High resolution optical mapping reveals conduction slowing in connexin43 deficient mice

Cardiovascular Research

Volumn 51, Issue 4, 2001, Pages 681-690

  Eloff, Benjamin C ^a   Lerner, Deborah L ^b   Yamada, Kathryn A ^b   Schuessler, Richard B ^b   Saffitz, Jeffrey E ^b   Rosenbaum, David S ^a  

^a Case Western Reserve University   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell communication; Gap junctions; Gene expression; Mapping

Indexed keywords

CONNEXIN 43;

ALLELE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRODE; EPICARDIUM MAPPING; GENOTYPE; HEART MUSCLE; HEART MUSCLE POTENTIAL; HEART VENTRICLE CONDUCTION; ISOLATED HEART; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; TRANSGENIC MOUSE;

ACTION POTENTIALS; ANALYSIS OF VARIANCE; ANIMALS; CONNEXIN 43; IMMUNOBLOTTING; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MICROSCOPY, FLUORESCENCE; MYOCARDIUM; PERFUSION; PURKINJE FIBERS; VIDEO RECORDING;

EID: 0034877413     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00341-8     Document Type: Article

References (39)

1. Three-dimensional structure of the gap junction connexon
2. Gap junctional conductance is a simple and sensitive function of intracellular pH
3. The discontinuous nature of propagation in normal canine cardiac muscle
4. The relation between discontinuous propagation in anisotropic cardiac muscle and the 'vulnerable period' of reentry
5. Unidirectional block and reentry of cardiac excitation: A model study
6. Ionic mechanisms of propagation in cardiac tissue - Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling
7. Slow conduction in cardiac tissue. I: Effects of a reduction of excitability versus a reduction of electrical coupling on microconduction
8. Slow conduction in cardiac tissue. II: Effects of branching tissue geometry
9. Spatiotemporal relation between gap junctions and fascia adherens junctions during postnatal development of human ventricular myocardium
10. Mice lacking connexin40 have cardiac conduction abnormalities characteristic of atrioventricular block and bundle branch block
11. Electrical uncoupling and impulse propagation in isolated sheep purkinje fibers
12. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice
13. Rapid turnover of connexin43 in the adult rat heart
14. Heptanol-induced decrease in cardiac gap junctional conductance is mediated by a decrease in the fluidity of membranous cholesterol-rich domains
15. Gap junction uncoupling and discontinuous propagation in the heart. A comparison of experimental data with computer simulations
16. Block of sodium current by heptanol in voltage-clamped canine cardiac Purkinje cells
17. Mechanims of heptanol-induced uncoupling of cardiac gap junctions: A perforated patch-clamp study
18. Octanol, a gap junction uncoupling agent, changes intracellular [H+] in rat astrocytes
19. Cardiac malformation in neonatal mice lacking connexin43
20. Conduction slowing and sudden arrhythmic death in mice with cardiac-restricted inactivation of connexin43
21. Slow ventricular conduction in mice heterozygous for a connexin43 null mutation
22. + channel activity and connexin expression in Cx43-deficient cardiac myocytes
23. Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction - Evidence for chamber-specific molecular determinants of conduction
24. Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mapping
25. Unique properties of cardiac action potentials recorded with voltage-sensitive dyes
26. Modulation of ventricular repolarization by a premature stimulus: Role of epicardial dispersion of repolarization kinetics demonstrated by optical mapping of the intact guinea pig heart
27. A tandem-lens epifluorescence macroscope: Hundred-fold brightness advantage for wide-field imaging
28. Characterization of a slowly inactivating outward current in adult mouse ventricular myocytes
29. Electrocardiogram of the normal mouse, mus musculus: General considerations and genetic aspects
30. Optical mapping in a new guinea pig model of ventricular tachycardia reveals mechanisms for multiple wavelengths in a single reentrant circuit
31. Estimation of conduction velocity vector fields from epicardial mapping data
32. Analysis of the effects of changes in rate and rhythm upon electrical activity in the heart
33. Effects of diminished expression of connexin43 on gap junction number and size in ventricular myocardium
34. A model study of the effects of the discrete cellular structure on electrical propagation in cardiac tissue
35. Technical features of a C.C.D. video camera system to record cardiac fluorescence data
36. Current thresholds and liminal size in excitations of heart muscle
37. Acute voltage, charge, and energy thresholds as functions of electrode size for electrical stimulation of the canine heart
38. Connexins and impulse propagation in the mouse heart
39. Accelerated onset and increased incidence of ventricular arrhythmias induced by ischemia in Cx43-deficient mice