Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes

Journal of Molecular and Cellular Cardiology

Volumn 32, Issue 10, 2000, Pages 1859-1872

  Kondo, Richard P ^a   Wang, Sheng Yong ^a   John, Scott A ^a   Weiss, James N ^a   Goldhaber, Joshua I ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Connexins; Fluorescent dyes; Ion channels; Myocardial ischemia; Patch clamp techniques

Indexed keywords

GAP JUNCTION PROTEIN; ION CHANNEL;

ANIMAL CELL; ARTICLE; ELECTROPHYSIOLOGY; GENE OVEREXPRESSION; HEART ARRHYTHMIA; HEART INJURY; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; ION CURRENT; NONHUMAN; PATCH CLAMP; PATHOGENESIS; POTASSIUM TRANSPORT; PRIORITY JOURNAL; RABBIT; SODIUM TRANSPORT;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0033745550     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmcc.2000.1220     Document Type: Article

References (40)

1. Connexin-43 hemichannels opened by metabolic inhibition
2. Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells
3. Cell biology and protein composition of cardiac gap junctions
4. Excitation-contraction coupling in single guinea-pig ventricular myocytes exposed to hydrogen peroxide
5. Mechanisms of excitation-contraction coupling failure during metabolic inhibition in guinea-pig ventricular myocytes
6. + channels: Evidence for preferential regulation by glycolysis
7. Improved patch-clamp techniques for high-resolution current-recording from cells and cell-free membrane patches
8. Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells
9. Rapid determination of gap junction formation using HeLa cells microinjected with cDNAs encoding wild-type and chimeric connexins
10. Transfected connexin45 alters gap junction permeability in cells expressing endogenous connexin43
11. Gap junctional communication modulates gene expression in osteoblastic cells
12. Energy dependence of contraction band formation in perfused hearts and isolated adult myocytes
13. Calcium-activated non-selective cation channel in ventricular cells isolated from adult guinea-pig hearts
14. ATP-sensitive K channels and cellular K loss in hypoxic and ischaemic mammalian ventricle
15. Adenosine 5’-triphosphate-sensitive potassium channels
16. + loss during hypoxia, ischaemia and metabolic inhibition in mammalian ventricle
17. Oxygen-derived free radical stress activates nonselective cation current in guinea pig ventricular myocytes role of sulfhydryl groups
18. Unitary Cl channel activated by cytoplasmic Ca in canine ventricular myocytes
19. Properties of single outwardly-rectifying Cl channel in heart
20. Hemi-gap-junction channels in solitary horizontal cells of the catfish retina
21. Xenopus connexin38 forms hemi-gapjunctional channels in the nonjunctional plasma membrane of Xenopus oocytes
22. Evidence for hemigap junctional channels in isolated horizontal cells of the skate retina
23. Connexin46, a novel lens gap junction protein, induces voltage-gated currents in nonjunctional plasma membrane of Xenopus oocytes
24. Two main conductive states of connexin43 hemichannels detected in various cell types in culture
25. Monovalent ion selectivity sequences of the rat connexin43 gap junction channel
26. Description of a nonselective cation current in human atrium
27. Background current in sino-atrial node cells of the rabbit heart
28. Two ATP-activated conductances in bullfrog atrial cells
29. Novel cation-selective mechanosensitive ion channel in the atrial cell membrane
30. Stretch-activated ion channels in tissue-cultured chick heart
31. An ATP-activated nonselective cation channel in guinea pig ventricular myocytes
32. Connexins, connexons, and intercellular communication
33. Connexin45 expression is preferentially associated with the ventricular conduction system in mouse and rat heart
34. Rapid turnover of connexin43 in the adult rat heart
35. Morphology and metabolism of intact muscle cells isolated from adult rat heart
36. Dissociation of adult mammalian heart into single cell suspension: An ultrastructural study
37. Fate of gap junctions in isolated adult mammalian cardiomyocytes
38. 23Na-NMR measurements of intracellular sodium in intact perfused ferret hearts during ischemia and reperfusion
39. 2+ exchange
40. Mechanism of hypoxic K loss in rabbit ventricle