Cardiac ischemia and uncoupling: Gap junctions in ischemia and infarction

Advances in Cardiology

Volumn 42, Issue , 2006, Pages 198-212

  Dhein, Stefan ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; CELL COMMUNICATION; CELL JUNCTION; HEART; HEART INFARCTION; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; HEART MUSCLE ISCHEMIA; HEART VENTRICLE REMODELING; HUMAN; PATHOPHYSIOLOGY; PHYSIOLOGY; REVIEW;

ANIMALS; CELL COMMUNICATION; GAP JUNCTIONS; HEART; HEART CONDUCTION SYSTEM; HUMANS; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCYTES, CARDIAC; VENTRICULAR REMODELING;

EID: 33744455507     PISSN: 00652326     EISSN: None     Source Type: Book Series    
DOI: 10.1159/000092570     Document Type: Review

References (55)

1. Noma A, Tsuboi N: Dependence of junctional conductance on proton, calcium and magnesium ions in cardiac paired cells of guinea pig. J Physiol 1987;382:193-211.
2. Rüdisüli A, Weingart R: Electrical properties of gap junction channels in guinea pig ventricular cell pairs revealed by exposure to heptanol. Pflügers Arch 1989;415:12-21.
3. i on nexal membrane resistance. Pflügers Arch 1987;409:394-402.
4. Firek L, Weingart R: Modification of gap junction conductance by divalent cations and protons in neonatal rat heart cells. J Mol Cell Cardiol 1995;27:1633-1643.
5. Ek JF, Delmar M, Perzova R, Taffet SM: Role of histidine 95 on pH gating of the cardiac gap junction protein connexin43. Circ Res 1994;74:1058-1064.
6. Hermans MMP, Kortekaas P, Jongsma HJ, Rook MB: pH sensitivity of the cardiac gap junction proteins, connexin45 and 43. Pflügers Arch 1995;431:138-140.
7. Liu S, Taffet S, Stoner L, Delmar M, Vallano ML, Jalife J: A structural basis for the unequal sensitivity of the major cardiac and liver gap junctions to intracellular acidification: the carboxy tail length. Biophys J 1993;64:1422-1433.
8. Morley GE, Taffet SM, Delmar M: Intramolecular interactions mediate pH regulation of connexin 43 channels. Biophys J 1996;70:1294-1302.
9. Wu J, McHowat J, Saffitz JE, Yamada KA, Corr PB: Inhibition of gap junctional conductance by long chain acylcarnitines and their preferential accumulation in junctional sarcolemma during hypoxia. Circ Res 1993;72:879-889.
10. DaTorre SD, Creer MH, Pogwizd SM, Corr PB: Amphipathic lipid metabolites and their relation to arrhythmogenesis in the ischemic heart. J Mol Cell Cardiol 1991;23(suppl 1):11-22.
11. Corr PB, Creer MH, Yamada KA, Saffitz JE, Sobel BE: Prophylaxis of early ventricular fibrillation by inhibition of acylcarnitine accumulation. J Clin Invest 1989;83:927-936.
12. Sugiura H, Toyama J, Tsuboi N, Kamiya K, Kodama I: ATP directly affects junctional conductance between paired ventricular myocytes isolated from guinea pig heart. Circ Res 1990;66:1095-1102.
13. Verrecchia F, Duthe F, Duval S, Duchatelle I, Sarrouilhe D, Hervé JC: ATP counteracts the run-down of gap junctional channels of rat ventricular myocytes by promoting protein phosphorylation. J Physiol 1999;516:447-459.
14. Garcia-Dorado D, Inserte J, Ruiz-Meana M, Gonzalez MA, Solares J, Julia M, Barrabes JA, Soler-Soler J: Gap junction uncoupler heptanol prevents cell-to-cell progression of hypercontracture and limits necrosis during myocardial reperfusion. Circulation 1997;96:3579-3586.
15. Kanno S, Kovacs A, Yamada KA, Saffitz JE: Connexin43 as a determinant of myocardial infarct size following coronary occlusion in mice. J Am Coll Cardiol 2003;41:681-686.
16. Yasui K, Kada K, Hojo M, Lee JK, Kamiya K, Toyama J, Opthof T, Kodama I: Cell-to-cell interaction prevents cell death in cultured neonatal rat ventricular myocytes. Cardiovasc Res 2000;48:68-76.
17. Li G, Whittaker P, Yao M, Kloner RA, Przyklenk K: The gap junction uncoupler heptanol abrogates infarct size reduction with preconditioning in mouse hearts. Cardiovasc Pathol 2002;11:158-165.
18. Xing D, Kjolbye AL, Nielsen MS, Petersen JS, Harlow KW, Holstein-Rathlou NH, Martins JB: ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs. J Cardiovasc Electrophysiol 2003;14:510-520.
19. Grover R, Dhein S: Structure-activity relationships of novel peptides related to the antiarrhythmic peptide AAP10 which reduce the dispersion of epicardial action potential duration. Peptides 2001;22:1011-1021.
20. Buchanan JW Jr, Saito T, Gettes LS: The effect of antiarrhythmic drugs, stimulation frequency and potassium-induced resting membrane potential changes on conduction velocity and dV/dtmax in guinea pig myocardium. Circ Res 1985;56:696-703.
21. Kawara T, Derksen R, de Groot JR, Coronel R, Tasseron S, Linnenbank AC, Hauer RN, Kirkels H, Janse MJ, de Bakker JM: Activation delay after premature stimulation in chronically diseased human myocardium relates to the architecture of interstitial fibrosis. Circulation 2001;104:3069-3075.
22. Spach MS, Heidlage JF, Dolber PC, Barr RC: Electrophysiological effects of remodeling cardiac gap junctions and cell size: experimental and model studies of normal cardiac growth. Circ Res 2000;86:302-311.
23. Bedner P, Niessen H, Odermatt B, Willecke K, Harz H: A method to determine the relative cAMP permeability of connexin channels. Exp Cell Res 2003;291:25-35.
24. Dhein S: Gap junction channels in the cardiovascular system: pharmacological and physiological modulation. Trends Pharmacol Sci 1998;19:229-241.
25. Smith WT 4th, Fleet WF, Johnson TA, Engle CL, Cascio WE: The Ib phase of ventricular arrhythmias in ischemic in situ porcine heart is related to changes in cell-to-cell electrical coupling. Experimental Cardiology Group, University of North Carolina. Circulation 1995;92:3051-3060.
26. de Groot JR, Wilms-Schopman FJ, Opthof T, Remme CA, Coronel R: Late ventricular arrhythmias during acute regional ischemia in the isolated blood perfused pig heart. Role of electrical cellular coupling. Cardiovasc Res 2001;50:362-372.
27. 2+, intercellular electrical coupling and mechanical activity in ischemic rabbit papillary muscle. Effects of preconditioning and metabolic blockade. Circ Res 1996;79:237-246.
28. Müller A, Gottwald M, Tudyka T, Linke W, Klaus W, Dhein S: Increase in gap junction conductance by an antiarrhythmic peptide. Eur J Pharmacol 1997;327:65-72.
29. Dhein S, Müller A, Gerwin R, Klaus W: Comparative study on the proarrhythmic effects of some antiarrhythmic agents. Circulation 1993;87:617-630.
30. Dhein S: Epicardial mapping in isolated hearts. Use in safety pharmacology, analysis of torsade de pointes arrhythmia, and ischemia-reperfusion-related arrhythmia; in Dhein S, Mohr FW, Delmar M (eds): Practical Methods in Cardiovascular Research. Heidelberg, Springer, 2005, pp 248-263.
31. Durrer D, Van der Tweel LH: Spread of activation in the left ventricular wall of the dog. Activation conditions at the epicardial surface. Am Heart J 1954;47:192-203.
32. Burt JM, Massey KD, Minnich BN: Uncoupling of cardiac cells by fatty acids: structure-activity relationships. Am J Physiol 1991;260:C439-C448.
33. Dhein S, Krüsemann K, Schaefer T: Effects of the gap junction uncoupler palmitoleic acid on activation and repolarization pattern in isolated rabbit hearts. A mapping study. Br J Pharmacol 1999;128:1375-1384.
34. Delmar M, Michaels DC, Johnson T, Jalife J: Effects of increasing intercellular resistance on transverse and longitudinal propagation in sheep epicardial muscle. Circ Res 1987;60: 780-785.
35. Müller A, Klaus W, Dhein S: Heterogeneously distributed sensitivities to potassium as a cause of hypokalemic arrhythmias in isolated rabbit hearts. J Cardiovasc Electrophysiol 1991;2: 145-155.
36. Jongsma HJ, Wilders R: Gap junctions in cardiovascular disease. Circ Res 2000;86:1193-1197.
37. Morley GE, Vaidya D, Samie FH, Lo C, Delmar M, Jalife J: Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mapping. J Cardiovasc Electrophysiol 1999;10:1361-1375.
38. Lerner DL, Yamada KA, Schuessler RB, Saffitz JE: Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice. Circulation 2000;101:547-552.
39. Thomas SP, Kucera JP, Bircher-Lehmann L, Rudy Y, Saffitz JE, Kleber AG: Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43. Circ Res 2003;92:1209-1216.
40. De Groot JR, Schumacher CA, Verkerk AO, Baartscheer A, Fiolet JWT, Coronel R: Intrinsic heterogeneity in repolarization is increased in isolated failing rabbit cardiomyocytes during simulated ischemia. Cardiovasc Res 2003;59:705-714.
41. Dhein S, Manicone N, Müller A, Gerwin R, Ziskoven U, Irankhahi A, Minke C, Klaus W: A new synthetic antiarrhythmic peptide reduces dispersion of epicardial activation recovery interval diminishes alterations of epicardial activation patterns induced by regional ischemia. A mapping study. Naunyn Schmiedebergs Arch Pharmacol 1994;350:174-184.
42. Dhein S, Weng S, Grover R, Tudyka T, Gottwald M, Schaefer T, Polontchouk L: Protein kinase Cα mediates the effect of antiarrhythmic peptide on gap junction conductance. Cell Commun Adhes 2001;8:257-264.
43. Shaw RM, Rudy Y: Electrophysiologic effects of acute myocardial ischemia. A mechanistic investigation of action potential conduction and conduction failure. Circ Res 1997;80:124-138.
44. Shaw RM, Rudy Y: Ionic mechanisms of propagation in cardiac tissue: roles of the sodium and L-type calcium currents during reduced excitability and decreased gap-junction coupling. Circ Res 1997;81:727-741.
45. Rohr S, Kucera JP, Fast VG, Kleber AG: Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling. Science 1997;275:841-844.
46. Doble BW, Kardami E: Basic fibroblast growth factor stimulates connexin-43 expression and intercellular communication of cardiac fibroblasts. Mol Cell Biochem 1995;143:81-87.
47. Doble BW, Chen Y, Bose DG, Litchfield DW, Kardami E: Fibroblast growth factor-2 decreases metabolic coupling and stimulates phosphorylation as well as masking of connexin43 epitopes in cardiac myocytes. Circ Res 1996;79:647-658.
48. Saffitz JE, Hoyt RH, Luke RA, Kanter HL, Beyer EC: Cardiac myocyte interconnections at gap junctions: role in normal and abnormal electrical conduction. Trends Cardiovasc Med 1992;2:56-60.
49. Dillon SM, Allessie MA, Ursell PC, Wit AL: Influences of anisotropic tissue structure on reentrant circuits in the epicardial border zone of subacute canine infarcts. Circ Res 1988;63:182-206.
50. Zeevi-Levin N, Barac YD, Reisner Y, Reiter I, Yaniv G, Meiry G, Abassi Z, Kostin S, Schaper J, Rosen MR, Resnick N, Binah O: Gap junctional remodeling by hypoxia in cultured neonatal rat ventricular myocytes. Cardiovasc Res 2005;66:64-73.
51. Severs NJ: Pathophysiology of gap junctions in heart disease. J Cardiovasc Electrophysiol 1994;5:462-475.
52. Spach MS, Dolber PC, Heidlage JF: Influence of the passive anisotropic properties on directional differences in propagation following modification of the sodium conductance in human atrial muscle. A model of reentry based on anisotropic discontinuous propagation. Circ Res 1988;62:811-832.
53. Ursell PC, Gardner PI, Albala A, Fenoglio JJ, Wit AL: Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing. Circ Res 1985;56:436-451.
54. Peters NS, Green CR, Poole-Wilson PA, Severs NJ: Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts. Circulation 1993;88:864-875.
55. Rohr S: Role of gap junctions in the propagation of the cardiac action potential. Cardiovasc Res 2004;62:309-322.