Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient mice

Circulation Research

Volumn 87, Issue 5, 2000, Pages 399-405

  Kirchhoff, Susanne ^a   Kim, Jung Sun ^b   Hagendorff, Andreas ^c   Thönnissen, Eva ^a   Krüger, Olaf ^a   Lamers, Wouter H ^b   Willecke, Klaus ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Conduction; Defects; Electrocardiography; Mice; Myocardium; Transgenic

Indexed keywords

CONNEXIN 40; CONNEXIN 43;

ANIMAL MODEL; ARTICLE; CONGENITAL HEART MALFORMATION; EMBRYO; HEART HYPERTROPHY; HEART MUSCLE CONDUCTION DISTURBANCE; HEART RIGHT VENTRICLE OUTFLOW TRACT; HEART VENTRICLE SEPTUM DEFECT; HETEROZYGOSITY; KNOCKOUT MOUSE; LETHALITY; MORPHOGENESIS; MOUSE; NONHUMAN; PATENT DUCTUS ARTERIOSUS; PRIORITY JOURNAL;

EID: 0034283421     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.87.5.399     Document Type: Article

References (23)

1. Connexins, connexons and intercellular communication
2. Cloning of a new gap junction gene (Cx36) highly expressed in mammalian brain neurons
3. The murine gap junction gene connexin36 is highly expressed in mouse retina and regulated during brain development
4. Molecular cloning and functional expression of the mouse gap junction gene connexin-57 in human HeLa cells
5. Connexin 43 and connexin 40 gap junctional proteins are present in arteriolar smooth muscle and endothelium in vivo
6. Spatial distribution of connexin43, the major cardiac gap junction protein, in the developing and adult rat heart
7. Immunolabelling patterns of gap junction connexins in the developing and mature heart
8. Developmental regulation of connexin40 gene expression in mouse heart correlates with the differentiation of the conduction system
9. Expression pattern of connexin gene products at the early developmental stages of the mouse cardiovascular system
10. Alteration in connexin 43 gap junction gene dosage impairs conotrucal heart development
11. Cardiac malformation in neonatal mice lacking connexin43
12. Heart defects in connexin43-deficient mice
13. Disparate effects of deficient expression of connexin43 on atrial and ventricular conduction
14. Characterization of conduction in the ventricles of normal and heterozygous Cx43 knockout mice using optical mapping
15. Reduced cardiac conduction velocity and predisposition to arrhythmias in connexin40-deficient mice
16. Mice lacking connexin40 have cardiac conduction abnormalities characteristics of atrioventricular block and bundle branch block
17. Cardiac conduction abnormalities in mice lacking the gap junction protein connexin40
18. Conduction disturbances and increased atrial vulnerability in connexin40 deficient mice analyzed by transesophageal stimulation
19. Doubly mutant mice, deficient in connexin32 and -43, show normal prenatal development of organs where the two gap junction proteins are expressed in the same cells
20. Spatial and temporal patterns of distribution of the gap junction protein connexin43 during mouse gastrulation and organogenesis
21. Down regulation of connexin45 gene products during mouse development
22. Mechanism of deficient septation in the mouse with trisomy 16
23. Cardiac morphology at late fetal stages in the mouse with trisomy 16: Consequences for different formation of the atrioventricular junction when compared to humans with trisomy 21