Cardiac connexins Cx43 and Cx45: Formation of diverse gap junction channels with diverse electrical properties

Pflugers Archiv European Journal of Physiology

Volumn 448, Issue 4, 2004, Pages 363-375

  Desplantez, Thomas ^a   Halliday, Deborah ^b   Dupont, Emmanuel ^b   Weingart, Robert ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Connexin43; Connexin45; Electrical properties; Heteromeric channels; Heterotypic channels

Indexed keywords

GAP JUNCTION PROTEIN;

ARTICLE; CONTROLLED STUDY; ELECTRICITY; GAP JUNCTION; GENETIC TRANSFECTION; HEART MUSCLE FIBER MEMBRANE; HUMAN; HUMAN CELL; KINETICS; MEMBRANE CURRENT; PRIORITY JOURNAL; STEADY STATE; VOLTAGE CLAMP;

EID: 3442896550     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00424-004-1250-0     Document Type: Article

References (37)

1. Bader P, Weingart R (2003) Conductive and kinetic properties of connexin45 hemichannels (abstract). Pflugers Arch 445:R69
2. Banach K, Weingart R (2000) Voltage gating of Cx43 gap junction channels involves fast and slow current transitions. Pflugers Arch 439:248-250
3. Barrio LC, Capel J, Jarillo JA, Castro C, Revilla A (1997) Species-specific voltage-gating properties of connexin-45 junctions expressed in Xenopus oocytes. Biophys J 73:757-769
4. Brink PR, Cronin K, Banach K, Peterson E, Westphale EM, Seul KH, Ramanan SV, Beyer EC (1997) Evidence for heteromeric gap junction channels formed from rat connexin43 and human connexin37. Am J Physiol 273:C1386-C1396
5. Bruzzone R, White WT, Paul DL (1996) Connection with connexins: the molecular basis of direct intercellular signaling. Eur J Biochem 138:1-27
6. Chen-Izu Y, Moreno AP, Spangler RA (2001) Opposing gates model for voltage gating of gap junction channels. Am J Physiol 281:C1604-C1613
7. Contreras JE, Saez JC, Bukauskas FF, Bennett MVL (2003) Gating and regulation of connexin 43 (Cx43) hemichannels. Proc Natl Acad Sci USA 100:11388-11393
8. Coppen SR, Kodama I, Boyett MR, Dobrzynski H, Takagishi Y, Honjo H, Yeh HI, Severs NJ (1999) Connexin45, a major connexin of the rabbit sinoatrial node, is co-expressed with connexin43 in a restricted zone at the nodal-crista terminalis border. J Histochem Cytochem 47:907-918
9. Cottrell GT, Wu Y, Burt JM (2002) Cx40 and Cx43 expression ratio influences heteromeric/heterotypic gap junction channel properties. Am J Physiol 282:C1469-C1482
10. Davis LM, Rodefeld ME, Green K, Beyer EC, Saffitz JE (1995) Gap junction protein phenotypes of the human heart and conduction system. J Cardiovasc Electrophysiol 6:813-822
11. Desplantez T, Weingart R (2003) Connexins Cx43 and Cx45: diversity of channels - diversity of electrical properties. In: Proceedings of the 2003 International Gap Junction Conference, Cambridge, UK, August 23-28, p 57
12. Elenes S, Martinez AD, Delmar M, Beyer EC, Moreno AP (2001) Heterotypic docking of Cx43 and Cx45 connexons blocks fast voltage gating of Cx43. Biophys J 81:1406-1418
13. Gros DB, Jongsma HJ (1996) Connexins in mammalian heart function. Bioessays 18:719-730
14. Halliday D, Dupont E, Coppen SR, Severs NJ (2003) Development of a cell model for functional and structural analysis of connexin co-expression: achieving homogeneous and inducible expression of multiple connexins in stable transfectants. Cell Commun Adhes 10:1-7
15. Harris AL (2001) Emerging issues of connexin channels: biophysics fills the gap. Q Rev Biophys 34:325-472
16. He DS, Jiang JX, Taffet SM, Burt JM (1999) Formation of heteromeric gap junction channels by connexins 40 and 43 in vascular smooth muscle cells. Proc Natl Acad Sci USA 96:6495-6500
17. Kanter HL, Laing JG, Beau SL, Beyer EC, Saffitz JE (1993) Distinct patterns of connexin expression in canine Purkinje fibers and ventricular muscle. Circ Res 72:1124-1131
18. Kanter HL, Laing JG, Beyer EC, Green KG, Saffitz JE (1993) Multiple connexins colocalize in canine ventricular myocyte gap junctions. Circ Res 73:344-350
19. Kistler J, Lin JS, Bond J, Green C, Eckert R, Merriman R, Tunstall M, Donaldson P (1999) Connexins in the lens: are they to blame in diabetic cataractogenesis? In: Gap junction-mediated intercellular signalling in health and disease (Novartis Foundation Symposium series, Vol. 219). Wiley, Chichester, pp 97-108
20. Kléber AG, Rudy Y (2004) Basic mechanisms of cardiac impulse propagation and associated arrhythmias. Physiol Rev 84:431-488
21. Lee MJ, Rhee SK (1998) Heteromeric gap junction channels in rat hepatocytes in which the expression of connexin26 is induced. Mol Cells 8:295-300
22. Moreno AP, Fishman GI, Beyer EC, Spray DC (1995) Voltage dependent gating and single channels analysis of heterotypic gap junction channels formed of Cx45 and Cx43. Progr Cell Res 4:405-408
23. Polontchouk, LD, Valiunas V, Haefliger J-A, Eppenberger HM, Weingart R (2002) Expression and regulation of connexins in cultured ventricular myocytes isolated from adult rat hearts. Pflugers Arch 443:676-689
24. Severs NJ (1999) Cardiovascular disease. In: Gap Junction-mediated intercellular signalling in health and disease (Novartis Foundation Symposium series, Vol. 219). Wiley, Chichester, pp 188-210
25. Steiner E, Ebihara L (1996) Functional characterization of canine connexin45. J Membr Biol 150:153-161
26. Trexler EB, Bennett, MVL, Bargiello TA, Verselis VK (1996) Voltage gating and permeation in a gap junction hemichannel. Proc Natl Acad Sci USA 93:5836-5841
27. Valiunas V (2002) Biophysical properties of connexin-45 gap junction hemichannels studied in vertebrate cells. J Gen Physiol 119:147-164
28. Valiunas V, Bukauskas FF, Weingart R (1997) Conductances and selective permeability of connexin43 gap junction channels examined in neonatal rat heart cells. Circ Res 80:708-719
29. Valiunas V, Manthey D, Vogel R, Willecke K, Weingart R (1999) Biophysical properties of mouse connexin30 gap junction channels studied in transfected human HeLa cells. J Physiol (Lond) 519:631-644
30. Valiunas V, Weingart R (2000) Electrical properties of gap junction hemichannels identified in transfected HeLa cells. Pflugers Arch 440:366-379
31. Valiunas V, Weingart R, Brink PR (2000) Formation of heterotypic gap junction channels by connexins 40 and 43. Circ Res 86:E42-E49
32. Valiunas V, Gemel J, Brink PR, Beyer EC (2001) Gap junction channels formed by coexpressed connexin40 and connexin43. Am J Physiol 281: H1675-H1689
33. Van Rijen HVM, Wilders R, Van Ginneken ACG, Jongsma HJ (1998) Quantitative analysis of dual whole-cell voltage-clamp determination of gap junctional conductance. Pflugers Arch 436:141-151
34. Van Veen AA, van Rijen HV, Opthof T (2001) Cardiac gap junction channels: modulation of expression and channel properties. Cardiovasc Res 51:217-229
35. Vogel R, Weingart R (1998) Mathematical model of vertebrate gap junctions derived from electrical measurements on homotypic and heterotypic channels. J Physiol (Lond) 510:177-189
36. Wang XG, Peracchia C (1998) Chemical gating of heteromeric and heterotypic gap junction channels. J Membr Biol 1998 162:169-176
37. Willecke K, Eiberger J, Degen J, Eckardt D, Romualdi A, Guldenagel M, Deutsch U, Sohl G (2002) Structural and functional diversity of connexin genes in the mouse and human genome. Biol Chem 383:725-737