990.
    • (2001) Circulation , vol.104 , pp. 1194-1199
    • Gutstein, D.E.1    Morley, G.E.2    Vaidya, D.3    Liu, F.4    Chen, F.L.5    Stuhlmann, H.6
  • 81
    • 0034129050 scopus 로고    scopus 로고
    • Connexin37 in normal and pathological development of mouse heart and great arteries
    • Haefliger, J. A., Polikar, R., Schnyder, G., Burdet, M., Sutter, E., Pexieder, T., et al. (2000). Connexin37 in normal and pathological development of mouse heart and great arteries. Dev. Dyn. 218, 331-344.
    • (2000) Dev. Dyn. , vol.218 , pp. 331-344
    • Haefliger, J.A.1    Polikar, R.2    Schnyder, G.3    Burdet, M.4    Sutter, E.5    Pexieder, T.6
  • 82
    • 0033596919 scopus 로고    scopus 로고
    • Conduction disturbances and increased atrial vulnerability in Connexin40-deficient mice analyzed by transesophageal stimulation
    • doi: 10.1161/01.CIR.99.11.1508
    • Hagendorff, A., Schumacher, B., Kirchhoff, S., Luderitz, B., and Willecke, K. (1999). Conduction disturbances and increased atrial vulnerability in Connexin40-deficient mice analyzed by transesophageal stimulation. Circulation 99, 1508-1515. doi: 10.1161/01.CIR.99.11.1508.
    • (1999) Circulation , vol.99 , pp. 1508-1515
    • Hagendorff, A.1    Schumacher, B.2    Kirchhoff, S.3    Luderitz, B.4    Willecke, K.5
  • 83
    • 33644973530 scopus 로고    scopus 로고
    • Differentiation of cardiac Purkinje fibers requires precise spatiotemporal regulation of Nkx2-5 expression
    • doi: 10.1002/dvdy.20580
    • Harris, B. S., Spruill, L., Edmonson, A. M., Rackley, M. S., Benson, D. W., O'brien, T. X., et al. (2006). Differentiation of cardiac Purkinje fibers requires precise spatiotemporal regulation of Nkx2-5 expression. Dev. Dyn. 235, 38-49. doi: 10.1002/dvdy.20580.
    • (2006) Dev. Dyn. , vol.235 , pp. 38-49
    • Harris, B.S.1    Spruill, L.2    Edmonson, A.M.3    Rackley, M.S.4    Benson, D.W.5    O'brien, T.X.6
  • 84
    • 0001203743 scopus 로고    scopus 로고
    • Formation of heteromeric gap junction channels by connexins 40 and 43 in vascular smooth muscle cells
    • doi: 10.1073/pnas.96.11.6495
    • He, D. S., Jiang, J. X., Taffet, S. M., and Burt, J. M. (1999). Formation of heteromeric gap junction channels by connexins 40 and 43 in vascular smooth muscle cells. Proc. Natl. Acad. Sci. U.S.A. 96, 6495-6500. doi: 10.1073/pnas.96.11.6495.
    • (1999) Proc. Natl. Acad. Sci. U. S. A. , vol.96 , pp. 6495-6500
    • He, D.S.1    Jiang, J.X.2    Taffet, S.M.3    Burt, J.M.4
  • 85
    • 34248994869 scopus 로고    scopus 로고
    • Gap junctional complexes: from partners to functions
    • doi: 10.1016/j.pbiomolbio.2007.03.010
    • Herve, J. C., Bourmeyster, N., Sarrouilhe, D., and Duffy, H. S. (2007). Gap junctional complexes: from partners to functions. Prog. Biophys. Mol. Biol. 94, 29-65. doi: 10.1016/j.pbiomolbio.2007.03.010.
    • (2007) Prog. Biophys. Mol. Biol. , vol.94 , pp. 29-65
    • Herve, J.C.1    Bourmeyster, N.2    Sarrouilhe, D.3    Duffy, H.S.4
  • 86
    • 78649831043 scopus 로고    scopus 로고
    • Peptides targeting gap junctional structures
    • doi: 10.2174/138161210793292528
    • Herve, J. C., and Dhein, S. (2010). Peptides targeting gap junctional structures. Curr. Pharm. Des. 16, 3056-3070. doi: 10.2174/138161210793292528.
    • (2010) Curr. Pharm. Des. , vol.16 , pp. 3056-3070
    • Herve, J.C.1    Dhein, S.2
  • 87
    • 2442513900 scopus 로고    scopus 로고
    • The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart
    • doi: 10.1016/j.cardiores.2004.01.030
    • Hoogaars, W. M., Tessari, A., Moorman, A. F., De Boer, P. A., Hagoort, J., Soufan, A. T., et al. (2004). The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart. Cardiovasc. Res. 62, 489-499. doi: 10.1016/j.cardiores.2004.01.030.
    • (2004) Cardiovasc. Res. , vol.62 , pp. 489-499
    • Hoogaars, W.M.1    Tessari, A.2    Moorman, A.F.3    De Boer, P.A.4    Hagoort, J.5    Soufan, A.T.6
  • 88
    • 0033808250 scopus 로고    scopus 로고
    • Properties of gap junction channels formed by Cx46 alone and in combination with Cx50
    • doi: 10.1016/S0006-3495(00)76444-7
    • Hopperstad, M. G., Srinivas, M., and Spray, D. C. (2000). Properties of gap junction channels formed by Cx46 alone and in combination with Cx50. Biophys. J. 79, 1954-1966. doi: 10.1016/S0006-3495(00)76444-7.
    • (2000) Biophys. J. , vol.79 , pp. 1954-1966
    • Hopperstad, M.G.1    Srinivas, M.2    Spray, D.C.3
  • 89
    • 0345561557 scopus 로고    scopus 로고
    • Doubly mutant mice, deficient in connexin32 and -43, show normal prenatal development of organs where the two gap junction proteins are expressed in the same cells
    • Houghton, F. D., Thonnissen, E., Kidder, G. M., Naus, C. C., Willecke, K., and Winterhager, E. (1999). Doubly mutant mice, deficient in connexin32 and -43, show normal prenatal development of organs where the two gap junction proteins are expressed in the same cells. Dev. Genet. 24, 5-12.
    • (1999) Dev. Genet. , vol.24 , pp. 5-12
    • Houghton, F.D.1    Thonnissen, E.2    Kidder, G.M.3    Naus, C.C.4    Willecke, K.5    Winterhager, E.6
  • 90
    • 0032100436 scopus 로고    scopus 로고
    • Alteration in connexin 43 gap junction gene dosage impairs conotruncal heart development
    • doi: 10.1016/S0012-1606(98)80027-4
    • Huang, G. Y., Wessels, A., Smith, B. R., Linask, K. K., Ewart, J. L., and Lo, C. W. (1998). Alteration in connexin 43 gap junction gene dosage impairs conotruncal heart development. Dev. Biol. 198, 32-44. doi: 10.1016/S0012-1606(98)80027-4.
    • (1998) Dev. Biol. , vol.198 , pp. 32-44
    • Huang, G.Y.1    Wessels, A.2    Smith, B.R.3    Linask, K.K.4    Ewart, J.L.5    Lo, C.W.6
  • 91
    • 41949135424 scopus 로고    scopus 로고
    • Connexin 43 expression delineates two discrete pathways in the human atrioventricular junction
    • doi: 10.1002/ar.20631
    • Hucker, W. J., McCain, M. L., Laughner, J. I., Iaizzo, P. A., and Efimov, I. R. (2008). Connexin 43 expression delineates two discrete pathways in the human atrioventricular junction. Anat. Rec. (Hoboken) 291, 204-215. doi: 10.1002/ar.20631.
    • (2008) Anat. Rec. (Hoboken) , vol.291 , pp. 204-215
    • Hucker, W.J.1    McCain, M.L.2    Laughner, J.I.3    Iaizzo, P.A.4    Efimov, I.R.5
  • 92
    • 15244362230 scopus 로고    scopus 로고
    • Genes controlling multiple functional pathways are transcriptionally regulated in connexin43 null mouse heart
    • doi: 10.1152/physiolgenomics.00229.2003
    • Iacobas, D. A., Iacobas, S., Li, W. E., Zoidl, G., Dermietzel, R., and Spray, D. C. (2005). Genes controlling multiple functional pathways are transcriptionally regulated in connexin43 null mouse heart. Physiol. Genomics 20, 211-223. doi: 10.1152/physiolgenomics.00229.2003.
    • (2005) Physiol. Genomics , vol.20 , pp. 211-223
    • Iacobas, D.A.1    Iacobas, S.2    Li, W.E.3    Zoidl, G.4    Dermietzel, R.5    Spray, D.C.6
  • 93
    • 84859312522 scopus 로고    scopus 로고
    • Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice
    • doi: 10.1016/j.hrthm.2011.11.025
    • Jansen, J. A., Noorman, M., Musa, H., Stein, M., De Jong, S., van Der Nagel, R., et al. (2012a). Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice. Heart Rhythm 9, 600-607. doi: 10.1016/j.hrthm.2011.11.025.
    • (2012) Heart Rhythm , vol.9 , pp. 600-607
    • Jansen, J.A.1    Noorman, M.2    Musa, H.3    Stein, M.4    De Jong, S.5    van Der Nagel, R.6
  • 95
    • 0032953756 scopus 로고    scopus 로고
    • Connexin-43 hemichannels opened by metabolic inhibition
    • doi: 10.1074/jbc.274.1.236
    • John, S. A., Kondo, R., Wang, S. Y., Goldhaber, J. I., and Weiss, J. N. (1999). Connexin-43 hemichannels opened by metabolic inhibition. J. Biol. Chem. 274, 236-240. doi: 10.1074/jbc.274.1.236.
    • (1999) J. Biol. Chem. , vol.274 , pp. 236-240
    • John, S.A.1    Kondo, R.2    Wang, S.Y.3    Goldhaber, J.I.4    Weiss, J.N.5
  • 96
    • 0032870163 scopus 로고    scopus 로고
    • Voltage-gated Na+ channel activity and connexin expression in Cx43-deficient cardiac myocytes
    • doi: 10.1111/j.1540-8167.1999.tb00195.x
    • Johnson, C. M., Green, K. G., Kanter, E. M., Bou-Abboud, E., Saffitz, J. E., and Yamada, K. A. (1999). Voltage-gated Na+ channel activity and connexin expression in Cx43-deficient cardiac myocytes. J. Cardiovasc. Electrophysiol. 10, 1390-1401. doi: 10.1111/j.1540-8167.1999.tb00195.x.
    • (1999) J. Cardiovasc. Electrophysiol. , vol.10 , pp. 1390-1401
    • Johnson, C.M.1    Green, K.G.2    Kanter, E.M.3    Bou-Abboud, E.4    Saffitz, J.E.5    Yamada, K.A.6
  • 97
    • 0023029058 scopus 로고
    • Propagation through electrically coupled cells. How a small SA node drives a large atrium
    • doi: 10.1016/S0006-3495(86)83559-7
    • Joyner, R. W., and van Capelle, F. J. (1986). Propagation through electrically coupled cells. How a small SA node drives a large atrium. Biophys. J. 50, 1157-1164. doi: 10.1016/S0006-3495(86)83559-7.
    • (1986) Biophys. J. , vol.50 , pp. 1157-1164
    • Joyner, R.W.1    van Capelle, F.J.2
  • 99
    • 84867124087 scopus 로고    scopus 로고
    • Cardiac electrophysiology in mice: a matter of size
    • doi: 10.3389/fphys.2012.00345
    • Kaese, S., and Verheule, S. (2012). Cardiac electrophysiology in mice: a matter of size. Front. Physiol. 3:345. doi: 10.3389/fphys.2012.00345.
    • (2012) Front. Physiol. , vol.3 , pp. 345
    • Kaese, S.1    Verheule, S.2
  • 100
    • 38049177215 scopus 로고    scopus 로고
    • Gap junction remodeling and cardiac arrhythmogenesis in a murine model of oculodentodigital dysplasia
    • doi: 10.1073/pnas.0705472105
    • Kalcheva, N., Qu, J., Sandeep, N., Garcia, L., Zhang, J., Wang, Z., et al. (2007). Gap junction remodeling and cardiac arrhythmogenesis in a murine model of oculodentodigital dysplasia. Proc. Natl. Acad. Sci. U.S.A. 104, 20512-20516. doi: 10.1073/pnas.0705472105.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 20512-20516
    • Kalcheva, N.1    Qu, J.2    Sandeep, N.3    Garcia, L.4    Zhang, J.5    Wang, Z.6
  • 101
    • 0037005778 scopus 로고    scopus 로고
    • Relative expression of immunolocalized connexins 40 and 43 correlates with human atrial conduction properties
    • doi: 10.1016/S0735-1097(01)01710-7
    • Kanagaratnam, P., Rothery, S., Patel, P., Severs, N. J., and Peters, N. S. (2002). Relative expression of immunolocalized connexins 40 and 43 correlates with human atrial conduction properties. J. Am. Coll. Cardiol. 39, 116-123. doi: 10.1016/S0735-1097(01)01710-7.
    • (2002) J. Am. Coll. Cardiol. , vol.39 , pp. 116-123
    • Kanagaratnam, P.1    Rothery, S.2    Patel, P.3    Severs, N.J.4    Peters, N.S.5
  • 102
    • 0037454041 scopus 로고    scopus 로고
    • Connexin43 as a determinant of myocardial infarct size following coronary occlusion in mice
    • doi: 10.1016/S0735-1097(02)02893-0
    • Kanno, S., Kovacs, A., Yamada, K. A., and Saffitz, J. E. (2003). Connexin43 as a determinant of myocardial infarct size following coronary occlusion in mice. J. Am. Coll. Cardiol. 41, 681-686. doi: 10.1016/S0735-1097(02)02893-0.
    • (2003) J. Am. Coll. Cardiol. , vol.41 , pp. 681-686
    • Kanno, S.1    Kovacs, A.2    Yamada, K.A.3    Saffitz, J.E.4
  • 103
    • 79954578710 scopus 로고    scopus 로고
    • Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes
    • doi: 10.1074/jbc.M110.185298
    • Kapoor, N., Galang, G., Marban, E., and Cho, H. C. (2011). Transcriptional suppression of connexin43 by TBX18 undermines cell-cell electrical coupling in postnatal cardiomyocytes. J. Biol. Chem. 286, 14073-14079. doi: 10.1074/jbc.M110.185298.
    • (2011) J. Biol. Chem. , vol.286 , pp. 14073-14079
    • Kapoor, N.1    Galang, G.2    Marban, E.3    Cho, H.C.4
  • 104
    • 0034283421 scopus 로고    scopus 로고
    • Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient mice
    • doi: 10.1161/01.RES.87.5.399
    • Kirchhoff, S., Kim, J. S., Hagendorff, A., Thonnissen, E., Kruger, O., Lamers, W. H., et al. (2000). Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient mice. Circ. Res. 87, 399-405. doi: 10.1161/01.RES.87.5.399.
    • (2000) Circ. Res. , vol.87 , pp. 399-405
    • Kirchhoff, S.1    Kim, J.S.2    Hagendorff, A.3    Thonnissen, E.4    Kruger, O.5    Lamers, W.H.6
  • 105
    • 0032567957 scopus 로고    scopus 로고
    • Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice
    • doi: 10.1016/S0960-9822(98)70114-9
    • Kirchhoff, S., Nelles, E., Hagendorff, A., Kruger, O., Traub, O., and Willecke, K. (1998). Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice. Curr. Biol. 8, 299-302. doi: 10.1016/S0960-9822(98)70114-9.
    • (1998) Curr. Biol. , vol.8 , pp. 299-302
    • Kirchhoff, S.1    Nelles, E.2    Hagendorff, A.3    Kruger, O.4    Traub, O.5    Willecke, K.6
  • 106
    • 0033745550 scopus 로고    scopus 로고
    • Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes
    • doi: 10.1006/jmcc.2000.1220
    • Kondo, R. P., Wang, S. Y., John, S. A., Weiss, J. N., and Goldhaber, J. I. (2000). Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes. J. Mol. Cell. Cardiol. 32, 1859-1872. doi: 10.1006/jmcc.2000.1220.
    • (2000) J. Mol. Cell. Cardiol. , vol.32 , pp. 1859-1872
    • Kondo, R.P.1    Wang, S.Y.2    John, S.A.3    Weiss, J.N.4    Goldhaber, J.I.5
  • 107
    • 44349149895 scopus 로고    scopus 로고
    • Short-term pacing in the mouse alters cardiac expression of connexin43
    • doi: 10.1186/1472-6793-8-8
    • Kontogeorgis, A., Kaba, R. A., Kang, E., Feig, J. E., Gupta, P. P., Ponzio, M., et al. (2008a). Short-term pacing in the mouse alters cardiac expression of connexin43. BMC Physiol. 8:8. doi: 10.1186/1472-6793-8-8.
    • (2008) BMC Physiol , vol.8 , pp. 8
    • Kontogeorgis, A.1    Kaba, R.A.2    Kang, E.3    Feig, J.E.4    Gupta, P.P.5    Ponzio, M.6
  • 108
    • 57049113751 scopus 로고    scopus 로고
    • Decreased connexin43 expression in the mouse heart potentiates pacing-induced remodeling of repolarizing currents
    • doi: 10.1152/ajpheart.590.2008
    • Kontogeorgis, A., Li, X., Kang, E. Y., Feig, J. E., Ponzio, M., Kang, G., et al. (2008b). Decreased connexin43 expression in the mouse heart potentiates pacing-induced remodeling of repolarizing currents. Am. J. Physiol. Heart Circ. Physiol. 295, H1905-H1916. doi: 10.1152/ajpheart.590.2008.
    • (2008) Am. J. Physiol. Heart Circ. Physiol. , vol.295
    • Kontogeorgis, A.1    Li, X.2    Kang, E.Y.3    Feig, J.E.4    Ponzio, M.5    Kang, G.6
  • 109
    • 14044256554 scopus 로고    scopus 로고
    • Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure
    • doi: 10.1161/01.RES.0000156274.72390.2c
    • Kostetskii, I., Li, J., Xiong, Y., Zhou, R., Ferrari, V. A., Patel, V. V., et al. (2005). Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ. Res. 96, 346-354. doi: 10.1161/01.RES.0000156274.72390.2c.
    • (2005) Circ. Res. , vol.96 , pp. 346-354
    • Kostetskii, I.1    Li, J.2    Xiong, Y.3    Zhou, R.4    Ferrari, V.A.5    Patel, V.V.6
  • 110
    • 33745700309 scopus 로고    scopus 로고
    • Normal embryonic development and cardiac morphogenesis in mice with Wnt1-Cre-mediated deletion of connexin43
    • doi: 10.1002/dvg.20204
    • Kretz, M., Eckardt, D., Kruger, O., Kim, J. S., Maurer, J., Theis, M., et al. (2006). Normal embryonic development and cardiac morphogenesis in mice with Wnt1-Cre-mediated deletion of connexin43. Genesis 44, 269-276. doi: 10.1002/dvg.20204.
    • (2006) Genesis , vol.44 , pp. 269-276
    • Kretz, M.1    Eckardt, D.2    Kruger, O.3    Kim, J.S.4    Maurer, J.5    Theis, M.6
  • 111
    • 61449170916 scopus 로고    scopus 로고
    • Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system
    • doi: 10.1016/j.yjmcc.2008.12.007
    • Kreuzberg, M. M., Liebermann, M., Segschneider, S., Dobrowolski, R., Dobrzynski, H., Kaba, R., et al. (2009). Human connexin31.9, unlike its orthologous protein connexin30.2 in the mouse, is not detectable in the human cardiac conduction system. J. Mol. Cell. Cardiol. 46, 553-559. doi: 10.1016/j.yjmcc.2008.12.007.
    • (2009) J. Mol. Cell. Cardiol. , vol.46 , pp. 553-559
    • Kreuzberg, M.M.1    Liebermann, M.2    Segschneider, S.3    Dobrowolski, R.4    Dobrzynski, H.5    Kaba, R.6
  • 112
    • 33645806085 scopus 로고    scopus 로고
    • Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node
    • doi: 10.1073/pnas.0508512103
    • Kreuzberg, M. M., Schrickel, J. W., Ghanem, A., Kim, J. S., Degen, J., Janssen-Bienhold, U., et al. (2006). Connexin30.2 containing gap junction channels decelerate impulse propagation through the atrioventricular node. Proc. Natl. Acad. Sci. U.S.A. 103, 5959-5964. doi: 10.1073/pnas.0508512103.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 5959-5964
    • Kreuzberg, M.M.1    Schrickel, J.W.2    Ghanem, A.3    Kim, J.S.4    Degen, J.5    Janssen-Bienhold, U.6
  • 113
    • 20444465223 scopus 로고    scopus 로고
    • Functional properties of mouse connexin30.2 expressed in the conduction system of the heart
    • doi: 10.1161/01.RES.0000169271.33675.05
    • Kreuzberg, M. M., Sohl, G., Kim, J. S., Verselis, V. K., Willecke, K., and Bukauskas, F. F. (2005). Functional properties of mouse connexin30.2 expressed in the conduction system of the heart. Circ. Res. 96, 1169-1177. doi: 10.1161/01.RES.0000169271.33675.05.
    • (2005) Circ. Res. , vol.96 , pp. 1169-1177
    • Kreuzberg, M.M.1    Sohl, G.2    Kim, J.S.3    Verselis, V.K.4    Willecke, K.5    Bukauskas, F.F.6
  • 114
    • 33750373636 scopus 로고    scopus 로고
    • Cardiac morphogenetic defects and conduction abnormalities in mice homozygously deficient for connexin40 and heterozygously deficient for connexin45
    • doi: 10.1016/j.yjmcc.2006.07.005
    • Kruger, O., Maxeiner, S., Kim, J. S., van Rijen, H. V., De Bakker, J. M., Eckardt, D., et al. (2006). Cardiac morphogenetic defects and conduction abnormalities in mice homozygously deficient for connexin40 and heterozygously deficient for connexin45. J. Mol. Cell. Cardiol. 41, 787-797. doi: 10.1016/j.yjmcc.2006.07.005.
    • (2006) J. Mol. Cell. Cardiol. , vol.41 , pp. 787-797
    • Kruger, O.1    Maxeiner, S.2    Kim, J.S.3    van Rijen, H.V.4    De Bakker, J.M.5    Eckardt, D.6
  • 115
    • 0033824984 scopus 로고    scopus 로고
    • Loss of connexin45 causes a cushion defect in early cardiogenesis
    • Kumai, M., Nishii, K., Nakamura, K., Takeda, N., Suzuki, M., and Shibata, Y. (2000). Loss of connexin45 causes a cushion defect in early cardiogenesis. Development 127, 3501-3512.
    • (2000) Development , vol.127 , pp. 3501-3512
    • Kumai, M.1    Nishii, K.2    Nakamura, K.3    Takeda, N.4    Suzuki, M.5    Shibata, Y.6
  • 116
    • 55449124569 scopus 로고    scopus 로고
    • Connexin40 imparts conduction heterogeneity to atrial tissue
    • doi: 10.1161/CIRCRESAHA.107.168997
    • Leaf, D. E., Feig, J. E., Vasquez, C., Riva, P. L., Yu, C., Lader, J. M., et al. (2008). Connexin40 imparts conduction heterogeneity to atrial tissue. Circ. Res. 103, 1001-1008. doi: 10.1161/CIRCRESAHA.107.168997.
    • (2008) Circ. Res. , vol.103 , pp. 1001-1008
    • Leaf, D.E.1    Feig, J.E.2    Vasquez, C.3    Riva, P.L.4    Yu, C.5    Lader, J.M.6
  • 118
    • 24744444972 scopus 로고    scopus 로고
    • Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis
    • doi: 10.1161/01.RES.0000181132.11393.18
    • Li, J., Patel, V. V., Kostetskii, I., Xiong, Y., Chu, A. F., Jacobson, J. T., et al. (2005). Cardiac-specific loss of N-cadherin leads to alteration in connexins with conduction slowing and arrhythmogenesis. Circ. Res. 97, 474-481. doi: 10.1161/01.RES.0000181132.11393.18.
    • (2005) Circ. Res. , vol.97 , pp. 474-481
    • Li, J.1    Patel, V.V.2    Kostetskii, I.3    Xiong, Y.4    Chu, A.F.5    Jacobson, J.T.6
  • 119
    • 0036333778 scopus 로고    scopus 로고
    • An essential role for connexin43 gap junctions in mouse coronary artery development
    • Li, W. E., Waldo, K., Linask, K. L., Chen, T., Wessels, A., Parmacek, M. S., et al. (2002). An essential role for connexin43 gap junctions in mouse coronary artery development. Development 129, 2031-2042.
    • (2002) Development , vol.129 , pp. 2031-2042
    • Li, W.E.1    Waldo, K.2    Linask, K.L.3    Chen, T.4    Wessels, A.5    Parmacek, M.S.6
  • 120
    • 0347635344 scopus 로고    scopus 로고
    • Role of connexin 43 in ischemic preconditioning does not involve intercellular communication through gap junctions
    • doi: 10.1016/j.yjmcc.2003.10.019
    • Li, X., Heinzel, F. R., Boengler, K., Schulz, R., and Heusch, G. (2004). Role of connexin 43 in ischemic preconditioning does not involve intercellular communication through gap junctions. J. Mol. Cell. Cardiol. 36, 161-163. doi: 10.1016/j.yjmcc.2003.10.019.
    • (2004) J. Mol. Cell. Cardiol. , vol.36 , pp. 161-163
    • Li, X.1    Heinzel, F.R.2    Boengler, K.3    Schulz, R.4    Heusch, G.5
  • 121
    • 78650448740 scopus 로고    scopus 로고
    • Modeling electrical activity of myocardial cells incorporating the effects of ephaptic coupling
    • doi: 10.1073/pnas.1010154107
    • Lin, J., and Keener, J. P. (2010). Modeling electrical activity of myocardial cells incorporating the effects of ephaptic coupling. Proc. Natl. Acad. Sci. U.S.A. 107, 20935-20940. doi: 10.1073/pnas.1010154107.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 20935-20940
    • Lin, J.1    Keener, J.P.2
  • 122
    • 13944261228 scopus 로고    scopus 로고
    • Dynamic model for ventricular junctional conductance during the cardiac action potential
    • doi: 10.1152/ajpheart.00882.2004
    • Lin, X., Gemel, J., Beyer, E. C., and Veenstra, R. D. (2005). Dynamic model for ventricular junctional conductance during the cardiac action potential. Am. J. Physiol. Heart Circ. Physiol. 288, H1113-H1123. doi: 10.1152/ajpheart.00882.2004.
    • (2005) Am. J. Physiol. Heart Circ. Physiol. , vol.288
    • Lin, X.1    Gemel, J.2    Beyer, E.C.3    Veenstra, R.D.4
  • 123
    • 73049105161 scopus 로고    scopus 로고
    • Connexin40 and connexin43 determine gating properties of atrial gap junction channels
    • doi: 10.1016/j.yjmcc.2009.05.014
    • Lin, X., Gemel, J., Glass, A., Zemlin, C. W., Beyer, E. C., and Veenstra, R. D. (2010). Connexin40 and connexin43 determine gating properties of atrial gap junction channels. J. Mol. Cell. Cardiol. 48, 238-245. doi: 10.1016/j.yjmcc.2009.05.014.
    • (2010) J. Mol. Cell. Cardiol. , vol.48 , pp. 238-245
    • Lin, X.1    Gemel, J.2    Glass, A.3    Zemlin, C.W.4    Beyer, E.C.5    Veenstra, R.D.6
  • 124
    • 1942533482 scopus 로고    scopus 로고
    • Action potential modulation of connexin40 gap junctional conductance
    • doi: 10.1152/ajpheart.00943.2003
    • Lin, X., and Veenstra, R. D. (2004). Action potential modulation of connexin40 gap junctional conductance. Am. J. Physiol. Heart Circ. Physiol. 286, H1726-H1735. doi: 10.1152/ajpheart.00943.2003.
    • (2004) Am. J. Physiol. Heart Circ. Physiol. , vol.286
    • Lin, X.1    Veenstra, R.D.2
  • 125
    • 33745094980 scopus 로고    scopus 로고
    • Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube
    • doi: 10.1242/dev.02374
    • Liu, S., Liu, F., Schneider, A. E., St Amand, T., Epstein, J. A., and Gutstein, D. E. (2006). Distinct cardiac malformations caused by absence of connexin 43 in the neural crest and in the non-crest neural tube. Development 133, 2063-2073. doi: 10.1242/dev.02374.
    • (2006) Development , vol.133 , pp. 2063-2073
    • Liu, S.1    Liu, F.2    Schneider, A.E.3    St Amand, T.4    Epstein, J.A.5    Gutstein, D.E.6
  • 126
    • 0030960952 scopus 로고    scopus 로고
    • Cx43 gap junction gene expression and gap junctional communication in mouse neural crest cells
    • Lo, C. W., Cohen, M. F., Huang, G. Y., Lazatin, B. O., Patel, N., Sullivan, R., et al. (1997). Cx43 gap junction gene expression and gap junctional communication in mouse neural crest cells. Dev. Genet. 20, 119-132.
    • (1997) Dev. Genet. , vol.20 , pp. 119-132
    • Lo, C.W.1    Cohen, M.F.2    Huang, G.Y.3    Lazatin, B.O.4    Patel, N.5    Sullivan, R.6
  • 127
    • 70849099466 scopus 로고    scopus 로고
    • Cx43 CT domain influences infarct size and susceptibility to ventricular tachyarrhythmias in acute myocardial infarction
    • doi: 10.1093/cvr/cvp250
    • Maass, K., Chase, S. E., Lin, X., and Delmar, M. (2009). Cx43 CT domain influences infarct size and susceptibility to ventricular tachyarrhythmias in acute myocardial infarction. Cardiovasc. Res. 84, 361-367. doi: 10.1093/cvr/cvp250.
    • (2009) Cardiovasc. Res. , vol.84 , pp. 361-367
    • Maass, K.1    Chase, S.E.2    Lin, X.3    Delmar, M.4
  • 128
    • 4644269182 scopus 로고    scopus 로고
    • Defective epidermal barrier in neonatal mice lacking the C-terminal region of connexin43
    • doi: 10.1091/mbc.E04-04-0324
    • Maass, K., Ghanem, A., Kim, J. S., Saathoff, M., Urschel, S., Kirfel, G., et al. (2004). Defective epidermal barrier in neonatal mice lacking the C-terminal region of connexin43. Mol. Biol. Cell 15, 4597-4608. doi: 10.1091/mbc.E04-04-0324.
    • (2004) Mol. Biol. Cell , vol.15 , pp. 4597-4608
    • Maass, K.1    Ghanem, A.2    Kim, J.S.3    Saathoff, M.4    Urschel, S.5    Kirfel, G.6
  • 129
    • 37349087184 scopus 로고    scopus 로고
    • C-terminal truncation of connexin43 changes number, size, and localization of cardiac gap junction plaques
    • doi: 10.1161/CIRCRESAHA.107.162818
    • Maass, K., Shibayama, J., Chase, S. E., Willecke, K., and Delmar, M. (2007). C-terminal truncation of connexin43 changes number, size, and localization of cardiac gap junction plaques. Circ. Res. 101, 1283-1291. doi: 10.1161/CIRCRESAHA.107.162818.
    • (2007) Circ. Res. , vol.101 , pp. 1283-1291
    • Maass, K.1    Shibayama, J.2    Chase, S.E.3    Willecke, K.4    Delmar, M.5
  • 130
    • 56549116154 scopus 로고    scopus 로고
    • Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant
    • doi: 10.1093/cvr/cvn203
    • Manias, J. L., Plante, I., Gong, X. Q., Shao, Q., Churko, J., Bai, D., et al. (2008). Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant. Cardiovasc. Res. 80, 385-395. doi: 10.1093/cvr/cvn203.
    • (2008) Cardiovasc. Res. , vol.80 , pp. 385-395
    • Manias, J.L.1    Plante, I.2    Gong, X.Q.3    Shao, Q.4    Churko, J.5    Bai, D.6
  • 132
    • 2942612343 scopus 로고    scopus 로고
    • Architectural and functional asymmetry of the His-Purkinje system of the murine heart
    • doi: 10.1016/j.cardiores.2004.03.007
    • Miquerol, L., Meysen, S., Mangoni, M., Bois, P., van Rijen, H. V., Abran, P., et al. (2004). Architectural and functional asymmetry of the His-Purkinje system of the murine heart. Cardiovasc. Res. 63, 77-86. doi: 10.1016/j.cardiores.2004.03.007.
    • (2004) Cardiovasc. Res. , vol.63 , pp. 77-86
    • Miquerol, L.1    Meysen, S.2    Mangoni, M.3    Bois, P.4    van Rijen, H.V.5    Abran, P.6
  • 133
    • 68949162221 scopus 로고    scopus 로고
    • Connexin43 in cardiomyocyte mitochondria contributes to mitochondrial potassium uptake
    • doi: 10.1093/cvr/cvp157
    • Miro-Casas, E., Ruiz-Meana, M., Agullo, E., Stahlhofen, S., Rodriguez-Sinovas, A., Cabestrero, A., et al. (2009). Connexin43 in cardiomyocyte mitochondria contributes to mitochondrial potassium uptake. Cardiovasc. Res. 83, 747-756. doi: 10.1093/cvr/cvp157
    • (2009) Cardiovasc. Res. , vol.83 , pp. 747-756
    • Miro-Casas, E.1    Ruiz-Meana, M.2    Agullo, E.3    Stahlhofen, S.4    Rodriguez-Sinovas, A.5    Cabestrero, A.6
  • 134
    • 0028900935 scopus 로고
    • Properties of gap junction channels formed of connexin 45 endogenously expressed in human hepatoma (SKHep1) cells
    • Moreno, A. P., Laing, J. G., Beyer, E. C., and Spray, D. C. (1995). Properties of gap junction channels formed of connexin 45 endogenously expressed in human hepatoma (SKHep1) cells. Am. J. Physiol. 268, C356-C365.
    • (1995) Am. J. Physiol. , vol.268
    • Moreno, A.P.1    Laing, J.G.2    Beyer, E.C.3    Spray, D.C.4
  • 135
    • 15244353801 scopus 로고    scopus 로고
    • Reduced intercellular coupling leads to paradoxical propagation across the Purkinje-ventricular junction and aberrant myocardial activation
    • doi: 10.1073/pnas.0500881102
    • Morley, G. E., Danik, S. B., Bernstein, S., Sun, Y., Rosner, G., Gutstein, D. E., et al. (2005). Reduced intercellular coupling leads to paradoxical propagation across the Purkinje-ventricular junction and aberrant myocardial activation. Proc. Natl. Acad. Sci. U.S.A. 102, 4126-4129. doi: 10.1073/pnas.0500881102.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 4126-4129
    • Morley, G.E.1    Danik, S.B.2    Bernstein, S.3    Sun, Y.4    Rosner, G.5    Gutstein, D.E.6
  • 136
    • 0034151472 scopus 로고    scopus 로고
    • Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mapping
    • doi: 10.1111/j.1540-8167.2000.tb01811.x
    • Morley, G. E., Vaidya, D., and Jalife, J. (2000). Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mapping. J. Cardiovasc. Electrophysiol. 11, 375-377. doi: 10.1111/j.1540-8167.2000.tb01811.x.
    • (2000) J. Cardiovasc. Electrophysiol. , vol.11 , pp. 375-377
    • Morley, G.E.1    Vaidya, D.2    Jalife, J.3
  • 137
    • 84871682633 scopus 로고    scopus 로고
    • Absence of venous valves in mice lacking Connexin37
    • doi: 10.1016/j.ydbio.2012.10.032
    • Munger, S. J., Kanady, J. D., and Simon, A. M. (2013). Absence of venous valves in mice lacking Connexin37. Dev. Biol. 373, 338-348. doi: 10.1016/j.ydbio.2012.10.032.
    • (2013) Dev. Biol. , vol.373 , pp. 338-348
    • Munger, S.J.1    Kanady, J.D.2    Simon, A.M.3
  • 138
    • 69049085659 scopus 로고    scopus 로고
    • Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay
    • doi: 10.1242/dev.038562
    • Munshi, N. V., McAnally, J., Bezprozvannaya, S., Berry, J. M., Richardson, J. A., Hill, J. A., et al. (2009). Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay. Development 136, 2665-2674. doi: 10.1242/dev.038562.
    • (2009) Development , vol.136 , pp. 2665-2674
    • Munshi, N.V.1    McAnally, J.2    Bezprozvannaya, S.3    Berry, J.M.4    Richardson, J.A.5    Hill, J.A.6
  • 139
    • 0346496105 scopus 로고    scopus 로고
    • Mice lacking connexin45 conditionally in cardiac myocytes display embryonic lethality similar to that of germline knockout mice without endocardial cushion defect
    • Nishii, K., Kumai, M., Egashira, K., Miwa, T., Hashizume, K., Miyano, Y., et al. (2003). Mice lacking connexin45 conditionally in cardiac myocytes display embryonic lethality similar to that of germline knockout mice without endocardial cushion defect. Cell Commun. Adhes. 10, 365-369.
    • (2003) Cell Commun. Adhes. , vol.10 , pp. 365-369
    • Nishii, K.1    Kumai, M.2    Egashira, K.3    Miwa, T.4    Hashizume, K.5    Miyano, Y.6
  • 140
    • 0032913131 scopus 로고    scopus 로고
    • Gating of cx46 gap junction hemichannels by calcium and voltage
    • doi: 10.1007/s004240050788
    • Pfahnl, A., and Dahl, G. (1999). Gating of cx46 gap junction hemichannels by calcium and voltage. Pflugers Arch. 437, 345-353. doi: 10.1007/s004240050788.
    • (1999) Pflugers Arch , vol.437 , pp. 345-353
    • Pfahnl, A.1    Dahl, G.2
  • 141
    • 20344377885 scopus 로고    scopus 로고
    • Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum
    • doi: 10.1128/MCB.25.12.5073-5083.2005
    • Pizard, A., Burgon, P. G., Paul, D. L., Bruneau, B. G., Seidman, C. E., and Seidman, J. G. (2005). Connexin 40, a target of transcription factor Tbx5, patterns wrist, digits, and sternum. Mol. Cell. Biol. 25, 5073-5083. doi: 10.1128/MCB.25.12.5073-5083.2005.
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 5073-5083
    • Pizard, A.1    Burgon, P.G.2    Paul, D.L.3    Bruneau, B.G.4    Seidman, C.E.5    Seidman, J.G.6
  • 142
    • 0034699350 scopus 로고    scopus 로고
    • Unique and shared functions of different connexins in mice
    • doi: 10.1016/S0960-9822(00)00690-4
    • Plum, A., Hallas, G., Magin, T., Dombrowski, F., Hagendorff, A., Schumacher, B., et al. (2000). Unique and shared functions of different connexins in mice. Curr. Biol. 10, 1083-1091. doi: 10.1016/S0960-9822(00)00690-4.
    • (2000) Curr. Biol. , vol.10 , pp. 1083-1091
    • Plum, A.1    Hallas, G.2    Magin, T.3    Dombrowski, F.4    Hagendorff, A.5    Schumacher, B.6
  • 143
    • 82855182237 scopus 로고    scopus 로고
    • Increased cell-cell coupling increases infarct size and does not decrease incidence of ventricular tachycardia in mice
    • doi: 10.3389/fphys.2011.00001
    • Prestia, K. A., Sosunov, E. A., Anyukhovsky, E. P., Dolmatova, E., Kelly, C. W., Brink, P. R., et al. (2011). Increased cell-cell coupling increases infarct size and does not decrease incidence of ventricular tachycardia in mice. Front. Physiol. 2:1. doi: 10.3389/fphys.2011.00001.
    • (2011) Front. Physiol. , vol.2 , pp. 1
    • Prestia, K.A.1    Sosunov, E.A.2    Anyukhovsky, E.P.3    Dolmatova, E.4    Kelly, C.W.5    Brink, P.R.6
  • 144
    • 77953058721 scopus 로고    scopus 로고
    • Diversity and properties of connexin gap junction channels
    • Rackauskas, M., Neverauskas, V., and Skeberdis, V. A. (2010). Diversity and properties of connexin gap junction channels. Medicina (Kaunas) 46, 1-12.
    • (2010) Medicina (Kaunas) , vol.46 , pp. 1-12
    • Rackauskas, M.1    Neverauskas, V.2    Skeberdis, V.A.3
  • 145
    • 0028907907 scopus 로고
    • Cardiac malformation in neonatal mice lacking connexin43
    • doi: 10.1126/science.7892609
    • Reaume, A. G., De Sousa, P. A., Kulkarni, S., Langille, B. L., Zhu, D., Davies, T. C., et al. (1995). Cardiac malformation in neonatal mice lacking connexin43. Science 267, 1831-1834. doi: 10.1126/science.7892609.
    • (1995) Science , vol.267 , pp. 1831-1834
    • Reaume, A.G.1    De Sousa, P.A.2    Kulkarni, S.3    Langille, B.L.4    Zhu, D.5    Davies, T.C.6
  • 146
    • 0027409355 scopus 로고
    • Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein
    • doi: 10.1172/JCI116321
    • Reed, K. E., Westphale, E. M., Larson, D. M., Wang, H. Z., Veenstra, R. D., and Beyer, E. C. (1993). Molecular cloning and functional expression of human connexin37, an endothelial cell gap junction protein. J. Clin. Invest. 91, 997-1004. doi: 10.1172/JCI116321.
    • (1993) J. Clin. Invest. , vol.91 , pp. 997-1004
    • Reed, K.E.1    Westphale, E.M.2    Larson, D.M.3    Wang, H.Z.4    Veenstra, R.D.5    Beyer, E.C.6
  • 147
    • 79958774848 scopus 로고    scopus 로고
    • Phosphatase-resistant gap junctions inhibit pathological remodeling and prevent arrhythmias
    • doi: 10.1161/CIRCRESAHA.111.244046
    • Remo, B. F., Qu, J., Volpicelli, F. M., Giovannone, S., Shin, D., Lader, J., et al. (2011). Phosphatase-resistant gap junctions inhibit pathological remodeling and prevent arrhythmias. Circ. Res. 108, 1459-1466. doi: 10.1161/CIRCRESAHA.111.244046.
    • (2011) Circ. Res. , vol.108 , pp. 1459-1466
    • Remo, B.F.1    Qu, J.2    Volpicelli, F.M.3    Giovannone, S.4    Shin, D.5    Lader, J.6
  • 148
    • 79551521516 scopus 로고    scopus 로고
    • Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways
    • doi: 10.1172/JCI44470
    • Rentschler, S., Harris, B. S., Kuznekoff, L., Jain, R., Manderfield, L., Lu, M. M., et al. (2011). Notch signaling regulates murine atrioventricular conduction and the formation of accessory pathways. J. Clin. Invest. 121, 525-533. doi: 10.1172/JCI44470.
    • (2011) J. Clin. Invest. , vol.121 , pp. 525-533
    • Rentschler, S.1    Harris, B.S.2    Kuznekoff, L.3    Jain, R.4    Manderfield, L.5    Lu, M.M.6
  • 149
    • 34249111083 scopus 로고    scopus 로고
    • The modulatory effects of connexin 43 on cell death/survival beyond cell coupling
    • doi: 10.1016/j.pbiomolbio.2007.03.003
    • Rodriguez-Sinovas, A., Cabestrero, A., Lopez, D., Torre, I., Morente, M., Abellan, A., et al. (2007). The modulatory effects of connexin 43 on cell death/survival beyond cell coupling. Prog. Biophys. Mol. Biol. 94, 219-232. doi: 10.1016/j.pbiomolbio.2007.03.003.
    • (2007) Prog. Biophys. Mol. Biol. , vol.94 , pp. 219-232
    • Rodriguez-Sinovas, A.1    Cabestrero, A.2    Lopez, D.3    Torre, I.4    Morente, M.5    Abellan, A.6
  • 150
    • 77952895520 scopus 로고    scopus 로고
    • Effects of substitution of Cx43 by Cx32 on myocardial energy metabolism, tolerance to ischaemia and preconditioning protection
    • doi: 10.1113/jphysiol.2009.186577
    • Rodriguez-Sinovas, A., Sanchez, J. A., Gonzalez-Loyola, A., Barba, I., Morente, M., Aguilar, R., et al. (2010). Effects of substitution of Cx43 by Cx32 on myocardial energy metabolism, tolerance to ischaemia and preconditioning protection. J. Physiol. 588, 1139-1151. doi: 10.1113/jphysiol.2009.186577.
    • (2010) J. Physiol. , vol.588 , pp. 1139-1151
    • Rodriguez-Sinovas, A.1    Sanchez, J.A.2    Gonzalez-Loyola, A.3    Barba, I.4    Morente, M.5    Aguilar, R.6
  • 151
    • 38849201088 scopus 로고    scopus 로고
    • Mitochondrial connexin43 as a new player in the pathophysiology of myocardial ischaemia-reperfusion injury
    • doi: 10.1093/cvr/cvm062
    • Ruiz-Meana, M., Rodriguez-Sinovas, A., Cabestrero, A., Boengler, K., Heusch, G., and Garcia-Dorado, D. (2008). Mitochondrial connexin43 as a new player in the pathophysiology of myocardial ischaemia-reperfusion injury. Cardiovasc. Res. 77, 325-333. doi: 10.1093/cvr/cvm062.
    • (2008) Cardiovasc. Res. , vol.77 , pp. 325-333
    • Ruiz-Meana, M.1    Rodriguez-Sinovas, A.2    Cabestrero, A.3    Boengler, K.4    Heusch, G.5    Garcia-Dorado, D.6
  • 152
    • 79954602236 scopus 로고    scopus 로고
    • Adrenergic control of cardiac gap junction function and expression
    • doi: 10.1007/s00210-011-0603-4
    • Salameh, A., and Dhein, S. (2011). Adrenergic control of cardiac gap junction function and expression. Naunyn Schmiedebergs Arch. Pharmacol. 383, 331-346. doi: 10.1007/s00210-011-0603-4.
    • (2011) Naunyn Schmiedebergs Arch. Pharmacol. , vol.383 , pp. 331-346
    • Salameh, A.1    Dhein, S.2
  • 153
    • 84865201683 scopus 로고    scopus 로고
    • The effect of connexin40 deficiency on ventricular conduction system function during development
    • doi: 10.1093/cvr/cvs210
    • Sankova, B., Benes, J. Jr., Krejci, E., Dupays, L., Theveniau-Ruissy, M., Miquerol, L., et al. (2012). The effect of connexin40 deficiency on ventricular conduction system function during development. Cardiovasc. Res. 95, 469-479. doi: 10.1093/cvr/cvs210.
    • (2012) Cardiovasc. Res. , vol.95 , pp. 469-479
    • Sankova, B.1    Benes Jr, J.2    Krejci, E.3    Dupays, L.4    Theveniau-Ruissy, M.5    Miquerol, L.6
  • 154
    • 63349097563 scopus 로고    scopus 로고
    • Normal impulse propagation in the atrioventricular conduction system of Cx30.2/Cx40 double deficient mice
    • doi: 10.1016/j.yjmcc.2009.02.012
    • Schrickel, J. W., Kreuzberg, M. M., Ghanem, A., Kim, J. S., Linhart, M., Andrie, R., et al. (2009). Normal impulse propagation in the atrioventricular conduction system of Cx30.2/Cx40 double deficient mice. J. Mol. Cell. Cardiol. 46, 644-652. doi: 10.1016/j.yjmcc.2009.02.012.
    • (2009) J. Mol. Cell. Cardiol. , vol.46 , pp. 644-652
    • Schrickel, J.W.1    Kreuzberg, M.M.2    Ghanem, A.3    Kim, J.S.4    Linhart, M.5    Andrie, R.6
  • 156
    • 0030665763 scopus 로고    scopus 로고
    • Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling
    • doi: 10.1161/01.RES.81.5.727
    • Shaw, R. M., and Rudy, Y. (1997). Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ. Res. 81, 727-741. doi: 10.1161/01.RES.81.5.727.
    • (1997) Circ. Res. , vol.81 , pp. 727-741
    • Shaw, R.M.1    Rudy, Y.2
  • 157
    • 0031016934 scopus 로고    scopus 로고
    • Female infertility in mice lacking connexin 37
    • doi: 10.1038/385525a0
    • Simon, A. M., Goodenough, D. A., Li, E., and Paul, D. L. (1997). Female infertility in mice lacking connexin 37. Nature 385, 525-529. doi: 10.1038/385525a0.
    • (1997) Nature , vol.385 , pp. 525-529
    • Simon, A.M.1    Goodenough, D.A.2    Li, E.3    Paul, D.L.4
  • 158
    • 0032567887 scopus 로고    scopus 로고
    • Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block
    • doi: 10.1016/S0960-9822(98)70113-7
    • Simon, A. M., Goodenough, D. A., and Paul, D. L. (1998). Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr. Biol. 8, 295-298. doi: 10.1016/S0960-9822(98)70113-7.
    • (1998) Curr. Biol. , vol.8 , pp. 295-298
    • Simon, A.M.1    Goodenough, D.A.2    Paul, D.L.3
  • 159
    • 0346022967 scopus 로고    scopus 로고
    • Heart and head defects in mice lacking pairs of connexins
    • doi: 10.1016/j.ydbio.2003.09.036
    • Simon, A. M., McWhorter, A. R., Dones, J. A., Jackson, C. L., and Chen, H. (2004). Heart and head defects in mice lacking pairs of connexins. Dev. Biol. 265, 369-383. doi: 10.1016/j.ydbio.2003.09.036.
    • (2004) Dev. Biol. , vol.265 , pp. 369-383
    • Simon, A.M.1    McWhorter, A.R.2    Dones, J.A.3    Jackson, C.L.4    Chen, H.5
  • 161
    • 84862784582 scopus 로고    scopus 로고
    • Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane
    • doi: 10.1161/CIRCRESAHA.111.257964
    • Smyth, J. W., Vogan, J. M., Buch, P. J., Zhang, S. S., Fong, T. S., Hong, T. T., et al. (2012). Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane. Circ. Res. 110, 978-989. doi: 10.1161/CIRCRESAHA.111.257964.
    • (2012) Circ. Res. , vol.110 , pp. 978-989
    • Smyth, J.W.1    Vogan, J.M.2    Buch, P.J.3    Zhang, S.S.4    Fong, T.S.5    Hong, T.T.6
  • 162
    • 1942438964 scopus 로고    scopus 로고
    • Gap junctions and the connexin protein family
    • doi: 10.1016/j.cardiores.2003.11.013
    • Sohl, G., and Willecke, K. (2004). Gap junctions and the connexin protein family. Cardiovasc. Res. 62, 228-232. doi: 10.1016/j.cardiores.2003.11.013.
    • (2004) Cardiovasc. Res. , vol.62 , pp. 228-232
    • Sohl, G.1    Willecke, K.2
  • 163
    • 64249170988 scopus 로고    scopus 로고
    • Connexin43 phosphorylation: structural changes and biological effects
    • doi: 10.1042/BJ20082319
    • Solan, J. L., and Lampe, P. D. (2009). Connexin43 phosphorylation: structural changes and biological effects. Biochem. J. 419, 261-272. doi: 10.1042/BJ20082319.
    • (2009) Biochem. J. , vol.419 , pp. 261-272
    • Solan, J.L.1    Lampe, P.D.2
  • 164
    • 0037195733 scopus 로고    scopus 로고
    • An electric field mechanism for transmission of excitation between myocardial cells
    • doi: 10.1161/01.RES.0000045656.34731.6D
    • Sperelakis, N. (2002). An electric field mechanism for transmission of excitation between myocardial cells. Circ. Res. 91, 985-987. doi: 10.1161/01.RES.0000045656.34731.6D.
    • (2002) Circ. Res. , vol.91 , pp. 985-987
    • Sperelakis, N.1
  • 165
    • 67649331915 scopus 로고    scopus 로고
    • Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction
    • doi: 10.1093/cvr/cvp124
    • Stein, M., van Veen, T. A., Remme, C. A., Boulaksil, M., Noorman, M., van Stuijvenberg, L., et al. (2009). Combined reduction of intercellular coupling and membrane excitability differentially affects transverse and longitudinal cardiac conduction. Cardiovasc. Res. 83, 52-60. doi: 10.1093/cvr/cvp124.
    • (2009) Cardiovasc. Res. , vol.83 , pp. 52-60
    • Stein, M.1    van Veen, T.A.2    Remme, C.A.3    Boulaksil, M.4    Noorman, M.5    van Stuijvenberg, L.6
  • 166
    • 37349083542 scopus 로고    scopus 로고
    • Propagated endothelial Ca2+ waves and arteriolar dilation in vivo: measurements in Cx40BAC GCaMP2 transgenic mice
    • doi: 10.1161/CIRCRESAHA.107.149484
    • Tallini, Y. N., Brekke, J. F., Shui, B., Doran, R., Hwang, S. M., Nakai, J., et al. (2007). Propagated endothelial Ca2+ waves and arteriolar dilation in vivo: measurements in Cx40BAC GCaMP2 transgenic mice. Circ. Res. 101, 1300-1309. doi: 10.1161/CIRCRESAHA.107.149484.
    • (2007) Circ. Res. , vol.101 , pp. 1300-1309
    • Tallini, Y.N.1    Brekke, J.F.2    Shui, B.3    Doran, R.4    Hwang, S.M.5    Nakai, J.6
  • 167
    • 0034634288 scopus 로고    scopus 로고
    • High-resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system
    • doi: 10.1161/01.RES.87.10.929
    • Tamaddon, H. S., Vaidya, D., Simon, A. M., Paul, D. L., Jalife, J., and Morley, G. E. (2000). High-resolution optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system. Circ. Res. 87, 929-936. doi: 10.1161/01.RES.87.10.929.
    • (2000) Circ. Res. , vol.87 , pp. 929-936
    • Tamaddon, H.S.1    Vaidya, D.2    Simon, A.M.3    Paul, D.L.4    Jalife, J.5    Morley, G.E.6
  • 168
    • 0032562189 scopus 로고    scopus 로고
    • Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: evidence for chamber-specific molecular determinants of conduction
    • doi: 10.1161/01.CIR.97.7.686
    • Thomas, S. A., Schuessler, R. B., Berul, C. I., Beardslee, M. A., Beyer, E. C., Mendelsohn, M. E., et al. (1998). Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction: evidence for chamber-specific molecular determinants of conduction. Circulation 97, 686-691. doi: 10.1161/01.CIR.97.7.686.
    • (1998) Circulation , vol.97 , pp. 686-691
    • Thomas, S.A.1    Schuessler, R.B.2    Berul, C.I.3    Beardslee, M.A.4    Beyer, E.C.5    Mendelsohn, M.E.6
  • 169
    • 0037704231 scopus 로고    scopus 로고
    • Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43
    • doi: 10.1161/01.RES.0000074916.41221.EA
    • Thomas, S. P., Kucera, J. P., Bircher-Lehmann, L., Rudy, Y., Saffitz, J. E., and Kleber, A. G. (2003). Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43. Circ. Res. 92, 1209-1216. doi: 10.1161/01.RES.0000074916.41221.EA.
    • (2003) Circ. Res. , vol.92 , pp. 1209-1216
    • Thomas, S.P.1    Kucera, J.P.2    Bircher-Lehmann, L.3    Rudy, Y.4    Saffitz, J.E.5    Kleber, A.G.6
  • 170
    • 0028338523 scopus 로고
    • Immunochemical and electrophysiological characterization of murine connexin40 and -43 in mouse tissues and transfected human cells
    • Traub, O., Eckert, R., Lichtenberg-Frate, H., Elfgang, C., Bastide, B., Scheidtmann, K. H., et al. (1994). Immunochemical and electrophysiological characterization of murine connexin40 and -43 in mouse tissues and transfected human cells. Eur. J. Cell Biol. 64, 101-112.
    • (1994) Eur. J. Cell Biol. , vol.64 , pp. 101-112
    • Traub, O.1    Eckert, R.2    Lichtenberg-Frate, H.3    Elfgang, C.4    Bastide, B.5    Scheidtmann, K.H.6
  • 171
    • 0029905253 scopus 로고    scopus 로고
    • Voltage gating and permeation in a gap junction hemichannel
    • doi: 10.1073/pnas.93.12.5836
    • Trexler, E. B., Bennett, M. V., Bargiello, T. A., and Verselis, V. K. (1996). Voltage gating and permeation in a gap junction hemichannel. Proc. Natl. Acad. Sci. U.S.A. 93, 5836-5841. doi: 10.1073/pnas.93.12.5836.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 5836-5841
    • Trexler, E.B.1    Bennett, M.V.2    Bargiello, T.A.3    Verselis, V.K.4
  • 172
    • 79955096951 scopus 로고    scopus 로고
    • Atrial tachycardia/fibrillation in the connexin 43 G60S mutant (Oculodentodigital dysplasia) mouse
    • doi: 10.1152/ajpheart.01094.2010
    • Tuomi, J. M., Tyml, K., and Jones, D. L. (2011). Atrial tachycardia/fibrillation in the connexin 43 G60S mutant (Oculodentodigital dysplasia) mouse. Am. J. Physiol. Heart Circ. Physiol. 300, H1402-H1411. doi: 10.1152/ajpheart.01094.2010.
    • (2011) Am. J. Physiol. Heart Circ. Physiol. , vol.300
    • Tuomi, J.M.1    Tyml, K.2    Jones, D.L.3
  • 173
    • 0035827720 scopus 로고    scopus 로고
    • Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development
    • doi: 10.1161/hh1101.091107
    • Vaidya, D., Tamaddon, H. S., Lo, C. W., Taffet, S. M., Delmar, M., Morley, G. E., et al. (2001). Null mutation of connexin43 causes slow propagation of ventricular activation in the late stages of mouse embryonic development. Circ. Res. 88, 1196-1202. doi: 10.1161/hh1101.091107.
    • (2001) Circ. Res. , vol.88 , pp. 1196-1202
    • Vaidya, D.1    Tamaddon, H.S.2    Lo, C.W.3    Taffet, S.M.4    Delmar, M.5    Morley, G.E.6
  • 174
    • 0033198518 scopus 로고    scopus 로고
    • Biophysical properties of mouse connexin30 gap junction channels studied in transfected human HeLa cells
    • doi: 10.1111/j.1469-7793.1999.0631n.x
    • Valiunas, V., Manthey, D., Vogel, R., Willecke, K., and Weingart, R. (1999). Biophysical properties of mouse connexin30 gap junction channels studied in transfected human HeLa cells. J. Physiol. 3, 631-644. doi: 10.1111/j.1469-7793.1999.0631n.x.
    • (1999) J. Physiol. , vol.3 , pp. 631-644
    • Valiunas, V.1    Manthey, D.2    Vogel, R.3    Willecke, K.4    Weingart, R.5
  • 175
    • 0034602889 scopus 로고    scopus 로고
    • Formation of heterotypic gap junction channels by connexins 40 and 43
    • doi: 10.1161/01.RES.86.2.e42
    • Valiunas, V., Weingart, R., and Brink, P. R. (2000). Formation of heterotypic gap junction channels by connexins 40 and 43. Circ. Res. 86, E42-E49. doi: 10.1161/01.RES.86.2.e42.
    • (2000) Circ. Res. , vol.86
    • Valiunas, V.1    Weingart, R.2    Brink, P.R.3
  • 176
    • 0033756670 scopus 로고    scopus 로고
    • Connexin40-deficient mice exhibit atrioventricular nodal and infra-Hisian conduction abnormalities
    • doi: 10.1046/j.1540-8167.2000.01270.x
    • Vanderbrink, B. A., Sellitto, C., Saba, S., Link, M. S., Zhu, W., Homoud, M. K., et al. (2000). Connexin40-deficient mice exhibit atrioventricular nodal and infra-Hisian conduction abnormalities. J. Cardiovasc. Electrophysiol. 11, 1270-1276. doi: 10.1046/j.1540-8167.2000.01270.x.
    • (2000) J. Cardiovasc. Electrophysiol. , vol.11 , pp. 1270-1276
    • Vanderbrink, B.A.1    Sellitto, C.2    Saba, S.3    Link, M.S.4    Zhu, W.5    Homoud, M.K.6
  • 177
    • 0029142424 scopus 로고
    • Differential connexin distribution accommodates cardiac function in different species
    • doi: 10.1002/jemt.1070310511
    • van Kempen, M. J., Ten Velde, I., Wessels, A., Oosthoek, P. W., Gros, D., Jongsma, H. J., et al. (1995). Differential connexin distribution accommodates cardiac function in different species. Microsc. Res. Tech. 31, 420-436. doi: 10.1002/jemt.1070310511.
    • (1995) Microsc. Res. Tech. , vol.31 , pp. 420-436
    • van Kempen, M.J.1    Ten Velde, I.2    Wessels, A.3    Oosthoek, P.W.4    Gros, D.5    Jongsma, H.J.6
  • 178
    • 1442359119 scopus 로고    scopus 로고
    • Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43
    • doi: 10.1161/01.CIR.0000117402.70689.75
    • van Rijen, H. V., Eckardt, D., Degen, J., Theis, M., Ott, T., Willecke, K., et al. (2004). Slow conduction and enhanced anisotropy increase the propensity for ventricular tachyarrhythmias in adult mice with induced deletion of connexin43. Circulation 109, 1048-1055. doi: 10.1161/01.CIR.0000117402.70689.75.
    • (2004) Circulation , vol.109 , pp. 1048-1055
    • van Rijen, H.V.1    Eckardt, D.2    Degen, J.3    Theis, M.4    Ott, T.5    Willecke, K.6
  • 179
    • 0035916936 scopus 로고    scopus 로고
    • Impaired conduction in the bundle branches of mouse hearts lacking the gap junction protein connexin40
    • doi: 10.1161/01.CIR.103.11.1591
    • van Rijen, H. V., van Veen, T. A., Van Kempen, M. J., Wilms-Schopman, F. J., Potse, M., Krueger, O., et al. (2001). Impaired conduction in the bundle branches of mouse hearts lacking the gap junction protein connexin40. Circulation 103, 1591-1598. doi: 10.1161/01.CIR.103.11.1591.
    • (2001) Circulation , vol.103 , pp. 1591-1598
    • van Rijen, H.V.1    van Veen, T.A.2    Van Kempen, M.J.3    Wilms-Schopman, F.J.4    Potse, M.5    Krueger, O.6
  • 180
    • 25444509189 scopus 로고    scopus 로고
    • Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging
    • van Veen, T. A., Stein, M., Royer, A., Le Quang, K., Charpentier, F., Colledge, W. H., et al. (2005a). Impaired impulse propagation in Scn5a-knockout mice: combined contribution of excitability, connexin expression, and tissue architecture in relation to aging. Circulation 112, 1927-1935.
    • (2005) Circulation , vol.112 , pp. 1927-1935
    • van Veen, T.A.1    Stein, M.2    Royer, A.3    Le Quang, K.4    Charpentier, F.5    Colledge, W.H.6
  • 181
    • 26844568870 scopus 로고    scopus 로고
    • Discontinuous conduction in mouse bundle branches is caused by bundle-branch architecture
    • van Veen, T. A., van Rijen, H. V., Van Kempen, M. J., Miquerol, L., Opthof, T., Gros, D., et al. (2005b). Discontinuous conduction in mouse bundle branches is caused by bundle-branch architecture. Circulation 112, 2235-2244.
    • (2005) Circulation , vol.112 , pp. 2235-2244
    • van Veen, T.A.1    van Rijen, H.V.2    Van Kempen, M.J.3    Miquerol, L.4    Opthof, T.5    Gros, D.6
  • 182
    • 0034846097 scopus 로고    scopus 로고
    • Electrophysiological features of the mouse sinoatrial node in relation to connexin distribution
    • doi: 10.1016/S0008-6363(01)00364-9
    • Verheijck, E. E., van Kempen, M. J., Veereschild, M., Lurvink, J., Jongsma, H. J., and Bouman, L. N. (2001). Electrophysiological features of the mouse sinoatrial node in relation to connexin distribution. Cardiovasc. Res. 52, 40-50. doi: 10.1016/S0008-6363(01)00364-9.
    • (2001) Cardiovasc. Res. , vol.52 , pp. 40-50
    • Verheijck, E.E.1    van Kempen, M.J.2    Veereschild, M.3    Lurvink, J.4    Jongsma, H.J.5    Bouman, L.N.6
  • 183
  • 185
    • 0030939161 scopus 로고    scopus 로고
    • Characterization of gap junction channels in adult rabbit atrial and ventricular myocardium
    • doi: 10.1161/01.RES.80.5.673
    • Verheule, S., van Kempen, M. J., Te Welscher, P. H., Kwak, B. R., and Jongsma, H. J. (1997). Characterization of gap junction channels in adult rabbit atrial and ventricular myocardium. Circ. Res. 80, 673-681. doi: 10.1161/01.RES.80.5.673.
    • (1997) Circ. Res. , vol.80 , pp. 673-681
    • Verheule, S.1    van Kempen, M.J.2    Te Welscher, P.H.3    Kwak, B.R.4    Jongsma, H.J.5
  • 186
    • 1942470601 scopus 로고    scopus 로고
    • Alterations of intercellular communication in neonatal cardiac myocytes from connexin43 null mice
    • doi: 10.1016/j.cardiores.2004.01.015
    • Vink, M. J., Suadicani, S. O., Vieira, D. M., Urban-Maldonado, M., Gao, Y., Fishman, G. I., et al. (2004). Alterations of intercellular communication in neonatal cardiac myocytes from connexin43 null mice. Cardiovasc. Res. 62, 397-406. doi: 10.1016/j.cardiores.2004.01.015.
    • (2004) Cardiovasc. Res. , vol.62 , pp. 397-406
    • Vink, M.J.1    Suadicani, S.O.2    Vieira, D.M.3    Urban-Maldonado, M.4    Gao, Y.5    Fishman, G.I.6
  • 187
    • 0033136119 scopus 로고    scopus 로고
    • Chamber-related differences in connexin expression in the human heart
    • doi: 10.1006/jmcc.1999.0937
    • Vozzi, C., Dupont, E., Coppen, S. R., Yeh, H. I., and Severs, N. J. (1999). Chamber-related differences in connexin expression in the human heart. J. Mol. Cell. Cardiol. 31, 991-1003. doi: 10.1006/jmcc.1999.0937.
    • (1999) J. Mol. Cell. Cardiol. , vol.31 , pp. 991-1003
    • Vozzi, C.1    Dupont, E.2    Coppen, S.R.3    Yeh, H.I.4    Severs, N.J.5
  • 188
    • 23944514316 scopus 로고    scopus 로고
    • Connexin43 deficiency causes dysregulation of coronary vasculogenesis
    • doi: 10.1016/j.ydbio.2005.06.004
    • Walker, D. L., Vacha, S. J., Kirby, M. L., and Lo, C. W. (2005). Connexin43 deficiency causes dysregulation of coronary vasculogenesis. Dev. Biol. 284, 479-498. doi: 10.1016/j.ydbio.2005.06.004.
    • (2005) Dev. Biol. , vol.284 , pp. 479-498
    • Walker, D.L.1    Vacha, S.J.2    Kirby, M.L.3    Lo, C.W.4
  • 189
    • 84869863191 scopus 로고    scopus 로고
    • Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury
    • doi: 10.1007/s00395-012-0309-x
    • Wang, N., De Vuyst, E., Ponsaerts, R., Boengler, K., Palacios-Prado, N., Wauman, J., et al. (2013). Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury. Basic Res. Cardiol. 108, 309. doi: 10.1007/s00395-012-0309-x.
    • (2013) Basic Res. Cardiol. , vol.108 , pp. 309
    • Wang, N.1    De Vuyst, E.2    Ponsaerts, R.3    Boengler, K.4    Palacios-Prado, N.5    Wauman, J.6
  • 190
    • 0029743057 scopus 로고    scopus 로고
    • Multiple connexin proteins in single intercellular channels: connexin compatibility and functional consequences
    • doi: 10.1007/BF02110110
    • White, T. W., and Bruzzone, R. (1996). Multiple connexin proteins in single intercellular channels: connexin compatibility and functional consequences. J. Bioenerg. Biomembr. 28, 339-350. doi: 10.1007/BF02110110.
    • (1996) J. Bioenerg. Biomembr. , vol.28 , pp. 339-350
    • White, T.W.1    Bruzzone, R.2
  • 192
    • 61949215108 scopus 로고    scopus 로고
    • Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3
    • doi: 10.1161/CIRCRESAHA.108.187062
    • Wiese, C., Grieskamp, T., Airik, R., Mommersteeg, M. T., Gardiwal, A., De Gier-De Vries, C., et al. (2009). Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by Tbx18 and Tbx3. Circ. Res. 104, 388-397. doi: 10.1161/CIRCRESAHA.108.187062.
    • (2009) Circ. Res. , vol.104 , pp. 388-397
    • Wiese, C.1    Grieskamp, T.2    Airik, R.3    Mommersteeg, M.T.4    Gardiwal, A.5    De Gier-De Vries, C.6
  • 193
    • 34247105350 scopus 로고    scopus 로고
    • Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart
    • doi: 10.1186/1471-213X-7-26
    • Winterhager, E., Pielensticker, N., Freyer, J., Ghanem, A., Schrickel, J. W., Kim, J. S., et al. (2007). Replacement of connexin43 by connexin26 in transgenic mice leads to dysfunctional reproductive organs and slowed ventricular conduction in the heart. BMC Dev. Biol. 7:26. doi: 10.1186/1471-213X-7-26.
    • (2007) BMC Dev. Biol. , vol.7 , pp. 26
    • Winterhager, E.1    Pielensticker, N.2    Freyer, J.3    Ghanem, A.4    Schrickel, J.W.5    Kim, J.S.6
  • 194
    • 84856151294 scopus 로고    scopus 로고
    • The role of gap junctions in the arrhythmias of ischemia and infarction
    • doi: 10.1016/j.hrthm.2011.09.056
    • Wit, A. L., and Peters, N. S. (2012). The role of gap junctions in the arrhythmias of ischemia and infarction. Heart Rhythm 9, 308-311. doi: 10.1016/j.hrthm.2011.09.056.
    • (2012) Heart Rhythm , vol.9 , pp. 308-311
    • Wit, A.L.1    Peters, N.S.2
  • 196
    • 2942527401 scopus 로고    scopus 로고
    • Transmural distribution of connexins in rodent hearts
    • doi: 10.1046/j.1540-8167.2004.03514.x
    • Yamada, K. A., Kanter, E. M., Green, K. G., and Saffitz, J. E. (2004). Transmural distribution of connexins in rodent hearts. J. Cardiovasc. Electrophysiol. 15, 710-715. doi: 10.1046/j.1540-8167.2004.03514.x.
    • (2004) J. Cardiovasc. Electrophysiol. , vol.15 , pp. 710-715
    • Yamada, K.A.1    Kanter, E.M.2    Green, K.G.3    Saffitz, J.E.4
  • 198
    • 78249241534 scopus 로고    scopus 로고
    • Remodeling of cardiac fibroblasts following myocardial infarction results in increased gap junction intercellular communication
    • doi: 10.1016/j.carpath.2009.12.002
    • Zhang, Y., Kanter, E. M., and Yamada, K. A. (2010a). Remodeling of cardiac fibroblasts following myocardial infarction results in increased gap junction intercellular communication. Cardiovasc. Pathol. 19, e233-e240. doi: 10.1016/j.carpath.2009.12.002.
    • (2010) Cardiovasc. Pathol. , vol.19
    • Zhang, Y.1    Kanter, E.M.2    Yamada, K.A.3
  • 199
    • 74949129439 scopus 로고    scopus 로고
    • Reduced expression of Cx43 attenuates ventricular remodeling after myocardial infarction via impaired TGF-beta signaling
    • doi: 10.1152/ajpheart.00806.2009
    • Zhang, Y., Wang, H., Kovacs, A., Kanter, E. M., and Yamada, K. A. (2010b). Reduced expression of Cx43 attenuates ventricular remodeling after myocardial infarction via impaired TGF-beta signaling. Am. J. Physiol. Heart Circ. Physiol. 298, H477-H487. doi: 10.1152/ajpheart.00806.2009.
    • (2010) Am. J. Physiol. Heart Circ. Physiol. , vol.298
    • Zhang, Y.1    Wang, H.2    Kovacs, A.3    Kanter, E.M.4    Yamada, K.A.5
  • 200
    • 33645095705 scopus 로고    scopus 로고
    • Connexin31 cannot functionally replace connexin43 during cardiac morphogenesis in mice
    • doi: 10.1242/jcs.02800
    • Zheng-Fischhofer, Q., Ghanem, A., Kim, J. S., Kibschull, M., Schwarz, G., Schwab, J. O., et al. (2006). Connexin31 cannot functionally replace connexin43 during cardiac morphogenesis in mice. J. Cell. Sci. 119, 693-701. doi: 10.1242/jcs.02800.
    • (2006) J. Cell. Sci. , vol.119 , pp. 693-701
    • Zheng-Fischhofer, Q.1    Ghanem, A.2    Kim, J.S.3    Kibschull, M.4    Schwarz, G.5    Schwab, J.O.6
  • 201
    • 27744522672 scopus 로고    scopus 로고
    • Atrioventricular nodal reverse facilitation in connexin40-deficient mice
    • doi: 10.1016/j.hrthm.2005.07.022
    • Zhu, W., Saba, S., Link, M. S., Bak, E., Homoud, M. K., Estes, N. A., et al. (2005). Atrioventricular nodal reverse facilitation in connexin40-deficient mice. Heart Rhythm 2, 1231-1237. doi: 10.1016/j.hrthm.2005.07.022.
    • (2005) Heart Rhythm , vol.2 , pp. 1231-1237
    • Zhu, W.1    Saba, S.2    Link, M.S.3    Bak, E.4    Homoud, M.K.5    Estes, N.A.6


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