Erratum: Manipulating connexin communication channels: Use of peptidomimetics and the translational outputs (J Membrane Biol (2012) 245 (451) 10.1007/s00232-012-9488-5;Manipulating connexin communication channels: Use of peptidomimetics and the translational outputs

Journal of Membrane Biology

Volumn 245, Issue 8, 2012, Pages 437-449

  Evans, W Howard ^a   Bultynck, Geert ^b   Leybaert, Luc ^c  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^b UNIVERSITY OF LEUVEN   (Belgium)

^c GHENT UNIVERSITY   (Belgium)

Author keywords

Clinical translation; Connexin hemichannels; Peptidomimetics

Indexed keywords

CONNEXIN 26; CONNEXIN 43; CONNEXPROTEIN GAP27; GAP JUNCTION PROTEIN; MYOSIN ADENOSINE TRIPHOSPHATASE; PEPTIDOMIMETIC AGENT; ROTIGAPTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; BRAIN FUNCTION; CELL COMMUNICATION; CELL CULTURE; CELL MEMBRANE; GAP JUNCTION; HEART VENTRICLE TACHYCARDIA; ISCHEMIC CARDIOMYOPATHY; NONHUMAN; OLIGOMERIZATION; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSLATION REGULATION;

EID: 84866729771     PISSN: 00222631     EISSN: 14321424     Source Type: Journal    
DOI: 10.1007/s00232-012-9501-z     Document Type: Erratum

References (137)

1. 2+ signals across the inner ear. Proc Natl Acad Sci USA 105(48):18770-18775
2. Bao B, Jiang J et al (2011) Connexon-mediated cell adhesion drives microtissue self-assembly. FASEB J 25(1):255-264
3. Becker DL, Evans WH et al (1995) Functional analysis of amino acid sequences in connexin43 involved in intercellular communication through gap junctions. J Cell Sci 108(Pt 4):1455-1467
4. Bennett MV, Contreras JE et al (2003) New roles for astrocytes: gap junction hemichannels have something to communicate. Trends Neurosci 26(11):610-617
5. Berman RS, Martin PE et al (2002) Relative contributions of NO and gap junctional communication to endothelium-dependent relaxations of rabbit resistance arteries vary with vessel size. Microvasc Res 63(1):115-128
6. Bhabra G, Sood A et al (2009) Nanoparticles can cause DNA damage across a cellular barrier. Nature Nanotechnol 4(12):876-883
7. Bissiere S, Zelikowsky M et al (2011) Electrical synapses control hippocampal contributions to fear learning and memory. Science
8. Bodendiek SB, Raman G (2010) Connexin modulators and their potential targets under the magnifying glass. Curr Med Chem 17(34):4191-4230
9. Boengler K, Stahlhofen S et al (2009) Presence of connexin43 in subsarcolemmal, but not in interfibrillar cardiomyocyte mitochondria. Basic Res Cardiol 104(2):141-147
10. 2+ signaling through gap junctions in airway cells. Am J Physiol Lung Cell Mol Physiol 279(4):L623-L630
11. Boitano S, Dirksen ER et al (1998) Sequence-specific antibodies to connexins block intercellular calcium signaling through gap junctions. Cell Calcium 23(1):1-9
12. Chaytor AT, Evans WH et al (1997) Peptides homologous to extracellular loop motifs of connexin43 reversibly abolish rhythmic contractile activity in rabbit arteries. J Physiol 503(Pt 1): 99-110
13. Chaytor AT, Martin PE et al (1999) The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication. J Physiol 520(Pt 2): 539-550
14. Chaytor AT, Bakker LM et al (2005) Connexin-mimetic peptides dissociate electrotonic EDHF-type signalling via myoendothelial and smooth muscle gap junctions in the rabbit iliac artery. Br J Pharmacol 144(1):108-114
15. Chew SS, Johnson CS et al (2010) Role of connexin43 in central nervous system injury. Exp Neurol 225(2):250-261
16. Clair C, Combettes L et al (2008) Extracellular-loop peptide antibodies reveal a predominant hemichannel organization of connexins in polarized intestinal cells. Exp Cell Res 314(6): 1250-1265
17. Clarke TC, Thomas D et al (2006) The antiarrhythmic peptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing conn-exin43. Br J Pharmacol 147(5):486-495
18. Clarke TC, Williams OJ et al (2009) ATP release by cardiac myocytes in a simulated ischaemia model: inhibition by a connexin mimetic and enhancement by an antiarrhythmic peptide. Eur J Pharmacol 605(1-3):9-14
19. Contreras JE, Saez JC et al (2003) Gating and regulation of connexin43 (Cx43) hemichannels. Proc Natl Acad Sci USA 100(20):11388-11393
20. Cotrina ML, Lin JH et al (1998) Connexins regulate calcium signaling by controlling ATP release. Proc Natl Acad Sci USA 95(26): 1574-15735
21. Cotrina ML, Lin JH et al (2008) Adhesive properties of connexin hemichannels. Glia 56(16):1791-1798
22. Dahl G, Nonner W et al (1994) Attempts to define functional domains of gap junction proteins with synthetic peptides. Biophys J 67(5): 1816-1822
23. Danesh-Meyer HV, Kerr NM et al (2012) Connexin43 mimetic peptide reduces vascular leak and retinal ganglion cell death following retinal ischaemia. Brain 135(Pt 2):506-520
24. Davidson JO, Green CR et al (2012) Connexin hemichannel blockade improves outcomes in a model of fetal ischemia. Ann Neurol 71(1):121-132
25. De Bock M, Culot M et al (2011) Connexin channels provide a target to manipulate brain endothelial calcium dynamics and blood-brain barrier permeability. J Cereb Blood Flow Metab 31(9): 1942-1957
26. 2+ entry pathway. J Biol Chem 287 (15):12250-12266
27. De Vriese AS, Van de Voorde J et al (2002) Effects of connexin-mimetic peptides on nitric oxide synthase-and cyclooxygenase-independent renal vasodilation. Kidney Int 61(1):177-185
28. De Vuyst E, Decrock E et al (2006) Intracellular calcium changes trigger connexin32 hemichannel opening. EMBO J 25(1):34-44
29. De Vuyst E, Decrock E et al (2007) Connexin hemichannels and gap junction channels are differentially influenced by lipopolysac-charide and basic fibroblast growth factor. Mol Biol Cell 18(1): 34-46
30. 2+ regulation of connexin43 hemichannels in C6 glioma and glial cells. Cell Calcium 46(3):176-187
31. De Vuyst E, Boengler K et al (2011) Pharmacological modulation of connexin-formed channels in cardiac pathophysiology. Br J Pharmacol 163(3):469-483
32. Decrock E, De Vuyst E et al (2009a) Connexin43 hemichannels contribute to the propagation of apoptotic cell death in a rat C6 glioma cell model. Cell Death Differ 16(1):151-163
33. Decrock E, Vinken M et al (2009b) Connexin-related signaling in cell death: to live or let die? Cell Death Differ 16(4):524-536
34. Decrock E, Vinken M et al (2011) Calcium and connexin-based intercellular communication, a deadly catch? Cell Calcium 50 (3):310-321
35. Delmar M, Coombs W et al (2004) Structural bases for the chemical regulation of connexin43 channels. Cardiovasc Res 62(2): 268-275
36. Desplantez T, Verma V et al (2012) Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels. Pharmacol Res 65(5):546-552
37. D'Hondt C, Ponsaerts R et al (2009) Pannexins, distant relatives of the connexin family with specific cellular functions? Bioessays 31(9):953-974
38. D'Hondt C, Ponsaerts R et al (2011) Pannexin channels in ATP release and beyond: an unexpected rendezvous at the endoplas-mic reticulum. Cell Signal 23(2):305-316
39. Dora KA, Martin PE et al (1999) Role of heterocellular gap junctional communication in endothelium-dependent smooth muscle hyper-polarization: inhibition by a connexin-mimetic peptide. Biochem Biophys Res Commun 254(1):27-31
40. Ebihara L, Steiner E (1993) Properties of a nonjunctional current expressed from a rat connexin46 cDNA in Xenopus oocytes. J Gen Physiol 102(1):59-74
41. Ek-Vitorin JF, Burt JM (2012) Structural basis for the selective permeability of channels made of communicating junction proteins. Biochim Biophys Acta (in press)
42. Eltzschig HK, Eckle T et al (2006) ATP release from activated neutrophils occurs via connexin43 and modulates adenosine-dependent endothelial cell function. Circ Res 99(10):1100-1108
43. Evans WH, Boitano S (2001) Connexin mimetic peptides: specific inhibitors of gap-junctional intercellular communication. Bio-chem Soc Trans 29(Pt 4):606-612
44. Evans WH, De Vuyst E et al (2006) The gap junction cellular internet: connexin hemichannels enter the signalling limelight. Biochem J 397(1):1-14
45. Flores CE, Nannapaneni S et al (2012) Trafficking of gap junction channels at a vertebrate electrical synapse in vivo. Proc Natl Acad Sci USA 109(9):E573-E582
46. Froger N, Orellana JA et al (2010) Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective. Mol Cell Neurosci 45(1):37-46
47. Gomes P, Srinivas SP et al (2005) ATP-dependent paracrine intercellular communication in cultured bovine corneal endothelial cells. Invest Ophthalmol Vis Sci 46(1):104-113
48. Goodenough DA, Paul DL (2003) Beyond the gap: functions of unpaired connexon channels. Nat Rev Mol Cell Biol 4(4):285-294
49. Goodenough DA, Paul DL (2009) Gap junctions. Cold Spring Harb Perspect Biol 1(1):a002576
50. Goodenough DA, Paul DL et al (1988) Topological distribution of two connexin32 antigenic sites in intact and split rodent hepatocyte gap junctions. J Cell Biol 107(5):1817-1824
51. Hagen A, Dietze A et al (2009) Human cardiac gap-junction coupling: effects of antiarrhythmic peptide AAP10. Cardiovasc Res 83(2): 405-415
52. Harris AL (2001) Emerging issues of connexin channels: biophysics fills the gap. Q Rev Biophys 34(3):325-472
53. Harris A, Locke D (eds) (2009) Connexins: a guide. Springer, New York
54. Hawat G, Benderdour M et al (2010) Connexin43 mimetic peptide Gap26 confers protection to intact heart against myocardial ischemia injury. Pflugers Arch 460(3):583-592
55. Hennan JK, Swillo RE et al (2009) GAP-134 ([2S,4R]-1-[2-amino-acetyl]4- benzamidopyrrolidine-2-carboxylic acid) prevents spontaneous ventricular arrhythmias and reduces infarct size during myocardial ischemia/reperfusion injury in open-chest dogs. J Cardiovasc Pharmacol Ther 14(3):207-214
56. Herve JC, Dhein S (2010) Peptides targeting gap junctional structures. Curr Pharm Des 16(28):3056-3070
57. Herve JC, Derangeon M et al (2011) Gap junctional channels are parts of multiprotein complexes. Biochim Biophys Acta 1818(8): 1844-1865
58. Hirst-Jensen BJ, Sahoo P et al (2007) Characterization of the pH-dependent interaction between the gap junction protein connexin43 carboxyl terminus and cytoplasmic loop domains. J Biol Chem 282(8):5801-5813
59. Huang C, Han X et al (2012) Critical role of connexin43 in secondary expansion of traumatic spinal cord injury. J Neurosci 32(10): 3333-3338
60. Hunter AW, Barker RJ et al (2005) Zonula occludens-1 alters connexin43 gap junction size and organization by influencing channel accretion. Mol Biol Cell 16(12):5686-5698
61. 2. Circ Res 84(1):53-63
62. 2+ signaling in alveolar epithelial cells through gap junctions and by extracellular ATP. Am J Physiol Lung Cell Mol Physiol 280(2):L221-L228
63. Isakson BE, Seedorf GJ et al (2003) Cell-cell communication in heterocellular cultures of alveolar epithelial cells. Am J Respir Cell Mol Biol 29(5):552-561
64. 2+ channel, hemichannel, and gap junction to promote osteoblast differentiation. J Cell Biol 193(7):1257-1274
65. Jarver P, Langel U (2006) Cell-penetrating peptides - a brief introduction. Biochim Biophys Acta 1758(3):260-263
66. Jiang S, Yuan H et al (2011) Glutamate release through connexin43 by cultured astrocytes in a stimulated hypertonicity model. Brain Res 1392:8-15
67. Juszczak GR, Swiergiel AH (2009) Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: animal and human studies. Prog Neuropsychophar-macol Biol Psychiatry 33(2):181-198
68. Kameritsch P, Pogoda K et al (2011) Channel-independent influence of connexin43 on cell migration. Biochim Biophys Acta 1818 (8):1993-2001
69. Kang J, Kang N et al (2008) Connexin43 hemichannels are permeable to ATP. J Neurosci 28(18):4702-4711
70. Karpuk N, Burkovetskaya M et al (2011) Neuroinflammation leads to region-dependent alterations in astrocyte gap junction communication and hemichannel activity. J Neurosci 31(2):414-425
71. Kjenseth A, Fykerud TA et al (2012) The gap junction channel protein connexin43 is covalently modified and regulated by SUMOylation. J Biol Chem 287(19):15851-15861
72. Kwak BR, Jongsma HJ (1999) Selective inhibition of gap junction channel activity by synthetic peptides. J Physiol 516(Pt 3): 679-685
73. Lai A, Le DN et al (2006) Oculodentodigital dysplasia connexin43 mutations result in non-functional connexin hemichannels and gap junctions in C6 glioma cells. J Cell Sci 119(Pt 3):532-541
74. Laird DW (2006) Life cycle of connexins in health and disease. Biochem J 394(Pt 3):527-543
75. Lewandowski R, Procida K et al (2008) RXP-E: a connexin43-binding peptide that prevents action potential propagation block. Circ Res 103(5):519-526
76. Li H, Liu TF et al (1996) Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells. J Cell Biol 134(4):1019-1030
77. Liu F, Arce FT et al (2006) Nanomechanics of hemichannel conformations: connexin flexibility underlying channel opening and closing. J Biol Chem 281(32):23207-23217
78. Maeda S, Nakagawa S et al (2009) Structure of the connexin26 gap junction channel at 3.5 A resolution. Nature 458(7238):597-602
79. Malchow RP, Qian H et al (1993) Evidence for hemi-gap junctional channels in isolated horizontal cells of the skate retina. J Neurosci Res 35(3):237-245
80. Matchkov VV, Rahman A et al (2006) Analysis of effects of connexin-mimetic peptides in rat mesenteric small arteries. Am J Physiol Heart Circ Physiol 291(1):H357-H367
81. Mendoza-Naranjo A, Bouma G et al (2011) Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation. J Immunol 187(6):3121-3132
82. Myllykoski M, Kuczera K et al (2009) Complex formation between calmodulin and a peptide from the intracellular loop of the gap junction protein connexin43: molecular conformation and energetics of binding. Biophys Chem 144(3):130-135
83. O'Carroll SJ, Alkadhi M et al (2008) Connexin43 mimetic peptides reduce swelling, astrogliosis, and neuronal cell death after spinal cord injury. Cell Commun Adhes 15(1):27-42
84. O'Quinn MP, Palatinus JA et al (2011) A peptide mimetic of the connexin43 carboxyl terminus reduces gap junction remodeling and induced arrhythmia following ventricular injury. Circ Res 108(6):704-715
85. Orellana JA, Froger N et al (2011) ATP and glutamate released via astroglial connexin43 hemichannels mediate neuronal death through activation of pannexin1 hemichannels. J Neurochem 118(5):826-840
86. 2+ in tanycytes via ATP released through connexin43 hemichannels. Glia 60(1):53-68
87. Orellana JA, Sanchez HA et al (2012b) Regulation of intercellular calcium signaling through calcium interactions with connexin-based channels. Adv Exp Med Biol 740:777-794
88. Oshima A, Tani K et al (2011) Asymmetric configurations and N-terminal rearrangements in connexin26 gap junction channels. J Mol Biol 405(3):724-735
89. Oviedo-Orta E, Gasque P et al (2001) Immunoglobulin and cytokine expression in mixed lymphocyte cultures is reduced by disruption of gap junction intercellular communication. FASEB J 15(3):768-774
90. Oviedo-Orta E, Errington RJ et al (2002) Gap junction intercellular communication during lymphocyte transendothelial migration. Cell Biol Int 26(3):253-263
91. Oviedo-Orta E, Perreau M et al (2010) Control of the proliferation of activated CD4+ T cells by connexins. J Leukoc Biol 88(1):79-86
92. Paemeleire K, Martin PE et al (2000) Intercellular calcium waves in HeLa cells expressing GFP-labeled connexin43, 32, or 26. Mol Biol Cell 11(5):1815-1827
93. Palatinus JA, Rhett JM et al (2011) The connexin43 carboxyl terminus and cardiac gap junction organization. Biochim Bio-phys Acta 1818(8):1831-1843
94. 2+-dependent proinflammatory responses in lung capillaries. J Clin Invest 116(8):2193-2200
95. Pearson RA, Dale N et al (2005) ATP released via gap junction hemichannels from the pigment epithelium regulates neural retinal progenitor proliferation. Neuron 46(5):731-744
96. Pollok S, Pfeiffer AC et al (2011) Connexin43 mimetic peptide Gap27 reveals potential differences in the role of Cx43 in wound repair between diabetic and non-diabetic cells. J Cell Mol Med 15(4):861-873
97. Ponsaerts R, De Vuyst E et al (2010) Intramolecular loop/tail interactions are essential for connexin43-hemichannel activity. FASEB J 24(11):4378-4395
98. Ponsaerts R, Wang N et al (2012) The contractile system as a negative regulator of the connexin43 hemichannel. Biol Cell 104(7): 367-377
99. Rahman S, Carlile G et al (1993) Assembly of hepatic gap junctions. Topography and distribution of connexin32 in intracellular and plasma membranes determined using sequence-specific antibodies. J Biol Chem 268(2):1260-1265
100. Retamal MA, Cortes CJ et al (2006) S-Nitrosylation and permeation through connexin43 hemichannels in astrocytes: induction by oxidant stress and reversal by reducing agents. Proc Natl Acad Sci USA 103(12):4475-4480
101. Rhett JM, Gourdie RG (2012) The perinexus: a new feature of Cx43 gap junction organization. Heart Rhythm 9(4):619-623
102. + T cells. J Allergy Clin Immunol 125(1):237-246
103. Robertson J, Lang S et al (2010) Peptidoglycan derived from Staphylococcus epidermidis induces connexin43 hemichannel activity with consequences on the innate immune response in endothelial cells. Biochem J 432(1):133-143
104. + channels. Proc Natl Acad Sci USA 109(5):E242-E251
105. Saez JC, Retamal MA et al (2005) Connexin-based gap junction hemichannels: gating mechanisms. Biochim Biophys Acta 1711 (2):215-224
106. Saez JC, Schalper KA et al (2010) Cell membrane permeabilization via connexin hemichannels in living and dying cells. Exp Cell Res 316(15):2377-2389
107. Samoilova M, Wentlandt K et al (2008) Connexin43 mimetic peptides inhibit spontaneous epileptiform activity in organotypic hippo-campal slice cultures. Exp Neurol 210(2):762-775
108. Sarieddine MZ, Scheckenbach KE et al (2009) Connexin43 modulates neutrophil recruitment to the lung. J Cell Mol Med 13(11-12):4560-4570
109. Sato PY, Coombs W et al (2011) Interactions between ankyrin-G, plakophilin-2, and connexin43 at the cardiac intercalated disc. Circ Res 109(2):193-201
110. Scemes E, Spray DC et al (2009) Connexins, pannexins, innexins: novel roles of "hemi-channels". Pflugers Arch 457(6):1207-1226
111. Schalper KA, Riquelme MA et al (2012) Modulation of gap junction channels and hemichannels by growth factors. Mol Biosyst 8(3):685-698
112. Scott CA, Kelsell DP (2011) Key functions for gap junctions in skin and hearing. Biochem J 438(2):245-254
113. Shibayama J, Lewandowski R et al (2006) Identification of a novel peptide that interferes with the chemical regulation of connex-in43. Circ Res 98(11):1365-1372
114. Shintani-Ishida K, Uemura K et al (2007) Hemichannels in cardio-myocytes open transiently during ischemia and contribute to reperfusion injury following brief ischemia. Am J Physiol Heart Circ Physiol 293(3):H1714-H1720
115. Solan JL, Lampe PD (2009) Connexin43 phosphorylation: structural changes and biological effects. Biochem J 419(2):261-272
116. Sood A, Salih S et al (2011) Signalling of DNA damage and cytokines across cell barriers exposed to nanoparticles depends on barrier thickness. Nat Nanotechnol 6(12):824-833
117. Sosinsky GE, Nicholson BJ (2005) Structural organization of gap junction channels. Biochim Biophys Acta 1711(2):99-125
118. Sosinsky GE, Solan JL et al (2007) The C-terminus of connexin43 adopts different conformations in the Golgi and gap junction as detected with structure-specific antibodies. Biochem J 408(3): 375-385
119. Spray DC, Ye ZC et al (2006) Functional connexin "hemichannels" : a critical appraisal. Glia 54(7):758-773
120. Srisakuldee W, Jeyaraman MM et al (2009) Phosphorylation of connexin-43 at serine 262 promotes a cardiac injury-resistant state. Cardiovasc Res 83(4):672-681
121. Stehberg J, Moraga-Amaro R, Salazar C, Becerra A, Echeverría C, Orellana JA, Bultynck G, Ponsaerts R, Leybaert L, Simon F, Sáez JC, Retamal MA (2012) Release of gliotransmitters through astroglial connexin 43 hemichannels is necessary for fear memory consolidation in the basolateral amygdala. FASEB J. doi:10.1096/fj.11-198416
122. Stong BC, Chang Q et al (2006) A novel mechanism for connexin26 mutation linked deafness: cell death caused by leaky gap junction hemichannels. Laryngoscope 116(12):2205-2210
123. Sun JD, Liu Y et al (2012) Gap junction dysfunction in the prefrontal cortex induces depressive-like behaviors in rats. Neuropsycho-pharmacology 37(5):1305-1320
124. Thimm J, Mechler A et al (2005) Calcium-dependent open/closed conformations and interfacial energy maps of reconstituted hemichannels. J Biol Chem 280(11):10646-10654
125. Vaiyapuri S, Jones CI et al (2012) Gap junctions and connexin hemichannels underpin hemostasis and thrombosis. Circulation 125(20):2479-2491
126. Verma V, Larsen BD et al (2009a) Novel pharmacophores of connexin43 based on the "RXP" series of Cx43-binding peptides. Circ Res 105(2):176-184
127. Verma V, Hallett MB et al (2009b) Perturbing plasma membrane hemichannels attenuates calcium signalling in cardiac cells and HeLa cells expressing connexins. Eur J Cell Biol 88(2):79-90
128. Wang J, Ma M et al (2007) "Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters. Am J Physiol Cell Physiol 293(3):C1112-C1119
129. Warner A, Clements DK et al (1995) Specific motifs in the external loops of connexin proteins can determine gap junction formation between chick heart myocytes. J Physiol 488(Pt 3):721-728
130. Wright CS, van Steensel MA et al (2009) Connexin mimetic peptides improve cell migration rates of human epidermal keratinocytes and dermal fibroblasts in vitro. Wound Repair Regen 17(2):240-249
131. Wright CS, Pollok S et al (2012a) The connexin mimetic peptide Gap27 increases human dermal fibroblast migration in hyper-glycemic and hyperinsulinemic conditions in vitro. J Cell Physiol 227(1):77-87
132. Wright JA, Richards T, Becker DL (2012b) Connexins and diabetes. Cardiol Res Pract 2012:496904
133. Xing D, Kjolbye AL et al (2003) ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs. J Cardiovasc Electrophysiol 14(5):510-520
134. Yang J, Darley RL et al (2009) Low connexin channel-dependent intercellular communication in human adult hematopoietic progenitor/stem cells: probing mechanisms of autologous stem cell therapy. Cell Commun Adhes 16(5-6):138-145
135. Yoon JJ, Green CR et al (2010) Dose-dependent protective effect of connexin43 mimetic peptide against neurodegeneration in an ex vivo model of epileptiform lesion. Epilepsy Res 92(2-3):153-162
136. Zhou Y, Yang W et al (2007) Identification of the calmodulin binding domain of connexin 43. J Biol Chem 282(48):35005-35017
137. Zimmer DB, Green CR et al (1987) Topological analysis of the major protein in isolated intact rat liver gap junctions and gap junction -derived single membrane structures. J Biol Chem 262 (16):7751-7763