Connexin45 is the first connexin to be expressed in the central conduction system of the mouse heart

Experimental and Clinical Cardiology

Volumn 6, Issue 1, 2001, Pages 17-23

  Coppen, S R ^a   Gourdie, R G ^a   Severs, N J ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Conduction system; Connexin45; Development; Gap junction; Mouse

Indexed keywords

CONNEXIN 40; CONNEXIN 43; CONNEXIN 45;

ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CONFOCAL MICROSCOPY; DEVELOPMENT; GAP JUNCTION; HEART; HEART ATRIUM SEPTUM; HEART MUSCLE; HEART MUSCLE CONDUCTION SYSTEM; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

EID: 0035045165     PISSN: 12056626     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Connexins, connexons, and intercellular communication
2. Role of connexin genes in growth control
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4. Connexins in mammalian heart function
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6. Immunocytochemical analysis of connexin expression in the healthy and diseased cardiovascular system
7. Size and selectivity of gap junction channels formed from different connexins
8. Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart
9. Connexin45, a major connexin of the rabbit sinoatrial node, is co-expressed with connexin43 in a restricted zone at the nodal-crista terminalis border
10. Connexin45 (α6) expression delineates an extended conduction system in the embryonic and mature rodent heart
11. The spatial distribution and relative abundance of gap-junctional connexin40 and connexin43 correlate to functional properties of the cardiac atrioventricular conduction system
12. Restricted distribution of connexin40, a gap junctional protein, in mammalian heart
13. Developmental changes of connexin40 and connexin43 messenger RNA
14. Developmental regulation of connexin 40 gene expression in mouse heart correlates with the differentiation of the conduction system
15. Gap junctions and heart development
16. Downregulation of connexin 45 gene products during mouse heart development
17. Regional differentiation of desmin, connexin43 and connexin45 expression patterns in rat aortic smooth muscle
18. Spatial distribution of "tissue-specific" antigens in the developing human heart and skeletal muscle. III. An immunohistochemical analysis of the distribution of the neural tissue antigen G1N2 in the embryonic heart; implications for the development of the atrioventricular conduction system
19. Conducting the embryonic heart: Orchestrating development of specialized cardiac tissues
20. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice
21. Mice lacking connexin40 have cardiac conduction abnormalities characteristics of atrioventricular block and bundle branch block
22. Loss of connexin45 causes a cushion defect in early cardiogenesis