Junctional communication between isolated pairs of canine atrial cells is mediated by homogeneous and heterogeneous gap junction channels

Journal of Cardiovascular Electrophysiology

Volumn 10, Issue 7, 1999, Pages 990-1004

  Elenes, Sergio ^a   Rubart, Michael ^a   Moreno, Alonso P ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Heterotypic gap junction channels; Isolated atrial cells

Indexed keywords

GAP JUNCTION PROTEIN;

ANIMAL CELL; ARTICLE; CELL COMMUNICATION; CELL ISOLATION; CELL SUSPENSION; DOG; EXCITATION CONTRACTION COUPLING; GAP JUNCTION; HEART ATRIUM MUSCLE; HEART MUSCLE CELL; MEMBRANE CONDUCTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; VOLTAGE CLAMP;

EID: 0032992532     PISSN: 10453873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1540-8167.1999.tb01270.x     Document Type: Article

References (50)

1. 1. Bruzzone R, White TW, Paul DL: Connections with connexins: The molecular basis of direct intercellular signaling. Eur J Biochem 1996;238:1-27.
2. 2. Kumar NM, Gilula NB: The gap junction communication channel. Cell 1996;84:381-388.
3. 3. van der Velden HM, van Kempen MJ, Wijffels MC, et al: Altered pattern of connexin40 distribution in persistent atrial fibrillation in the goat. J Cardiovasc Electrophysiol 1998;9:596-607.
4. 4. Kanter HL, Saffitz JE, Beyer EC: Molecular cloning of two human cardiac gap junction proteins, connexin40, and connexin45. J Mol Cell Cardiol 1994;26:861-868.
5. 5. Gourdie RG, Green CR, Severs NJ, et al: Immunolabelling patterns of gap junction connexins in the developing and mature rat heart. Anat Embryol 1992;185:363-378.
6. 6. Gros DB, Jongsma HJ: Connexins in mammalian heart function. Bioessays 1996;18:719-730.
7. 7. Kanter HL, Laing JG, Beyer EC, et al: Distinct patterns of connexin expression in canine Purkinje fibers and ventricular muscle, Circ Res 1993;72:1124-1131.
8. 8. Gourdie RG, Severs NJ, Green CR, et al: The spatial distribution and relative abundance of gap junctional connexin40 and connexin43 correlate to functional properties of components of the cardiac atrioventricular conduction system. J Cell Sci 1998;105:985-991.
9. 9. Ionasescu V, Searby C, Ionasescu R, et al: New point mutations and deletions of the connexin 32 gene in X-linked Charcot-Marie-Tooth neuropathy. Neuromuscul Disord 1995;5:297-299.
10. 10. Kanter HL, Laing JG, Beyer EC, et al: Multiple connexins colocalize in canine cardiac myocyte gap junctions. Circ Res 1993;73:344-350.
11. 11. Coppen SR, Dupont E, Rothery S, et al: Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart. Circ Res 1998;82:232-243.
12. 12. Gros D, Jarry-Guichard T, Ten Velde I, et al: Restricted distribution of connexin40, a gap junctional protein, in mammalian heart. Circ Res 1994;74:839-851.
13. 13. Kwong KF, Schuessler RB, Green KG, et al: Differential expression of gap junction proteins in the canine sinus node. Circ Res 1998;82:604-612.
14. 14. Peters NS, Green CR, Poole-Wilson PA, et al: Reduced content of connexin43 gap junctions in ventricular myocardium from hypertrophied and ischemic human hearts. Circulation 1993;88:864-875.
15. 15. Wang XG, Peracchia C: Chemical gating of heteromeric and heterotypic gap junction channels. J Membr Biol 1998;162:169-176.
16. 16. Brink PR, Cronin K, Banach K, et al: Evidence for heteromeric gap junction channels formed from rat connexin43 and human connexin37. Am J Physiol 1997;273:C1386-C1396.
17. 17. Verheule S, van Kempen MJ, te Welscher PH, et al: Characterization of gap junction channels in adult rabbit atrial and ventricular myocardium. Circ Res 1997;80:673-681.
18. 18. Moreno AP, Rook MB, Fishman GI, et al: Gap junction channels: Distinct voltage-sensitive and -insensitive conductance states. Biophys J 1994;67:113-119.
19. 19. Moreno AP, Fishman GI, Spray DC: Phosphorylation shifts unitary conductance and modifies voltage dependent kinetics of human connexin43 gap junction channels. Biophys J 1992;62:51-53.
20. 20. Takens Kwak BR, Jongsma HJ: Cardiac gap junctions: Three distinct single channel conductances and their modulation by phosphorylating treatments. Pflügers Arch 1992;422:198-200.
21. 21. Beblo DA, Wang HZ, Beyer EC, et al: Unique conductance, gating, and selective permeability properties of gap junction channels formed by connexin40. Circ Res 1995;77:813-822.
22. 22. Rook MB, Jongsma HJ, de Jonge B: Single channel currents of homo- and heterologous gap junctions between cardiac fibroblasts and myocytes. Pflugers Arch 1989;414:95-98.
23. 23. Moreno AP, Saez JC, Fishman GI, et al: Human connexin43 gap junction channels. Regulation of unitary conductances by phosphorylation. Circ Res 1994;74:1050-1057.
24. 24. Moreno AP, Laing JG, Beyer EC, et al: Properties of gap junction channels formed of connexin45 endogenously expressed in human hepatoma (SKHep1) cells. Am J Physiol 1995;268:C356-C365.
25. 25. Bukauskas FF, Elfgang C, Willecke K, et al: Biophysical properties of gap junction channels formed by mouse connexin40 in induced pairs of transfected human HeLa cells. Biophys J 1995;68:2289-2298.
26. 26. Valiunas V, Bukauskas FF, Weingart R: Conductances and selective permeability of connexin43 gap junction channels examined in neonatal rat heart cells. Circ Res 1997;80:708-719.
27. 27. Traub O, Eckert R, Lichtenberg-Frate H, et al: Immunochemical and electrophysiological characterization of murine connexin40 and -43 in mouse tissues and transfected human cells. Eur J Cell Biol 1994;64:101-112.
28. 28. He DS, Burt JM: Function of gap junction channels formed in cells coexpressing connexins40 and 43. In Werner R, ed: Gap Junctions. IOS Press, Amsterdam, 1998. pp. 40-44.
29. 29. Elenes S, Moreno AP: Connexin45 and connexin43 form heteromeric connexons and preferentially heterotypic channels. (Abstract) Mol Biol Cell 1998;9:95A.
30. 30. Yue L, Feng J, Li GR, et al: Transient outward and delayed rectifier currents in canine atrium: Properties and role of isolation methods. Am J Physiol 1996;270:H2157-H2168.
31. 31. Fabiato A, Fabiato F: Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J Physiol Paris 1979;75:463-505.
32. 32. Graham FL, Eb AJ, van der: A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 1973;52;456-467.
33. 33. Veenstra RD, DeHaan RL: Measurement of single channel currents from cardiac gap junctions. Science 1986;233:972-974.
34. 34. White TW, Paul DL, Goodenough DA, et al: Functional analysis of selective interactions among rodent connexins. Mol Biol Cell 1995;6:459-470.
35. 35. Burt JM, Spray DC: Volatile anesthetics block intercellular communication between neonatal rat myocardial cells. Circ Res 1989;65:829-837.
36. 36. Moreno AP, Eghbali B, Spray DC: Connexin32 gap junction channels in stably transfected cells: Unitary conductance. Biophys J 1991;60:1254-1266.
37. 37. Burt JM, Spray DC: Single-channel events and gating behavior of the cardiac gap junction channel. Proc Natl Acad Sci U S A 1988;85:3431-3434.
38. 38. Moreno AP, Fishman GI, Beyer EC, et al: Voltage dependent gating and single channel analysis of heterotypic gap junction channels formed of connexin45 and connexin43. In Kanno Y, Kataoka K, Shiba Y, et al., eds: Intercellular Communication Through Gap Junctions. Elsevier Science B.V., Amsterdam, 1995, pp. 405-408.
39. 39. Howe JR: Homomeric and heteromeric ion channels formed from the kainate-type subunits GluR6 and KA2 have very small, but different, unitary conductances. J Neurophysiol 1996;76:510-519.
40. 40. Kwak BR, Hermans MM, De Jonge HR, et al: Differential regulation of distinct types of gap junction channels by similar phosphorylating conditions. Mol Biol Cell 1995;6:1707-1719.
41. 41. Kwak BR, Saez JC, Wilders R, et al: Effects of cGMP-dependent phosphorylation on rat and human connexin43 gap junction channels. Pflügers Archiv 1995;430:770-778.
42. 42. van Rijen H, Hermans M, Jongsma H, et al: Human connexin40 gap junction channels are modulated by cAMP. (Abstract) Int Gap Junction Conf 1998.
43. 43. Haubrich S, Schwarz HJ, Bukauskas F, et al: Incompatibility of connexin40 and connexin43: Hemichannels in gap junctions between mammalian cells is determined by intracellular domains. Mol Biol Cell 1996;7:1995-2006.
44. 44. Jiang JX, Goodenough DA: Heteromeric connexons in lens gap junction channels. Proc Natl Acad Sci U S A 1996;93:1287-1291.
45. 45. Po S, Roberds S, Snyders DJ, et al: Heteromultimeric assembly of human potassium channels molecular basis of a transient outward current? Circ Res 1993;72:1326-1336.
46. 46. Hermans MM, Kortekaus P, Jongsma HJ, et al: pH sensitivity of the cardiac gap junction proteins, connexin45 and connexin43. Pflügers Archiv 1995;431:138-140.
47. 47. Morley GE, Taffet SM, Delmar M: Intramolecular interactions mediate pH regulation of connexin43 channels. Biophys J 1996:70:1294-1302.
48. 48. Buehler LK, Stauffer KA, Gilula NB, et al: Single channel behavior of recombinant beta 2 gap junction connexons reconstituted into planar lipid bilayers. Biophys J 1995;68:1767-1775.
49. 49. Kwak BR, Jongsma HJ: Regulation of cardiac gap junction channel permeability and conductance by several phosphorylating conditions. Mol Cell Biochem 1996;157:93-99.
50. +-dependent protein kinases modulate connexin43 intercellular coupling through independent mechanisms. J Membr Biol 1999 (under review).