Reduced heterogeneous expression of Cx43 results in decreased Nav1.5 expression and reduced sodium current that accounts for arrhythmia vulnerability in conditional Cx43 knockout mice

Heart Rhythm

Volumn 9, Issue 4, 2012, Pages 600-607

  Jansen, John A ^a   Noorman, Maartje ^a,b   Musa, Hassan ^c   Stein, Mra ^a   De Jong, Sanne ^a   Van Der Nagel, Roel ^a   Hund, Thomas J ^d   Mohler, Peter J ^e   Vos, Marc A ^a   Van Veen, Toon A ^a   De Bakker, Jacques M ^b   Delmar, Mario ^f   Van Rijen, Harold V ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^d THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^e OHIO STATE UNIVERSITY   (United States)

^f NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arrhythmia; Cx43; Heterogeneity; Nav1.5; Sodium current

Indexed keywords

CONNEXIN 43; SODIUM CHANNEL NAV1.5; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; FIBROSIS; HEART CONDUCTION; HEART ELECTROPHYSIOLOGY; HEART MUSCLE REFRACTORY PERIOD; HEART PACING; HEART STIMULATION; HEART VENTRICLE TACHYCARDIA; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QRS COMPLEX; SODIUM TRANSPORT;

ANIMALS; ARRHYTHMIAS, CARDIAC; COLLAGEN; CONNEXIN 43; DISEASE MODELS, ANIMAL; FEMALE; FIBROSIS; MALE; MICE; MICE, KNOCKOUT; MUSCLE CELLS; RISK; SODIUM CHANNELS; TACHYCARDIA, VENTRICULAR;

EID: 84859312522     PISSN: 15475271     EISSN: 15563871     Source Type: Journal    
DOI: 10.1016/j.hrthm.2011.11.025     Document Type: Article

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