Conduction disturbances and increased atrial vulnerability in connexin40-deficient mice analyzed by transesophageal stimulation

Circulation

Volumn 99, Issue 11, 1999, Pages 1508-1515

  Hagendorff, Andreas ^a   Schumacher, Burghard ^b   Kirchhoff, Susanne ^b   Lüderitz, Berndt ^b   Willecke, Klaus ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b NONE

Author keywords

Arrhythmia; Atrium; Conduction; Electrophysiology; Proteins

Indexed keywords

BROMETHOL; CONNEXIN 40; GAP JUNCTION PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATRIOVENTRICULAR CONDUCTION; CONTROLLED STUDY; FEMALE; HEART ATRIUM ARRHYTHMIA; HEART ATRIUM CONDUCTION; HEART ATRIUM PACING; HEART MUSCLE CONDUCTION DISTURBANCE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINUS NODE; WENCKEBACH PERIOD;

EID: 0033596919     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.99.11.1508     Document Type: Article

References (36)

1. Kumar NM, Gilula NB. The gap junction communication channel. Cell. 1996;84:381-388.
2. Goodenough DA, Goliger JA, Paul DL. Connexins, connexons, and intercellular communication. Ann Rev Biochem. 1996;65:475-502.
3. Elfgang C, Eckert R, Lichtenberg-Frate H, Butterweck A, Traub O, Klein RA, Hülser DF, Willecke K. Specific permeability and selective formation of gap junctional channels in connexin-transfected HeLa cells. J Cell Biol. 1995;129:805-817.
4. Veenstra RD, Wang HZ, Beblo DA, Chilton MG, Harris AL, Beyer EC, Brink PR. Selectivity of connexin-specific gap junctions does not correlate with channel conductance. Circ Res. 1995;77:1156-1165.
5. Gros D, Jongsma HJ. Connexins in mammalian heart function. Bioessays. 1996;18:719-730.
6. Van Kempen MA, Ten Velde I, Wessels A, Oosthoek PW, Gros D, Jongsma H, Moorman A, Lamers WH. Differential connexin distribution accommodates cardiac function in different species. Microsc Res Tech. 1995;31:420-436.
7. Van Kempen MA, Fromaget C, Gros D, Moorman A, Lamers W. Spatial distribution of connexin43, the major cardiac gap junction protein, in the developing and adult rat heart. Circ Res. 1991;68:1638-1651.
8. Gourdie R, Green C, Severs N, Thompson R. Immunolabeling patterns of gap junctional connexins in the developing and mature rat heart. Anat Embryol. 1992;185:363-378.
9. Delorme B, Dahl E, Jarry-Guichard T, Marics I, Briand JP, Willecke K, Gros D, Theveniau-Ruissy M. Developmental regulation of connexin40 gene expression in mouse heart correlates with the differentiation of the conduction system. Dev Dyn. 1995;204:358-371.
10. Kwong KF, Schuessler RB, Green KG, Laing JG, Beyer EC, Boineau JP, Saffitz JE. Differential expression of gap junction proteins in the canine sinus node. Circ Res. 1998;82:604-612.
11. Severs NJ. Pathophysiology of gap junctions in heart disease. J Cardiovasc Electrophysiol. 1994;5:462-475.
12. Severs NJ. Gap junction alterations in the failing heart. Eur Heart J. 1994;15(suppl D):53-57.
13. Guerrero PA, Schuessler RB, Davis LM, Beyer EC, Johnson CM, Yamada KA, Saffitz JE. Slow ventricular conduction in mice heterozygous for a connexin43 null mutation. J Clin Invest. 1997;99: 1991-1998.
14. Thomas SA, Schuessler RB, Berul CI, Beardslee MA, Beyer EC, Mendelsohn ME, Saffitz JE. Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction. Circulanon. 1998;97: 686-691.
15. Kirchhoff S, Nelles E, Hagendorff A, Krüger O, Traub O, Willecke K. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice. Curr Biol. 1998;8:299-302.
16. Simon AM, Goodenough DA, Paul DL. Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block. Curr Biol. 1998;8:295-298.
17. Saffitz JE, Davis LM, Darrow BJ, Kanter HL, Laing JG, Beyer EC. The molecular basis of anisotropy: role of gap junctions. J Cardiovasc Electrophysiol. 1995;6:498-510.
18. Peters NS, Green CR, Poole-Wilson PA, Severs NJ. Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts. Circulation. 1993;88:864-875.
19. Peters NS, Coromilas J, Severs NJ, Wit AL. Disturbed connexin43 gap junction distribution correlates with the location of reentrant circuits in the epicardial border zone of healing canine infarcts that cause ventricular tachycardia. Circulation. 1997;95:988-996.
20. Saffitz JE, Kanter LH, Green KG, Toley TK, Beyer EC. Tissue-specific determinants of anisotropic conduction velocity in canine atrial and ventricular myocardium. Circ Res. 1994;74:1065-1070.
21. Anumonwo JMB, Wang HZ, Trabka-Janik E, Dunham B. Gap junctional channels in adult mammalian sinus nodal cells: immunolocalization and electrophysiology. Circ Res. 1992;72:229-239.
22. Trabka-Janik E, Coombs W, Lemanski LF, Delmar M, Jalife J. Immunohistochemical localization of gap junction protein channels in hamster sinoatrial node in correlation with electrophysiologic mapping of the pacemaker region. J Cardiovasc Electrophysiol. 1994;5:125-137.
23. Opthof T. Gap junctions in the sinoatrial node: immunohistochemical localization and correlation with activation pattern. J Cardiovasc Electrophysiol. 1994;5:138-143.
24. Gourdie RG, Green CR, Severs NJ, Anderson RH, Thompson RP. Evidence for a distinct gap-junctional phenotype in ventricular conduction tissue of the developing and mature avian heart. Circ Res. 1993; 72:278-289.
25. Kanter HL, Laing JG, Beau SL, Beyer EC, Saffitz JE. Distinct patterns of connexin expression in canine Purkinje fibers and ventricular muscle. Circ Res. 1993;72:1124-1131.
26. Gros D, Jarry-Guichard T, TenVelde I, deMaziere A, vanKempen MJ, Davoust J, Briand JP, Moorman AF, Jongsma HJ. Restricted distribution of connexin40, a gap junctional protein, in mammalian heart. Circ Res. 1994;74:839-851.
27. Luke RA, Saffitz JE. Remodeling of ventricular conduction pathways in healed canine infarct border zones. J Clin Invest. 1991;87:1594-1602.
28. Ursell PC, Gardner PI, Albala A, Fenoglio JJ, Wit AL. Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing. Circ Res. 1985;56:436-451.
29. Dillon SM, Allessie MA, Ursell PC, Wit AL. Influences of anisotropic tissue structure on reentrant circuits in the epicardial border zone of subacute canine infarcts. Circ Res. 1988;63:182-206.
30. Spach MS, Dolber PC, Heidlage JF. Influence of the passive anisotropic properties on directional differences in propagation following modification of the sodium conductance in human atrial muscle: a model of reentry based on anisotropic discontinuous propagation. Circ Res. 1988; 62:811-832.
31. Janse MJ, Witt AL. Electrophysiological mechanisms of ventricular arrhythmias resulting from myocardial ischemia and infarction. Physiol Rev. 1989;69:1049-1069.
32. Bruzzone R, Haefliger J-A, Gimlich RL, Paul DL. Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins. Mol Biol Cell. 1993;4:7-19.
33. Davis LM, Kanter LH, Beyer EC, Saffitz JE. Distinct gap junction protein phenotypes in cardiac tissues with disparate conduction system. J Am Coll Cardiol. 1994;24:1124-1132.
34. Hoyt RH, Cohen ML, Saffitz JE. Distribution and 3-dimensional structure of intercellular junctions in canine myocardium. Circ Res. 1989;64: 563-574.
35. de Bakker MJT, van Capelle FJL, Janse MJ, Tasseron S, Vermeulen JT, de Jonge N, Lahpor JR. Slow conduction in the infarcted human heart: "zigzag" course of activation. Circulation. 1992;86:426-430.
36. Berul CI, Aronovitz, MJ, Wang PJ, Mendelsohn ME. In vivo cardiac electrophysiology studies in the mouse. Circulation. 1996;94:2641-2648.